All Outputs (100)

Delivering on sustainable development goals in wastewater reuse for agriculture: Initial prioritization of emerging pollutants in the Tula Valley, Mexico (2023)
Journal Article

Wastewater reuse for agricultural irrigation is a widespread beneficial practice, in line with the sustainable development goals. However, contaminants of emerging concern (CECs) present in wastewater, such as pharmaceuticals, pose... Read More about Delivering on sustainable development goals in wastewater reuse for agriculture: Initial prioritization of emerging pollutants in the Tula Valley, Mexico.

Rational design of hydrogels for immunomodulation (2022)
Journal Article

The immune system protects organisms against endogenous and exogenous harm and plays a key role in tissue development, repair and regeneration. Traditional immunomodulatory biologics exhibit limitations including degradation by enzymes, short half-li... Read More about Rational design of hydrogels for immunomodulation.

Light-controlled micron-scale molecular motion (2021)
Journal Article

The micron-scale movement of biomolecules along supramolecular pathways, mastered by nature, is a remarkable system requiring strong yet reversible interactions between components under the action of a suitable stimulus. Responsive microscopic system... Read More about Light-controlled micron-scale molecular motion.

Osteogenic Response of Human Mesenchymal Stem Cells Analysed Using Combined Intracellular and Extracellular Metabolomic Monitoring (2021)
Journal Article

Modelling the influence of UV curing strategies for optimisation of inkjet based 3D printing (2021)
Journal Article

A predictive model is developed to assist in the design and manufacture of structures by inkjet based 3D printing (IJ3DP)/additive manufacturing. IJ3DP often exploits photopolymerisation to rapidly convert a photoreactive liquid ink into a solid prod... Read More about Modelling the influence of UV curing strategies for optimisation of inkjet based 3D printing.

Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices (2021)
Journal Article

As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi-material inkjet-bas... Read More about Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.

Quantitative Bioreactor Monitoring of Intracellular Bacterial Metabolites in Clostridium autoethanogenum Using Liquid Chromatography–Isotope Dilution Mass Spectrometry (2021)
Journal Article

We report a liquid chromatography–isotope dilution mass spectrometry method for the simultaneous quantification of 131 intracellular bacterial metabolites of Clostridium autoethanogenum. A comprehensive mixture of uniformly 13C-labeled internal stand... Read More about Quantitative Bioreactor Monitoring of Intracellular Bacterial Metabolites in Clostridium autoethanogenum Using Liquid Chromatography–Isotope Dilution Mass Spectrometry.

Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels (2021)
Journal Article

Fluorescent ligand technologies have proved to be powerful tools to improve our understanding of ligand-receptor interactions. Here we have characterized a small focused library of nine fluorescent ligands based on the highly selective β2-adrenocepto... Read More about Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels.

Staff-Student Partnership: Reforming a UK School of Pharmacy to Promote Racial Inclusion (2021)
Journal Article

Britain has become more ethnically and culturally diverse (Office for National Statistics, 2018), but it is evident that this change in the demographic has not been fully reflected in education, including our School of Pharmacy. The need for inclusiv... Read More about Staff-Student Partnership: Reforming a UK School of Pharmacy to Promote Racial Inclusion.

An imidazolium-based supramolecular gelator enhancing interlayer adhesion in 3D printed dual network hydrogels (2021)
Journal Article

The variety of UV-curable monomers for 3D printing is limited by a requirement for rapid curing after each sweep depositing a layer. This study proposes to trigger supramolecular self-assembly during the process by a gemini imidazolium-based low-mole... Read More about An imidazolium-based supramolecular gelator enhancing interlayer adhesion in 3D printed dual network hydrogels.

Sequential Orbitrap Secondary Ion Mass Spectrometry and Liquid Extraction Surface Analysis-Tandem Mass Spectrometry-Based Metabolomics for Prediction of Brain Tumor Relapse from Sample-Limited Primary Tissue Archives (2021)
Journal Article

We present here a novel surface mass spectrometry strategy to perform untargeted metabolite profiling of formalin-fixed paraffin-embedded pediatric ependymoma archives. Sequential Orbitrap secondary ion mass spectrometry (3D OrbiSIMS) and liquid extr... Read More about Sequential Orbitrap Secondary Ion Mass Spectrometry and Liquid Extraction Surface Analysis-Tandem Mass Spectrometry-Based Metabolomics for Prediction of Brain Tumor Relapse from Sample-Limited Primary Tissue Archives.

Institutional injustice: Implications for system transformation emerging from the mental health recovery narratives of people experiencing marginalisation (2021)
Journal Article

Background: Institutional injustice refers to structures that create disparities in resources, opportunities and representation. Marginalised people experience institutional injustice, inequalities and discrimination through intersecting personal c... Read More about Institutional injustice: Implications for system transformation emerging from the mental health recovery narratives of people experiencing marginalisation.

Use of NanoBiT and NanoBRET to monitor fluorescent VEGF-A binding kinetics to VEGFR2/NRP1 heteromeric complexes in living cells (2021)
Journal Article

Background and Purpose: VEGF‐A is a key mediator of angiogenesis, primarily signalling via VEGF receptor 2 (VEGFR2). Endothelial cells also express the co‐receptor neuropilin‐1 (NRP1) that potentiates VEGF‐A/VEGFR2 signalling. VEGFR2 and NRP1 had d... Read More about Use of NanoBiT and NanoBRET to monitor fluorescent VEGF-A binding kinetics to VEGFR2/NRP1 heteromeric complexes in living cells.

Development of Conductive Gelatine-Methacrylate Inks for Two-Photon Polymerisation (2021)
Journal Article

Opioid prescription at postoperative discharge: a retrospective observational cohort study (2021)
Journal Article

Opioid misuse is now considered a major public health epidemic in North America, with substantial social and financial consequences. As well as socio-economic and commercial drivers, modifiable risk-factors that have resulted in this crisis have been... Read More about Opioid prescription at postoperative discharge: a retrospective observational cohort study.

Efficient G protein coupling is not required for agonist?mediated internalization and membrane reorganization of the adenosine A 3 receptor (2021)
Journal Article

Organization of G protein-coupled receptors at the plasma membrane has been the focus of much recent attention. Advanced microscopy techniques have shown that these receptors can be localized to discrete microdomains and reorganization upon ligand ac... Read More about Efficient G protein coupling is not required for agonist?mediated internalization and membrane reorganization of the adenosine A 3 receptor.

Metabolic signatures of osteoarthritis in urine using liquid chromatography?high resolution tandem mass spectrometry (2021)
Journal Article

Introduction: Osteoarthritis (OA) is a common cause of disability in older people, but its aetiology is not yet fully understood. Biomarkers of OA from metabolomics studies have shown potential use in understanding the progression and pathophysiology... Read More about Metabolic signatures of osteoarthritis in urine using liquid chromatography?high resolution tandem mass spectrometry.

Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink (2021)
Journal Article

Self-controlled study designs can be used to assess the association between exposures and acute outcomes while controlling for important confounders. Using routinely collected health data, a self-controlled case series design was used to investigate... Read More about Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink.

Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation (2021)
Journal Article

One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation 20 of purines and pyrimidines, biogenic amines, proteins and phospholipids. Our understanding of 21 how 1C pathways operate, however, pertains mostly to the (rat)... Read More about Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation.

Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus (2021)
Journal Article

The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to in-clude antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass va... Read More about Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus.