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All Outputs (1511)

A proximity labelling-based approach to directly detect mRNA delivery to specific subcellular locations (2025)
Journal Article
Smart, A. D., Hughes, M. E., Ruiz Velasco, A. D., Hori, N., Stolnik, S., & Jopling, C. L. (2025). A proximity labelling-based approach to directly detect mRNA delivery to specific subcellular locations. Molecular Therapy: Nucleic Acids, Article 102602. https://doi.org/10.1016/j.omtn.2025.102602

Messenger RNA (mRNA) therapeutics show considerable promise but face delivery challenges, as effective cytosolic entry and subsequent translation are normally limited by endosomal entrapment. While various approaches have been used to investigate det... Read More about A proximity labelling-based approach to directly detect mRNA delivery to specific subcellular locations.

Harnessing enzymes for greener polymerisations: advances in chain and step growth processes (2025)
Journal Article
Dixon, E. G., Ciano, L., Pordea, A., Alvey, K., & Taresco, V. (2025). Harnessing enzymes for greener polymerisations: advances in chain and step growth processes. Polymer Chemistry, https://doi.org/10.1039/d5py00223k

Synthetic organic polymers face increasing scrutiny due to their environmental impact, as most industrial monomers are petrol-based. Key concerns include fossil fuel consumption, greenhouse gas emissions, reliance on non-renewable feedstocks, insuffi... Read More about Harnessing enzymes for greener polymerisations: advances in chain and step growth processes.

Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex (2025)
Journal Article
Duncan, J., Pathak, M., King, B., Bamber, H., Radford, P., Dey, J., Richardson, C., Astbury, S., McClure, P., Ball, J. K., Urbanowicz, R. A., & Tarr, A. (2025). Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex. Journal of General Virology, 106(6), Article 002120. https://doi.org/10.1099/jgv.0.002120

Entry of Zaire ebolavirus (EBOV) into a host cell is a complex process requiring interactions between the viral glycoproteins (GPs) and cellular factors. These entry factors are cell-specific and can include cell surface lectins and phosphatidylserin... Read More about Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex.

Alpha-linolenic acid-modified liposomes associate with and modulate antibiotic activity against Helicobacter pylori (2025)
Journal Article
Osborne, N. C., Catania, R., Stolnik, S., & Robinson, K. (2025). Alpha-linolenic acid-modified liposomes associate with and modulate antibiotic activity against Helicobacter pylori. Microbiology, 171(5), Article 001562. https://doi.org/10.1099/mic.0.001562

Fatty acids have antimicrobial activity against a wide range of bacteria. We therefore aimed to incorporate omega-3 unsaturated alpha-linolenic acid (αLA) into the membrane of antibiotic-loaded liposomes to create a system with dual antibacterial act... Read More about Alpha-linolenic acid-modified liposomes associate with and modulate antibiotic activity against Helicobacter pylori.

Study on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry (2025)
Journal Article
Kotowska, A. M., Fay, M., Watts, J. A., Gilmore, I. S., Scurr, D. J., Howe, A., Capka, V., Perez, C., Doud, D., Patel, S., Umbarger, M., Langer, R., & Alexander, M. R. (2025). Study on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry. Communications Chemistry, 8, Article 160. https://doi.org/10.1038/s42004-025-01526-x

Lipid nanoparticle RNA (LNP-RNA) formulations are used for the delivery of vaccines and other therapies. RNA molecules are encapsulated within their interior through electrostatic interactions with positively charged lipids. The identity of the lipid... Read More about Study on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry.

Exploring community pharmacy and general practice views on primary care communication and pathways to access antibiotics in England (2025)
Journal Article
Lee, M. X., Hayes, C., Ashiru-Oredope, D., Thornley, T., Howard, P., Saei, A., Eastwood, L., & Lecky, D. M. (2025). Exploring community pharmacy and general practice views on primary care communication and pathways to access antibiotics in England. Journal of Antimicrobial Chemotherapy, https://doi.org/10.1093/jac/dkaf135

Background

With most antimicrobials in England being prescribed in primary care, collaboration on antimicrobial stewardship (AMS) between general practitioners (GPs) and community pharmacists (CPs) is important. Previous research identified barrie... Read More about Exploring community pharmacy and general practice views on primary care communication and pathways to access antibiotics in England.

