All Outputs (480)

Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK) (2011)
Journal Article
Glazebrook, C., Batty, M. J., Mullan, N., MacDonald, I., Nathan, D., Sayal, K., …Hollis, C. (2011). Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK). BMC Public Health, 11, Article 830. https://doi.org/10.1186/1471-2458-11-830

Background Low levels of physical activity in children have been linked to an increased risk of obesity, but many children lack confidence in relation to exercise (exercise self-efficacy). Factors which can impact on confidence include a chronic hea... Read More about Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK).

MysiRNA-designer: a workflow for efficient siRNA design (2011)
Journal Article
Mysara, M., Garibaldi, J. M., & ElHefnawi, M. (2011). MysiRNA-designer: a workflow for efficient siRNA design. PLoS ONE, 6(10), Article e25642. https://doi.org/10.1371/journal.pone.0025642

The design of small interfering RNA (siRNA) is a multi factorial problem that has gained the attention of many researchers in the area of therapeutic and functional genomics. MysiRNA score was previously introduced that improves the correlation of si... Read More about MysiRNA-designer: a workflow for efficient siRNA design.

Fundamental properties of Ca²⁺ signals (2011)
Journal Article
Thurley, K., Skupin, A., Thul, R., & Falcke, M. (2011). Fundamental properties of Ca²⁺ signals. BBA - General Subjects, 1820(8), https://doi.org/10.1016/j.bbagen.2011.10.007

Background Ca²⁺ is a ubiquitous and versatile second messenger that transmits information through changes of the cytosolic Ca²⁺ concentration. Recent investigations changed basic ideas on the dynamic character of Ca²⁺ signals and challenge tradition... Read More about Fundamental properties of Ca²⁺ signals.

A fresh insight into transmission of schistosomiasis: A misleading tale of biomphalaria in Lake Victoria (2011)
Journal Article
Standley, C. J., Wade, C. M., & Stothard, J. R. (2011). A fresh insight into transmission of schistosomiasis: A misleading tale of biomphalaria in Lake Victoria. PLoS ONE, 6(10), Article e26563. https://doi.org/10.1371/journal.pone.0026563

Lake Victoria is a known hot-spot for Schistosoma mansoni, which utilises freshwater snails of the genus Biomphalaria as intermediate hosts. Different species of Biomphalaria are associated with varying parasite compatibility, affecting local transmi... Read More about A fresh insight into transmission of schistosomiasis: A misleading tale of biomphalaria in Lake Victoria.

A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA (2011)
Journal Article
Kruse, S., Zhong, S., Bodi, Z., Button, J., Alcocer, M. J., Hayes, C. J., & Fray, R. (2011). A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA. Scientific Reports, 1, Article 126. https://doi.org/10.1038/srep00126

A method is described for the detection of certain nucleotide modifications adjacent to the 5' 7-methyl guanosine cap of mRNAs from individual genes. The method quantitatively measures the relative abundance of 2'-O-methyl and N 6.

Enhancement of soil thermo-physical properties using microencapsulated phase change materials for ground source heat pump applications (2011)
Journal Article
Dehdezi, P. K., Hall, M. R., & Dawson, A. (in press). Enhancement of soil thermo-physical properties using microencapsulated phase change materials for ground source heat pump applications. Applied Mechanics and Materials, 110-116, https://doi.org/10.4028/www.scientific.net/AMM.110-116.1191

Soil can be modified with Phase Change materials (PCM) in order to enhance its thermophysical properties and energy storage for ground source heat pump applications. This paper studies thermo-physical properties of soil modified with different amount... Read More about Enhancement of soil thermo-physical properties using microencapsulated phase change materials for ground source heat pump applications.

Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants (2011)
Journal Article
Gibbs, D. J., Lee, S. C., Md Isa, N., Gramuglia, S., Fukao, T., Bassel, G. W., …Holdsworth, M. J. (2011). Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants. Nature, 479(7373), 415-418. https://doi.org/10.1038/nature10534

Plants and animals are obligate aerobes, requiring oxygen for mitochondrial respiration and energy production. In plants, an unanticipated decline in oxygen availability (hypoxia), as caused by roots becoming waterlogged or foliage submergence, trigg... Read More about Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants.

Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration (2011)
Journal Article
Oliver, P. L., Finelli, M. J., Edwards, B., Bitoun, E., Butts, D. L., Becker, E. B. E., …Davies, K. E. (2011). Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration. PLoS Genetics, 7(10), Article e1002338. https://doi.org/10.1371/journal.pgen.1002338

Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Ox... Read More about Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration.

Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis (2011)
Journal Article
Brown, D. M., Parr, T., & Brameld, J. M. (2012). Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis. Journal of Muscle Research and Cell Motility, 32(6), 383-390. https://doi.org/10.1007/s10974-011-9267-4

The regulation of muscle fibre transitions has mainly been studied in vivo using conventional histological or immunohistochemical techniques. In order to investigate the molecular regulation of myosin heavy chain (MyHC) isoform expression in cell cul... Read More about Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis.

Mechanism of Action of a Nanomolar Potent, Allosteric Antagonist of the Thyroid-Stimulating Hormone Receptor (2011)
Journal Article
van Koppen, C. J., de Gooyer, M. E., Karstens, W., Plate, R., Conti, P. G. M., van Achterberg, T. A. E., …Timmers, C. M. (2012). Mechanism of Action of a Nanomolar Potent, Allosteric Antagonist of the Thyroid-Stimulating Hormone Receptor. British Journal of Pharmacology, 165(7), 2314-2324. https://doi.org/10.1111/j.1476-5381.2011.01709.x

Background and purpose  Graves' disease (GD) is an autoimmune disease in which the thyroid is overactive, producing excessive amounts of thyroid hormones, caused by TSHR-stimulating immunoglobulins (TSIs). A large proportion of GD patients also suffe... Read More about Mechanism of Action of a Nanomolar Potent, Allosteric Antagonist of the Thyroid-Stimulating Hormone Receptor.

Amplifying single impurities immersed in a gas of ultracold atoms (2011)
Journal Article
Olmos, B., Li, W., Hofferberth, S., & Lesanovsky, I. (2011). Amplifying single impurities immersed in a gas of ultracold atoms. Physical Review A, 84(4), Article 041607(R). https://doi.org/10.1103/PhysRevA.84.041607

We present a method for amplifying a single or scattered impurities immersed in a background gas of ultracold atoms so that they can be optically imaged and spatially resolved. Our approach relies on a Raman transfer between two stable atomic hyperfi... Read More about Amplifying single impurities immersed in a gas of ultracold atoms.

Thermoresponsive polymer colloids for drug delivery and cancer therapy (2011)
Journal Article
Abulateefeh, S. R., Spain, S. G., Aylott, J. W., Chan, W. C., Garnett, M. C., & Alexander, C. (2011). Thermoresponsive polymer colloids for drug delivery and cancer therapy. Macromolecular Bioscience, 11(12), 1722-1734. https://doi.org/10.1002/mabi.201100252

Many difficulties in treating cancer arise from the problems in directing highly cytotoxic agents to the deseased tissues, cells and intracellular compartments. Many drug delivery systems have been devised to address this problem, including those tha... Read More about Thermoresponsive polymer colloids for drug delivery and cancer therapy.

Reducing heterotic M-theory to five dimensional supergravity on a manifold with boundary (2011)
Journal Article
Moss, I. G., Omotani, J. T., & Saffin, P. M. (2011). Reducing heterotic M-theory to five dimensional supergravity on a manifold with boundary. Journal of High Energy Physics, 2011(10), https://doi.org/10.1007/JHEP10%282011%29088

This paper constructs the reduction of heterotic M-theory in eleven dimensions to a supergravity model on a manifold with boundary in five dimensions using a Calabi-Yau three-fold. New results are presented for the boundary terms in the action and fo... Read More about Reducing heterotic M-theory to five dimensional supergravity on a manifold with boundary.

