All Outputs (317)

How and why do community stakeholders participate in the national stroke audit in England? Findings from a mixed-method online survey (2024)
Journal Article
Russell, L., Chouliara, N., Lewis, S., James, M., & Fisher, R. (2024). How and why do community stakeholders participate in the national stroke audit in England? Findings from a mixed-method online survey. BMC Health Services Research, 24(1), Article 1358. https://doi.org/10.1186/s12913-024-11653-1

Background: National audit programmes are a recognised means of assessing quality of healthcare by collecting and reporting data in relation to evidence-based standards. The Sentinel Stroke National Audit Programme is a prospective audit of processes... Read More about How and why do community stakeholders participate in the national stroke audit in England? Findings from a mixed-method online survey.

Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis (2024)
Journal Article
Smith, S. L., Paul, L., Steultjens, M. P. M., & Jones, R. L. (2024). Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis. Arthritis Research and Therapy, 26, Article 189. https://doi.org/10.1186/s13075-024-03419-1

Objectives: Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of osteoarthritis disability. Th... Read More about Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis.

Communities of Practice (CoP) - a public health tool for facilitating implementation of research into practice for a falls prevention exercise intervention; an ethnographic study (2024)
Preprint / Working Paper
Orton, E., Alderman, V., Carpenter, H., Coupland, C., Gladman, J., Iliffe, S., Kendrick, D., Lafond, N., Logan, P., Okereke, U., Skelton, D., Masud, T., & Timmons, S. (2024). Communities of Practice (CoP) - a public health tool for facilitating implementation of research into practice for a falls prevention exercise intervention; an ethnographic study

Introduction
In public health there is often a disconnect in translating research into practice.
The Falls Management Exercise (FaME) programme is an evidence-based exercise programme aimed at reducing falls in older adults. Whilst recommended as... Read More about Communities of Practice (CoP) - a public health tool for facilitating implementation of research into practice for a falls prevention exercise intervention; an ethnographic study.

Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study (2024)
Journal Article
Agosti, P., Kouraki, A., Dionisi, T., Addolorato, G., D’Innocenzo, L., Sorrentino, S., De Maio, F., De Candia, E., Blanco-Miguez, A., Bazzani, D., Bonadiman, A., Tonidandel, G., Bolzan, M., Gianniello, F., Passamonti, S. M., Abbattista, M., Valdes, A. M., Bucciarelli, P., Peyvandi, F., & Menni, C. (2024). Gut Microbiome Diversity and Composition Correlates With Time in the Therapeutic Range in Patients on Warfarin Treatment: A Pilot Study. Arteriosclerosis, Thrombosis, and Vascular Biology, https://doi.org/10.1161/ATVBAHA.124.321490

PRevention Intervention and Support in Mental health for people with aphasia (Aphasia PRISM): protocol and mixed methods analysis plan for two feasibility studies (2024)
Journal Article
Baker, C., Rose, M. L., Wong, D., Ryan, B., Thomas, S., Cadilhac, D., & Kneebone, I. (in press). PRevention Intervention and Support in Mental health for people with aphasia (Aphasia PRISM): protocol and mixed methods analysis plan for two feasibility studies. Discover Psychology, 4(1), Article 153. https://doi.org/10.1007/s44202-024-00210-w

Background People with aphasia commonly experience depression and anxiety. The individual therapy program, Aphasia PRevention Intervention and Support in Mental health (Aphasia PRISM) offers low intensity psychotherapeutic interventions using communi... Read More about PRevention Intervention and Support in Mental health for people with aphasia (Aphasia PRISM): protocol and mixed methods analysis plan for two feasibility studies.

FreshLanDiv: A Global Database of Freshwater Biodiversity Across Different Land Uses (2024)
Journal Article
Shen, M., van Klink, R., Sagouis, A., Petsch, D. K., Abong'o, D. A., Alahuhta, J., Al‐Shami, S. A., Armendáriz, L. C., Bae, M., Begot, T. O., Belliard, J., Benstead, J. P., Bomfim, F. F., Bredenhand, E., Budnick, W. R., Callisto, M., Calvão, L. B., Camacho‐Rozo, C. P., Cañedo‐Argüelles, M., Carvalho, F. G., …Chase, J. M. (2024). FreshLanDiv: A Global Database of Freshwater Biodiversity Across Different Land Uses. Global Ecology and Biogeography, 33(12), Article e13917. https://doi.org/10.1111/geb.13917

Motivation
Freshwater ecosystems have been heavily impacted by land-use changes, but data syntheses on these impacts are still limited. Here, we compiled a global database encompassing 241 studies with species abundance data (from multiple biologica... Read More about FreshLanDiv: A Global Database of Freshwater Biodiversity Across Different Land Uses.

Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study (2024)
Journal Article
De Dios Perez, B., Holmes, J., Elder, T., Lindley, R., Evangelou, N., das Nair, R., Senior, C., Booth, V., Hassard, J., Ford, H. L., Newsome, I., & Radford, K. (2025). Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study. Disability and Rehabilitation, 47(12), 3124-3136. https://doi.org/10.1080/09638288.2024.2417031

Purpose: To implement a job retention vocational rehabilitation (VR) intervention (MSVR) for people with multiple sclerosis (MS) and their employers in the UK National Health Service (NHS). Methods: Multicentre, single-arm feasibility study with post... Read More about Implementing vocational rehabilitation for people with multiple sclerosis in the UK National Health Service: a mixed-methods feasibility study.

Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain (2024)
Journal Article
Georgopoulos, V., Smith, S., McWilliams, D. F., Ferguson, E., Wakefield, R., Platts, D., Ledbury, S., Wilson, D., & Walsh, D. A. (2024). Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain. Arthritis Research and Therapy, 26(1), Article 175. https://doi.org/10.1186/s13075-024-03407-5

Background: Pain, the primary complaint in rheumatoid arthritis (RA), is multifaceted, and may be driven by inflammatory disease activity and central sensitisation. We aimed to ascertain what proportion of RA pain severity is explained by markers of... Read More about Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain.

Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach (2024)
Journal Article
Radford, K., Kettlewell, J., das Nair, R., Morriss, R., Holmes, J., Kellezi, B., Timmons, S., Jones, T., Tressider, H., Andrews, I., Bridger, K., Patel, P., Lindley, R., De Dios Perez, B., Statham, A., Jones, T., Hoffman, K., James, M., Kendrick, D., & ROWTATE study team. (2024). Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach. BMJ Open, 14(10), Article e085724. https://doi.org/10.1136/bmjopen-2024-085724

Objectives: Major trauma centres save lives but rehabilitation to support return-to-work (RTW) is lacking. This paper describes development of a vocational rehabilitation intervention (the ROWTATE intervention) to support RTW following traumatic inju... Read More about Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach.

What do employers need when supporting stroke survivors to return to work?: a mixed-methods study (2024)
Journal Article
Craven, K., Kettlewell, J., De Dios Pérez, B., Powers, K., Holmes, J., & Radford, K. A. (2024). What do employers need when supporting stroke survivors to return to work?: a mixed-methods study. Topics in Stroke Rehabilitation, 32(4), 392-404. https://doi.org/10.1080/10749357.2024.2409005

Background: Employers are key in supporting stroke survivors to return to work (RTW) but do not always have knowledge/skills or guidance to do so. Objectives: To explore employers’ needs for provision of post-stroke RTW support. Methods: Mixed-method... Read More about What do employers need when supporting stroke survivors to return to work?: a mixed-methods study.

Mixed-methods evaluation of the Falls Management Exercise (FaME) Programme Implementation Toolkit (2024)
Preprint / Working Paper
Singh, S., Kendrick, D., Vickers, R., & Orton, E. (2024). Mixed-methods evaluation of the Falls Management Exercise (FaME) Programme Implementation Toolkit

Background
The Falls Management Exercise (FaME) programme has been shown to be effective in reducing falls in older adults. This study explores how a falls prevention toolkit (FaME toolkit) can be improved to increase adoption and fidelity of FaME.... Read More about Mixed-methods evaluation of the Falls Management Exercise (FaME) Programme Implementation Toolkit.

‘Going through the motions’; a rich account of the complexity of the anterior cruciate ligament reconstruction pathway, a UK qualitative study (2024)
Journal Article
Carter, H. M., Beard, D. J., Leighton, P., Moffatt, F., Smith, B. E., Webster, K. E., & Logan, P. (2024). ‘Going through the motions’; a rich account of the complexity of the anterior cruciate ligament reconstruction pathway, a UK qualitative study. BMJ Open, 14(9), Article e079468. https://doi.org/10.1136/bmjopen-2023-079468

Objectives: This study aimed to understand the lived experiences of patients on the anterior cruciate ligament reconstruction (ACLR) pathway up to 3 months before, 3 months after and 1 year after surgery. Study objectives were to explore (1) patient... Read More about ‘Going through the motions’; a rich account of the complexity of the anterior cruciate ligament reconstruction pathway, a UK qualitative study.

Short-Term Risk of Cardiovascular Events in People Newly Diagnosed With Gout (2024)
Journal Article
Cipolletta, E., Nakafero, G., Richette, P., Avery, A. J., Mamas, M. A., Tata, L. J., & Abhishek, A. (2025). Short-Term Risk of Cardiovascular Events in People Newly Diagnosed With Gout. Arthritis and Rheumatology, 77(2), 202-211. https://doi.org/10.1002/art.42986

Objective
To investigate the temporal association between first diagnosis of gout and cardiovascular events in the short-term.

Methods
We performed a self-controlled case series analysis and a cohort study using data from linked primary care, ho... Read More about Short-Term Risk of Cardiovascular Events in People Newly Diagnosed With Gout.

