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All Outputs (838)

Development and evaluation of a mental health recovery priority measure for cross-cultural research: global INSPIRE (2025)
Journal Article
Kotera, Y., Hara, A., Newby, C., Miyamoto, Y., Ozaki, A., Ali, Y., Clinton, P., Felix, S., John, C., Inta, N., & Slade, M. (2025). Development and evaluation of a mental health recovery priority measure for cross-cultural research: global INSPIRE. Social Psychiatry and Psychiatric Epidemiology, https://doi.org/10.1007/s00127-025-02946-9

Purpose
This study developed and evaluated a new personal recovery scale—Global INSPIRE—in English and Japanese, and compared responses between Japan and the UK. Personal recovery—living a satisfying and meaningful life despite mental health challen... Read More about Development and evaluation of a mental health recovery priority measure for cross-cultural research: global INSPIRE.

Outcomes of patient and public involvement in the development of the Cognitive Decline after Brain Radiosurgery (CoDe B-Rad) study: refining the research question and methodology (2025)
Journal Article
Bangiri, A., Horobin, A., Baker, J., Pszczolkowski, S., Thust, S., & Morgan, P. S. (2025). Outcomes of patient and public involvement in the development of the Cognitive Decline after Brain Radiosurgery (CoDe B-Rad) study: refining the research question and methodology. BMJ Open, 15(6), Article e094788. https://doi.org/10.1136/bmjopen-2024-094788

Objectives

Patient and public involvement (PPI) was sought in the development of the protocol for the Cognitive Decline after Brain Radiosurgery (CoDe B-Rad) study, which aims to identify potential side effects of stereotactic radiosurgery (SRS).... Read More about Outcomes of patient and public involvement in the development of the Cognitive Decline after Brain Radiosurgery (CoDe B-Rad) study: refining the research question and methodology.

Continuous Glucose Monitoring in the Management of Medication in Care Home Residents with Type2 Diabetes (eDMED): A Protocol for a Feasibility Study (2025)
Journal Article
Welford, A. E., Ridgeway, J., Gillies, C., Choudhary, P., Hegde, V., Khunti, K., & Seidu, S. (2025). Continuous Glucose Monitoring in the Management of Medication in Care Home Residents with Type2 Diabetes (eDMED): A Protocol for a Feasibility Study. Diabetes Therapy, 16, 1511-1524. https://doi.org/10.1007/s13300-025-01740-9

Aims
Overprescribing is common in older adults with diabetes, potentially leading to hospitalisation and reduced quality of life. Additionally, diabetes care in older adults is often complicated by multiple interacting conditions and cognitive impa... Read More about Continuous Glucose Monitoring in the Management of Medication in Care Home Residents with Type2 Diabetes (eDMED): A Protocol for a Feasibility Study.

Recorded mental health recovery narratives for people with mental health problems and informal carers: the NEON research programme including 3 RCTs (2025)
Journal Article
Slade, M., Rennick-Egglestone, S., Ali, Y., Newby, C., Yeo, C., Roe, J., Hui, A., Charles, A., Hare-Duke, L., Paterson, L., Gavan, S. P., Slade, E., Kotera, Y., Priebe, S., Thornicroft, G., Keppens, J., Elliott, R., Pollock, K., Repper, J., Robotham, D., …Llewellyn-Beardsley, J. (in press). Recorded mental health recovery narratives for people with mental health problems and informal carers: the NEON research programme including 3 RCTs. Programme Grants for Applied Research,

Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, United Kingdom (2025)
Journal Article
Wilson, L. E., Knaggs, R. D., Avery, A. J., Thornley, T., Moss, J., Baamer, R. M., & Boyd, M. J. (2025). Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, United Kingdom. PAIN Reports, 10(2), Article e1246. https://doi.org/10.1097/PR9.0000000000001246

Introduction:
Knowledge of the potential for harm and adverse effects from long-term opioid medicines has led to reduced prescribing in recent years. However, the number of patients receiving opioid prescriptions from primary care in England remains... Read More about Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, United Kingdom.

Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception (2025)
Journal Article
McGing, J. J., Serres, S., Nicholas, R., Gupta, A., Radford, S. J., Nixon, A. V., Mallinson, J., Bradley, C., Bawden, S., Francis, S. T., Greenhaff, P. L., & Moran, G. W. (2025). Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception. Journal of Crohn's and Colitis, 19(1), Article jjae194. https://doi.org/10.1093/ecco-jcc/

Background & Objective

IBD fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and functio... Read More about Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception.

Wound imaging software and digital platform to assist review of surgical wounds using patient smartphones: The development and evaluation of artificial intelligence (WISDOM AI study) (2024)
Journal Article
Rochon, M., Tanner, J., Jurkiewicz, J., Beckhelling, J., Aondoakaa, A., Wilson, K., Dhoonmoon, L., Underwood, M., Mason, L., Harris, R., & Cariaga, K. (2024). Wound imaging software and digital platform to assist review of surgical wounds using patient smartphones: The development and evaluation of artificial intelligence (WISDOM AI study). PLoS ONE, 19(12), Article e0315384. https://doi.org/10.1371/journal.pone.0315384

Introduction Surgical patients frequently experience post-operative complications at home. Digital remote monitoring of surgical wounds via image-based systems has emerged as a promising solution for early detection and intervention. However, the inc... Read More about Wound imaging software and digital platform to assist review of surgical wounds using patient smartphones: The development and evaluation of artificial intelligence (WISDOM AI study).

Synthetic cerebral blood vessel generator for training anatomically plausible deep learning models (2024)
Presentation / Conference Contribution
Kenyon, G., Lau, S., Perperidis, A., CHAPPELL, M., & Jenkinson, M. (2024, July). Synthetic cerebral blood vessel generator for training anatomically plausible deep learning models. Presented at MIUA - Medical Image Understanding and Analysis - 2024, Manchester

Blood vessel networks, with their complex geometrical and topological characteristics, play a significant role in diagnosing and understanding various cerebrovascular diseases. Deep learning (DL) segmentation methods can aid in analysing these struct... Read More about Synthetic cerebral blood vessel generator for training anatomically plausible deep learning models.

Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task (2024)
Journal Article
Hock, R. M., Owusu-Amoah, N., Waite, L., Muir, C., Stevenson, C. W., Bonardi, C., & Cassaday, H. J. (2024). Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task. Behavioral Neuroscience, 138(6), 420-432. https://doi.org/10.1037/bne0000603

Healthy cognition requires inhibitory modulation of associative learning; conversely, impaired inhibitory discrimination is implicated in behavioral disorders. The medial prefrontal cortex (mPFC) and its dopamine innervation are key to understanding... Read More about Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task.

A longitudinal study assessing the impact of elexacaftor/tezacaftor/ivacaftor on gut transit and function in people with cystic fibrosis using magnetic resonance imaging (MRI) (2024)
Journal Article
Yule, A., Ng, C., Recto, A., Lockwood, F., Dellschaft, N. S., Hoad, C. L., Zagoya, C., Mainz, J. G., Major, G., Barr, H. L., Gowland, P. A., Stewart, I., Marciani, L., Spiller, R. C., & Smyth, A. R. (2024). A longitudinal study assessing the impact of elexacaftor/tezacaftor/ivacaftor on gut transit and function in people with cystic fibrosis using magnetic resonance imaging (MRI). Journal of Cystic Fibrosis, 23(5), 984-990. https://doi.org/10.1016/j.jcf.2024.08.001

Background

Gastrointestinal (GI) symptoms in cystic fibrosis (CF) are common and disruptive. The effect of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the GI tract is not fully understood. The aim was to use magnetic r... Read More about A longitudinal study assessing the impact of elexacaftor/tezacaftor/ivacaftor on gut transit and function in people with cystic fibrosis using magnetic resonance imaging (MRI).

Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences (2024)
Preprint / Working Paper
Deakin, B., Liddle, E., Rathnaiah, M., Gregory, C., Katshu, M., Wiliams, G., Conen, S., Smallman, R., Koelewijn, L. C., Anton, A., Kumar, J., Gasgoyne, L. E., Chen, C., Nikkheslat, N., Evans, J., Lanz, B., Walters, J., Talbot, P., Palaniyappan, L., Singh, K. D., …Liddle, P. F. Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences

It is widely thought that the onset of psychotic symptoms in schizophrenia may arise from an early neurotoxic phase, possibly related to oxidative stress or inflammation, and a late residual damage phase associated with persistent negative symptoms.... Read More about Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences.

