All Outputs (329)

The Effect of Acute Knee Injuries and Related Knee Surgery on Serum Levels of Pro- and Anti-inflammatory Lipid Mediators and Their Associations With Knee Symptoms. (2024)
Journal Article
Turnbull, J., Jha, R. R., Barrett, D. A., Valdes, A. M., Alderson, J., Williams, A., Vincent, T. L., Watt, F. E., & Chapman, V. (2024). The Effect of Acute Knee Injuries and Related Knee Surgery on Serum Levels of Pro- and Anti-inflammatory Lipid Mediators and Their Associations With Knee Symptoms. American Journal of Sports Medicine, 52(4), 987-997. https://doi.org/10.1177/03635465241228209

Despite an acute knee injury being a major risk factor for osteoarthritis, the factors that initiate and maintain this risk of longer-term knee symptoms are poorly understood. Bioactive lipids derived from omega-3 and -6 polyunsaturated fatty acids h... Read More about The Effect of Acute Knee Injuries and Related Knee Surgery on Serum Levels of Pro- and Anti-inflammatory Lipid Mediators and Their Associations With Knee Symptoms..

Understanding barriers and facilitators to long-term participation needs in children and young people following acquired brain injuries: a qualitative multi-stakeholder study (2024)
Journal Article
Keetley, R., Manning, J. C., Williams, J., Bennett, E., Westlake, M., & Radford, K. (2024). Understanding barriers and facilitators to long-term participation needs in children and young people following acquired brain injuries: a qualitative multi-stakeholder study. Brain Impairment, 25(1), Article IB23100. https://doi.org/10.1071/IB23100

Background This study focused on exploring the longer-term participation needs of children and young people with acquired brain injury (CYP-ABI) and their families in one region of the UK and identifying the barriers and facilitators of their partici... Read More about Understanding barriers and facilitators to long-term participation needs in children and young people following acquired brain injuries: a qualitative multi-stakeholder study.

The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England (2024)
Journal Article
Chaplin, W. J., Lewis, H. R., Shahtaheri, S. M., Millar, B. S., McWilliams, D. F., Gladman, J. R. F., & Walsh, D. A. (2024). The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England. BMC Geriatrics, 24, Article 158. https://doi.org/10.1186/s12877-023-04602-w

Introduction
The association between chronic pain and frailty might indicate that pain is an independent driver of frailty but might alternatively be explained by inclusion within frailty identification tools of morbidities that commonly lead to chr... Read More about The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England.

Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats (2024)
Journal Article
Li, H., Zhou, B., Wu, J., Zhang, Y., Zhang, W., Doherty, M., Deng, X., Wang, N., Xie, D., Wang, Y., Xie, H., Li, C., Wei, J., Lei, G., & Zeng, C. (2024). Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats. Journal of Pineal Research, 76(2), Article e12945. https://doi.org/10.1111/jpi.12945

Melatonin exhibits potential for pain relief and long-term safety profile. We examined the analgesic effects of oral melatonin on osteoarthritis (OA) and investigated the underlying mechanism. Using data from a UK primary care database, we conducted... Read More about Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats.

Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism (2024)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Constantin, D., Cordon, S. M., Constantin-Teodosiu, D., Stephens, F. B., Brook, M. S., Atherton, P. J., Smith, K., Wilkinson, D. J., Mougin, O. E., Bradley, C., Macdonald, I. A., & Greenhaff, P. L. (2024). Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism. Journal of Cachexia, Sarcopenia and Muscle, 15(2), 603-614. https://doi.org/10.1002/jcsm.13431

Background
Bed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same ind... Read More about Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism.

Effects of colour-coded compartmentalised syringe trays on anaesthetic drug error detection under cognitive load (2024)
Journal Article
Laxton, V., Maratos, F. A., Hewson, D. W., Baird, A., Archer, S., & Stupple, E. J. N. (2024). Effects of colour-coded compartmentalised syringe trays on anaesthetic drug error detection under cognitive load. British Journal of Anaesthesia, 132(5), 911-917. https://doi.org/10.1016/j.bja.2023.12.033

Background
Anaesthetic drug administration is complex, and typical clinical environments can entail significant cognitive load. Colour-coded anaesthetic drug trays have shown promising results for error identification and reducing cognitive load.... Read More about Effects of colour-coded compartmentalised syringe trays on anaesthetic drug error detection under cognitive load.

