All Outputs (3111)

Proof of Concept Study for Designed Multiple Ligands Targeting the Dopamine D2, Serotonin 5-HT2A, and Muscarinic M1 Acetylcholine Receptors (2015)
Journal Article
Szabo, M., Lim, H. D., Klein Herenbrink, C., Christopoulos, A., Lane, J. R., & Capuano, B. (2015). Proof of Concept Study for Designed Multiple Ligands Targeting the Dopamine D2, Serotonin 5-HT2A, and Muscarinic M1 Acetylcholine Receptors. Journal of Medicinal Chemistry, 58(3), 1550-1555. https://doi.org/10.1021/jm5013243

Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors (2015)
Journal Article
Szabo, M., Lim, H. D., Herenbrink, C. K., Christopoulos, A., Lane, J. R., & Capuano, B. (2015). Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors. Journal of Medicinal Chemistry, 58(3), 1550-1555. https://doi.org/10.1021/jm5013243

Herein we describe the hybridization of a benzoxazinone M1 scaffold with D2 privileged structures derived from putative and clinically relevant antipsychotics to develop designed multiple ligands. The M1 mAChR is an attractive target for the cognitiv... Read More about Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors.

Organic semiconductors with a charge carrier life time of over 2 hours at room temperature (2015)
Journal Article

Recently, Gao et al. reported being able to measure significant quantities of photogenerated charge up to one hour after it had been generated in an organic semiconductor device. The aim of this paper is twofold; (a) to provide conclusive experimenta... Read More about Organic semiconductors with a charge carrier life time of over 2 hours at room temperature.

An international perspective II: a view from private international law (2015)
Book Chapter
Torremans, P. (2015). An international perspective II: a view from private international law. In J. Pila, & C. Wadlow (Eds.), The unitary EU patent system. Oxford: Hart Publishing

Inter-ply stitching optimisation of highly drapeable multi-ply preforms (2015)
Journal Article
Chen, S., Endruweit, A., Harper, L., & Warrior, N. (2015). Inter-ply stitching optimisation of highly drapeable multi-ply preforms. Composites Part A: Applied Science and Manufacturing, 71, https://doi.org/10.1016/j.compositesa.2015.01.016

An efficient finite element model has been developed in Abaqus/Explicit to solve highly non-linear fabric forming problems, using a non-orthogonal constitutive relation and membrane elements to model bi-axial fabrics. 1D cable-spring elements have be... Read More about Inter-ply stitching optimisation of highly drapeable multi-ply preforms.

Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity (2015)
Journal Article
Fisher, L. E., Hook, A. L., Ashraf, W., Yousef, A., Barrett, D. A., Scurr, D. J., …Bayston, R. (2015). Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity. Journal of Controlled Release, 202, 57-64. https://doi.org/10.1016/j.jconrel.2015.01.037

© 2015 Published by Elsevier B.V. Catheter-associated urinary tract infection (CAUTI) is the commonest hospital-acquired infection, accounting for over 100,000 hospital admissions within the USA annually. Biomaterials and processes intended to reduce... Read More about Biomaterial modification of urinary catheters with antimicrobials to give long-term broadspectrum antibiofilm activity.

A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers (2015)
Journal Article
Kilpatrick, L. E., Humphrys, L. J., & Holliday, N. D. (in press). A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers. Molecular Pharmacology, 87(4), https://doi.org/10.1124/mol.114.095356

The ability of G protein-coupled receptors (GPCRs) to form dimers, and particularly heterodimers, offers potential for targeted therapeutics with improved selectivity. However, studying dimer pharmacology is challenging, because of signaling cross-ta... Read More about A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers.

Human lectins and their roles in viral infections (2015)
Journal Article
Mason, C. P., & Tarr, A. W. (2015). Human lectins and their roles in viral infections. Molecules, 20(2), 2229-2271. https://doi.org/10.3390/molecules20022229

© 2015 by the authors; licensee MDPI. Innate recognition of virus proteins is an important component of the immune response to viral pathogens. A component of this immune recognition is the family of lectins; pattern recognition receptors (PRRs) that... Read More about Human lectins and their roles in viral infections.

Sub-terahertz amplification in a semiconductor superlattice with moving charge domains (2015)
Journal Article

We theoretically study the high-frequency response of charge domains traveling through a strongly coupled semiconductor superlattice with an applied harmonic electromagnetic signal. Our calculations show that the superlattice alone can amplify signal... Read More about Sub-terahertz amplification in a semiconductor superlattice with moving charge domains.

Work engagement and its association with occupational sitting time: results from the Stormont Study (2015)
Journal Article
Munir, F., Houdmont, J., Clemes, S., Wilson, K., Kerr, R., & Addley, K. (2015). Work engagement and its association with occupational sitting time: results from the Stormont Study. BMC Public Health, 15, Article 30. https://doi.org/10.1186/s12889-015-1427-9

The Eucharist: Origins and Contemporary Understandings (2015)
Book
O'Loughlin, T. (2015). The Eucharist: Origins and Contemporary Understandings. T. & T. Clark / Bloomsbury

Theological reflection upon the Eucharist is dominated by two paradigms: One approach interprets the Eucharist almost exclusively in theological terms, shaped by Scholasticism and the Reformation. Most discussions about the nature of the Eucharist, E... Read More about The Eucharist: Origins and Contemporary Understandings.

Less-tight versus tight control of hypertension in pregnancy (2015)
Journal Article
Magee, L. A., von Dadelszen, P., Rey, E., Ross, S., Asztalos, E., Murphy, K. E., Menzies, J., Sanchez, J., Singer, J., Gafni, A., Gruslin, A., Helewa, M., Hutton, E., Lee, S. K., Lee, T., Logan, A. G., Ganzevoort, W., Welch, R., Thornton, J., & Moutquin, J.-M. (2015). Less-tight versus tight control of hypertension in pregnancy. New England Journal of Medicine, 372(5), https://doi.org/10.1056/NEJMoa1404595

BACKGROUND
The effects of less-tight versus tight control of hypertension on pregnancy complications are unclear.
METHODS
We performed an open, international, multicenter trial involving women at 14 weeks 0 days to 33 weeks 6 days of gestation who... Read More about Less-tight versus tight control of hypertension in pregnancy.

IGM constraints from the SDSS-III/BOSS DR9 Lyα forest transmission probability distribution function (2015)
Journal Article
Lee, K. G., Lee, K.-G., Hennawi, J., Spergel, D. N., Weinberg, D. H., Hogg, D. W., …Yeche, C. (2015). IGM constraints from the SDSS-III/BOSS DR9 Lyα forest transmission probability distribution function. Astrophysical Journal, 799(2), 196. https://doi.org/10.1088/0004-637X/799/2/196

© 2015. The American Astronomical Society. All rights reserved. The Lyα forest transmission probability distribution function (PDF) is an established probe of the intergalactic medium (IGM) astrophysics, especially the temperature-density relationshi... Read More about IGM constraints from the SDSS-III/BOSS DR9 Lyα forest transmission probability distribution function.

A tale of two Londons: locating Shakespeare and Dickens in 2012 (2015)
Book Chapter
Kirwan, P., & Mathieson, C. (2015). A tale of two Londons: locating Shakespeare and Dickens in 2012. In P. Prescott, & E. Sullivan (Eds.), Shakespeare on the global stage: performance and festivity in the Olympic year. Bloomsbury

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (2015)
Journal Article
John, M., Cockcroft, J. R., McKeever, T. M., Coward, W. R., Shale, D. J., Johnson, S. R., …Bolton, C. E. (2015). Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease, 10(1), https://doi.org/10.2147/COPD.S76061

BACKGROUND:

There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the... Read More about Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial..

In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver (2015)
Journal Article
Drake, A. J., O'Shaughnessy, P. J., Bhattachyrya, S., Monteiro, A., Kerrigan, D., Goetz, S., …Fowler, P. A. (2015). In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver. BMC Medicine, 13, https://doi.org/10.1186/s12916-014-0251-x

Background: Maternal smoking is one of the most important modifiable risk factors for low birthweight, which is strongly associated with increased cardiometabolic disease risk in adulthood. Maternal smoking reduces the levels of the methyl donor vita... Read More about In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver.

Complex financial networks and systemic risk: a review (2015)
Book Chapter
Bougheas, S., & Kirman, A. (2015). Complex financial networks and systemic risk: a review. In P. Commendatore, S. Kayam, & I. Kubin (Eds.), Complexity and Geographical Economics: Topics and Tools. Springer International Publishing. https://doi.org/10.1007/978-3-319-12805-4_6

In this paper we review recent advances in financial economics in relation to the measurement of systemic risk. We start by reviewing studies that apply traditional measures of risk to financial institutions. However, the main focus of the review is... Read More about Complex financial networks and systemic risk: a review.

Theoretical study of M+ RG2: (M+= Ca, Sr, Ba and Ra; RG= He–Rn) (2015)
Journal Article
Andrejeva, A., Gardner, A. M., Graneek, J. B., Breckenridge, W., & Wright, T. G. (2015). Theoretical study of M+ RG2: (M+= Ca, Sr, Ba and Ra; RG= He–Rn). Journal of Physical Chemistry A, 119(23), https://doi.org/10.1021/jp511817g

Ab initio calculations were employed to investigate M+ RG2 species, where M+ = Ca, Sr, Ba and Ra and RG= He–Rn. Geometries have been optimized, and cuts through the potential energy surfaces containing each global minimum have been calculated at the... Read More about Theoretical study of M+ RG2: (M+= Ca, Sr, Ba and Ra; RG= He–Rn).

Comparing the accuracies of remote sensing global burned area products using stratified random sampling and estimation (2015)
Journal Article
Padilla, M., Stehman, S. V., Ramo, R., Corti, D., Hantson, S., Oliva, P., …Chuvieco, E. (2015). Comparing the accuracies of remote sensing global burned area products using stratified random sampling and estimation. Remote Sensing of Environment, 160, 114-121. https://doi.org/10.1016/j.rse.2015.01.005

© 2015 Elsevier Inc. The accuracies of six global burned area (BA) products for year 2008 were compared using the same validation methods and reference data to quantify accuracy of each product. The selected products include MCD64, MCD45 and Geoland2... Read More about Comparing the accuracies of remote sensing global burned area products using stratified random sampling and estimation.

The value relevance and information content of cash and stock dividends in China (2015)
Journal Article
Dedman, E., Jiang, W., & Stark, A. (2017). The value relevance and information content of cash and stock dividends in China. European Journal of Finance, 23(7-9), 648-673. https://doi.org/10.1080/1351847x.2014.996658

Due to their unique institutional features, the Chinese stock markets provide an interesting experimental setting in which to examine how cash and stock dividends convey value-relevant information about future performance and future cash dividends. A... Read More about The value relevance and information content of cash and stock dividends in China.