All Outputs (226)

High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer (2020)
Presentation / Conference Contribution
Heyman, T., Joseph, C., Craze, M., Green, A., Nolan, C., Rueda, O., Provenzano, E., Rakha, E., Ellis, I. O., & Mukherjee, A. (2020, December). High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer. Presented at 32nd Congress of the ESP and XXXIII International Congress of the IAP, Glasgow, UK (virtual)

Background & objectives
TIMP2, tissue inhibitor of matrix-metalloproteinase 2, inhibits the matrix-metalloproteinase, MMP2, but may activate pro-MMP2. Hence its correlation with prognosis in breast cancer (BC) is contradictory. This study investigat... Read More about High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer.

Test Record (2020)
Presentation / Conference Contribution
Veasey, B., CREATORS_FN: Price, C. V., CREATORS_FN: Green, C. J., CREATORS_FN: Sperring, C. D., CREATORS_FN: Houghton, C. L., Bloggs, & Person, N. U. (2017, August). Test Record. Presented at CHI 2017: ACM CHI Conference on Human Factors in Computing Systems, Magicland

ABSTRACT: This is a test record for the purposes of analysis of collected meta against particular input fieldname titles and how it is exposed through JSON export from eprints (Everything Version)

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This is an adjusted abstract with two ne... Read More about Test Record.

TBIO-14. Characterisation of the arginine pathway enzymes in paediatric brain tumours to determine susceptibility to therapeutic arginine depletion (2020)
Presentation / Conference Contribution
Bishop, E., Dimitrova, M., Storer, L., Grundy, R., & Dandapani, M. TBIO-14. Characterisation of the arginine pathway enzymes in paediatric brain tumours to determine susceptibility to therapeutic arginine depletion

INTRODUCTION
Extracellular arginine dependency (auxotrophy) is increasingly being recognised in several tumours. This is due to the inability of cancer cells to recycle or synthesise intracellular arginine through the urea cycle pathway compared to... Read More about TBIO-14. Characterisation of the arginine pathway enzymes in paediatric brain tumours to determine susceptibility to therapeutic arginine depletion.

Epen-22. Single-cell RNA sequencing identifies upregulation of IKZF1 in PFA2 myeloid subpopulation driving an anti-tumor phenotype (2020)
Presentation / Conference Contribution
Griesinger, A., Prince, E., Donson, A., Riemondy, K., Ritzman, T., Harris, F., Amani, V., Handler, M., Hankinson, T., Grundy, R., Jackson, A., & Foreman, N. Epen-22. Single-cell RNA sequencing identifies upregulation of IKZF1 in PFA2 myeloid subpopulation driving an anti-tumor phenotype

We have previously shown immune gene phenotype variations between posterior fossa ependymoma subgroups. PFA1 tumors chronically secrete IL-6, which pushes the infiltrating myeloid cells to an immune suppressive function. In contrast, PFA2 tumors have... Read More about Epen-22. Single-cell RNA sequencing identifies upregulation of IKZF1 in PFA2 myeloid subpopulation driving an anti-tumor phenotype.

Epen-23. A computational analysis of the tumour immune microenvironment in paediatric ependymoma (2020)
Presentation / Conference Contribution
Ritzmann, T., Lourdusamy, A., Jackson, A., Storer, L., Donson, A., Griesinger, A., Foreman, N., Rogers, H., & Grundy, R. Epen-23. A computational analysis of the tumour immune microenvironment in paediatric ependymoma

Ependymoma is the third commonest childhood brain tumour. Relapse is frequent, often fatal and current therapeutic strategies are inadequate. Previous ependymoma research describes an immunosuppressive environment with T-cell exhaustion, indicating a... Read More about Epen-23. A computational analysis of the tumour immune microenvironment in paediatric ependymoma.

A Universal Stiffening Sleeve Designed for All Types of Continuum Robot Systems (2020)
Presentation / Conference Contribution
Fang, Y., Bishop, C., Ba, W., Díez, J. B., Mohammad, A., & Dong, X. (2020, September). A Universal Stiffening Sleeve Designed for All Types of Continuum Robot Systems. Presented at Towards Autonomous Robotic Systems: 21st Annual Conference, TAROS 2020, Nottingham, UK, September 16, 2020, Proceedings, Nottingham, UK

© 2020, Springer Nature Switzerland AG. Continuum robots have been utilized for several light-duty applications, such as minimally invasive surgery in the medical field and inspection in the industry. However, the existing design solutions do not off... Read More about A Universal Stiffening Sleeve Designed for All Types of Continuum Robot Systems.

On the Capability of Heat Dissipation in Thermally Aged Electrical Machines (2020)
Presentation / Conference Contribution
Madonna, V., Giangrande, P., & Galea, M. (2020, August). On the Capability of Heat Dissipation in Thermally Aged Electrical Machines. Presented at 2020 International Conference on Electrical Machines (ICEM), Gothenburg, Sweden

Thermal aging is one of the main causes of progressive deterioration of the insulation system in electrical machines. This because the thermo-physical properties of dielectric materials can undergo severe changes when exposed to high temperature. Acc... Read More about On the Capability of Heat Dissipation in Thermally Aged Electrical Machines.