Unlocking the biological potential of emulsion-templated matrices through surface engineering for biomedical applications (2025)
Journal Article
Sert, E., Ozmen, E., Owen, R., & Aldemir Dikici, B. (2025). Unlocking the biological potential of emulsion-templated matrices through surface engineering for biomedical applications. Polymer, 333, Article 128549. https://doi.org/10.1016/j.polymer.2025.128549

Emulsion templating is a highly advantageous route for the fabrication of porous materials, enabling the development of matrices with high porosity, high interconnectivity, and precise morphological control. Synthetic polymers are most widely used in... Read More about Unlocking the biological potential of emulsion-templated matrices through surface engineering for biomedical applications.

An evaluation of spraying as a delivery method for human mesenchymal stem cells suspended in low-methyl pectin solutions (2025)
Journal Article
Nash, A., Lee, I.-N., Fox, G., Phillips, J., White, L. J., & Marlow, M. (2025). An evaluation of spraying as a delivery method for human mesenchymal stem cells suspended in low-methyl pectin solutions. Stem Cell Research and Therapy, 16(1), Article 246. https://doi.org/10.1186/s13287-025-04331-4

Background: Mesenchymal stem cells have shown promise in many areas of regenerative medicine due to the anti-inflammatory and pro-regenerative effects of the secreted factors. However, successful delivery remains problematic, particularly for deliver... Read More about An evaluation of spraying as a delivery method for human mesenchymal stem cells suspended in low-methyl pectin solutions.

Experiences and knowledge of nurses, occupational therapists, pharmacists and physiotherapists about certifying fit notes: a UK-wide survey (2025)
Journal Article
Kettlewell, J., Trusson, D., Powers, K., Drummond, A., Anderson, C., Phillips, G., Holmes, J., Radford, K., Pahl, N., Martin, S., Timmons, S., & Kendrick, D. (2025). Experiences and knowledge of nurses, occupational therapists, pharmacists and physiotherapists about certifying fit notes: a UK-wide survey. BMJ Open, 15(5), Article e092211. https://doi.org/10.1136/bmjopen-2024-092211

Objective To identify facilitators and barriers to fit note certification among nurses, occupational therapists, pharmacists and physiotherapists (NOPPs), and identify ongoing training needs.

Design An online survey informed by the Theoretical Dom... Read More about Experiences and knowledge of nurses, occupational therapists, pharmacists and physiotherapists about certifying fit notes: a UK-wide survey.

An Exploration into Student Pharmacists’ Experiences of Practice-based Interprofessional Education during Experiential Learning Placements (2025)
Journal Article
Depasquale, C., Arnold, A., Cunningham, S., Kerr, A., Jacob, S. A., Boyter, A., Boyd, M., Power, A., & Addison, B. (2025). An Exploration into Student Pharmacists’ Experiences of Practice-based Interprofessional Education during Experiential Learning Placements. American Journal of Pharmaceutical Education, 89(6), Article 101418. https://doi.org/10.1016/j.ajpe.2025.101418

OBJECTIVE:
This study aimed to explore student pharmacists' experiences of interprofessional education (IPE) during experiential learning (EL) placements.

METHOD:
A paper questionnaire was used to collect data; distributed to all penultimate/... Read More about An Exploration into Student Pharmacists’ Experiences of Practice-based Interprofessional Education during Experiential Learning Placements.

Exploring the development and implementation of practice-based interprofessional education for student pharmacists in Scotland: A case study (2025)
Presentation / Conference Contribution
Depasquale, C., Arnold, A., Cunningham, S., Power, A., Boyter, A., Boyd, M., & Addison, B. (2025, August). Exploring the development and implementation of practice-based interprofessional education for student pharmacists in Scotland: A case study. Presented at FIP Pharmacy Practice Research Summer Meeting for PhD students, postdoctoral fellows and supervisors, Copenhagen, Denmark

Drug-like Antagonists of P2Y Receptor Subtypes: An Update (2025)
Journal Article
Puthanveedu, M., Knight, R., & Stocks, M. J. (2025). Drug-like Antagonists of P2Y Receptor Subtypes: An Update. Journal of Medicinal Chemistry, 68(9), 9057–9083. https://doi.org/10.1021/acs.jmedchem.5c00249

The hunt for drug-like P2YR antagonists continues, stimulated by ever-increasing pharmacological evidence for their clinical benefit and the astonishing array of biological functions which they orchestrate, including platelet aggregation, cancer prol... Read More about Drug-like Antagonists of P2Y Receptor Subtypes: An Update.

