Skip to main content

Research Repository

Advanced Search

Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration

Oliver, Peter L.; Finelli, Matt�a J.; Edwards, Benjamin; Bitoun, Emmanuelle; Butts, Darcy L.; Becker, Esther B. E.; Cheeseman, Michael T.; Davies, Ben; Davies, Kay E.

Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration Thumbnail


Authors

Peter L. Oliver

Benjamin Edwards

Emmanuelle Bitoun

Darcy L. Butts

Esther B. E. Becker

Michael T. Cheeseman

Ben Davies

Kay E. Davies



Abstract

Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Oxr1) as a vital protein that controls the sensitivity of neuronal cells to oxidative stress; mice lacking Oxr1 display cerebellar neurodegeneration, and neurons are less susceptible to exogenous stress when the gene is over-expressed. A conserved short isoform of Oxr1 is also sufficient to confer this neuroprotective property both in vitro and in vivo. In addition, biochemical assays indicate that Oxr1 itself is susceptible to cysteine-mediated oxidation. Finally we show up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease.

Citation

Oliver, P. L., Finelli, M. J., Edwards, B., Bitoun, E., Butts, D. L., Becker, E. B. E., Cheeseman, M. T., Davies, B., & Davies, K. E. (2011). Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration. PLoS Genetics, 7(10), Article e1002338. https://doi.org/10.1371/journal.pgen.1002338

Journal Article Type Article
Acceptance Date Aug 24, 2011
Online Publication Date Oct 20, 2011
Publication Date Oct 20, 2011
Deposit Date Jul 25, 2021
Publicly Available Date Jul 26, 2021
Journal PLoS Genetics
Print ISSN 1553-7390
Electronic ISSN 1553-7404
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 7
Issue 10
Article Number e1002338
DOI https://doi.org/10.1371/journal.pgen.1002338
Keywords Cancer Research; Genetics(clinical); Genetics; Molecular Biology; Ecology, Evolution, Behavior and Systematics
Public URL https://nottingham-repository.worktribe.com/output/5832734
Publisher URL https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002338

Files





You might also like



Downloadable Citations