3D Printing as a Technology Enabler for Electrical Machines: Manufacturing and Testing of a Salient Pole Rotor for SRM (2020)
Presentation / Conference Contribution
Gargalis, L., Madonna, V., Giangrande, P., Hardy, M., Ashcroft, I., Galea, M., & Hague, R. (2020, August). 3D Printing as a Technology Enabler for Electrical Machines: Manufacturing and Testing of a Salient Pole Rotor for SRM. Presented at 2020 International Conference on Electrical Machines (ICEM), Gothenburg, Sweden

Among the various technology enablers for modern electrical machines, additive manufacturing plays a key role. The advantage of having a precise control of the shape of ferromagnetic structures, whilst achieving good electromagnetic performance, fits... Read More about 3D Printing as a Technology Enabler for Electrical Machines: Manufacturing and Testing of a Salient Pole Rotor for SRM.

Further Exploration of Necrotic Control of Evolved Art (2020)
Presentation / Conference Contribution
Ashlock, D., & Greensmith, J. (2020, December). Further Exploration of Necrotic Control of Evolved Art. Presented at 2020 IEEE Symposium Series on Computational Intelligence (SSCI), Canberra, ACT, Australia

This study is the second in investigating the use of necrosis based filtration as a method of steering evolutionary algorithms to create evolved art. We use a technique inspired by the danger theory of immune system activation - a method employed in... Read More about Further Exploration of Necrotic Control of Evolved Art.

Novel Parameter Identification Method for Lithium-Ion Batteries Based on Curve Fitting (2020)
Presentation / Conference Contribution
Lukic, M., Giangrande, P., Klumpner, C., & Galea, M. (2020, November). Novel Parameter Identification Method for Lithium-Ion Batteries Based on Curve Fitting. Presented at 2020 IEEE Vehicle Power and Propulsion Conference (VPPC), Gijon, Spain

This paper describes a new curve-fitting lithium-ion battery parameter identification method for equivalent circuit models. The current pulse/relaxation test is carried out and the corresponding terminal voltage is used for extracting the battery mod... Read More about Novel Parameter Identification Method for Lithium-Ion Batteries Based on Curve Fitting.

Generation of open-source genomics resources for African orphan tree crops by African Orphan Crops Consortium (AOCC), a public-private partnership for promoting food and nutritional security in Africa (2020)
Presentation / Conference Contribution
Hendre, P. S., Muchugi, A., Chang, Y., Fu, Y., Song, Y., Liu, M., Liao, X., Liu, H., Song, B., Xu, X., Cheng, S., Liu, X., Odney, D. A., Kuan Ho, W., Mayes, S., Muthemba, S., Kariba, R., Featherston, J., Hefer, C., Rees, J., …Jamnadass, R. (2018, August). Generation of open-source genomics resources for African orphan tree crops by African Orphan Crops Consortium (AOCC), a public-private partnership for promoting food and nutritional security in Africa. Presented at XXX International Horticultural Congress IHC2018: V International Symposium on Plant Genetic Resources and International Symposium on Applied Functional Molecular Biology, Istanbul

© 2020 International Society for Horticultural Science. All rights reserved. The growing African population needs a substantial increase in food production along with nutritious food options to address hunger, malnutrition and stunting. The indigenou... Read More about Generation of open-source genomics resources for African orphan tree crops by African Orphan Crops Consortium (AOCC), a public-private partnership for promoting food and nutritional security in Africa.

PoWerS Study: Psychological impacts of COVID-19 on healthcare trainees and perceptions towards a digital wellbeing support package (2020)
Presentation / Conference Contribution
Blake, H., Mahmood, I., Gay, E., & Dushi, G. (2020, November). PoWerS Study: Psychological impacts of COVID-19 on healthcare trainees and perceptions towards a digital wellbeing support package. Poster presented at 3rd National British Islamic Medical Association Conference (BIMA), Online

Background: In this study we explore the impact of COVID-19 on the psychological wellbeing of healthcare trainees, and the perceived value of a digital support package to mitigate the psychological impacts of the pandemic.
Design and Methods: Mixed... Read More about PoWerS Study: Psychological impacts of COVID-19 on healthcare trainees and perceptions towards a digital wellbeing support package.

Single Integration for Multi-objective Control (2020)
Presentation / Conference Contribution
Chen, L., Shao, S., Gao, F., Tarisciotti, L., Dragicevic, T., & Wheeler, P. (2020, November). Single Integration for Multi-objective Control. Presented at 2020 IEEE 9th International Power Electronics and Motion Control Conference, IPEMC 2020 ECCE Asia, Nanjing, China (online)

The saturation issue with paralleled PI controllers in multi-objective control is investigated. Dual-Active-Bridge (DAB) enabled DC micro-grid stabilization is chosen as a case study. The DAB converter has two control objectives: battery current regu... Read More about Single Integration for Multi-objective Control.

Reliability oriented thermal management of aircraft power converters (2020)
Presentation / Conference Contribution
Harikumaran, J., Buticchi, G., MIgliazza, G., Wheeler, P., & Galea, M. (2020, November). Reliability oriented thermal management of aircraft power converters. Presented at 2020 IEEE 9th International Power Electronics and Motion Control Conference (IPEMC2020-ECCE Asia), Nanjing, China

On board electrical power generation continue to increase as more aircraft systems are being electrified. Increasingly power converters are the interface of power generation and electrical loads in aircrafts. Reliability of aircraft power electronics... Read More about Reliability oriented thermal management of aircraft power converters.

Numerical modelling of non-equilibrium condensation of carbon dioxide (CO2) in a converging-diverging nozzle (2020)
Presentation / Conference Contribution
Wen, C., Zhu, X., Yang, Y., Ding, H., & Yan, Y. (2019, September). Numerical modelling of non-equilibrium condensation of carbon dioxide (CO2) in a converging-diverging nozzle. Presented at International Conference of Numerical Analysis and Applied Mathematics (ICNAAM 2019), Rhodes, Greece

The condensing flow model is developed to predict the non-equilibrium condensation of CO2 in a converging-diverging nozzle using computational fluid dynamics modelling, which is expected to contribute to the carbon capture and storage. The numerical... Read More about Numerical modelling of non-equilibrium condensation of carbon dioxide (CO2) in a converging-diverging nozzle.

A PM-Assisted Synchronous Reluctance Motor with Two Slot-Pitch Winding (2020)
Presentation / Conference Contribution
Zhu, S., Cox, T., Xu, Z., & Gerada, C. (2020, November). A PM-Assisted Synchronous Reluctance Motor with Two Slot-Pitch Winding. Presented at 2020 23rd International Conference on Electrical Machines and Systems (ICEMS), Hamamatsu, Japan

This paper presents a novel electric motor solution to tackle the increasing demand on the traction motor for electric vehicles. The proposed electric motor has a 24 slots 10 poles fractional slot two-slot pitch winding and a PM-assisted synchronous... Read More about A PM-Assisted Synchronous Reluctance Motor with Two Slot-Pitch Winding.

AC loss Analysis in Winding of Electrical Machines with varying Strands-in-hand and Bundle Shapes (2020)
Presentation / Conference Contribution
Bardalai, A., Gerada, D., Xu, Z., & Gerada, C. (2020, November). AC loss Analysis in Winding of Electrical Machines with varying Strands-in-hand and Bundle Shapes. Presented at 2020 23rd International Conference on Electrical Machines and Systems (ICEMS), Hamamatsu, Japan

This paper presents an investigation into the sensitivity of high-frequency AC effects on the winding with varying number of parallel strands. Based on numerical analysis, a methodology to segregate the losses into components is presented. It is show... Read More about AC loss Analysis in Winding of Electrical Machines with varying Strands-in-hand and Bundle Shapes.

PM Halbach Arrays in Motors: Loss Reduction and Performance Improvements (2020)
Presentation / Conference Contribution
Hebala, A., Nuzzo, S., Connor, P. H., Giangrande, P., Gerada, C., & Galea, M. (2020, November). PM Halbach Arrays in Motors: Loss Reduction and Performance Improvements. Presented at 2020 23rd International Conference on Electrical Machines and Systems (ICEMS), Hamamatsu, Japan

© 2020 The Institute of Electrical Engineers of Japan. Halbach array configurations represent a common choice in high-performance electrical machines, since a stronger magnetic field is generated for the same Permanent Magnet (PM) volume. Hence, high... Read More about PM Halbach Arrays in Motors: Loss Reduction and Performance Improvements.

On single-phase operation of three-phase synchronous generators (2020)
Presentation / Conference Contribution
Spagnolo, C., Nuzzo, S., Giangrande, P., Galea, M., & Serra, G. (2020, November). On single-phase operation of three-phase synchronous generators. Presented at 2020 23rd International Conference on Electrical Machines and Systems (ICEMS), Hamamatsu, Japan

Classical synchronous generators have been used for decades in the field of power generation. The traditional manner of operation of these systems is the balanced, three phase configuration. However, recently there has been an interest in re-configur... Read More about On single-phase operation of three-phase synchronous generators.

Influence of Thermal Aging on the Winding Thermal Conductivity in Low Voltage Electrical Machines (2020)
Presentation / Conference Contribution
Madonna, V., Giangrande, P., & Galea, M. (2020, November). Influence of Thermal Aging on the Winding Thermal Conductivity in Low Voltage Electrical Machines. Presented at 2020 23rd International Conference on Electrical Machines and Systems (ICEMS), Hamamatsu, Japan

It is widely acknowledged that thermal aging can have a detrimental effect on the reliability and lifetime expectancy of electrical machines. Long exposure times to high temperature can deteriorate the dielectric properties of the electrical insulati... Read More about Influence of Thermal Aging on the Winding Thermal Conductivity in Low Voltage Electrical Machines.