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All Outputs (342)

Development and validation of metrics for assessment of ultrasound-guided fascial block skills (2024)
Journal Article
McLeod, G., Seeley, J., Wilson, M., Hind, D., Cole, A., Hewson, D., Hyslop, M., Keetharuth, A., MacFarlane, A., Wilby, M., McKendrick, M., McKendrick, G., Mustafa, A., Chuan, A., Bangalore, P. R., Record, N., Rombach, I., Sadler, A., Swaby, L., Taylor, A., & Tripathi, S. (2024). Development and validation of metrics for assessment of ultrasound-guided fascial block skills. British Journal of Anaesthesia, 133(4), 862-873. https://doi.org/10.1016/j.bja.2024.06.039

Background

As few anaesthetists provide lumbar erector spinae block for disc surgery, there is a need to provide training to enable a randomised controlled trial investigating analgesia after painful spinal surgery (NIHR153170). The primary object... Read More about Development and validation of metrics for assessment of ultrasound-guided fascial block skills.

Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity (2024)
Journal Article
Valdes, A. M., Louca, P., Visconti, A., Asnicar, F., Bermingham, K., Nogal, A., Wong, K., Michelotti, G. A., Wolf, J., Segata, N., Spector, T. D., Berry, S. E., Falchi, M., & Menni, C. (2024). Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity. BMC Medicine, 22(1), Article 321. https://doi.org/10.1186/s12916-024-03543-4

Background: Vitamin A is essential for physiological processes like vision and immunity. Vitamin A’s effect on gut microbiome composition, which affects absorption and metabolism of other vitamins, is still unknown. Here we examined the relationship... Read More about Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity.

Pain relief after instrumented spinal surgery (2024)
Presentation / Conference Contribution
Wilson, M. J., Cole, A., Hewson, D., Hind, D., Hawksworth, O., Hyslop, M., Keetharuth, A., Macfarlane, A., Martin, B., Mcleod, G., Rombach, I., Swaby, L., Tripathi, S., & Wilby, M. (2024, June). Pain relief after instrumented spinal surgery. Presented at The Society for Back Pain Research (SBPR) 2024 Annual General Meeting: “Innovation in Research and Management of Spine Pain”, Aberdeen, Scotland

Background

Over 55,000 spinal operations are performed annually in the NHS. Effective postoperative analgesia facilitates early mobilisation and assists rehabilitation and hospital discharge, but is difficult to achieve with conventional, opioid-b... Read More about Pain relief after instrumented spinal surgery.

Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study (2024)
Journal Article
O'Sullivan, O., Stocks, J., Schofield, S., Bilzon, J., Boos, C. J., Bull, A. M., Fear, N. T., Watt, F. E., Bennett, A. N., Kluzek, S., & Valdes, A. M. (2024). Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study. Osteoarthritis and Cartilage, 32(12), 1636-1646. https://doi.org/10.1016/j.joca.2024.07.016

Objective: The ArmeD SerVices TrAuma RehabilitatioN OutComE (ADVANCE) study is investigating long-term combat-injury outcomes; this sub-study aims to understand the association of osteoarthritis (OA) biomarkers with knee radiographic OA (rOA), pain a... Read More about Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study.

Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case–control study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case–control study. The Lancet Rheumatology, 6(9), e615-e624. https://doi.org/10.1093/rheumatology/keae160

Background
People with immune-mediated inflammatory disease are at increased risk of pneumococcal pneumonia. The effectiveness of pneumococcal vaccination in people with immune-mediated inflammatory diseases has not been evaluated. We investigated t... Read More about Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case–control study.

Impact of COVID-19 on home care provision: A qualitative study (2024)
Journal Article
Darby, J., Allen, F., Bennett, C., Logan, P., & Kasonde, C. (2024). Impact of COVID-19 on home care provision: A qualitative study. Journal of Social Work, 24(5), 645-663. https://doi.org/10.1177/14680173241258900

Summary The COVID-19 pandemic and subsequent public health restrictions caused an unprecedented impact on long-term care services in the United Kingdom (UK). A qualitative study was conducted in the East Midlands, UK, to explore how home care provisi... Read More about Impact of COVID-19 on home care provision: A qualitative study.

Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite® to deliver BMP-2 in an ovine femoral condyle defect model (2024)
Journal Article
Marshall, K. M., McLaren, J. S., Wojciechowski, J. P., Callens, S. J. P., Echalier, C., Kanczler, J. M., Rose, F. R. A. J., Stevens, M. M., Dawson, J. I., & Oreffo, R. O. C. (2024). Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite® to deliver BMP-2 in an ovine femoral condyle defect model. Biomaterials Advances, 164, Article 213959. https://doi.org/10.1016/j.bioadv.2024.213959

Biomaterial-based approaches for bone regeneration seek to explore alternative strategies to repair non-healing fractures and critical-sized bone defects. Fracture non-union occurs due to a number of factors resulting in the formation of bone defects... Read More about Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite® to deliver BMP-2 in an ovine femoral condyle defect model.

Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation (2024)
Journal Article
Lorito, C. D., Pollock, K., Booth, V., Howe, L., Goldberg, S., Godfrey, M., Dunlop, M., Harwood, R. H., Van Der Wardt, V., & Lorito, C. D. (2024). Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation. BMC Geriatrics, 24(1), Article 615. https://doi.org/10.1186/s12877-024-05086-y

Background: Interventions promoting social activity may reduce behavioural psychological symptoms and improve quality of life in people living with dementia. This study aimed to identify social benefits for participants living with dementia in the co... Read More about Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation.

