All Outputs (3392)

Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning (2021)
Journal Article
Bauer, M., Buckley, M. G., & Bast, T. (2021). Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning. Brain and Neuroscience Advances, 5, 1-17. https://doi.org/10.1177/23982128211002725

Spatial memory has been closely related to the medial temporal lobe (MTL) and theta-oscillations are thought to play a key role. However, it remains difficult to investigate MTL activation related to spatial memory with non-invasive electrophysiologi... Read More about Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning.

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes (2021)
Journal Article
Mai, Q. N., Shenoy, P., Quach, T., Retamal, J. S., Gondin, A. B., Yeatman, H. R., …Veldhuis, N. A. (2021). A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes. Journal of Biological Chemistry, 296, Article 100345. https://doi.org/10.1016/J.JBC.2021.100345

G-protein-coupled receptors (GPCRs) are traditionally known for signaling at the plasma membrane, but they can also signal from endosomes after internalization to control important pathophysiological processes. In spinal neurons, sustained endosomal... Read More about A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.

Optimal feedback law recovery by gradient-augmented sparse polynomial regression (2021)
Journal Article
Azmi, B., Kalise, D., & Kunisch, K. (2021). Optimal feedback law recovery by gradient-augmented sparse polynomial regression. Journal of Machine Learning Research, 22, 1-32

A sparse regression approach for the computation of high-dimensional optimal feedback laws arising in deterministic nonlinear control is proposed. The approach exploits the control-theoretical link between Hamilton-Jacobi-Bellman PDEs characterizing... Read More about Optimal feedback law recovery by gradient-augmented sparse polynomial regression.

ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma (2021)
Journal Article
Nasir, A., Cardall, A., Othman, R. T., Nicolaou, N., Lourdusamy, A., Linke, F., …Coyle, B. (2021). ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma. Neuro-Oncology Advances, 3(1), https://doi.org/10.1093/noajnl/vdab030

Background: Therapeutic intervention in metastatic medulloblastoma is dependent upon elucidating the underlying metastatic mechanism. We investigated whether an epithelialmesenchymal transition (EMT)-like pathway could drive medulloblastoma metastasi... Read More about ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function (2021)
Journal Article
Barnes, N. M., Ahern, G. P., Becamel, C., Bockaert, J., Camilleri, M., Chaumont-Dubel, S., …Hoyer, D. (2021). International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacological Reviews, 73(1), 310-520. https://doi.org/10.1124/pr.118.015552

Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics. 5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and fu... Read More about International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.

Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome (2021)
Journal Article
Bergero, R., Ellis, P., Haerty, W., Larcombe, L., Macaulay, I., Mehta, T., …Immler, S. (2021). Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome. Biological Reviews, 96(3), 822-841. https://doi.org/10.1111/brv.12680

The separation of germ cell populations from the soma is part of the evolutionary transition to multicellularity. Only genetic information present in the germ cells will be inherited by future generations, and any molecular processes affecting the ge... Read More about Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome.

Potential of Bioenergy in Rural Ghana (2021)
Journal Article
Nelson, N., Darkwa, J., Calautit, J., Worall, M., Mokaya, R., Adjei, E., …Ahiekpor, J. (2021). Potential of Bioenergy in Rural Ghana. Sustainability, 13(1), Article 381. https://doi.org/10.3390/su13010381

Crop residues are common in rural Ghana due to the predominant role agriculture plays in livelihood activities in these communities. In this paper we investigate the prospects of exploiting agricultural crop residues for rural development in Ghana th... Read More about Potential of Bioenergy in Rural Ghana.

AhaP, A Quorum Quenching Acylase from Psychrobacter sp. M9-54-1 That Attenuates Pseudomonas aeruginosa and Vibrio coralliilyticus Virulence (2021)
Journal Article
Reina, J. C., Romero, M., Salto, R., Cámara, M., & Llamas, I. (2021). AhaP, A Quorum Quenching Acylase from Psychrobacter sp. M9-54-1 That Attenuates Pseudomonas aeruginosa and Vibrio coralliilyticus Virulence. Marine Drugs, 19(1), Article 16. https://doi.org/10.3390/md19010016

Although Psychrobacter strain M9-54-1 had been previously isolated from the microbiota of holothurians and shown to degrade quorum sensing (QS) signal molecules C6 and C10-homoserine lactone (HSL), little was known about the gene responsible for this... Read More about AhaP, A Quorum Quenching Acylase from Psychrobacter sp. M9-54-1 That Attenuates Pseudomonas aeruginosa and Vibrio coralliilyticus Virulence.

Comparison of simple averaging and latent class modeling to estimate the area of land cover in the presence of reference data variability (2021)
Journal Article
Xing, D., Stehman, S. V., Foody, G. M., & Pengra, B. W. (2021). Comparison of simple averaging and latent class modeling to estimate the area of land cover in the presence of reference data variability. Land, 10(1), Article 35. https://doi.org/10.3390/land10010035

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Estimates of the area or percent area of the land cover classes within a study region are often based on the reference land cover class labels assigned by analysts interpreting satellite image... Read More about Comparison of simple averaging and latent class modeling to estimate the area of land cover in the presence of reference data variability.

The evidence for cognitive behavioural therapy in any condition, population or context: a meta-review of systematic reviews and panoramic meta-analysis (2021)
Journal Article
Fordham, B., Sugavanam, T., Edwards, K., Stallard, P., Howard, R., Das Nair, R., …Lamb, S. E. (2021). The evidence for cognitive behavioural therapy in any condition, population or context: a meta-review of systematic reviews and panoramic meta-analysis. Psychological Medicine, 51(1), 21-29. https://doi.org/10.1017/s0033291720005292

The majority of psychological treatment research is dedicated to investigating the effectiveness of cognitive behavioural therapy (CBT) across different conditions, population and contexts. We aimed to summarise the current systematic review evidence... Read More about The evidence for cognitive behavioural therapy in any condition, population or context: a meta-review of systematic reviews and panoramic meta-analysis.

Reinforcement Learning approaches to hippocampus-dependent flexible spatial navigation (2021)
Journal Article
Bast, T., Coombes, S., O’Dea, R., & Tessereau, C. (2021). Reinforcement Learning approaches to hippocampus-dependent flexible spatial navigation. Brain and Neuroscience Advances, 5, https://doi.org/10.1177/2398212820975634

Humans and non-human animals show great flexibility in spatial navigation, including the ability to return to specific locations based on as few as one single experience. To study spatial navigation in the laboratory, watermaze tasks, in which rats h... Read More about Reinforcement Learning approaches to hippocampus-dependent flexible spatial navigation.

Machining-induced thermal damage in cortical bone: Necrosis and micro-mechanical integrity (2021)
Journal Article
Robles-Linares, J. A., Axinte, D., Liao, Z., & Gameros, A. (2021). Machining-induced thermal damage in cortical bone: Necrosis and micro-mechanical integrity. Materials and Design, 197, Article 109215. https://doi.org/10.1016/j.matdes.2020.109215

In bone cutting, the tissue is exposed to necrosis due to temperature elevation, which can significantly influence postoperative results in orthopaedic surgeries. This damage is usually revealed through histological analysis to show the necrotic exte... Read More about Machining-induced thermal damage in cortical bone: Necrosis and micro-mechanical integrity.