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All Outputs (252)

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection (2022)
Preprint / Working Paper
Packer, R., Shrine, N., Hall, R., Melbourne, C., Thompson, R., Williams, A., …Wain, L. Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection

Background Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve understanding o... Read More about Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.

Enhancement of Syngas Production in Co-Pyro-Gasification of Biomass and Plastic Waste Materials: Computational Study (2022)
Preprint / Working Paper
Darkwa, J., Kwawu, C., Corner, J., Kemausuor, F., Adei, E., Agyekum, K., & Boateng, I. D. Enhancement of Syngas Production in Co-Pyro-Gasification of Biomass and Plastic Waste Materials: Computational Study

The process of co-pyro-gasification of biomass and plastics appears to have the potential for increasing syngas production for power generation and thus minimizing the impact of plastic waste on the environment. This study was based on co-pyro-gasifi... Read More about Enhancement of Syngas Production in Co-Pyro-Gasification of Biomass and Plastic Waste Materials: Computational Study.

Undirected, Pd-catalysed deuteration of indoles with programmable regioselectivity (2022)
Preprint / Working Paper
Fitzgerald, L., McNulty, R., Greener, A., & O'Duill, M. Undirected, Pd-catalysed deuteration of indoles with programmable regioselectivity

Methods for selective deuterium-incorporation into drug-like molecules have become extremely valuable due to the commercial and biological importance of deuterated compounds. Selective C2-deuteration of indoles currently requires the installation of... Read More about Undirected, Pd-catalysed deuteration of indoles with programmable regioselectivity.

Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand (2022)
Preprint / Working Paper
Blount, B. A., Lu, X., Driessen, M. R. M., Jovicevic, D., Sanchez, M. I., Ciurkot, K., …Ellis, T. Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand

We describe construction of the 660 kilobase synthetic yeast chromosome XI (synXI) and reveal how synthetic redesign of non-coding DNA elements impact the cell. To aid construction from synthesized 5 to 10 kilobase DNA fragments, we implemented CRISP... Read More about Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand.

White Matter Microstructural Alteration in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging (2022)
Preprint / Working Paper
Alotaibi, A., Podlasek, A., AlTokhis, A., Tench, C. R., Mohammadi-Nejad, A., Sotiropoulos, S. N., …Dineen, R. A. White Matter Microstructural Alteration in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging

Background: Type 2 diabetes mellitus impacts the brain microstructural environment. Diffusion tensor imaging (DTI) has been widely used to characterize white matter microstructural abnormalities in type 2 diabetes but fails to fully characterise dise... Read More about White Matter Microstructural Alteration in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging.

Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites (2022)
Preprint / Working Paper
he, Y., Begines, B., Trindade, G., Abdi, M., dubern, J., Prina, E., …Wildman, R. Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites

As our understanding of disease grows, it is becoming established that treatment needs to be personalized and targeted to the needs of the individual. In this paper we show that multi-material inkjet-based 3D printing, when backed with generative des... Read More about Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites.

The Impact of Covid-19 on Productivity (2022)
Preprint / Working Paper
Bloom, N., Bunn, P., Mizen, P., Smietanka, P., & Thwaites, G. The Impact of Covid-19 on Productivity

We analyse the impact of Covid-19 on productivity using data from an innovative monthly firm survey panel that asks for quantitative impacts of Covid on inputs and outputs. We find total factor productivity (TFP) fell by up to 5% during 2020-21. The... Read More about The Impact of Covid-19 on Productivity.

Laboratory strains of Escherichia coli K-12: not such perfect role models after all (2022)
Preprint / Working Paper
Browning, D. F., Hobman, J. L., & Busby, S. J. Laboratory strains of Escherichia coli K-12: not such perfect role models after all

Escherichia coli K-12 was originally isolated 100 years ago and since then, it has become an invaluable model organism and a cornerstone of molecular biology research. However, despite its apparent pedigree, since its initial isolation, E. coli K-12... Read More about Laboratory strains of Escherichia coli K-12: not such perfect role models after all.

Understanding Trust and Sustained Use or Abandonment after a Year with the NHS Covid-19 Contact Tracing App in the United Kingdom: A Longitudinal Mixed-Method Study (2022)
Preprint / Working Paper
Pepper, C., Reyes-Cruz, G., Pena, A. R., Dowthwaite, L., Babbage, C. M., Wagner, H. G., …Fischer, J. E. Understanding Trust and Sustained Use or Abandonment after a Year with the NHS Covid-19 Contact Tracing App in the United Kingdom: A Longitudinal Mixed-Method Study

Background: Digital contact tracing (DCT) apps have been recently implemented widely as a response to the Covid-19 pandemic. Research has focused on understanding the acceptance and adoption of these apps, but more work is needed to understand which... Read More about Understanding Trust and Sustained Use or Abandonment after a Year with the NHS Covid-19 Contact Tracing App in the United Kingdom: A Longitudinal Mixed-Method Study.

The Centre for Rehabilitation and Ageing Research in Nottingham and Derby 2022. Excellence in care through world class research (2022)
Preprint / Working Paper
Gladman, Logan, Gordon, Harwood, Goldberg, & Radford. The Centre for Rehabilitation and Ageing Research in Nottingham and Derby 2022. Excellence in care through world class research

It is with pleasure that we present this brochure outlining the work of the Centre for Rehabilitation and Ageing and Research (CRAR) at the University of Nottingham and its partner NHS Trusts in Nottingham, and Derby and Burton.

Navigating Incommensurability Between Ethnomethodology, Conversation Analysis, and Artificial Intelligence (2022)
Preprint / Working Paper
Reeves, S. Navigating Incommensurability Between Ethnomethodology, Conversation Analysis, and Artificial Intelligence

Like many research communities, ethnomethodologists and conversation analysts have begun to get caught up -- yet again -- in the pervasive spectacle of surging interests in Artificial Intelligence (AI). Inspired by discussions amongst a growing netwo... Read More about Navigating Incommensurability Between Ethnomethodology, Conversation Analysis, and Artificial Intelligence.

Rights Lab Ecosystems and the Environment Programme Submission to the United Nations Special Rapporteur on trafficking in persons, especially women and children (2022)
Preprint / Working Paper
Jackson, B. (2022). Rights Lab Ecosystems and the Environment Programme Submission to the United Nations Special Rapporteur on trafficking in persons, especially women and children. https://owncloud.unog.ch/s/kFQa8RmZP4mSGn9?path=%2F2)%20Other%20Stakeholders#pdfviewer: OHCHR Special Rapporteur on trafficking in persons, especially women and children

Rights Lab Ecosystems and the Environment Programme Submission to the United Nations Special Rapporteur on trafficking in persons, especially women and children. May 2022.

NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022 (2022)
Preprint / Working Paper
Gladman, J., Piasecki, M., & Frost, K. NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022

This paper gives summaries of the keynote lectures given and the research abstracts presented at the NIHR Nottingham Biomedical Research Centre Musculoskeletal theme virtual conference held on 24th and 25th February 2022.
The purpose of the confere... Read More about NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022.

Temporal trends in the incidence of haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003-2018 (2022)
Preprint / Working Paper
West, J., Stilwell, P., Liu, H., Ban, L., Bythell, M., Card, T. R., …Crooks, C. J. Temporal trends in the incidence of haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003-2018

Background Haemophagocytic lymphohistiocytosis (HLH) is rare, results in high mortality and is increasingly being diagnosed. Little is known about what is driving the apparent rise in the incidence of this disease.

Methods Using national linked el... Read More about Temporal trends in the incidence of haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003-2018.

'Queer/ing China': Theorizing Chinese genders and sexualities through a transnational lens (2022)
Preprint / Working Paper
Zhao, J. J., & Bao, H. 'Queer/ing China': Theorizing Chinese genders and sexualities through a transnational lens

In this viewpoint essay, using ‘queer/ing China’ as a heuristic, we explore ‘queerness’ and ‘Chineseness’ through an intersectional approach that is attuned to the encounters, syntheses and dissonances of local, transnational and global queer and fem... Read More about 'Queer/ing China': Theorizing Chinese genders and sexualities through a transnational lens.

Older adult forensic mental health patients’ views on barriers, facilitators and ‘what works’ to enable better quality of life, health and wellbeing and to reduce risk of reoffending and harm to self and others (2022)
Preprint / Working Paper
Walker, K., Yates, J., Dening, T., Vollm, B., Tomlin, J., & Griffiths, C. Older adult forensic mental health patients’ views on barriers, facilitators and ‘what works’ to enable better quality of life, health and wellbeing and to reduce risk of reoffending and harm to self and others

Introduction
Research evidence that can inform service provision and treatment requirements for older (aged 55 years and above) forensic mental health patients is lacking, particularly that which is based on patients’ own preferences and experience... Read More about Older adult forensic mental health patients’ views on barriers, facilitators and ‘what works’ to enable better quality of life, health and wellbeing and to reduce risk of reoffending and harm to self and others.

Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis (2022)
Preprint / Working Paper
Middleton, S., Chalitsios, C., McKeever, T. M., Jenkins, A. R., & Bolton, C. E. Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis

Background Acute COVID-19 clinical symptoms have been clearly documented, but long-term functional and symptomatic recovery from COVID -19 is less well described.

Methods A systematic review and meta-analysis were conducted to describe patient-rep... Read More about Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis.

Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space (2022)
Preprint / Working Paper
Warrington, S., Thompson, E., Bastiani, M., Dubois, J., Baxter, L., Slater, R., …Sotiropoulos, S. N. Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space

Developmental and evolutionary effects on brain organisation are complex, yet linked, as evidenced by the striking correspondence in cortical expansion changes. However, it is still not possible to study concurrently the ontogeny and phylogeny of cor... Read More about Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space.

Geographical Distribution of Biomphalaria snails in East Africa (2022)
Preprint / Working Paper
Magero, V. O., Kisara, S., & Wade, C. M. Geographical Distribution of Biomphalaria snails in East Africa

There is limited information on the distribution of Biomphalaria snails, an important snail intermediate host of schistosomiasis, in East Africa. This study assessed the incidence and geographical distribution of Biomphalaria snails in Kenya, Uganda... Read More about Geographical Distribution of Biomphalaria snails in East Africa.