Peter L. Oliver
Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration
Oliver, Peter L.; Finelli, Matt�a J.; Edwards, Benjamin; Bitoun, Emmanuelle; Butts, Darcy L.; Becker, Esther B. E.; Cheeseman, Michael T.; Davies, Ben; Davies, Kay E.
Authors
Dr MATTEA FINELLI MATTEA.FINELLI@NOTTINGHAM.AC.UK
ASSISTANT PROFESSOR
Benjamin Edwards
Emmanuelle Bitoun
Darcy L. Butts
Esther B. E. Becker
Michael T. Cheeseman
Ben Davies
Kay E. Davies
Abstract
Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Oxr1) as a vital protein that controls the sensitivity of neuronal cells to oxidative stress; mice lacking Oxr1 display cerebellar neurodegeneration, and neurons are less susceptible to exogenous stress when the gene is over-expressed. A conserved short isoform of Oxr1 is also sufficient to confer this neuroprotective property both in vitro and in vivo. In addition, biochemical assays indicate that Oxr1 itself is susceptible to cysteine-mediated oxidation. Finally we show up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease.
Citation
Oliver, P. L., Finelli, M. J., Edwards, B., Bitoun, E., Butts, D. L., Becker, E. B. E., Cheeseman, M. T., Davies, B., & Davies, K. E. (2011). Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration. PLoS Genetics, 7(10), Article e1002338. https://doi.org/10.1371/journal.pgen.1002338
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 24, 2011 |
Online Publication Date | Oct 20, 2011 |
Publication Date | Oct 20, 2011 |
Deposit Date | Jul 25, 2021 |
Publicly Available Date | Jul 26, 2021 |
Journal | PLoS Genetics |
Print ISSN | 1553-7390 |
Electronic ISSN | 1553-7404 |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 7 |
Issue | 10 |
Article Number | e1002338 |
DOI | https://doi.org/10.1371/journal.pgen.1002338 |
Keywords | Cancer Research; Genetics(clinical); Genetics; Molecular Biology; Ecology, Evolution, Behavior and Systematics |
Public URL | https://nottingham-repository.worktribe.com/output/5832734 |
Publisher URL | https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002338 |
Files
Oliver And Finelli 2011
(3.5 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Enhancing research culture in academia: a spotlight on early career researchers
(2023)
Journal Article
Detection and Quantification of Novel C‐terminal TDP‐43 Fragments in ALS‐TDP
(2021)
Journal Article
The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour
(2020)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search