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All Outputs (259)

The relation between stimulated salivary flow and the temporal consumption experience of a liquid oral nutritional supplement (2021)
Journal Article
Lester, S., Hurst, K., Cornacchia, L., Kleijn, M., Ayed, C., Dinu, V., Taylor, M. A., & Fisk, I. (2021). The relation between stimulated salivary flow and the temporal consumption experience of a liquid oral nutritional supplement. Appetite, 166, Article 105325. https://doi.org/10.1016/j.appet.2021.105325

Use of oral nutritional supplements (ONS) in undernourished patients has proven clinical benefits, but this can be hampered by low adherence due to poor experience of palatability. Many patients, particularly older patients, experience hyposalivation... Read More about The relation between stimulated salivary flow and the temporal consumption experience of a liquid oral nutritional supplement.

Nitrergic modulation of neuronal excitability in the mouse hippocampus is mediated via regulation of Kv2 and voltage‐gated sodium channels (2021)
Journal Article
Scheiblich, H., & Steinert, J. R. (2021). Nitrergic modulation of neuronal excitability in the mouse hippocampus is mediated via regulation of Kv2 and voltage‐gated sodium channels. Hippocampus, 31(9), 1020-1038. https://doi.org/10.1002/hipo.23366

Regulation of neuronal activity is a necessity for communication and information transmission. Many regulatory processes which have been studied provide a complex picture of how neurons can respond to permanently changing functional requirements. One... Read More about Nitrergic modulation of neuronal excitability in the mouse hippocampus is mediated via regulation of Kv2 and voltage‐gated sodium channels.

Dose-Dependent Associations of Dietary Glycemic Index, Glycemic Load, and Fiber With 3-Year Weight Loss Maintenance and Glycemic Status in a High-Risk Population: A Secondary Analysis of the Diabetes Prevention Study PREVIEW (2021)
Journal Article
Zhu, R., Larsen, T. M., Fogelholm, M., Poppitt, S. D., Vestentoft, P. S., Silvestre, M. P., Jalo, E., Navas-Carretero, S., Huttunen-Lenz, M., Taylor, M. A., Stratton, G., Swindell, N., Drummen, M., Adam, T. C., Ritz, C., Sundvall, J., Valsta, L. M., Muirhead, R., Brodie, S., Handjieva-Darlenska, T., …Raben, A. (2021). Dose-Dependent Associations of Dietary Glycemic Index, Glycemic Load, and Fiber With 3-Year Weight Loss Maintenance and Glycemic Status in a High-Risk Population: A Secondary Analysis of the Diabetes Prevention Study PREVIEW. Diabetes Care, 44(7), 1672-1681. https://doi.org/10.2337/dc20-3092

OBJECTIVE: To examine longitudinal and dose-dependent associations of dietary glycemic index (GI), glycemic load (GL), and fiber with body weight and glycemic status during 3-year weight loss maintenance (WLM) in adults at high risk of type 2 diabete... Read More about Dose-Dependent Associations of Dietary Glycemic Index, Glycemic Load, and Fiber With 3-Year Weight Loss Maintenance and Glycemic Status in a High-Risk Population: A Secondary Analysis of the Diabetes Prevention Study PREVIEW.

Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET (2021)
Journal Article
Lay, C. S., Bridges, A., Goulding, J., Briddon, S. J., Soloviev, Z., Craggs, P. D., & Hill, S. J. (2022). Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET. Cell Chemical Biology, 29(1), 19-29.e6. https://doi.org/10.1016/j.chembiol.2021.05.002

Interleukin-23 (IL-23) is a pro-inflammatory cytokine involved in the host defense against pathogens but is also implicated in the development of several autoimmune disorders. The IL-23 receptor has become a key target for drug discovery, but the exa... Read More about Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET.

Tumour brain: pre‐treatment cognitive and affective disorders caused by peripheral cancers (2021)
Journal Article
Mampay, M., Flint, M. S., & Sheridan, G. K. (2021). Tumour brain: pre‐treatment cognitive and affective disorders caused by peripheral cancers. British Journal of Pharmacology, 178(19), 3977-3996. https://doi.org/10.1111/bph.15571

People that develop extracranial cancers often display co-morbid neurological disorders, such as anxiety, depression and cognitive impairment, even before commencement of chemotherapy. This suggests bidirectional crosstalk between non-CNS tumours and... Read More about Tumour brain: pre‐treatment cognitive and affective disorders caused by peripheral cancers.

Integrated Environmental and Genomic Analysis Reveals the Drivers of Local Adaptation in African Indigenous Chickens (2021)
Journal Article
Gheyas, A. A., Vallejo-Trujillo, A., Kebede, A., Lozano-Jaramillo, M., Dessie, T., Smith, J., & Hanotte, O. (2021). Integrated Environmental and Genomic Analysis Reveals the Drivers of Local Adaptation in African Indigenous Chickens. Molecular Biology and Evolution, 38(10), 4268-4285. https://doi.org/10.1093/molbev/msab156

Breeding for climate resilience is currently an important goal for sustainable livestock production. Local adaptations exhibited by indigenous livestock allow investigating the genetic control of this resilience. Ecological niche modeling (ENM) provi... Read More about Integrated Environmental and Genomic Analysis Reveals the Drivers of Local Adaptation in African Indigenous Chickens.

Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management (2021)
Journal Article
Bonifazi, A., Battiti, F. O., Sanchez, J., Zaidi, S. A., Bow, E., Makarova, M., Cao, J., Shaik, A. B., Sulima, A., Rice, K. C., Katritch, V., Canals, M., Lane, J. R., & Newman, A. H. (2021). Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management. Journal of Medicinal Chemistry, 64(11), 7778-7808. https://doi.org/10.1021/acs.jmedchem.1c00611

The need for safer pain-management therapies with decreased abuse liability inspired a novel drug design that retains μ-opioid receptor (MOR)-mediated analgesia, while minimizing addictive liability. We recently demonstrated that targeting the dopami... Read More about Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.

Real world SOF/VEL/VOX retreatment outcomes and viral resistance analysis for HCV patients with prior failure to DAA therapy (2021)
Journal Article
Smith, D. A., Bradshaw, D., Mbisa, J., Manso, C. F., Bibby, D., Singer, J., Thomson, E. C., Filipe, A., Aranday‐Cortes, E., Ansari, M. A., Brown, A., Hudson, E., Benselin, J., Healy, B., Troke, P., McLauchlan, J., Barnes, E., & Irving, W. L. (2021). Real world SOF/VEL/VOX retreatment outcomes and viral resistance analysis for HCV patients with prior failure to DAA therapy. Journal of Viral Hepatitis, 28(9), 1256-1264. https://doi.org/10.1111/jvh.13549

Sustained viral response (SVR) rates for direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection routinely exceed 95%. However, a small number of patients require retreatment. Sofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX)... Read More about Real world SOF/VEL/VOX retreatment outcomes and viral resistance analysis for HCV patients with prior failure to DAA therapy.

Glycosylation Regulates N-Terminal Proteolysis and Activity of the Chemokine CCL14 (2021)
Journal Article
Wang, S., Foster, S. R., Sanchez, J., Corcilius, L., Larance, M., Canals, M., Stone, M. J., & Payne, R. J. (2021). Glycosylation Regulates N-Terminal Proteolysis and Activity of the Chemokine CCL14. ACS Chemical Biology, 16(6), 973-981. https://doi.org/10.1021/acschembio.1c00006

Chemokines are secreted proteins that regulate leukocyte migration during inflammatory responses by signaling through chemokine receptors. Full length CC chemokine ligand 14, CCL14(1–74), is a weak agonist for the chemokine receptor CCR1, but its act... Read More about Glycosylation Regulates N-Terminal Proteolysis and Activity of the Chemokine CCL14.

Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release (2021)
Journal Article
Adala, I., Ramis, J., Ntone Moussinga, C., Janowski, I., Amer, M. H., Bennett, A. J., Alexander, C., & Rose, F. R. (2021). Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release. Journal of Materials Chemistry B, 9(20), 4120-4133. https://doi.org/10.1039/d1tb00129a

Effective regenerative medicine requires delivery systems which can release multiple components at appropriate levels and at different phases of tissue growth and repair. However, there are few biomaterials and encapsulation techniques that are fully... Read More about Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release.

Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe (2021)
Journal Article
Su, W., Jing, Y., Lin, S., Yue, Z., Yang, X., Xu, J., Wu, J., Zhang, Z., Xia, R., Zhu, J., An, N., Chen, H., Hong, Y., Yuan, Y., Long, T., Zhang, L., Jiang, Y., Liu, Z., Zhang, H., Gao, Y., …Liu, Z. (2021). Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe. Proceedings of the National Academy of Sciences, 118(20), 1-11. https://doi.org/10.1073/pnas.2101767118

Whole-genome duplication (WGD) plays important roles in plant evolution and function, yet little is known about how WGD underlies metabolic diversification of natural products that bear significant medicinal properties, especially in nonmodel trees.... Read More about Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe.

Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles (2021)
Journal Article
Trindade, G. F., Wang, F., Im, J., He, Y., Balogh, A., Scurr, D., Gilmore, I., Tiddia, M., Saleh, E., Pervan, D., Turyanska, L., Tuck, C. J., Wildman, R., Hague, R., & Roberts, C. J. (2021). Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles. Communications Materials, 2(1), Article 47. https://doi.org/10.1038/s43246-021-00151-0

Inkjet printing of metal nanoparticles allows for design flexibility, rapid processing and enables the 3D printing of functional electronic devices through co-deposition of multiple materials. However, the performance of printed devices, especially t... Read More about Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles.

Prevalence and risk factors of schistosomiasis among primary school children in four selected regions of the Gambia (2021)
Journal Article
Joof, E., Sanyang, A. M., Camara, Y., Seyid, A. P., Baldeh, I., Jah, S. L., Ceesay, S. J., Sambou, S. M., Sanyang, S., Wade, C. M., & Sanneh, B. (2021). Prevalence and risk factors of schistosomiasis among primary school children in four selected regions of the Gambia. PLoS Neglected Tropical Diseases, 15(5), Article e0009380. https://doi.org/10.1371/journal.pntd.0009380

Background The Gambia initiated a control programme for schistosomiasis in 2015. In light of this, recent and comprehensive data on schistosomiasis is required to effectively guide the control programme. This study aimed to evaluate the prevalence an... Read More about Prevalence and risk factors of schistosomiasis among primary school children in four selected regions of the Gambia.

A pilot of the feasibility and usefulness of an aged obese model for use in stroke research (2021)
Journal Article
Learoyd, A. E., Calmus, R., Cunningham, C. N., England, T. J., Farr, T. D., Fone, K. C., Kendall, D. A., O’Sullivan, S. E., & Trueman, R. C. (2021). A pilot of the feasibility and usefulness of an aged obese model for use in stroke research. Wellcome Open Research, 6, Article 104. https://doi.org/10.12688/wellcomeopenres.16592.1

Background: Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a combined aged and high-fat diet model,... Read More about A pilot of the feasibility and usefulness of an aged obese model for use in stroke research.

Evidence for Selection in the Abundant Accessory Gene Content of a Prokaryote Pangenome (2021)
Journal Article
Whelan, F. J., Hall, R. J., & McInerney, J. O. (2021). Evidence for Selection in the Abundant Accessory Gene Content of a Prokaryote Pangenome. Molecular Biology and Evolution, 38(9), 3697-3708. https://doi.org/10.1093/molbev/msab139

A pangenome is the complete set of genes (core and accessory) present in a phylogenetic clade. We hypothesize that a pangenome's accessory gene content is structured and maintained by selection. To test this hypothesis, we interrogated the genomes of... Read More about Evidence for Selection in the Abundant Accessory Gene Content of a Prokaryote Pangenome.

Inkjet 3D Printing of Polymers Resistant to Fungal Attachment (2021)
Journal Article
He, Y., Vallières, C., Alexander, M. R., Wildman, R. D., & Avery, S. V. (2021). Inkjet 3D Printing of Polymers Resistant to Fungal Attachment. Bio-protocol, 11(9), Article e4016. https://doi.org/10.21769/BioProtoc.4016

Inkjet 3D printing is an additive manufacturing method that allows the user to produce a small batch of customized devices for comparative study versus commercial products. Here, we describe the use of a commercial 2D ink development system (Dimatix... Read More about Inkjet 3D Printing of Polymers Resistant to Fungal Attachment.

Hypoalbuminemia in patients following their recovery from severe coronavirus disease 2019 (2021)
Journal Article
Ali, K. M., Ali, A. M., Tawfeeq, H. M., Figueredo, G. P., & Rostam, H. M. (2021). Hypoalbuminemia in patients following their recovery from severe coronavirus disease 2019. Journal of Medical Virology, 93(7), 4532-4536. https://doi.org/10.1002/jmv.27002

Coronavirus disease 2019 (COVID-19) is caused by a contagious virus that has spread to more than 200 countries, territories, and regions. Thousands of studies to date have examined all aspects of this disease, yet little is known about the postrecove... Read More about Hypoalbuminemia in patients following their recovery from severe coronavirus disease 2019.