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The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments (2012)
Journal Article
Hirt, B. V., Wattis, J. A., Preston, S. P., & Laughton, C. A. (2012). The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments. Journal of Theoretical Biology, 295, https://doi.org/10.1016/j.jtbi.2011.10.038

The pentacyclic acridinium salt RHPS4 displays anti-tumour properties in vitro as well as in vivo and is potentially cell-cycle specific. We have collected experimental data and formulated a compartmental model using ordinary differential equations t... Read More about The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments.

Dorsal hippocampal involvement in appetitive trace conditioning and interval timing (2012)
Journal Article
Tam, S. K. E., & Bonardi, C. (2012). Dorsal hippocampal involvement in appetitive trace conditioning and interval timing. Behavioral Neuroscience, 126(2), 258-269. https://doi.org/10.1037/a0027164

Involvement of the dorsal hippocampus (DHPC) in acquisition of Pavlovian trace conditioning and interval timing was examined in an appetitive preparation in which presentations of one conditioned stimulus (CS) were immediately followed by food (delay... Read More about Dorsal hippocampal involvement in appetitive trace conditioning and interval timing.

Identification of the validity range of Donnell and Sanders shell theories using an exact vibration analysis of functionally graded thick cylindrical shell panel (2012)
Journal Article
Hosseini-Hashemi, S., Ilkhani, M. R., & Fadaee, M. (2012). Identification of the validity range of Donnell and Sanders shell theories using an exact vibration analysis of functionally graded thick cylindrical shell panel. Acta Mechanica, 223(5), 1101-1118. https://doi.org/10.1007/s00707-011-0601-0

Free vibration of Levy-type thick functionally graded (FG) circular cylindrical shell panels is investigated to identify the validity range of two common shell theories namely Donnell and Sanders theories. FG material properties change through the th... Read More about Identification of the validity range of Donnell and Sanders shell theories using an exact vibration analysis of functionally graded thick cylindrical shell panel.

Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing (2012)
Journal Article
Tam, S. K., & Bonardi, C. (2012). Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing. Behavioural Brain Research, 230(1), 259-267. https://doi.org/10.1016/j.bbr.2012.02.016

The involvement of the rat dorsal hippocampus (dhpc) in Pavlovian conditioning and timing of conditioned responding was examined in an appetitive preparation in which presentation of a relatively long, 40-s auditory conditioned stimulus (CS) was foll... Read More about Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing.

Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite (2012)
Journal Article
Emara, M., Royer, P.-J., Mahdavi, J., Shakib, F., & Ghaemmaghami, A. M. (2012). Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite. Journal of Biological Chemistry, 287(8), https://doi.org/10.1074/jbc.M111.312520

Dendritic cells (DCs) have been shown to play a key role in the initiation and maintenance of immune responses to microbial pathogens as well as to allergens, but the exact mechanisms of their involvement in allergic responses and Th2 cell differenti... Read More about Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite.

A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor (2012)
Journal Article
Lane, J. R., Klein Herenbrink, C., van Westen, G. J. P., Spoorendonk, J. A., Hoffmann, C., & Ijzerman, A. P. (2012). A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor. Molecular Pharmacology, 81(3), 475-487. https://doi.org/10.1124/mol.111.075937

The recent publication of both the antagonist- and agonist-bound structures of the adenosine A(2A) receptor have revealed much about how a ligand may bind to a receptor and cause the conformational changes associated with agonist-mediated activation.... Read More about A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor.

Interactions of gold nanoparticles with the interior of hollow graphitized carbon nanofibers (2012)
Journal Article
La Torre, A., Fay, M. W., Rance, G. A., Del Carmen Gimenez-Lopez, M., Solomonsz, W. A., Brown, P. D., & Khlobystov, A. N. (2012). Interactions of gold nanoparticles with the interior of hollow graphitized carbon nanofibers. Small, 8(8), 1222-1228. https://doi.org/10.1002/smll.201102007

Interactions of free-standing gold nanoparticles and hollow graphitized nanofibers in colloidal suspension are investigated, revealing the first example of the controlled arrangement of nanoparticles inside nano-containers, as directed by their inter... Read More about Interactions of gold nanoparticles with the interior of hollow graphitized carbon nanofibers.

Similar behaviour, different brain patterns: age-related changes in neural signatures of ignoring (2012)
Journal Article
Allen, H. A., & Payne, H. (2012). Similar behaviour, different brain patterns: age-related changes in neural signatures of ignoring. NeuroImage, 59(4), https://doi.org/10.1016/j.neuroimage.2011.10.070

We measured behavioural performance and fMRI activity whilst old and young adults performed a temporal
segmentation task (‘preview search’). Being able to select parts of the visual world to be attended or ignored
is a critical visual skill. Both o... Read More about Similar behaviour, different brain patterns: age-related changes in neural signatures of ignoring.

Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems (2012)
Journal Article
Jbabdi, S., Sotiropoulos, S. N., Savio, A. M., Graña, M., & Behrens, T. E. (2012). Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems. Magnetic Resonance in Medicine, 68(6), https://doi.org/10.1002/mrm.24204

In this article, we highlight an issue that arises when using multiple b‐values in a model‐based analysis of diffusion MR data for tractography. The non‐monoexponential decay, commonly observed in experimental data, is shown to induce overfitting in... Read More about Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems.

The interaction of a vortex ring with a sloped sediment layer: critical criteria for incipient grain motion (2012)
Journal Article
Munro, R. J. (in press). The interaction of a vortex ring with a sloped sediment layer: critical criteria for incipient grain motion. Physics of Fluids, 24(2), https://doi.org/10.1063/1.3683555

Experiments were performed to analyse the interaction between a vortex ring and a sloped sediment layer. Attention focussed on interactions under “critical” conditions, in which sediment motion was only just induced by the ring's flow field. Both hyd... Read More about The interaction of a vortex ring with a sloped sediment layer: critical criteria for incipient grain motion.

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG (2012)
Journal Article
Jonsson, M. K., Vos, M. A., Mirams, G. R., Duker, G., Sartipy, P., De Boer, T. P., & Van Veen, T. A. (2012). Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. Journal of Molecular and Cellular Cardiology, 52(5), 998-1008. https://doi.org/10.1016/j.yjmcc.2012.02.002

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overal... Read More about Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

Associations between udder health and reproductive performance in United Kingdom dairy cows (2012)
Journal Article
Hudson, C., Bradley, A. J., Breen, J., & Green, M. J. (2012). Associations between udder health and reproductive performance in United Kingdom dairy cows. Journal of Dairy Science, 95(7), https://doi.org/10.3168/jds.2011-4629

The objective of this research was to evaluate the relationship between udder health and reproductive performance in UK dairy cows. Data from 80 herds were restructured such that each unit of data represented a 2-d period during lactation where a cow... Read More about Associations between udder health and reproductive performance in United Kingdom dairy cows.

Collaborative knowledge building with shared video representations: Special Issue on supporting shared representations in collaborative activities (2012)
Journal Article
BARTHEL, R., AINSWORTH, S., & SHARPLES, M. (2013). Collaborative knowledge building with shared video representations: Special Issue on supporting shared representations in collaborative activities. International Journal of Human-Computer Studies, 71(1), 59--75. https://doi.org/10.1016/j.ijhcs.2012.02.006

Online video has become established as a fundamental part of the fabric of the web; widely used by people for information sharing, learning and entertainment. We report results from a design study that explored how people interact to create shared mu... Read More about Collaborative knowledge building with shared video representations: Special Issue on supporting shared representations in collaborative activities.

Evidence and belief in regulatory decisions – incorporating expected utility into decision modelling (2012)
Journal Article
Li, J., Davies, G., Kendall, G., Soane, E., Bai, R., Rocks, S., & Pollard, S. (2012). Evidence and belief in regulatory decisions – incorporating expected utility into decision modelling. Expert Systems with Applications, 39(10), https://doi.org/10.1016/j.eswa.2012.01.193

Recent changes in the assessment and management of risks has had the effect that greater importance has been placed on relationships between individuals and within groups to inform decision making. In this paper, we provide the theoretical underpinni... Read More about Evidence and belief in regulatory decisions – incorporating expected utility into decision modelling.

A new sequential covering strategy for inducing classification rules with ant colony algorithms (2012)
Journal Article
Otero, F. E. B., Freitas, A. A., & Johnson, C. G. (2012). A new sequential covering strategy for inducing classification rules with ant colony algorithms. IEEE Transactions on Evolutionary Computation, 17(1), 64-76. https://doi.org/10.1109/TEVC.2012.2185846

Ant colony optimization (ACO) algorithms have been successfully applied to discover a list of classification rules. In general, these algorithms follow a sequential covering strategy, where a single rule is discovered at each iteration of the algorit... Read More about A new sequential covering strategy for inducing classification rules with ant colony algorithms.

Handedness and the excitability of cortical inhibitory circuits (2012)
Journal Article
Reid, C. S., & Serrien, D. J. (in press). Handedness and the excitability of cortical inhibitory circuits. Behavioural Brain Research, 230(1), https://doi.org/10.1016/j.bbr.2012.02.008

Inhibitory processes play a significant role in the control of goal-directed actions. To increase insights into these mechanisms as a function of handedness, we measured the transient inhibition of volitional motor activity induced by single pulse tr... Read More about Handedness and the excitability of cortical inhibitory circuits.