Interleukin-4 receptor alpha gene variants and allergic disease

Hall, Ian P.

Abstract

The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor alpha (IL-4Ralpha) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Ralpha polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme

Citation

Hall, I. P. (2000). Interleukin-4 receptor alpha gene variants and allergic disease. Respiratory Research, 1(1),

• Journal Article Type: Article
• Publication Date: Jan 1, 2000
• Deposit Date: May 4, 2004
• Publicly Available Date: Oct 9, 2007
• Journal: Respiratory Research
• Print ISSN: 1465-9921
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Issue: 1
• Public URL: https://nottingham-repository.worktribe.com/output/1023713