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Neuronal spike-train responses in the presence of threshold noise (2012)
Journal Article
Coombes, S., Thul, R., Laudanski, J., Palmer, A., & Sumner, C. (in press). Neuronal spike-train responses in the presence of threshold noise. Frontiers in Life Science, 5(3-4), https://doi.org/10.1080/21553769.2011.556016

The variability of neuronal firing has been an intense topic of study for many years. From a modelling perspective it has often been studied in conductance based spiking models with the use of additive or multiplicative noise terms to represent chan... Read More about Neuronal spike-train responses in the presence of threshold noise.

Coupling of kinesin ATP turnover to translocation and microtubule regulation: One engine, many machines (2012)
Journal Article
Friel, C. T., & Howard, J. (2012). Coupling of kinesin ATP turnover to translocation and microtubule regulation: One engine, many machines. Journal of Muscle Research and Cell Motility, 33(6), 377-383. https://doi.org/10.1007/s10974-012-9289-6

The cycle of ATP turnover is integral to the action of motor proteins. Here we discuss how variation in this cycle leads to variation of function observed amongst members of the kinesin superfamily of microtubule associated motor proteins. Variation... Read More about Coupling of kinesin ATP turnover to translocation and microtubule regulation: One engine, many machines.

Vacuolation in hepatocyte nuclei is a marker of senescence. (2012)
Journal Article
Aravinthan, A., Verma, S., Coleman, N., Davies, S., Allison, M., & Alexander, G. (2012). Vacuolation in hepatocyte nuclei is a marker of senescence. Journal of Clinical Pathology, 65(6), 557-560. https://doi.org/10.1136/jclinpath-2011-200641

Hepatocyte nuclear vacuolation is considered benign and associated with non-alcohol-related fatty liver disease. Vacuolated hepatocyte nuclei were compared with non-vacuolated hepatocyte nuclei in eight patients with advanced fibrosis and a spectrum... Read More about Vacuolation in hepatocyte nuclei is a marker of senescence..

Adenosine methylation in Arabidopsis mRNA is associated with the 3′ end and reduced levels cause developmental defects (2012)
Journal Article
Bodi, Z., Zhong, S., Mehra, S., Song, J., Graham, N., Li, H., May, S., & Fray, R. G. (2012). Adenosine methylation in Arabidopsis mRNA is associated with the 3′ end and reduced levels cause developmental defects. Frontiers in Plant Science, 3(48), Article 48. https://doi.org/10.3389/fpls.2012.00048

We previously showed that the N6-methyladenosine (m6A) mRNA methylase is essential during Arabidopsis thaliana embryonic development. We also demonstrated that this modification is present at varying levels in all mature tissues. However, the require... Read More about Adenosine methylation in Arabidopsis mRNA is associated with the 3′ end and reduced levels cause developmental defects.

Synthetic peptides derived from an N-terminal domain of the E2 protein of GB virus C in the study of GBV-C/HIV-1 co-infection (2012)
Journal Article
Fernández, L., Chan, W. C., Egido, M., Gómara, M. J., & Haro, I. (2012). Synthetic peptides derived from an N-terminal domain of the E2 protein of GB virus C in the study of GBV-C/HIV-1 co-infection. Journal of Peptide Science, 18(5), 326-335. https://doi.org/10.1002/psc.2403

Synthetic peptides derived from GB virus C (GBV-C) have previously been studied in our group for the development of new systems capable of diagnosing diseases caused by this humanotropic virus. We also recently described specific peptide domains of t... Read More about Synthetic peptides derived from an N-terminal domain of the E2 protein of GB virus C in the study of GBV-C/HIV-1 co-infection.

The grooved-dielectric Fresnel zone plate: An effective terahertz lens and antenna (2012)
Journal Article
Hristov, H., Rodriguez, J., & Grote, W. (2012). The grooved-dielectric Fresnel zone plate: An effective terahertz lens and antenna. Microwave and Optical Technology Letters, 54(6), 1343-1348. https://doi.org/10.1002/mop.26812

A number of microwave and terahertz grooved-dielectric Fresnel zone plate (FZP) and ordinary lenses and antennas are studed and compared numerically. Although the microwave (38 GHz) eight-step FZP lens is certainly inferior, the corresponding teraher... Read More about The grooved-dielectric Fresnel zone plate: An effective terahertz lens and antenna.

High through-put sequencing of the Parhyale hawaiensis mRNAs and microRNAs to aid comparative developmental studies (2012)
Journal Article
Blythe, M. J., Malla, S., Everall, R., Shih, Y.-H., Lemay, V., Moreton, J., Wilson, R., & Aboobaker, A. (2012). High through-put sequencing of the Parhyale hawaiensis mRNAs and microRNAs to aid comparative developmental studies. PLoS ONE, 7(3), Article e33784. https://doi.org/10.1371/journal.pone.0033784

Understanding the genetic and evolutionary basis of animal morphological diversity will require comparative developmental studies that use new model organisms. This necessitates development of tools for the study of genetics and also the generation o... Read More about High through-put sequencing of the Parhyale hawaiensis mRNAs and microRNAs to aid comparative developmental studies.

Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology (2012)
Journal Article
Blount, B. A., Weenink, T., Vasylechko, S., & Ellis, T. (2012). Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology. PLoS ONE, 7(3), Article e33279. https://doi.org/10.1371/journal.pone.0033279

Yeast is an ideal organism for the development and application of synthetic biology, yet there remain relatively few well-characterised biological parts suitable for precise engineering of this chassis. In order to address this current need, we prese... Read More about Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology.

Statistical inference of in vivo properties of human DNA methyltransferases from double-stranded methylation patterns (2012)
Journal Article
Fu, A. Q., Genereux, D. P., Stöger, R., Burden, A. F., Laird, C. D., & Stephens, M. (2012). Statistical inference of in vivo properties of human DNA methyltransferases from double-stranded methylation patterns. PLoS ONE, 7(3), Article e32225. https://doi.org/10.1371/journal.pone.0032225

DNA methyltransferases establish methylation patterns in cells and transmit these patterns over cell generations, thereby influencing each cell's epigenetic states. Three primary DNA methyltransferases have been identified in mammals: DNMT1, DNMT3A a... Read More about Statistical inference of in vivo properties of human DNA methyltransferases from double-stranded methylation patterns.

Recent French decisions on database protection: Towards a more consistent and compliant approach with the Court of Justice's case law? (2012)
Journal Article
Derclaye, E. (2012). Recent French decisions on database protection: Towards a more consistent and compliant approach with the Court of Justice's case law?. 00 Journal not listed, 3(2), 1-13

Since the official date of implementation of the Database Directive , namely the 1 January 1998, 14 years have now already passed. During this decade and a half, French courts have handed down around 30 decisions on database protection. Between 1998... Read More about Recent French decisions on database protection: Towards a more consistent and compliant approach with the Court of Justice's case law?.

Novel 3, 6, 7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A) (2012)
Journal Article
Blad, C. C., van Veldhoven, J. P. D., Klopman, C., Wolfram, D. R., Brussee, J., Lane, J. R., & Ijzerman, A. P. (2012). Novel 3, 6, 7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A). Journal of Medicinal Chemistry, 55(7), 3563-3567. https://doi.org/10.1021/jm300164q

A number of pyrazolopyrimidines were synthesized and tested for their positive allosteric modulation of the HCA(2) receptor (GPR109A). Compound 24, an efficacious and potent agonist and allosteric enhancer of nicotinic acid's action, was the basis fo... Read More about Novel 3, 6, 7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A).

Confocal surface plasmon microscopy with pupil function engineering (2012)
Journal Article
Zhang, B., Pechprasarn, S., Zhang, J., & Somekh, M. G. (2012). Confocal surface plasmon microscopy with pupil function engineering. Optics Express, 20(7), https://doi.org/10.1364/OE.20.007388

Surface Plasmon microscopy can measure local changes of refractive index on the micron scale. Interferometric plasmon imaging delivers quantitative high spatial resolution sensitive to refractive index. In addition the so called V(z) method allows im... Read More about Confocal surface plasmon microscopy with pupil function engineering.

Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes (2012)
Journal Article
Shakibaei, M., Allaway, D., Nebrich, S., & Mobasheri, A. (2012). Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes. Evidence-Based Complementary and Alternative Medicine, 2012, Article 509383. https://doi.org/10.1155/2012/509383

The aim of this study was to characterize the anti-inflammatory mode of action of botanical extracts from rosehip (Rosa canina), willow bark (Salix alba), and nettle leaf (Urtica dioica) in an in vitro model of primary canine articular chondrocytes.... Read More about Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes.

Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms (2012)
Journal Article
Tan, T. C., Rahman, R., Jaber-Hijazi, F., Felix, D. A., Chen, C., Louis, E. J., & Aboobaker, A. (2012). Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms. Proceedings of the National Academy of Sciences, 109(11), https://doi.org/10.1073/pnas.1118885109

In most sexually reproducing animals, replication and maintenance of telomeres occurs in the germ line and during early development in embryogenesis through the use of telomerase. Somatic cells generally do not maintain telomere sequences, and these... Read More about Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms.

Cytoplasmic RNA in undifferentiated neural stem cells: a potential label-free Raman spectral marker for assessing the undifferentiated status (2012)
Journal Article
Ghita, A., Pascut, F. C., Mather, M., Sottile, V., & Notingher, I. (2012). Cytoplasmic RNA in undifferentiated neural stem cells: a potential label-free Raman spectral marker for assessing the undifferentiated status. Analytical Chemistry, 84(7), https://doi.org/10.1021/ac202994e

Raman microspectroscopy (rms) was used to identify, image, and quantify potential molecular markers for label-free monitoring the differentiation status of live neural stem cells (NSCs) in vitro. Label-free noninvasive techniques for characterization... Read More about Cytoplasmic RNA in undifferentiated neural stem cells: a potential label-free Raman spectral marker for assessing the undifferentiated status.

When Nanoparticle Size and Molecular Geometry Matter: Analyzing the Degree of Surface Functionalization of Gold Nanoparticles with Sulfur Heterocyclic Compounds (2012)
Journal Article
Lanterna, A. E., Coronado, E. A., & Granados, A. M. (2012). When Nanoparticle Size and Molecular Geometry Matter: Analyzing the Degree of Surface Functionalization of Gold Nanoparticles with Sulfur Heterocyclic Compounds. Journal of Physical Chemistry C, 116(11), 6520-6529. https://doi.org/10.1021/jp209816g

The degree of surface functionalization of colloidal dispersions of Au nanoparticles (AuNPs) by sulfur heterocyclic compounds is determined using localized surface plasmon resonance spectroscopy (LSPRS), morphological characterization, and electrodyn... Read More about When Nanoparticle Size and Molecular Geometry Matter: Analyzing the Degree of Surface Functionalization of Gold Nanoparticles with Sulfur Heterocyclic Compounds.