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care (2025)
Journal Article
Harrisson, S. A., Jinks, C., Cornwall, N., Woodcock, C., Dikomitis, L., Helliwell, T., Higginbottom, A., Lefroy, J., Knaggs, R., Pincus, T., Santar, M., Sillitto, C., Webb, M., White, S., Mallen, C. D., & Ashworth, J. (2025). Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care. Health Expectations, 28(3), Article e70264. https://doi.org/10.1111/hex.70264

Background: Stakeholder involvement is a core element of the Medical Research Council (MRC) framework for developing and evaluating complex interventions, but approaches to involve stakeholders are not well-reported. We outline how stakeholders contr... Read More about Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care.

Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C. D., Avery, A., Knaggs, R., Pincus, T., White, S., Jinks, C., & PROMPPT team. (2025). Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study. Pilot and Feasibility Studies, 11, Article 53. https://doi.org/10.1186/s40814-025-01636-2

Background
Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence-based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the... Read More about Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study.

LDLR-targeted orlistat therapeutic nanoparticles: Peptide selection, assembly, characterization, and cell-uptake in breast cancer cell lines (2025)
Journal Article
Bebawy, G., Collier, P., Williams, P. M., Burley, J. C., & Needham, D. (2025). LDLR-targeted orlistat therapeutic nanoparticles: Peptide selection, assembly, characterization, and cell-uptake in breast cancer cell lines. International Journal of Pharmaceutics, 676, Article 125574. https://doi.org/10.1016/j.ijpharm.2025.125574

Motivation: Many cancers overexpress low-density lipoprotein receptors (LDLR), facilitating cholesterol metabolism for tumour growth. Targeting LDLR offers a promising strategy for selective drug delivery. Orlistat, a fatty acid synthase (FAS) inhibi... Read More about LDLR-targeted orlistat therapeutic nanoparticles: Peptide selection, assembly, characterization, and cell-uptake in breast cancer cell lines.

Lessons from the PROTECT-CH COVID-19 platform trial in care homes (2025)
Journal Article
Bath, P. M., Ball, J., Boyd, M., Gage, H., Glover, M., Godfrey, M., Guthrie, B., Hewitt, J., Howard, R., Jaki, T., Juszczak, E., Lasserson, D., Leighton, P., Leyland, V., Shen Lim, W., Logan, P., Meakin, G., Montgomery, A., Ogollah, R., Passmore, P., …Gordon, A. L. (2025). Lessons from the PROTECT-CH COVID-19 platform trial in care homes. Health Technology Assessment, https://doi.org/10.3310/MTRS8833

Background
Coronavirus disease-2019 was associated with significant mortality and morbidity in care homes in 2020–1. Repurposed antiviral drugs might reduce morbidity and mortality through reducing viral transmission, infection, replication and infl... Read More about Lessons from the PROTECT-CH COVID-19 platform trial in care homes.

Redox-responsive micellar-like nanoparticles can overcome intrinsic multi-drug resistance in tumour spheroids of triple negative breast cancer (2025)
Journal Article
Monteiro, C. J., Monteiro, P. F., Travanut, A., Gulfam, M., Heery, D. M., Grabowska, A., & Alexander, C. (2025). Redox-responsive micellar-like nanoparticles can overcome intrinsic multi-drug resistance in tumour spheroids of triple negative breast cancer. RSC Pharmaceutics, 2(3), 644-656. https://doi.org/10.1039/D4PM00336E

Triple negative breast cancer (TNBC) is one of the most difficult subtypes of breast cancer to treat, due its aggressiveness, high heterogeneity and lack of targeted therapies. Efforts have been made to elucidate the mechanisms by which TNBC cells be... Read More about Redox-responsive micellar-like nanoparticles can overcome intrinsic multi-drug resistance in tumour spheroids of triple negative breast cancer.

Spaceflight redefines ageing-associated microbiota (2025)
Journal Article
Sun, Y., Liu, S., Chen, L., Zhou, Z., Ma, M., Li, J., Lu, Y., Shi, Y., Yao, T., Feng, R., Lu, Q., Qassadi, F., Williams, P. M., Monaghan, T. M., Wang, G., Zhu, Z., & Li, X. (2025). Spaceflight redefines ageing-associated microbiota. iMeta, https://doi.org/10.1002/imt2.70023

Spaceflight reshapes microbiota and immune function, mitigating some ageing effects while accelerating immune aging, revealing crucial insights for astronaut health and longevity in space missions.