How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation (2024)
Journal Article
De Dios Pérez, B., Merchán-Baeza, J. A., Powers, K., Craven, K., Holmes, J., Phillips, J., Tyerman, R., & Radford, K. (2024). How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation. BMC Medical Research Methodology, 24(1), Article 142. https://doi.org/10.1186/s12874-024-02269-4

Background: Integrating complex interventions within healthcare settings can be challenging. Mentoring can be embedded within a randomised controlled trial (RCT) to upskill and support those delivering the intervention. This study aimed to understand... Read More about How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation.

Metabolic effects of very-low calorie diet, Semaglutide or combination of the two, in individuals with type 2 diabetes mellitus (2024)
Journal Article
Oluwaseun, A., Bethan, P., Katie, Q., Daniel, W., Kenneth, S., Philip, A., & Iskandar, I. (2024). Metabolic effects of very-low calorie diet, Semaglutide or combination of the two, in individuals with type 2 diabetes mellitus. Clinical Nutrition, 43(8), 1907-1913. https://doi.org/10.1016/j.clnu.2024.06.034

Background & aims

Very-low calorie diets (VLCD) and the glucagon-like peptide-1 receptor agonist (GLP1RA) Semaglutide induce significant weight loss and improve glycaemic control in individuals with type 2 diabetes (T2D). This pilot study was cond... Read More about Metabolic effects of very-low calorie diet, Semaglutide or combination of the two, in individuals with type 2 diabetes mellitus.

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 (2024)
Journal Article
Gupta, A., Nicholas, R., McGing, J. J., Nixon, A. V., Mallinson, J. E., McKeever, T. M., Bradley, C. R., Piasecki, M., Cox, E. F., Bonnington, J., Lord, J. M., Brightling, C. E., Evans, R. A., Hall, I. P., Francis, S. T., Greenhaff, P. L., & Bolton, C. E. (2024). DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19. Experimental Physiology, 109(8), 1274-1291. https://doi.org/10.1113/ep091590

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited... Read More about DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial (2024)
Journal Article
Harrison, S., Ogollah, R., Hollingworth, W., Mills, N., Karantana, A., Blazeby, J., Montgomery, A., Shafayat, A., Jarrett, H., & Davis, T. (2024). Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial. Trials, 25(1), Article 398. https://doi.org/10.1186/s13063-024-08003-1

Background: Dupuytren’s contractures (DC) are fibrous cords under the skin of the hand that cause one or more fingers to curl gradually and irreversibly towards the palm. These contractures are usually painless but can cause a loss of hand function.... Read More about Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial.

Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire (2024)
Journal Article
McWilliams, D., Georgopoulos, V., Patel, J., Millar, B., Smith, S., & Walsh, D. (2024). Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire. Rheumatology, 63(12), 3306-3314. https://doi.org/10.1093/rheumatology/keae342

Background

Neuropathic-like pain, fatigue, cognitive difficulty, catastrophizing, anxiety, sleep disturbance, depression and widespread pain associate with a single factor in people with knee pain. We report the Central Aspects of Pain questionnai... Read More about Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire.

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventin... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

Orthotist involvement in early gait rehabilitation after stroke: A cross-sectional survey of orthotists in the United Kingdom (2024)
Journal Article
Golding-Day, M., Young, J., Charlton, P., Houston, B., Thomas, S., & Walker, M. (2025). Orthotist involvement in early gait rehabilitation after stroke: A cross-sectional survey of orthotists in the United Kingdom. Prosthetics and Orthotics International, 49(3), 298-305. https://doi.org/10.1097/pxr.0000000000000365

Background:
The role of the orthotist in early gait rehabilitation after stroke in the United Kingdom is currently poorly understood.

Objectives:
The objective of this study was to capture current opinion and practice of orthotists on their ro... Read More about Orthotist involvement in early gait rehabilitation after stroke: A cross-sectional survey of orthotists in the United Kingdom.

Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse (2024)
Journal Article
Khoshkerdar, A., Eid, N., Batra, V., Baker, N., Holmes, N., Henson, S., Sang, F., Wright, V., McLaren, J., Shakesheff, K., Woad, K. J., Morgan, H. L., & Watkins, A. J. (2024). Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse. Nutrients, 16(12), Article 1879. https://doi.org/10.3390/nu16121879

Pregnancy represents a stage during which maternal physiology and homeostatic regulation undergo dramatic change and adaptation. The fundamental purpose of these adaptations is to ensure the survival of her offspring through adequate nutrient provisi... Read More about Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse.

Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing (2024)
Journal Article
Agbiki, T., Arm, R., Hewson, D. W., Erdody, S., Norris, A. M., Correia, R., Korposh, S., Hayes-Gill, B. R., Shahidi, A., & Morgan, S. P. (2024). Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing. BJA Open, 10, Article 100290. https://doi.org/10.1016/j.bjao.2024.100290

Introduction
Leakage of orogastric secretions past the cuff of a tracheal tube is a contributory factor in ventilator-associated pneumonia. Current bench test methods specified in the International Standard for Anaesthetic and Respiratory Equipment... Read More about Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing.

Sex disparities of human neuromuscular decline in older humans (2024)
Journal Article
Guo, Y., Jones, E. J., Smart, T. F., Altheyab, A., Gamage, N., Stashuk, D. W., Piasecki, J., Phillips, B. E., Atherton, P. J., & Piasecki, M. (2025). Sex disparities of human neuromuscular decline in older humans. Journal of Physiology, 603(1), 151-165. https://doi.org/10.1113/jp285653

Females typically live longer than males but, paradoxically, spend a greater number of later years in poorer health. The neuromuscular system is a critical component of the progression to frailty, and motor unit (MU) characteristics differ by sex in... Read More about Sex disparities of human neuromuscular decline in older humans.