Mechanisms of manipulation: a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation

Young, Kenneth J.; Leboeuf-Yde, Charlotte; Gorrell, Lindsay; Bergström, Cecilia; Evans, David W.; Axén, Iben; Chance-Larsen, Kenneth; Gagey, Olivier; Georgopoulos, Vasileios; Goncalves, Guillaume; Harris, Catherine; Harsted, Steen; Kerry, Roger; Lee, Edward; McCarthy, Christopher; Nim, Casper; Nyirö, Luana; Schweinhardt, Petra; Vogel, Steven

Abstract

Background
Spinal manipulation (SM) has been claimed to change anatomy, either in structure or position, and that these changes may be the cause of clinical improvements. The aim of this systematic review was to evaluate and synthesise the peer-reviewed literature on the current evidence of anatomical changes in response to SM.

Methods
The review was registered with PROSPERO (CRD42022304971) and reporting was guided by the standards of the PRISMA Statement. We searched Medline, Embase, CINAHL, AMED, Cochrane Library all databases, PEDro, and the Index to Chiropractic Literature from inception to 11 March 2022 and updated on 06 June 2023. Search terms included manipulation, adjustment, chiropractic, osteopathy, spine and spine-related structures. We included primary research studies that compared outcomes with and without SM regardless of study design. Manipulation was defined as high-velocity, low-amplitude thrust delivered by hand to the spine or directly related joints. Included studies objectively measured a potential change in an anatomical structure or in position. We developed a novel list of methodological quality items in addition to a short, customized list of risk of bias (RoB) items. We used quality and RoB items together to determine whether an article was credible or not credible. We sought differences in outcomes between SM and control groups for randomised controlled trials and crossover studies, and between pre- and post-SM outcomes for other study designs. We reported, in narrative form, whether there was a change or not.

Results
The search retrieved 19,572 articles and 20 of those were included for review. Study topics included vertebral position (n = 3) facet joint space (n = 5), spinal stiffness (n = 3), resting muscle thickness (n = 6), intervertebral disc pressure (n = 1), myofascial hysteresis (n = 1), and further damage to already damaged arteries (n = 1). Eight articles were considered credible. The credible articles indicated that lumbar facet joint space increased and spinal stiffness decreased but that the resting muscle thickness did not change.

Conclusion
We found few studies on this topic. However, there are two promising areas for future study: facet joint space and spinal stiffness. A research strategy should be developed with funding for high quality research centres.

Citation

Young, K. J., Leboeuf-Yde, C., Gorrell, L., Bergström, C., Evans, D. W., Axén, I., Chance-Larsen, K., Gagey, O., Georgopoulos, V., Goncalves, G., Harris, C., Harsted, S., Kerry, R., Lee, E., McCarthy, C., Nim, C., Nyirö, L., Schweinhardt, P., & Vogel, S. (2024). Mechanisms of manipulation: a systematic review of the literature on immediate anatomical structural or positional changes in response to manually delivered high-velocity, low-amplitude spinal manipulation. Chiropractic & Manual Therapies, 32(1), Article 28. https://doi.org/10.1186/s12998-024-00549-w

• Journal Article Type: Article
• Acceptance Date: Aug 27, 2024
• Online Publication Date: Sep 11, 2024
• Publication Date: Sep 11, 2024
• Deposit Date: Sep 13, 2024
• Publicly Available Date: Sep 18, 2024
• Journal: Chiropractic & Manual Therapies
• Print ISSN: 2045-709X
• Electronic ISSN: 2045-709X
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 1
• Article Number: 28
• DOI: https://doi.org/10.1186/s12998-024-00549-w
• Keywords: Physiotherapy, Spinal manipulation, Chiropractic, Systematic review, Mechanism, Osteopathy
• Public URL: https://nottingham-repository.worktribe.com/output/39463762
• Publisher URL: https://chiromt.biomedcentral.com/articles/10.1186/s12998-024-00549-w