Inner speech during silent reading reflects the reader's regional accent (2011)
Journal Article
Filik, R., & Barber, E. (2011). Inner speech during silent reading reflects the reader's regional accent. PLoS ONE, 6(10), Article e25782. https://doi.org/10.1371/journal.pone.0025782

While reading silently, we often have the subjective experience of inner speech. However, there is currently little evidence regarding whether this inner voice resembles our own voice while we are speaking out loud. To investigate this issue, we comp... Read More about Inner speech during silent reading reflects the reader's regional accent.

The Anti-Apoptotic Effect of Respiratory Syncytial Virus on Human Peripheral Blood Neutrophils is Mediated by a Monocyte Derived Soluble Factor (2011)
Journal Article
Coleman, C. M., Plant, K., Newton, S., Hobson, L., Whyte, M. K., & Everard, M. L. (2011). The Anti-Apoptotic Effect of Respiratory Syncytial Virus on Human Peripheral Blood Neutrophils is Mediated by a Monocyte Derived Soluble Factor. Open Virology Journal, 5(1), 114-123. https://doi.org/10.2174/1874357901105010114

A reconfigurable real-time compressive-sampling camera for biological applications (2011)
Journal Article
Fu, B., Pitter, M. C., & Russell, N. A. (2011). A reconfigurable real-time compressive-sampling camera for biological applications. PLoS ONE, 6(10), Article e26306. https://doi.org/10.1371/journal.pone.0026306

Many applications in biology, such as long-term functional imaging of neural and cardiac systems, require continuous high-speed imaging. This is typically not possible, however, using commercially available systems. The frame rate and the recording t... Read More about A reconfigurable real-time compressive-sampling camera for biological applications.

Histological and Confocal Microscopy Changes in Chronic Corneal Edema: Implications for Endothelial Transplantation (2011)
Journal Article
Alomar, T. S., Al-Aqaba, M., Gray, T., Lowe, J., & Dua, H. S. (2011). Histological and Confocal Microscopy Changes in Chronic Corneal Edema: Implications for Endothelial Transplantation. Investigative Ophthalmology & Visual Science, 52(11), 8193-8207. https://doi.org/10.1167/iovs.11-8047

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1 (2011)
Journal Article
Garcia, V., Phelps, S. E. L., Gray, S., & Neale, M. J. (2011). Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1. Nature, 479(7372), 241-244. https://doi.org/10.1038/nature10515

A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling (2011)
Journal Article
Sher, A. A., Wang, K., Wathen, A., Maybank, P. J., Mirams, G. R., Abramson, D., …Gavaghan, D. J. (2013). A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling. Future Generation Computer Systems, 29(2), 591-598. https://doi.org/10.1016/j.future.2011.09.006

Computational cardiac models provide important insights into the underlying mechanisms of heart function. Parameter estimation in these models is an ongoing challenge with many existing models being overparameterised. Sensitivity analysis presents a... Read More about A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling.

Adaptivity and a Posteriori Error Control for Bifurcation Problems III: Incompressible Fluid Flow in Open Systems with O(2) Symmetry (2011)
Journal Article
Cliffe, A., Hall, E., Houston, P., Phipps, E., & Salinger, A. (2012). Adaptivity and a Posteriori Error Control for Bifurcation Problems III: Incompressible Fluid Flow in Open Systems with O(2) Symmetry. Journal of Scientific Computing, 52(1), 153-179. https://doi.org/10.1007/s10915-011-9545-8

In this article we consider the a posteriori error estimation and adaptive mesh refinement of discontinuous Galerkin finite element approximations of the bifurcation problem associated with the steady incompressible Navier-Stokes equations. Particula... Read More about Adaptivity and a Posteriori Error Control for Bifurcation Problems III: Incompressible Fluid Flow in Open Systems with O(2) Symmetry.