Peer mentoring for people with acquired brain injury – a systematic review (2024)
Journal Article
De Dios Perez, B., Morris, R. P., Craven, K., & Radford, K. A. (2024). Peer mentoring for people with acquired brain injury – a systematic review. Brain Injury, 38(4), 316-329. https://doi.org/10.1080/02699052.2024.2310779

Introduction: Over 100 million people worldwide live with disabilities resulting from an acquired brain injury (ABI). ABI survivors experience cognitive and physical problems and require support to resume an active life. They can benefit from support... Read More about Peer mentoring for people with acquired brain injury – a systematic review.

2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice (2024)
Journal Article
Mandl, P., D'Agostino, M. A., Navarro-Compán, V., Geßl, I., Sakellariou, G., Abhishek, A., Becce, F., Dalbeth, N., Ea, H.-K., Filippucci, E., Hammer, H. B., Iagnocco, A., de Thurah, A., Naredo, E., Ottaviani, S., Pascart, T., Pérez-Ruiz, F., Pitsillidou, I. A., Proft, F., Rech, J., …Filippou, G. (2024). 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice. Annals of the Rheumatic Diseases, 83, 752-759. https://doi.org/10.1136/ard-2023-224771

Objective: To formulate evidence-based recommendations and overarching principles on the use of imaging in the clinical management of crystal-induced arthropathies (CiAs). Methods: An international task force of 25 rheumatologists, radiologists, meth... Read More about 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice.

Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health (2024)
Journal Article
Kirk, D., Costeira, R., Visconti, A., Khan Mirzaei, M., Deng, L., Valdes, A. M., & Menni, C. (2024). Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health. Cell Reports, 43(2), Article 113728. https://doi.org/10.1016/j.celrep.2024.113728

Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by ba... Read More about Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Stevenson, M. D., Nakafero, G., & Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), Article e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping m... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis (2024)
Journal Article
Aldafas, R., Crabtree, T., Alkharaiji, M., Vinogradova, Y., & Idris, I. (2024). Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis. Age and Ageing, 53(1), Article afad254. https://doi.org/10.1093/ageing/afad254

Objective: Sodium-glucose cotransporter-2 inhibitors (SGLT2Is) reduce cardio-metabolic and renal outcomes in patients with type 2 diabetes (T2D) but their efficacy and safety in older or frail individuals remains unclear. Methods: We searched PubMed,... Read More about Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis.

Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage (2024)
Journal Article
Toader, A.-M., Campbell, M. K., Quint, J. K., Robling, M., Sydes, M. R., Thorn, J., Wright-Hughes, A., Yu, L.-M., Abbott, T. E. F., Bond, S., Caskey, F. J., Clout, M., Collinson, M., Copsey, B., Davies, G., Driscoll, T., Gamble, C., Griffin, X. L., Hamborg, T., Harris, J., …Williamson, P. (2024). Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage. Trials, 25(1), Article 94. https://doi.org/10.1186/s13063-024-07926-z

Background: Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, issues to be considered before t... Read More about Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.

Feasibility of delivering a randomized controlled trial of weighted blanket intervention to help agitation and disturbed sleep after brain injury (2024)
Journal Article
Edwards, L. (2024). Feasibility of delivering a randomized controlled trial of weighted blanket intervention to help agitation and disturbed sleep after brain injury. Frontiers in Sleep, 3, Article 1325175. https://doi.org/10.3389/frsle.2024.1325175

Sleep disturbance and agitation are common after acquired brain injury (ABI). Weighted blankets may help these symptoms in other conditions, but have not been trialed in ABI. We aimed to determine acceptability and feasibility of weighted blankets to... Read More about Feasibility of delivering a randomized controlled trial of weighted blanket intervention to help agitation and disturbed sleep after brain injury.

The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study (2024)
Journal Article
De Dios Perez, B., Pritchard, C., Powers, K., das Nair, R., Evangelou, N., Ford, H., Tallantyre, E., Dobson, R., & Radford, K. (2024). The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study. International Journal of Ms Care, 26(Q3), 174-186. https://doi.org/10.7224/1537-2073.2023-049

Background: The COVID-19 pandemic led to approximately half of the working population in the United Kingdom being unable to work temporarily. This study aims to understand the employment needs and experiences of people with multiple sclerosis (MS) in... Read More about The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study.

A scoping review of remote group-based psychological interventions for people after transient ischemic attack and stroke (2024)
Journal Article
Kettlewell, J., Kontou, E., Lee, A. R., Thomas, S., Thorpe, N., & Wong, D. (2024). A scoping review of remote group-based psychological interventions for people after transient ischemic attack and stroke. Brain Impairment, 25(1), Article IB23071. https://doi.org/10.1071/IB23071

Background
Mental health and quality of life are commonly affected following a stroke or Transient Ischemic Attack (TIA) diagnosis, although many people are discharged without clear information about their psychological impact. Evidence suggests psy... Read More about A scoping review of remote group-based psychological interventions for people after transient ischemic attack and stroke.

Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults (2024)
Journal Article
Guo, Y., Jones, E. J., Škarabot, J., Inns, T. B., Phillips, B. E., Atherton, P. J., & Piasecki, M. (2024). Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults. GeroScience, 46, 3249-3261. https://doi.org/10.1007/s11357-024-01063-w

Although muscle atrophy may partially account for age-related strength decline, it is further influenced by alterations of neural input to muscle. Persistent inward currents (PIC) and the level of common synaptic inputs to motoneurons influence neuro... Read More about Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults.

The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK (2024)
Journal Article
Wilmington, R., Abuawwad, M., Holt, G., Anderson, R., Aldafas, R., Awad, S., & Idris, I. (2024). The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK. Obesity Surgery, 34, 850-854. https://doi.org/10.1007/s11695-023-06964-x

Background: Current recommendations advocate the achievement of an optimal glucose control (HbA1c < 69mmol/mol) prior to elective surgery to reduce risks of peri- and post-operative complications, but the relevance for this glycaemic threshold prior... Read More about The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK.

Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study (2024)
Journal Article
Cowie, R. M., Macri-Pellizzeri, L., McLaren, J., Sanderson, W. J., Felfel, R. M., Scotchford, C. A., Scammell, B. E., Grant, D. M., Sottile, V., & Jennings, L. M. (2024). Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study. Royal Society Open Science, 11(1), Article 230431. https://doi.org/10.1098/rsos.230431

Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different g... Read More about Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study.

The effectiveness of cupping therapy on low back pain: A systematic review and meta-analysis of randomized control trials (2024)
Journal Article
Zhang, Z., Pasapula, M., Wang, Z., Edwards, K., & Norrish, A. (2024). The effectiveness of cupping therapy on low back pain: A systematic review and meta-analysis of randomized control trials. Complementary Therapies in Medicine, 80, Article 103013. https://doi.org/10.1016/j.ctim.2024.103013

This study aims to investigate the effectiveness of cupping therapy on low back pain (LBP). Medline, Embase, Scopus and WANFANG databases were searched for relevant cupping RCTs on low back pain articles up to 2023. A complementary search was manuall... Read More about The effectiveness of cupping therapy on low back pain: A systematic review and meta-analysis of randomized control trials.

Comparing Self-Reported Running Distance and Pace With a Commercial Fitness Watch Data: Reliability Study (2024)
Journal Article
Bullock, G., Stocks, J., Feakins, B., Alizadeh, Z., Arundale, A., & Kluzek, S. (2024). Comparing Self-Reported Running Distance and Pace With a Commercial Fitness Watch Data: Reliability Study. JMIR Formative Research, 8(1), Article e39211. https://doi.org/10.2196/39211

Background There is substantial evidence exploring the reliability of running distance self-reporting and GPS wearable technology, but there are currently no studies investigating the reliability of participant self-reporting in comparison to GPS wea... Read More about Comparing Self-Reported Running Distance and Pace With a Commercial Fitness Watch Data: Reliability Study.