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All Outputs (117)

HiPhom𝜺: HIgh order Projection-based HOMogenisation for advection diffusion reaction problems (2024)
Journal Article
Conni, G., Piccardo, S., Michele Porta, G., & Icardi, M. (in press). HiPhom𝜺: HIgh order Projection-based HOMogenisation for advection diffusion reaction problems. Multiscale Modeling and Simulation: A SIAM Interdisciplinary Journal,

We propose a new model reduction technique for multiscale scalar transport problems that exhibit dominant axial dynamics. To this aim, we rely on the separation of variables to combine a Hierarchical Model (HiMod) reduction with a two-scale asymptoti... Read More about HiPhom𝜺: HIgh order Projection-based HOMogenisation for advection diffusion reaction problems.

Stratified distributional analysis—a novel perspective on RT distributions (2024)
Journal Article
Thul, R., Marsh, J., Dijkstra, T., & Conklin, K. (2024). Stratified distributional analysis—a novel perspective on RT distributions. Quarterly Journal of Experimental Psychology, https://doi.org/10.1177/17470218241288516

Abstract
Response times and their distributions serve as a powerful lens into cognitive processes. We present a novel statistical methodology called stratified distributional analysis (SDA) to quantitatively assess how key determinants of response t... Read More about Stratified distributional analysis—a novel perspective on RT distributions.

Comparative judgement modeling to map forced marriage at local levels (2024)
Journal Article
Seymour, R., Nyarko-Agyei, A., Mccabe, H., Severn, K., Sirl, D., Kypraios, T., & Taylor, A. (in press). Comparative judgement modeling to map forced marriage at local levels. Annals of Applied Statistics,

Forcing someone into marriage against their will is a violation of their human rights. In 2021, the county of Nottinghamshire, UK, launched a strategy to tackle forced marriage and violence against women and girls. We set out to map the risk of force... Read More about Comparative judgement modeling to map forced marriage at local levels.

Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping (2024)
Journal Article
Kyratzi, P., Matika, O., Brassington, A. H., Clare, C. E., Xu, J., Barrett, D. A., Emes, R. D., Archibald, A. L., Paldi, A., Sinclair, K. D., Wattis, J., & Rauch, C. (2024). Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping. Physiological Genomics, 56(11), 791-806. https://doi.org/10.1152/physiolgenomics.00049.2024

Identifying associations between phenotype and genotype is the fundamental basis of genetic analyses. Inspired by frequentist probability and the work of R.A. Fisher, genome-wide association studies (GWAS) extract information using averages and varia... Read More about Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping.

Complex-plane singularity dynamics for blow up in a nonlinear heat equation: analysis and computation (2024)
Journal Article
Fasondini, M., King, J. R., & Weideman, J. A. (2024). Complex-plane singularity dynamics for blow up in a nonlinear heat equation: analysis and computation. Nonlinearity, 37(10), Article 105005. https://doi.org/10.1088/1361-6544/ad700b

Blow-up solutions to a heat equation with spatial periodicity and a quadratic nonlinearity are studied through asymptotic analyses and a variety of numerical methods. The focus is on tracking the dynamics of the singularities in the complexified spac... Read More about Complex-plane singularity dynamics for blow up in a nonlinear heat equation: analysis and computation.

Topo-Geometric Analysis of Variability in Point Clouds using Persistence Landscapes (2024)
Journal Article
Matuk, J., Kurtek, S., & Bharath, K. (2024). Topo-Geometric Analysis of Variability in Point Clouds using Persistence Landscapes. IEEE Transactions on Pattern Analysis and Machine Intelligence, 46(12), 11035-11046. https://doi.org/10.1109/TPAMI.2024.3451328

Topological data analysis provides a set of tools to uncover low-dimensional structure in noisy point clouds. Prominent amongst the tools is persistence homology, which summarizes birth-death times of homological features using data objects known as... Read More about Topo-Geometric Analysis of Variability in Point Clouds using Persistence Landscapes.

Optimising experimental designs for model selection of ion channel drug binding mechanisms (2024)
Preprint / Working Paper
Patten-Elliott, F., Lei, C. L., Preston, S. P., Wilkinson, R. D., & Mirams, G. R. Optimising experimental designs for model selection of ion channel drug binding mechanisms

The rapid delayed rectifier current carried by the human Ether-à-go-go-Related Gene (hERG) channel is susceptible to drug-induced reduction which can lead to an increased risk of cardiac arrhythmia. Establishing the mechanism by which a specific drug... Read More about Optimising experimental designs for model selection of ion channel drug binding mechanisms.

MPeat2D - a fully coupled mechanical-ecohydrological model of peatland development in two dimensions (2024)
Journal Article
Mahdiyasa, A. W., Large, D. J., Icardi, M., & Muljadi, B. P. (2024). MPeat2D - a fully coupled mechanical-ecohydrological model of peatland development in two dimensions. Earth Surface Dynamics, 12(4), 929-952. https://doi.org/10.5194/esurf-12-929-2024

Higher-dimensional models of peatland development are required to analyse the influence of spatial heterogeneity and complex feedback mechanisms on peatland behaviour. However, the current models exclude the mechanical process that leads to uncertain... Read More about MPeat2D - a fully coupled mechanical-ecohydrological model of peatland development in two dimensions.

Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs (2024)
Preprint / Working Paper
Shuttleworth, J. G., Lei, C. L., Windley, M. J., Hill, A. P., Preston, S. P., & Mirams, G. R. Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs

Mathematical models are increasingly being relied upon to provide quantitatively accurate predictions of cardiac electrophysiology. Many such models concern the behaviour of particular subcellular components (namely, ion channels) which, together, al... Read More about Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs.

A range of voltage-clamp protocol designs for rapid capture of hERG kinetics (2024)
Preprint / Working Paper
Lei, C. L., Whittaker, D. G., Windley, M. J., Perry, M. D., Hill, A. P., & Mirams, G. R. A range of voltage-clamp protocol designs for rapid capture of hERG kinetics

We provide details of a series of short voltage-clamp protocols designed for gathering a large amount of information on hERG (Kv11.1) ion channel gating. The protocols have a limited number of steps and consist only of steps and ramps, making them ea... Read More about A range of voltage-clamp protocol designs for rapid capture of hERG kinetics.

Geometry of Spin(10) symmetry breaking (2024)
Journal Article
Krasnov, K. (2024). Geometry of Spin(10) symmetry breaking. Journal of Mathematical Physics, 65(8), Article 082302. https://doi.org/10.1063/5.0210073

We provide a new characterisation of the Standard Model gauge group GSM as a subgroup of Spin(10). The new description of GSM relies on the geometry of pure spinors. We show that GSM ⊂ Spin(10) is the group that stabilises a pure spinor Ψ1 and projec... Read More about Geometry of Spin(10) symmetry breaking.

Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping (2024)
Preprint / Working Paper
Kyratzi, P., Matika, O., Brassington, A. H., Connie, C. E., Xu, J., Barrett, D. A., Emes, R. D., Archibald, A. L., Paldi, A., Sinclair, K. D., Wattis, J., & Rauch, C. Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping

Identifying associations between phenotype and genotype is the fundamental basis of genetic analyses. Inspired by frequentist probability and the work of R.A. Fisher, genome-wide association studies (GWAS) extract information using averages and varia... Read More about Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping.

The Conversationality Index: A quantitative assessment of conversation in social media interactions (2024)
Journal Article
Cotgrove, L., Thul, R., & Conklin, K. (in press). The Conversationality Index: A quantitative assessment of conversation in social media interactions. Internet Pragmatics,

There has been an explosion in social media use, with Statista estimating that worldwide, Facebook has over 3 billion regular active users, YouTube 2.5 billion, and Instagram and WhatsApp 2 billion. While social media allows one to connect and intera... Read More about The Conversationality Index: A quantitative assessment of conversation in social media interactions.

Deep NURBS—admissible physics-informed neural networks (2024)
Journal Article
Saidaoui, H., Espath, L., & Tempone, R. (2024). Deep NURBS—admissible physics-informed neural networks. Engineering with Computers, 40, 4007-4021. https://doi.org/10.1007/s00366-024-02040-9

In this study, we propose a new numerical scheme for physics-informed neural networks (PINNs) that enables precise and inexpensive solutions for partial differential equations (PDEs) in case of arbitrary geometries while strongly enforcing Dirichlet... Read More about Deep NURBS—admissible physics-informed neural networks.

Nonassociative cyclic algebras and the semiassociative Brauer monoid (2024)
Journal Article
Pumplün, S. (2024). Nonassociative cyclic algebras and the semiassociative Brauer monoid. Rendiconti del Circolo Matematico di Palermo, 73, 3253-3275. https://doi.org/10.1007/s12215-024-01105-4

We look at classes of semiassociative algebras, with an emphasis on those that canonically generalize associative (generalized) cyclic algebras, and at their behaviour in the semiassociative Brauer monoid defined by Blachar, Haile, Matzri, Rein, an... Read More about Nonassociative cyclic algebras and the semiassociative Brauer monoid.

How to correctly fit an SIR model to data from an SEIR model? (2024)
Journal Article
KhudaBukhsh, W. R., & Rempała, G. A. (2024). How to correctly fit an SIR model to data from an SEIR model?. Mathematical Biosciences, 375, Article 109265. https://doi.org/10.1016/j.mbs.2024.109265

In epidemiology, realistic disease dynamics often require Susceptible-Exposed-Infected-Recovered (SEIR)-like models because they account for incubation periods before individuals become infectious. However, for the sake of analytica... Read More about How to correctly fit an SIR model to data from an SEIR model?.

Lubrication flow in grinding (2024)
Journal Article
Crowson, Z., Billingham, J., & Houston, P. (2024). Lubrication flow in grinding. Journal of Engineering Mathematics, 147(1), Article 12. https://doi.org/10.1007/s10665-024-10383-x

In the machining process known as grinding, fluid is applied to regulate the temperature of the workpiece and reduce the risk of expensive thermal damage. The factors that influence the transport of this grinding fluid are not well understood; howeve... Read More about Lubrication flow in grinding.