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The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway (2000)
Journal Article
Webster, K., Parish, J., Pandya, M., Stern, P. L., Clarke, A. R., & Gaston, K. (2000). The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. Journal of Biological Chemistry, 275(1), 87-94. https://doi.org/10.1074/jbc.275.1.87

The human papillomavirus (HPV) E2 protein regulates viral gene expression and is also required for viral replication. HPV-transformed cells often contain chromosomally integrated copies of the HPV genome in which the viral E2 gene is disrupted. We ha... Read More about The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.

'Exploiting problem structure in a genetic algorithm approach to a nurse rostering problem' (2000)
Journal Article
Aickelin, U., & Dowsland, K. (2000). 'Exploiting problem structure in a genetic algorithm approach to a nurse rostering problem'

There is considerable interest in the use of genetic algorithms to solve problems arising in the areas of scheduling and timetabling. However, the classical genetic algorithm paradigm is not well equipped to handle the conflict between objectives and... Read More about 'Exploiting problem structure in a genetic algorithm approach to a nurse rostering problem'.

A Lorentzian Signature Model for Quantum General Relativity (2000)
Journal Article
Barrett, J. W., & Crane, L. (2000). A Lorentzian Signature Model for Quantum General Relativity

We give a relativistic spin network model for quantum gravity based on the Lorentz group and its q-deformation, the Quantum Lorentz Algebra.
We propose a combinatorial model for the path integral given by an integral over suitable representations of... Read More about A Lorentzian Signature Model for Quantum General Relativity.

Structures of confinement in nineteenth-century asylums, using England and Ontario as a comparative study (2000)
Journal Article
Bartlett, P. (2000). Structures of confinement in nineteenth-century asylums, using England and Ontario as a comparative study. International Journal of Law and Psychiatry, 23(1), https://doi.org/10.1016/S0160-2527%2898%2900041-7

Traditionally, historians of the care of the insane have understood their work as a branch of medical history. This paper focuses instead on the administrative structures of nineteenth century asylums. These are geographically specific and historica... Read More about Structures of confinement in nineteenth-century asylums, using England and Ontario as a comparative study.

Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells (2000)
Journal Article
Bayraktutan, U., Blayney, L., & Shah, A. (2000). Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells

The production of reactive oxygen species (ROS) within endothelial cells may have several effects, including
alterations in the activity of paracrine factors, gene expression, apoptosis, and cellular injury. Recent studies indicate that
a phagocyte... Read More about Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells.

Structured cases in case-based reasoning: re-using and adapting cases for time-tabling problems (2000)
Journal Article
Burke, E., MacCarthy, B. L., Petrovic, S., & Qu, R. (2000). Structured cases in case-based reasoning: re-using and adapting cases for time-tabling problems. Knowledge-Based Systems, 13(2-3),

In this paper, we present a case-based reasoning (CBR) approach solving educational time-tabling problems. Following the basic idea behind CBR, the solutions of previously solved problems are employed to aid finding the solutions for new problems. A... Read More about Structured cases in case-based reasoning: re-using and adapting cases for time-tabling problems.

The Productive use of Failure to Generate Witnesses from Divergent Proof Attempts for Coinduction (2000)
Journal Article
Dennis, L. A., Bundy, A., & Green, I. (2000). The Productive use of Failure to Generate Witnesses from Divergent Proof Attempts for Coinduction. Annals of Mathematics and Artificial Intelligence, 29(1-4),

Coinduction is a proof rule. It is the dual of induction. It allows reasoning about non--well--founded structures such as lazy lists or streams and is of particular use for reasoning about equivalences. A central difficulty in the automation of coi... Read More about The Productive use of Failure to Generate Witnesses from Divergent Proof Attempts for Coinduction.

Interleukin-4 receptor alpha gene variants and allergic disease (2000)
Journal Article
Hall, I. P. (2000). Interleukin-4 receptor alpha gene variants and allergic disease. Respiratory Research, 1(1),

The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual.... Read More about Interleukin-4 receptor alpha gene variants and allergic disease.

Crowning glory: public law, power and the monarchy (2000)
Journal Article
Murphy, T., & Whitty, N. (2000). Crowning glory: public law, power and the monarchy. Social and Legal Studies, 9(1), https://doi.org/10.1177/096466390000900102

‘New public law’ has a keen interest in the deployment of power and the shifting nature of the public and private. In this article, we argue that the historical legacy of the Crown has hindered the ability of public lawyers to respond to changes in m... Read More about Crowning glory: public law, power and the monarchy.

Traffic exposure increases natural 15N and heavy metal concentrations in mosses (2000)
Journal Article
Pearson, J., Wells, D. M., Seller, K. J., Bennett, A., Soares, A., Woodall, J., & Ingrouille, M. J. (2000). Traffic exposure increases natural 15N and heavy metal concentrations in mosses. New Phytologist, 147(2), 317-326. https://doi.org/10.1046/j.1469-8137.2000.00702.x

Mosses have been used as biomonitors of atmospheric pollution for some years, but few studies have been carried out on the effect of NO(x) emissions from traffic on moss tissue N. Eight species of moss (102 samples) growing on walls or roofs next to... Read More about Traffic exposure increases natural 15N and heavy metal concentrations in mosses.

Maternal nutrient restriction during early to mid gestation alters the relationship between insulin-like growth factor I and bodyweight at term in fetal sheep (2000)
Journal Article
Heasman, L., Brameld, J., Mostyn, A., Budge, H., Dawson, J., Buttery, P., …Symonds, M. E. (2000). Maternal nutrient restriction during early to mid gestation alters the relationship between insulin-like growth factor I and bodyweight at term in fetal sheep. Reproduction, Fertility and Development, 12(7-8), 345-350. https://doi.org/10.1071/rd00115

The present study was designed to determine whether altered placental size, as a consequence of maternal nutrient restriction in sheep between 28 and 77 days gestation, is associated with a modified relationship between fetal weight or dimensions and... Read More about Maternal nutrient restriction during early to mid gestation alters the relationship between insulin-like growth factor I and bodyweight at term in fetal sheep.

Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites (1999)
Journal Article
Lewis, H., & Gaston, K. (1999). Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites. Journal of Molecular Biology, 294(4), 885-896. https://doi.org/10.1006/jmbi.1999.3314

The human papillomavirus 16 E2 protein binds to four specific DNA sequences present within the HPV 16 genome and regulates viral gene expression and DNA replication. However, the E2 protein can also bind tightly to non-specific DNA sequences. Here, w... Read More about Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites.