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All Outputs (787)

Spaceflight redefines ageing-associated microbiota (2025)
Journal Article
Sun, Y., Liu, S., Chen, L., Zhou, Z., Ma, M., Li, J., Lu, Y., Shi, Y., Yao, T., Feng, R., Lu, Q., Qassadi, F., Williams, P. M., Monaghan, T. M., Wang, G., Zhu, Z., & Li, X. (2025). Spaceflight redefines ageing-associated microbiota. iMeta, https://doi.org/10.1002/imt2.70023

Spaceflight reshapes microbiota and immune function, mitigating some ageing effects while accelerating immune aging, revealing crucial insights for astronaut health and longevity in space missions.

Current surveillance strategy is less effective for detecting early-stage hepatocellular carcinoma in patients with non-viral and non-cirrhotic liver disease (2025)
Journal Article
Spiers, J., Li, W., Aravinthan, A. D., Bannaga, A., Caddick, K., Culver, E. L., Faulkes, R. E., Gordon, V., Hussain, Y., Miller, H., Merry, J., Saad, M., Sheth, A., Shah, T., Shetty, S., Srivastava, A., Subhani, M., Tahir, M. N., Than, N. N., Unitt, E., & Alazawi, W. (2025). Current surveillance strategy is less effective for detecting early-stage hepatocellular carcinoma in patients with non-viral and non-cirrhotic liver disease. Liver Cancer, https://doi.org/10.1159/000542805

Introduction
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths. Current international guidelines recommend 6-monthly ultrasound surveillance in all patients with cirrhosis and those with hepatitis B virus-related risk facto... Read More about Current surveillance strategy is less effective for detecting early-stage hepatocellular carcinoma in patients with non-viral and non-cirrhotic liver disease.

Investigating the fluid and electrolyte prescribing knowledge of Foundation Year doctors (2025)
Journal Article
Johnson, D., Houdmont, J., Levy, N., & Lobo, D. N. (2025). Investigating the fluid and electrolyte prescribing knowledge of Foundation Year doctors. Annals of The Royal College of Surgeons of England, https://doi.org/10.1308/rcsann.2025.0004

Introduction
Changes to the medical curriculum have been advocated to improve knowledge on fluid and electrolytes. We aimed to determine the contemporary level of knowledge of trainee doctors on different aspects of fluid and electrolyte prescribing... Read More about Investigating the fluid and electrolyte prescribing knowledge of Foundation Year doctors.

Recurrent ascending cholangitis secondary to food reflux following transduodenal resection of an ampullary adenoma (2025)
Journal Article
Fouad, M., James, M. W., Zaitoun, A. M., Hanks, M., & Lobo, D. N. (2025). Recurrent ascending cholangitis secondary to food reflux following transduodenal resection of an ampullary adenoma. Annals of The Royal College of Surgeons of England, https://doi.org/10.1308/rcsann.2024.0110

Ampullary lesions, including adenomas and early-stage carcinomas, pose a diagnostic and therapeutic challenge due to their location and proximity to the pancreatic and bile ducts. Transduodenal ampullectomy offers a targeted approach for the resectio... Read More about Recurrent ascending cholangitis secondary to food reflux following transduodenal resection of an ampullary adenoma.

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors (2025)
Journal Article
Patel, A., Göbel, K., Ille, S., Hinz, F., Schoebe, N., Bogumil, H., Meyer, J., Brehm, M., Kardo, H., Schrimpf, D., Lomakin, A., Ritter, M., Göller, P., Kerbs, P., Pfeifer, L., Hamelmann, S., Blume, C., Ippen, F. M., Berghaus, N., Euskirchen, P., …Sahm, F. (2025). Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors. Nature Medicine, https://doi.org/10.1038/s41591-025-03562-5

Molecular data integration plays a central role in central nervous system (CNS) tumor diagnostics but currently used assays pose limitations due to technical complexity, equipment and reagent costs, as well as lengthy turnaround times. We previously... Read More about Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors.

A novel system to continuously estimate intradialytic blood pressure in real time (2025)
Journal Article
Viramontes-Hörner, D., Stewart, P., Stewart, J., Taal, M. W., & Selby, N. M. (2025). A novel system to continuously estimate intradialytic blood pressure in real time. Nephrology Dialysis Transplantation, https://doi.org/10.1093/ndt/gfaf058

Background
Intradialytic hypotension (IDH) is a common complication of haemodialysis that is associated with adverse patient outcomes. We have developed a new non-invasive approach to continuously estimate systolic blood pressure (SBP) in real time... Read More about A novel system to continuously estimate intradialytic blood pressure in real time.

Using normalisation process theory to understand implementation of effective early-onset type 2 diabetes treatment and care within England: a qualitative study (2025)
Journal Article
Chauhan, R., Davies, M. J., May, C., Misra, S., Sargeant, J. A., Skarlatos, M., Speight, J., Wilmot, E. G., Wilson, C., & Hadjiconstantinou, M. (2025). Using normalisation process theory to understand implementation of effective early-onset type 2 diabetes treatment and care within England: a qualitative study. BMC Health Services Research, 25(1), Article 422. https://doi.org/10.1186/s12913-025-12616-w

Background: Despite increasing prevalence, early-onset type 2 diabetes (EOT2D) has received little clinical and qualitative research attention within England. This qualitative study aimed to explore and understand the unmet needs of people living wit... Read More about Using normalisation process theory to understand implementation of effective early-onset type 2 diabetes treatment and care within England: a qualitative study.

Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis (2025)
Journal Article
Mader, J. K., Fornengo, R., Hassoun, A., Heinemann, L., Kulzer, B., Monica, M., Nguyen, T., Sieber, J., Renard, E., Reznik, Y., Ryś, P., Stożek-Tutro, A., & Wilmot, E. G. (2025). Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis. Journal of Diabetes Science and Technology, https://doi.org/10.1177/19322968251319806

Background:
Lipohypertrophy is a common skin complication in individuals with insulin-treated diabetes, but this condition in those using insulin pumps (continuous subcutaneous insulin infusion, CSII) remains poorly understood. This study aimed to i... Read More about Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis.

Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis (2025)
Journal Article
Mader, J. K., Fornengo, R., Hassoun, A., Heinemann, L., Kulzer, B., Monica, M., Nguyen, T., Sieber, J., Renard, E., Reznik, Y., Ryś, P., Stożek-Tutro, A., & Wilmot, E. G. (2025). Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis. Journal of Diabetes Science and Technology, https://doi.org/10.1177/19322968251319806

Background:
Lipohypertrophy is a common skin complication in individuals with insulin-treated diabetes, but this condition in those using insulin pumps (continuous subcutaneous insulin infusion, CSII) remains poorly understood. This study aimed to i... Read More about Existing Knowledge Gaps in Risk Factors and Consequences of Lipohypertrophy in People Using Continuous Subcutaneous Insulin Infusion Therapy: A Systematic Review and Meta-analysis.

Risk factors for Lipohypertrophy in People With Insulin-Treated Diabetes: A Systematic Meta-Analysis (2025)
Journal Article
Mader, J. K., Fornengo, R., Hassoun, A., Heinemann, L., Kulzer, B., Monica, M., Nguyen, T., Sieber, J., Renard, E., Reznik, Y., Ryś, P., Stożek-Tutro, A., & Wilmot, E. G. (2025). Risk factors for Lipohypertrophy in People With Insulin-Treated Diabetes: A Systematic Meta-Analysis. Journal of Diabetes Science and Technology, https://doi.org/10.1177/19322968251325569

Background:
Lipohypertrophy is a common skin complication in people with insulin-treated diabetes. Despite its high prevalence and potential impact on diabetes management and outcomes, published data regarding the risk factors for the development of... Read More about Risk factors for Lipohypertrophy in People With Insulin-Treated Diabetes: A Systematic Meta-Analysis.

Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity (2025)
Journal Article
Bingham, K., Zahrani, Y. A., Stewart, I., Portelli, M. A., Fogarty, A., McKeever, T. M., Singapuri, A., Heaney, L. G., Mansur, A. H., Chaudhuri, R., Thomson, N. C., Holloway, J. W., Howarth, P. H., Djukanovic, R., Blakey, J. D., Chauhan, A., Brightling, C. E., Pogson, Z. E., Hall, I. P., Martinez-Pomares, L., …Sayers, I. (2025). Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity. Immunity, Inflammation and Disease, 13(3), Article e70116. https://doi.org/10.1002/iid3.70116

Background:

Asthma is a heterogeneous disease characterized by overlapping clinical and inflammatory features.

Objective:

This study aimed to provide insight into the systemic inflammatory profile in asthma, greater understanding of asthma... Read More about Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity.

Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation (2025)
Journal Article
Wijayasiri, P., Astbury, S., Needham, G., Kaye, P., Bhat, M., Piccinini, A. M., & Aravinthan, A. D. (2025). Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation. Human Cell, 38(3), Article 70. https://doi.org/10.1007/s13577-025-01201-2

Accumulation of senescent hepatocytes is universal in chronic liver disease (CLD). This study investigates an association between hepatocyte senescence and hepatocellular carcinoma (HCC) and explores the therapeutic role of sirolimus. Background live... Read More about Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation.

Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review (2025)
Journal Article
AlMutairi, H., Mccullough, F., Siddiqui, K., Ghemlas, I., AlHarbi, M., Grundy, R., & Dandapani, M. (2025). Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review. Journal of Nutrition and Metabolism, https://doi.org/10.1155/jnme/7935879

Background: Evidence suggests the positive effects of ketogenic diet (KD) on cancers by limiting glucose availability to cancer cells. This systematic review aimed to explore the safety, feasibility, and effectiveness of KD in children with brain tum... Read More about Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review.

Cardiotoxicity of breast cancer drug treatments (2025)
Journal Article
Haque, M., Atallah, N., Patke, R., Harris, A. E., Woodcock, C. L., Varun, D., Thompson, R. L., Jackson-Oxley, J., Okui, C. H., Dean, A., Alsaleem, M., Rakha, E., Irshad, S., Davis, M. B., Jeyapalan, J. N., Mongan, N. P., & Rutland, C. S. (2025). Cardiotoxicity of breast cancer drug treatments. Translational Oncology, 55, Article 102352. https://doi.org/10.1016/j.tranon.2025.102352

Breast cancer (BC) is a leading cause of cancer-related mortality among women worldwide. BC is regarded as a systemic disease. Consequently, the majority of BC patients undergo systemic therapy to reduce the risk of distant metastasis (DM) and associ... Read More about Cardiotoxicity of breast cancer drug treatments.

Effect of COVID-19 with or without acute kidney injury on inpatient mortality in England: a national observational study using administrative data (2025)
Journal Article
Kolhe, N. V., Fluck, R., & Taal, M. (2025). Effect of COVID-19 with or without acute kidney injury on inpatient mortality in England: a national observational study using administrative data. BMJ Open, 15(3), Article e095020. https://doi.org/10.1136/bmjopen-2024-095020

Objectives To evaluate hospital outcomes and their predictors during the pandemic for patients with and without COVID-19, stratified by the presence of acute kidney injury (AKI). Design Retrospective observation study using the Hospital Episodes Stat... Read More about Effect of COVID-19 with or without acute kidney injury on inpatient mortality in England: a national observational study using administrative data.

A Biomarker Based Peptide Immunoassay for Clostridioides difficile: “Insights from Central India” (2025)
Journal Article
Biswas, R., Dhok, A., Nayak, A., Monaghan, T. M., & Kashyap, R. S. (2025). A Biomarker Based Peptide Immunoassay for Clostridioides difficile: “Insights from Central India”. International Journal of Peptide Research and Therapeutics, 31(3), Article 50. https://doi.org/10.1007/s10989-025-10709-y

Introduction: Clostridioides difficile infection (CDI) is a major healthcare challenge due to its virulence factors, Toxins A and B. Current diagnostic methods like NAAT and EIA face limitations, including overdiagnosis and cultural resistance to sto... Read More about A Biomarker Based Peptide Immunoassay for Clostridioides difficile: “Insights from Central India”.

Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice (2025)
Journal Article
Chrisp, R., Masterson, M., Pope, R., Roberts, C. J., Collins, H. M., Watson, D. J., O’Neil, D., Aagaard, K. M., Gibson, C. L., Heery, D. M., & Moran, P. M. (2025). Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice. Scientific Reports, 15(1), Article 8347. https://doi.org/10.1038/s41598-025-92938-1

NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism. We investigate... Read More about Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice.

Enhancing Health Outcomes through Optimized Body Composition in Prehabilitation (2025)
Journal Article
Kutnik, P., Da Silva, B. R., Shoemaker, M. E., Barbosa-Silva, T. G., Gonzalez, M. C., Lobo, D. N., & Prado, C. M. (2025). Enhancing Health Outcomes through Optimized Body Composition in Prehabilitation. Annals of Nutrition and Metabolism, 81(3), 180-190. https://doi.org/10.1159/000545026

Background: Prehabilitation, the process of optimizing a patient's physical and nutritional status before surgery, has gained increasing attention for its potential to improve outcomes by enhancing physiological reserves and functional capacity. Whil... Read More about Enhancing Health Outcomes through Optimized Body Composition in Prehabilitation.

Small bowel motility quantified by cine MRI to predict longer term response in patients with Crohn’s disease commencing biological therapy: The Motility study (2025)
Journal Article
Plumb, A. A., Moran, G., Chowdhury, K., Ahmed, N., Philpott, S., Ahmad, T., Bloom, S., Hart, A., Jacobs, I., Menys, A., Mooney, P., Tolan, D., Travis, S., Bhagwanani, A., Bhatnagar, G., Boone, D., Franklin, J., Gangi-Burton, A., Hameed, M., Helbren, E., …Taylor, S. A. (in press). Small bowel motility quantified by cine MRI to predict longer term response in patients with Crohn’s disease commencing biological therapy: The Motility study. Inflammatory Bowel Diseases, https://doi.org/10.1093/ibd/izaf023

Background:
Small bowel Crohn’s Disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients is difficult and complicates treatment strategy. We aimed to determine if motility magne... Read More about Small bowel motility quantified by cine MRI to predict longer term response in patients with Crohn’s disease commencing biological therapy: The Motility study.