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Base editing enables duplex point mutagenesis in Clostridium autoethanogenum at the price of numerous off-target mutations (2023)
Journal Article
Seys, F. M., Humphreys, C. M., Tomi-Andrino, C., Li, Q., Millat, T., Yang, S., & Minton, N. P. (2023). Base editing enables duplex point mutagenesis in Clostridium autoethanogenum at the price of numerous off-target mutations. Frontiers in Bioengineering and Biotechnology, 11, Article 1211197. https://doi.org/10.3389/fbioe.2023.1211197

Base editors are recent multiplex gene editing tools derived from the Cas9 nuclease of Streptomyces pyogenes. They can target and modify a single nucleotide in the genome without inducing double-strand breaks (DSB) of the DNA helix. As such, they hol... Read More about Base editing enables duplex point mutagenesis in Clostridium autoethanogenum at the price of numerous off-target mutations.

Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics (2023)
Journal Article
Bonifazi, A., Saab, E., Sanchez, J., Nazarova, A. L., Zaidi, S. A., Jahan, K., …Newman, A. H. (2023). Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics. Journal of Medicinal Chemistry, 66(15), 10304–10341. https://doi.org/10.1021/acs.jmedchem.3c00417

A new generation of dual-target μ opioid receptor (MOR) agonist/dopamine D3 receptor (D3R) antagonist/partial agonists with optimized physicochemical properties was designed and synthesized. Combining in vitro cell-based on-target/off-target affinity... Read More about Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.

Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers (2023)
Journal Article
Talhouni, S., Fadhil, W., Mongan, N. P., Field, L., Hunter, K., Makhsous, S., …Ramage, J. M. (2023). Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers. Frontiers in Immunology, 14, Article 1057292. https://doi.org/10.3389/fimmu.2023.1057292

Introduction: Characterization of the tumour immune infiltrate (notably CD8+ T-cells) has strong predictive survival value for cancer patients. Quantification of CD8 T-cells alone cannot determine antigenic experience, as not all infiltrating T-cells... Read More about Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers.

Morphological and osteological characterization of indigenous domestic chickens (Gallus gallus domesticus): validation of Rensch’s, Bergmann’s and Allen’s rules (2023)
Journal Article
Gebru, G., Belay, G., Dessie, T., Zenebe Kelkay, M., Birhanie Dagnhegn, M., & Hanotte, O. (2023). Morphological and osteological characterization of indigenous domestic chickens (Gallus gallus domesticus): validation of Rensch’s, Bergmann’s and Allen’s rules. Frontiers in Ecology and Evolution, 11, Article 1032082. https://doi.org/10.3389/fevo.2023.1032082

Ecogeographical habitat heterogeneity in wild endotherm species results in morphological variability associated with physiological mechanisms for maintaining their body temperature at a thermoneutral state in different environments. This habitat-indu... Read More about Morphological and osteological characterization of indigenous domestic chickens (Gallus gallus domesticus): validation of Rensch’s, Bergmann’s and Allen’s rules.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article
Metzler, V. M., de Brot, S., Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., …Jeyapalan, J. N. (2023). The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Frontiers in Cell and Developmental Biology, 11, Article 1116424. https://doi.org/10.3389/fcell.2023.1116424

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.

Numerical validation of novel scaling laws for air–water flows including compressibility and heat transfer (2023)
Journal Article
Catucci, D., Briganti, R., & Heller, V. (2023). Numerical validation of novel scaling laws for air–water flows including compressibility and heat transfer. Journal of Hydraulic Research, 61(4), 517-531. https://doi.org/10.1080/00221686.2023.2225462

Air–water flows are among the most important flow types in hydraulic engineering. Their experimental modelling at reduced size using Froude scaling laws introduces scale effects. This study introduces novel scaling laws for compressible air–water flo... Read More about Numerical validation of novel scaling laws for air–water flows including compressibility and heat transfer.

Anaphoric reference to mereological entities (2023)
Journal Article
Cokal, D., Filik, R., Sturt, P., & Poesio, M. (2023). Anaphoric reference to mereological entities. Discourse Processes, 60(3), 202-223. https://doi.org/10.1080/0163853x.2023.2197682

Corpus evidence suggests that in contexts in which the presence of multiple antecedents might favor plural reference, the disadvantage observed for singular reference may disappear if the potential antecedents are combined in a group-like plural enti... Read More about Anaphoric reference to mereological entities.

Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data (2023)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2023). Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data. Pain Practice, https://doi.org/10.1111/papr.13212

Purpose: Osteoarthritis (OA) is a chronic painful condition that often affects large joints such as the knee. Treatment guidelines recommend paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. Antidepressants and anti-epileptic d... Read More about Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data.