Assessing muscle protein synthesis rates in vivo in humans: the deuterated water (2H2O) method (2024)
Journal Article
Holwerda, A. M., Atherton, P. J., Smith, K., Wilkinson, D. J., Phillips, S. M., & van Loon, L. J. (2024). Assessing muscle protein synthesis rates in vivo in humans: the deuterated water (2H2O) method. Journal of Nutrition, 154(11), 3177-3189. https://doi.org/10.1016/j.tjnut.2024.09.012

Skeletal muscle tissue is in a constant state of turnover, with muscle tissue protein synthesis and breakdown rates ranging between 1-2 % across the day in vivo in humans. Muscle tissue remodeling is largely controlled by the up- and down-regulation... Read More about Assessing muscle protein synthesis rates in vivo in humans: the deuterated water (2H2O) method.

Mechanisms of manipulation: a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation (2024)
Journal Article
Young, K. J., Leboeuf-Yde, C., Gorrell, L., Bergström, C., Evans, D. W., Axén, I., Chance-Larsen, K., Gagey, O., Georgopoulos, V., Goncalves, G., Harris, C., Harsted, S., Kerry, R., Lee, E., McCarthy, C., Nim, C., Nyirö, L., Schweinhardt, P., & Vogel, S. (2024). Mechanisms of manipulation: a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation. Chiropractic & Manual Therapies, 32(1), Article 28. https://doi.org/10.1186/s12998-024-00549-w

Background: Spinal manipulation (SM) has been claimed to change anatomy, either in structure or position, and that these changes may be the cause of clinical improvements. The aim of this systematic review was to evaluate and synthesise the peer-revi... Read More about Mechanisms of manipulation: a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation.

Quality of life, pain and use of analgesic, anxiolytic and antidepressant medication, in people living in care homes (2024)
Journal Article
Collins, J. T., Irvine, L., Logan, P., Robinson, K., Sims, E., & Gordon, A. L. (2024). Quality of life, pain and use of analgesic, anxiolytic and antidepressant medication, in people living in care homes. Age and Ageing, 53(9), Article afae196. https://doi.org/10.1093/ageing/afae196

Background
People living in care homes often have problems with pain, anxiety and depression. Whether being on analgesia, anxiolytics or antidepressants has any bearing on pain severity and quality of life (QoL) in this population, requires further... Read More about Quality of life, pain and use of analgesic, anxiolytic and antidepressant medication, in people living in care homes.

Cross-education of lower limb muscle strength following resistance exercise training in males and females: A systematic review and meta-analysis (2024)
Journal Article
Altheyab, A., Alqurashi, H., England, T. J., Phillips, B. E., & Piasecki, M. (2024). Cross-education of lower limb muscle strength following resistance exercise training in males and females: A systematic review and meta-analysis. Experimental Physiology, https://doi.org/10.1113/EP091881

Cross-education describes the training of one limb that leads to performance enhancements in the contralateral untrained limb, driven by neural changes rather than muscle adaptation. In this systematic review and meta-analysis, we aimed to evaluate t... Read More about Cross-education of lower limb muscle strength following resistance exercise training in males and females: A systematic review and meta-analysis.

Provisions, Experiential Opportunities And Perceived Value Of Undergraduate Physiotherapy Clinical Placements Within Care Home Settings (2024)
Preprint / Working Paper
Cheng, K. S., Booth, V., Cowley, A., Robinson, K., & Logan, P. A. Provisions, Experiential Opportunities And Perceived Value Of Undergraduate Physiotherapy Clinical Placements Within Care Home Settings

Introduction
There is a growing ageing population who will live longer, but with a greater burden of comorbidity requiring care home placement. Despite evidence indicating that rehabilitation in long term care improves function and quality of life,... Read More about Provisions, Experiential Opportunities And Perceived Value Of Undergraduate Physiotherapy Clinical Placements Within Care Home Settings.

A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom (2024)
Journal Article
De Dios Perez, B., Booth, V., das Nair, R., Evangelou, N., Hassard, J., Ford, H. L., Newsome, I., & Radford, K. (2024). A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom. BMC Health Services Research, 24, Article 995. https://doi.org/10.1186/s12913-024-11424-y

Background
To explore how a vocational rehabilitation (VR) intervention can be integrated within existing healthcare services for people with multiple sclerosis (MS) in the United Kingdom (UK) National Health Service (NHS).

Methods
Data from 37... Read More about A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom.

Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients (2024)
Journal Article
Kouraki, A., Zheng, A. S., Miller, S., Kelly, A., Ashraf, W., Bazzani, D., Bonadiman, A., Tonidandel, G., Bolzan, M., Vijay, A., Nightingale, J., Menni, C., Ollivere, B. J., & Valdes, A. M. (2024). Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients. iScience, 27(9), Article 110783. https://doi.org/10.1016/j.isci.2024.110783

We investigated changes in microbiome composition and abundance of antimicrobial resistance (AMR) genes post-antibiotic treatment in severe trauma patients. Shotgun sequencing revealed beta diversity (Bray-Curtis) differences between 16 hospitalized... Read More about Metagenomic changes in response to antibiotic treatment in severe orthopedic trauma patients.