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All Outputs (239)

Variability in reported midpoints of (in)activation of cardiac INa (2024)
Preprint / Working Paper
Clerx, M., G.A. Volders, P., & R. Mirams, G. Variability in reported midpoints of (in)activation of cardiac INa

Electrically active cells like cardiomyocytes show variability in their size, shape, and electrical activity. But should we expect variability in the properties of their ionic currents? In this brief review we gather and visualise measurements of two... Read More about Variability in reported midpoints of (in)activation of cardiac INa.

Reinforcement learning when your life depends on it: a neuro-economic theory of learning (2024)
Preprint / Working Paper
Jiang, J., Foyard, E., & van Rossum, M. C. Reinforcement learning when your life depends on it: a neuro-economic theory of learning

Synaptic plasticity enables animals to adapt to their environment, but memory formation can consume a substantial amount of metabolic energy, potentially impairing survival. Hence, a neuro-economic dilemma arises whether learning is a profitable inve... Read More about Reinforcement learning when your life depends on it: a neuro-economic theory of learning.

Horse owners' and veterinary practitioners' experiences of decision-making for critical cases of colic (2024)
Preprint / Working Paper
Freeman, S., Burrell, K., Burford, J., & England, G. Horse owners' and veterinary practitioners' experiences of decision-making for critical cases of colic

Background: The survival of horses diagnosed with critical colic relies on rapid and effective decision-making by owner and veterinary practitioner. Objectives: To explore horse owners’ and veterinary practitioners’ experiences of decision-making for... Read More about Horse owners' and veterinary practitioners' experiences of decision-making for critical cases of colic.

Peer-Reviews and AI Feedback Compared: University Students’ Preferences (2024)
Preprint / Working Paper
Zapata, G. C., Saini, A. K., Cope, B., Kalantzis, M., & Searsmith, D. Peer-Reviews and AI Feedback Compared: University Students’ Preferences

This article seeks to contribute to the existing literature on peer review by comparing human with machine reviews based on the implementation of a chatbot responding with reference to a large language model for the review of open-ended student work.... Read More about Peer-Reviews and AI Feedback Compared: University Students’ Preferences.

Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach (2024)
Preprint / Working Paper
Batra, S., Ragan, T. J., Frank, A. M., Kaplan, M., Lancey, C., Assadipapari, M., …Campeotto, I. Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a significant global public health concern. It affects an estimated eight million individuals worldwide, with the majority remaining undiagnosed. Despite its profound health... Read More about Open and closed conformations of a sub-80 kDa Chagas vaccine candidate defined by a cryo-EM led integrative approach.

Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo (2024)
Preprint / Working Paper
Semizoglou, E., Lo Re, L., Middleton, S. J., Perez-Sanchez, J., Tufarelli, T., Bennett, D. L., & Chisholm, K. I. Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo

C-low threshold mechanoreceptors (C-LTMRs) in animals (termed C-tactile (CT) fibres in humans) are a subgroup of C-fibre primary afferents, which innervate hairy skin and respond to low threshold punctate indentations and brush stimuli. These afferen... Read More about Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo.

Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study (2024)
Preprint / Working Paper
Suzuki, T., Kaneda, Y., Kotera, Y., Tanimoto, T., Ozaki, A., Bhandari, D., …Tabuchi, T. Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study

Background: Non-consensual sex including rape and sexual assault has been a global concern and may have been influenced by the COVID-19 pandemic, however the information on this topic is limited. Therefore, our objective was to survey the incidence r... Read More about Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study.

Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction (2024)
Preprint / Working Paper
Thangamuthu, M., Burwell, T., Aliev, G., Ghaderzadeh, S., Kohlrausch, E., Chen, Y., …Khlobystov, A. Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction

Minimizing our reliance on bulk precious metals is to increase the fraction of surface atoms and improve the metal-support interface. In this work, we employ a solvent/ligand/counterion-free method to deposit copper in the atomic form directly onto a... Read More about Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction.

Assessing spontaneous sensory neuron activity usingin vivocalcium imaging (2024)
Preprint / Working Paper
Ingram, S. L., Chisholm, K. I., Wang, F., De Koninck, Y., Denk, F., & Goodwin, G. L. Assessing spontaneous sensory neuron activity usingin vivocalcium imaging

Heightened spontaneous activity in sensory neurons is often reported in individuals living with chronic pain. It is possible to study this activity in rodents using electrophysiology, but these experiments require great skill and can be prone to bias... Read More about Assessing spontaneous sensory neuron activity usingin vivocalcium imaging.

Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet (2024)
Preprint / Working Paper
de la Fuente, C., Grondin, A., Sine, B., Debieu, M., Belin, C., Hajjarpoor, A., …Laplaze, L. Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root sy... Read More about Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet.

Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells (2024)
Preprint / Working Paper
Al-Hayali, M. Z., Nge, C., Lim, K. H., Collins, H. M., Kam, T. S., & Bradshaw, T. D. Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells

Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbo... Read More about Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2023)
Preprint / Working Paper
Abhishek, A., Grainge, M. J., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Stevenson, M. D., Nakafero, G., & Riley, R. D. Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation

Background Sulfasalazine induced cytopenia, nephrotoxicity, and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend three monthly monitoring blood-tests indefinitely while others recommend stopping monitoring after one ye... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Glutaredoxin regulation of primary root growth confers early drought stress tolerance in pearl millet (2023)
Preprint / Working Paper
de la Fuente, C., Grondin, A., Sine, B., Debieu, M., Belin, C., Hajjarpoor, A., …Laplaze, L. Glutaredoxin regulation of primary root growth confers early drought stress tolerance in pearl millet

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root sy... Read More about Glutaredoxin regulation of primary root growth confers early drought stress tolerance in pearl millet.

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial (2023)
Preprint / Working Paper
Greaves, S., Harvey, C., & Kotera, Y. (2023). Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial

The study aimed to investigate the effect of climate change exposure on affect and pro-environmental behavioural intentions in a randomised controlled trial. An online survey was completed by 100 adult participants and included measures of affect and... Read More about Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial.

MPeat2D - A fully coupled mechanical-ecohydrological model of peatland development in two dimensions (2023)
Preprint / Working Paper
Mahdiyasa, A. W., Large, D. J., Icardi, M., & Muljadi, B. P. MPeat2D - A fully coupled mechanical-ecohydrological model of peatland development in two dimensions

Higher dimensional models of peatland development are required to analyse the influence of spatial heterogeneity and complex feedback mechanisms. However, the current models exclude the mechanical process that leads to uncertainties in simulating the... Read More about MPeat2D - A fully coupled mechanical-ecohydrological model of peatland development in two dimensions.

A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2 (2023)
Preprint / Working Paper
Mitchell-White, J. I., Briggs, D. A., Mistry, S. J., Mbiwan, H. A., Kellam, B., Holliday, N. D., …Kerr, I. D. A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2

The human ATP-binding cassette (ABC) transporter, ABCG2 is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial for understanding drug transport and resistance in cancer, and has implications for wider p... Read More about A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2.

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2023)
Preprint / Working Paper
Huang, J., Shek, N., Choy, A., Lang, C., Miller, B., Tal-Singer, R., …Brown, M. Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Progress in lignocellulosic biomass valorization for biofuels and value‐added chemical production in the EU: A focus on thermochemical conversion processes (2023)
Preprint / Working Paper
Güleç, F., Anburajan, P., Umenweke, G. C., Musa, U., Williams, O., Mortezaei, Y., …Okolie, J. A. Progress in lignocellulosic biomass valorization for biofuels and value‐added chemical production in the EU: A focus on thermochemical conversion processes

The demand for sustainable energy sources has increased owing to environmental concerns, such as climate change, rising energy demand and rapid industrialization. Biomass utilization for bioenergy and value‐added chemical production has become essent... Read More about Progress in lignocellulosic biomass valorization for biofuels and value‐added chemical production in the EU: A focus on thermochemical conversion processes.