Higher education student motivations for extracurricular activities: evidence from UK universities (2023)
Journal Article
Chapman, G., Emambocus, W., & Obembe, D. (2023). Higher education student motivations for extracurricular activities: evidence from UK universities. Journal of Education and Work, 36(2), 138-152. https://doi.org/10.1080/13639080.2023.2167955

Higher education students are required to demonstrate value beyond their curricula achievements to secure jobs in increasingly competitive labour markets. Focusing on extracurricular activities as one-way students can do so, this paper uses a motivat... Read More about Higher education student motivations for extracurricular activities: evidence from UK universities.

Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials (2023)
Journal Article
Kraglund, F., Christensen, D. H., Eiset, A. H., Villadsen, G. E., West, J., & Jepsen, P. (2023). Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials. Hepatology Communications, 7(1), Article e0013. https://doi.org/10.1097/HC9.0000000000000013

Background and Aims: Observational studies have shown an association between statin or aspirin use and a decreased risk of HCC, but the effects of a well-defined treatment strategy remain unknown. We emulated trials of the effects of continuous stati... Read More about Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials.

Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects (2023)
Journal Article
Diringer, M., Coliat, P., Mathieu, C., Laurent, N., Mura, C., Banerjee, M., …Detappe, A. (2023). Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects. Small, 19(12), Article 2205961. https://doi.org/10.1002/smll.202205961

Improving the tumor reoxygenation to sensitize the tumor to radiation therapy is a cornerstone in radiation oncology. Here, the pre‐clinical development of a clinically transferable liposomal formulation encapsulating trans sodium crocetinate (NP TSC... Read More about Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects.

HRT in Women Undergoing Pelvic Clearance for Endometriosis—A Case Report and a National Survey (2023)
Journal Article
Amer, S., & Bazmi, S. (2023). HRT in Women Undergoing Pelvic Clearance for Endometriosis—A Case Report and a National Survey. Journal of Clinical Medicine, 12(1), Article 336. https://doi.org/10.3390/jcm12010336

The optimal hormone replacement therapy (HRT) in women who have undergone pelvic clearance for endometriosis remains uncertain with insufficient evidence. The purpose of this case report and the national survey was to highlight the potential HRT-rela... Read More about HRT in Women Undergoing Pelvic Clearance for Endometriosis—A Case Report and a National Survey.

Deep Feature and Domain Knowledge Fusion Network for Mapping Surface Water Bodies by Fusing Google Earth RGB and Sentinel-2 images (2023)
Journal Article
Zhou, P., Li, X., Foody, G. M., Boyd, D. S., Wang, X., Ling, F., …Du, Y. (2023). Deep Feature and Domain Knowledge Fusion Network for Mapping Surface Water Bodies by Fusing Google Earth RGB and Sentinel-2 images. IEEE Geoscience and Remote Sensing Letters, 1-1. https://doi.org/10.1109/LGRS.2023.3234306

Mapping surface water bodies from fine spatial resolution optical remote sensing imagery is essential for the understanding of the global hydrologic cycle. Although satellite data are useful for mapping, the limited spectral information captured by s... Read More about Deep Feature and Domain Knowledge Fusion Network for Mapping Surface Water Bodies by Fusing Google Earth RGB and Sentinel-2 images.

Association between prealbumin, all-cause mortality, and response to nutrition treatment in patients at nutrition risk. Secondary analysis of a randomized controlled trial (2023)
Journal Article
Bretscher, C., Buergin, M., Gurzeler, G., Kägi-Braun, N., Gressies, C., Tribolet, P., …for the EFFORT study team. (2023). Association between prealbumin, all-cause mortality, and response to nutrition treatment in patients at nutrition risk. Secondary analysis of a randomized controlled trial. Journal of Parenteral and Enteral Nutrition, 47(3), 408-419. https://doi.org/10.1002/jpen.2470

Background: Because of the shorter half-life as compared with albumin, serum prealbumin concentrations have been proposed to be useful nutrition biomarkers for the assessment of patients at nutrition risk. In a post hoc analysis of patients at nutrit... Read More about Association between prealbumin, all-cause mortality, and response to nutrition treatment in patients at nutrition risk. Secondary analysis of a randomized controlled trial.

The Advanced Clinical Practitioner (ACP) in UK healthcare: Dichotomies in a new ‘multi-professional’ profession (2023)
Journal Article
Timmons, S., Mann, C., Evans, C., Pearce, R., Overton, C., & Hinsliff-Smith, K. (2023). The Advanced Clinical Practitioner (ACP) in UK healthcare: Dichotomies in a new ‘multi-professional’ profession. SSM - Qualitative Research in Health, 3, Article 100211. https://doi.org/10.1016/j.ssmqr.2022.100211

Advanced Clinical Practitioners (ACPs) work in a wide range of settings across the English National Health Service. ACPs come from a wide range of health professional backgrounds. This paper explores the ACP as a multi-professional role, and the impl... Read More about The Advanced Clinical Practitioner (ACP) in UK healthcare: Dichotomies in a new ‘multi-professional’ profession.