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 (2024)
Journal Article
Gupta, A., Nicholas, R., McGing, J. J., Nixon, A. V., Mallinson, J. E., McKeever, T. M., Bradley, C. R., Piasecki, M., Cox, E. F., Bonnington, J., Lord, J. M., Brightling, C. E., Evans, R. A., Hall, I. P., Francis, S. T., Greenhaff, P. L., & Bolton, C. E. (2024). DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19. Experimental Physiology, 109(8), 1274-1291. https://doi.org/10.1113/ep091590

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited... Read More about DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse (2024)
Journal Article
Khoshkerdar, A., Eid, N., Batra, V., Baker, N., Holmes, N., Henson, S., Sang, F., Wright, V., McLaren, J., Shakesheff, K., Woad, K. J., Morgan, H. L., & Watkins, A. J. (2024). Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse. Nutrients, 16(12), Article 1879. https://doi.org/10.3390/nu16121879

Pregnancy represents a stage during which maternal physiology and homeostatic regulation undergo dramatic change and adaptation. The fundamental purpose of these adaptations is to ensure the survival of her offspring through adequate nutrient provisi... Read More about Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse.

Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects (2024)
Journal Article
Joyce, M., Hodgkinson, T., Intini, C., Dixon, J. E., Kelly, D. J., & O’Brien, F. J. (2024). Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects. eCells and Materials Journal, 47, 91-108. https://doi.org/10.22203/eCM.v047a07

Articular cartilage (AC) has a poor capacity to repair once damaged, with progressive degeneration often leading to osteoarthritis (OA). While biomaterials fabricated with extra cellular matrix (ECM) native to the AC have shown promise for repair of... Read More about Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects.

Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles (2024)
Journal Article
Brown, T. J., Rutland, C. S., Rutland, C. S., Choi, K. K., Tse, F., Pfeffers, M. J., Peffers, M. J., Mongan, N. P., Arkill, K. P., Ritchie, A., Clarke, P. A., Ratan, H., Allegrucci, C., Grabowska, A. M., & James, V. (2024). Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles. Frontiers in Cell and Developmental Biology, 12, Article 1354606. https://doi.org/10.3389/fcell.2024.1354606

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formatio... Read More about Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.

Microaggression or micromessage? How choice of term influences working adults' emotional reactions to a training module about subtle slights (2023)
Journal Article
Smith, I. A., & Griffiths, A. (2023). Microaggression or micromessage? How choice of term influences working adults' emotional reactions to a training module about subtle slights. International Journal of Training and Development, https://doi.org/10.1111/ijtd.12316

The need for workplace training about diversity, equity and inclusion is widely acknowledged. To date, however, there is conflicting evidence as to its effectiveness. Various aspects of design and content may be influential. This study explored the r... Read More about Microaggression or micromessage? How choice of term influences working adults' emotional reactions to a training module about subtle slights.

Determining intra-standard-setter inconsistency in the Angoff method using the three-parameter item response theory (2023)
Journal Article
Tavakol, M., O'Brien, D., & Stewart, C. (in press). Determining intra-standard-setter inconsistency in the Angoff method using the three-parameter item response theory. International Journal of Medical Education, 14, 123-130. https://doi.org/10.5116/ijme.64ed.e296

Objectives:
To measure intra-standard-setter variability and assess the variations between the pass marks obtained from Angoff ratings, guided by the latent trait theory as the theoretical model.

Methods:
A non-experimental cross-sectional stu... Read More about Determining intra-standard-setter inconsistency in the Angoff method using the three-parameter item response theory.

Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries (2023)
Journal Article
Cassaday, H. J., Cavenagh, L., Aluthgamage, H., Crooks, A., Bonardi, C., Stevenson, C. W., Waite, L., & Muir, C. (2023). Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries. PLoS ONE, 18(8), Article e0290232. https://doi.org/10.1371/journal.pone.0290232

Three groups of participants (largely recruited from the UK) completed a survey to examine attitudes to the use of animals in biomedical research, after reading the lay (N = 182) or technical (N = 201) summary of a research project, or no summary (N... Read More about Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries.