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All Outputs (228)

Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells (2024)
Preprint / Working Paper
Al-Hayali, M. Z., Nge, C., Lim, K. H., Collins, H. M., Kam, T. S., & Bradshaw, T. D. Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells

Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbo... Read More about Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2023)
Preprint / Working Paper
Abhishek, A., Grainge, M. J., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. D. Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation

Background Sulfasalazine induced cytopenia, nephrotoxicity, and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend three monthly monitoring blood-tests indefinitely while others recommend stopping monitoring after one ye... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Glutaredoxin regulation of primary root growth confers early drought stress tolerance in pearl millet (2023)
Preprint / Working Paper
de la Fuente, C., Grondin, A., Sine, B., Debieu, M., Belin, C., Hajjarpoor, A., …Laplaze, L. Glutaredoxin regulation of primary root growth confers early drought stress tolerance in pearl millet

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root sy... Read More about Glutaredoxin regulation of primary root growth confers early drought stress tolerance in pearl millet.

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial (2023)
Preprint / Working Paper
Greaves, S., Harvey, C., & Kotera, Y. (2023). Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial

The study aimed to investigate the effect of climate change exposure on affect and pro-environmental behavioural intentions in a randomised controlled trial. An online survey was completed by 100 adult participants and included measures of affect and... Read More about Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial.

MPeat2D - A fully coupled mechanical-ecohydrological model of peatland development in two dimensions (2023)
Preprint / Working Paper
Mahdiyasa, A. W., Large, D. J., Icardi, M., & Muljadi, B. P. MPeat2D - A fully coupled mechanical-ecohydrological model of peatland development in two dimensions

Higher dimensional models of peatland development are required to analyse the influence of spatial heterogeneity and complex feedback mechanisms. However, the current models exclude the mechanical process that leads to uncertainties in simulating the... Read More about MPeat2D - A fully coupled mechanical-ecohydrological model of peatland development in two dimensions.

A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2 (2023)
Preprint / Working Paper
Mitchell-White, J. I., Briggs, D. A., Mistry, S. J., Mbiwan, H. A., Kellam, B., Holliday, N. D., …Kerr, I. D. A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2

The human ATP-binding cassette (ABC) transporter, ABCG2 is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial for understanding drug transport and resistance in cancer, and has implications for wider p... Read More about A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2.

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2023)
Preprint / Working Paper
Huang, J., Shek, N., Choy, A., Lang, C., Miller, B., Tal-Singer, R., …Brown, M. Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Progress in lignocellulosic biomass valorization for biofuels and value‐added chemical production in the EU: A focus on thermochemical conversion processes (2023)
Preprint / Working Paper
Güleç, F., Anburajan, P., Umenweke, G. C., Musa, U., Williams, O., Mortezaei, Y., …Okolie, J. A. Progress in lignocellulosic biomass valorization for biofuels and value‐added chemical production in the EU: A focus on thermochemical conversion processes

The demand for sustainable energy sources has increased owing to environmental concerns, such as climate change, rising energy demand and rapid industrialization. Biomass utilization for bioenergy and value‐added chemical production has become essent... Read More about Progress in lignocellulosic biomass valorization for biofuels and value‐added chemical production in the EU: A focus on thermochemical conversion processes.

Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education (2023)
Preprint / Working Paper
Church, H. R., Brown, M. E., Govender, L., & Clark, D. Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education

Background: The number of healthcare professionals leaving clinical practice and transitioning to alternative careers in health professions education is increasing. Among these non-practicing healthcare professionals, concerns have been reported rega... Read More about Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education.

A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data (2023)
Preprint / Working Paper
Zuffa, S., Schmid, R., Bauermeister, A., Gomes, P. W. P., Caraballo-Rodriguez, A. M., Abiead, Y. E., …Dorrestein, P. C. A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known... Read More about A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data.

Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror (2023)
Preprint / Working Paper
Dowthwaite, L., Reyez Cruz, G., Pena, A. R., Pepper, C., Jäger, N., Barnard, P., …Benford, S. Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror

The home is becoming a key location for healthcare delivery, including the use of technology driven by autonomous systems (AS) to monitor and support healthcare plans. Using the example of a smart mirror, this paper describes the outcomes of focus gr... Read More about Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror.

PDI-functionalised glass beads: efficient, metal-free heterogeneous photocatalysts suitable for flow photochemistry (2023)
Preprint / Working Paper
Ali, H., Ahmed, I., Robertson, K., & Lanterna, A. PDI-functionalised glass beads: efficient, metal-free heterogeneous photocatalysts suitable for flow photochemistry

Perylene diimides (PDI) have an extraordinary ability to activate both energy and electron transfer process upon light excitation, however, their extremely low solubility has hindered their wide use as photocatalysts. Here, we show a series of suppor... Read More about PDI-functionalised glass beads: efficient, metal-free heterogeneous photocatalysts suitable for flow photochemistry.

UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI) (2023)
Preprint / Working Paper
McClaughlin, E., Elliott, S., Jewitt, S., Smallman-Raynor, M., Dunham, S., Parnell, T., …Tarlinton, R. UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI)

The scale of the current outbreak of highly pathogenic avian influenza (HPAI) due to the A/H5N1 virus in the United Kingdom is unprecedented. In addition to its economic impact on the commercial poultry sector, the disease has devastated wild bird co... Read More about UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI).

Generative AI: Implications and Applications for Education (2023)
Preprint / Working Paper
Olga, A., Saini, A., Zapata, G., Searsmith, D., Cope, B., Kalantzis, M., …Polyxeni Kastania, N. Generative AI: Implications and Applications for Education

The launch of ChatGPT in November 2022 precipitated a panic among some educators while prompting qualified enthusiasm from others. Under the umbrella term Generative AI, ChatGPT is an example of a range of technologies for the delivery of computer-ge... Read More about Generative AI: Implications and Applications for Education.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Preprint / Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., …Gran, S. The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID) (2023)
Preprint / Working Paper
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L., …on behalf of the PHOSP-COVID Collaborative Group. Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged. PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitali... Read More about Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID).

Assessing the residual benefit of soil-applied zinc on grain zinc nutritional quality of maize grown under contrasting soil types in Malawi. (2023)
Preprint / Working Paper
Botoman, L., Chimungu, J. G., Bailey, E. H., Munthali, M. W., Ander, E. L., Mossa, A., …Nalivata, P. C. Assessing the residual benefit of soil-applied zinc on grain zinc nutritional quality of maize grown under contrasting soil types in Malawi

A proper understanding of the residual value of zinc (Zn) is necessary for sustainable biofortification of food crops. This study aimed to establish the extent to which application of Zn at the national rate, plus two experimentally elevated rates, i... Read More about Assessing the residual benefit of soil-applied zinc on grain zinc nutritional quality of maize grown under contrasting soil types in Malawi..