All Outputs (228)

Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings (2024)
Preprint / Working Paper
Lei, C. L., Clark, A. P., Clerx, M., Wei, S., Bloothooft, M., de Boer, T. P., Christini, D. J., Krogh-Madsen, T., & Mirams, G. R. Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings

Cellular electrophysiology is the foundation of many fields, from basic science in neurology, cardiology, oncology to safety critical applications for drug safety testing, clinical phenotyping, etc. Patch-clamp voltage clamp is the gold standard tech... Read More about Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings.

Theoretical and computational aspects of Hilbert-Maass forms (2024)
Preprint / Working Paper
Singh, S., & Strömberg, F. Theoretical and computational aspects of Hilbert-Maass forms

We introuce algorithms for computing Hilbert - Maass forms and present results obtained by using these algorithms. We also give an overview of the explicit Hecke theory for Hilbert -Maaass forms in the case of narrow class number one.

Applying Critical Discourse Analysis to Cross-Cultural Mental Health Recovery Research: Positive Changes and No Value Judgement (2024)
Preprint / Working Paper
Kotera, Y., Daryanani, R., Skipper, O., Jonathan Simpson, A., Takhi, S., McPhilbin, M., …Vilar-Lluch, S. Applying Critical Discourse Analysis to Cross-Cultural Mental Health Recovery Research: Positive Changes and No Value Judgement

The purpose of this paper is to demonstrate how Critical Discourse Analysis (CDA) frameworks can be used in cross-cultural mental health recovery research. CDA is a qualitative approach that critically appraises how language contributes to produce an... Read More about Applying Critical Discourse Analysis to Cross-Cultural Mental Health Recovery Research: Positive Changes and No Value Judgement.

Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences (2024)
Preprint / Working Paper
Deakin, B., Liddle, E., Rathnaiah, M., Gregory, C., Katshu, M., Wiliams, G., Conen, S., Smallman, R., Koelewijn, L. C., Anton, A., Kumar, J., Gasgoyne, L. E., Chen, C., Nikkheslat, N., Evans, J., Lanz, B., Walters, J., Talbot, P., Palaniyappan, L., Singh, K. D., …Liddle, P. F. Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences

It is widely thought that the onset of psychotic symptoms in schizophrenia may arise from an early neurotoxic phase, possibly related to oxidative stress or inflammation, and a late residual damage phase associated with persistent negative symptoms.... Read More about Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences.

Vivaldi: An amplicon-based whole genome sequencing method for the four seasonal human coronaviruses 229E, NL63, OC43 & HKU1, alongside SARS-CoV-2 (2024)
Preprint / Working Paper
McClure, C. P., Tsoleridis, T., Holmes, N., Chappell, J. G., Byaruhanga, T., Duncan, J., Tofan, M., Khater, A., Berry, L., Clark, G., Irving, W. L., Tarr, A. W., Ball, J. K., Astbury, S., & Loose, M. Vivaldi: An amplicon-based whole genome sequencing method for the four seasonal human coronaviruses 229E, NL63, OC43 & HKU1, alongside SARS-CoV-2

Prior to the emergence of SARS-CoV-2 in 2019, Alphacoronaviruses 229E and NL63 and Betacoronaviruses OC43 and HKU1 were already established endemic ‘common cold’ viral infections. Despite their collective contribution towards global respiratory morbi... Read More about Vivaldi: An amplicon-based whole genome sequencing method for the four seasonal human coronaviruses 229E, NL63, OC43 & HKU1, alongside SARS-CoV-2.

2,2-Difluoroethylation of heteroatom nucleophiles via a hypervalent iodine strategy (2024)
Preprint / Working Paper
Das, S., McIvor, C., Greener, A., Suwita, C., Argent, S., & O'Duill, M. 2,2-Difluoroethylation of heteroatom nucleophiles via a hypervalent iodine strategy

The 2,2-difluoroethyl group is an important lipophilic hydrogen bond donor in medicinal chemistry, but its incorporation into small molecules is often challenging. Herein, we demonstrate electrophilic 2,2 difluoroethylation of thiol, amine and alcoho... Read More about 2,2-Difluoroethylation of heteroatom nucleophiles via a hypervalent iodine strategy.

A systematic review and narrative synthesis exploring the relationship between friendships and peer relationships, and self-harm ideation and behaviour among young people (2024)
Preprint / Working Paper
Bilello, D., Townsend, E., Broome, M. R., Armstrong, G., & Burnett Heyes, S. A systematic review and narrative synthesis exploring the relationship between friendships and peer relationships, and self-harm ideation and behaviour among young people

Friendships and peer relationships have an important role in the experience of self-harm ideation and behaviour in young people, yet they typically remain overlooked. The present systematic review and narrative synthesis explore the extant literature... Read More about A systematic review and narrative synthesis exploring the relationship between friendships and peer relationships, and self-harm ideation and behaviour among young people.

A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD (2024)
Preprint / Working Paper
Vinogradova, Y., Iyen, B., Masud, T., Taylor, L., & Kai, J. A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD

Menopausal hormone therapy (MHT) is prescribed to women with severe symptoms of menopause. Various studies have demonstrated increased bone density and decreased fracture risk in women using MHT. The randomised controlled trials were, however, run ov... Read More about A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD.

An experimental investigation of rundown of the L-type calcium current [version 1; peer review: awaiting peer review] (2024)
Preprint / Working Paper
Agrawal, A., Clerx, M., Wang, K., Gissinger, E., J. Gavaghan, D., Polonchuk, L., & R. Mirams, G. An experimental investigation of rundown of the L-type calcium current [version 1; peer review: awaiting peer review]

Background L-type calcium channels (LCCs) are multi-protein macro-molecular ion channel complexes that are involved in several critical functions in cardiac, skeletal, neuronal, smooth muscle, and endocrine cells. Like other ion channels, LCCs can... Read More about An experimental investigation of rundown of the L-type calcium current [version 1; peer review: awaiting peer review].

Variability in reported midpoints of (in)activation of cardiac INa (2024)
Preprint / Working Paper
Clerx, M., G.A. Volders, P., & R. Mirams, G. Variability in reported midpoints of (in)activation of cardiac INa

Electrically active cells like cardiomyocytes show variability in their size, shape, and electrical activity. But should we expect variability in the properties of their ionic currents? In this brief review we gather and visualise measurements of two... Read More about Variability in reported midpoints of (in)activation of cardiac INa.

Reinforcement learning when your life depends on it: a neuro-economic theory of learning (2024)
Preprint / Working Paper
Jiang, J., Foyard, E., & van Rossum, M. C. Reinforcement learning when your life depends on it: a neuro-economic theory of learning

Synaptic plasticity enables animals to adapt to their environment, but memory formation can consume a substantial amount of metabolic energy, potentially impairing survival. Hence, a neuro-economic dilemma arises whether learning is a profitable inve... Read More about Reinforcement learning when your life depends on it: a neuro-economic theory of learning.

Horse owners' and veterinary practitioners' experiences of decision-making for critical cases of colic (2024)
Preprint / Working Paper
Freeman, S., Burrell, K., Burford, J., & England, G. Horse owners' and veterinary practitioners' experiences of decision-making for critical cases of colic

Background: The survival of horses diagnosed with critical colic relies on rapid and effective decision-making by owner and veterinary practitioner. Objectives: To explore horse owners’ and veterinary practitioners’ experiences of decision-making for... Read More about Horse owners' and veterinary practitioners' experiences of decision-making for critical cases of colic.

Peer-Reviews and AI Feedback Compared: University Students’ Preferences (2024)
Preprint / Working Paper
Zapata, G. C., Saini, A. K., Cope, B., Kalantzis, M., & Searsmith, D. Peer-Reviews and AI Feedback Compared: University Students’ Preferences

This article seeks to contribute to the existing literature on peer review by comparing human with machine reviews based on the implementation of a chatbot responding with reference to a large language model for the review of open-ended student work.... Read More about Peer-Reviews and AI Feedback Compared: University Students’ Preferences.

Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach (2024)
Preprint / Working Paper
Batra, S., Ragan, T. J., Frank, A. M., Kaplan, M., Lancey, C., Assadipapari, M., …Campeotto, I. Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a significant global public health concern. It affects an estimated eight million individuals worldwide, with the majority remaining undiagnosed. Despite its profound health... Read More about Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach.

Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo (2024)
Preprint / Working Paper
Semizoglou, E., Lo Re, L., Middleton, S. J., Perez-Sanchez, J., Tufarelli, T., Bennett, D. L., & Chisholm, K. I. Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo

C-low threshold mechanoreceptors (C-LTMRs) in animals (termed C-tactile (CT) fibres in humans) are a subgroup of C-fibre primary afferents, which innervate hairy skin and respond to low threshold punctate indentations and brush stimuli. These afferen... Read More about Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo.

Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study (2024)
Preprint / Working Paper
Suzuki, T., Kaneda, Y., Kotera, Y., Tanimoto, T., Ozaki, A., Bhandari, D., …Tabuchi, T. Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study

Background: Non-consensual sex including rape and sexual assault has been a global concern and may have been influenced by the COVID-19 pandemic, however the information on this topic is limited. Therefore, our objective was to survey the incidence r... Read More about Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study.

Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction (2024)
Preprint / Working Paper
Thangamuthu, M., Burwell, T., Aliev, G., Ghaderzadeh, S., Kohlrausch, E., Chen, Y., …Khlobystov, A. Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction

Minimizing our reliance on bulk precious metals is to increase the fraction of surface atoms and improve the metal-support interface. In this work, we employ a solvent/ligand/counterion-free method to deposit copper in the atomic form directly onto a... Read More about Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction.

Assessing spontaneous sensory neuron activity usingin vivocalcium imaging (2024)
Preprint / Working Paper
Ingram, S. L., Chisholm, K. I., Wang, F., De Koninck, Y., Denk, F., & Goodwin, G. L. Assessing spontaneous sensory neuron activity usingin vivocalcium imaging

Heightened spontaneous activity in sensory neurons is often reported in individuals living with chronic pain. It is possible to study this activity in rodents using electrophysiology, but these experiments require great skill and can be prone to bias... Read More about Assessing spontaneous sensory neuron activity usingin vivocalcium imaging.

A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom (2024)
Preprint / Working Paper
De Dios Perez, B., Booth, V., das Nair, R., Evangelou, N., Hassard, J., Ford, H. L., …Radford, K. A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom

Background To explore how a vocational rehabilitation (VR) intervention can be integrated within existing healthcare services for people with multiple sclerosis (MS) in the United Kingdom (UK) National Health Service (NHS). Methods Data from 37... Read More about A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom.

Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet (2024)
Preprint / Working Paper
de la Fuente, C., Grondin, A., Sine, B., Debieu, M., Belin, C., Hajjarpoor, A., …Laplaze, L. Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root sy... Read More about Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet.