Skip to main content

Research Repository

Advanced Search

All Outputs (315)

“I’ve still got a job to go back to”: the importance of early vocational rehabilitation after stroke (2023)
Journal Article
Moore, N., Reeder, S., O’Keefe, S., Alves-Stein, S., Schneider, E., Moloney, K., Radford, K., & Lannin, N. A. (2024). “I’ve still got a job to go back to”: the importance of early vocational rehabilitation after stroke. Disability and Rehabilitation, 46(13), 2769-2776. https://doi.org/10.1080/09638288.2023.2230125

Purpose
Returning to work is an important goal after stroke, not only as a recovery indicator but also for facilitating independent living and improved social identity. The aim of this study was to explore the lived experiences of vocational rehabil... Read More about “I’ve still got a job to go back to”: the importance of early vocational rehabilitation after stroke.

#3716 EFFECT OF IMMUNO-NUTRITION ON SYSTEMIC INFLAMMATION AND MUSCLE MASS IN A HAEMODIALYSIS POPULATION: A FEASIBILITY STUDY (2023)
Presentation / Conference Contribution
Hörner, D. V., Phillips, B., Atherton, P., Smith, K., Wilkinson, D., Selby, N., & Taal, M. (2023, June). #3716 EFFECT OF IMMUNO-NUTRITION ON SYSTEMIC INFLAMMATION AND MUSCLE MASS IN A HAEMODIALYSIS POPULATION: A FEASIBILITY STUDY. Presented at 60th European Renal Association Congress, Milan, Italy and online

Background and Aims
Decreased skeletal muscle mass (SMM) and systemic inflammation are frequent complications associated with poor outcomes in people receiving haemodialysis. Although these problems are widely acknowledged, it has become clear that... Read More about #3716 EFFECT OF IMMUNO-NUTRITION ON SYSTEMIC INFLAMMATION AND MUSCLE MASS IN A HAEMODIALYSIS POPULATION: A FEASIBILITY STUDY.

Characterization of a Helicobacter pylori strain with high biofilm-forming ability (2023)
Journal Article
Wilkinson, D., Alsharaf, L., Thompson, S., Paulin, A., Takor, R., Zaitoun, A., Robinson, K., Thomas, J., McVicker, G., & Winter, J. (2023). Characterization of a Helicobacter pylori strain with high biofilm-forming ability. Journal of Medical Microbiology, 72(6), Article 001710. https://doi.org/10.1099/jmm.0.001710

Introduction. Helicobacter pylori is highly polymorphic, and some strains are much more likely to cause disease than others. Biofilm formation can help bacteria to survive antibiotic treatment, immune attack and other stresses, promoting persistent i... Read More about Characterization of a Helicobacter pylori strain with high biofilm-forming ability.

Cognitive Impairment and Self-Reported Dementia in UK Retired Professional Soccer Players: A Cross Sectional Comparative Study (2023)
Journal Article
Macnab, T.-M. P., Espahbodi, S., Hogervorst, E., Thanoon, A., Fernandes, G. S., Millar, B., Duncan, A., Goodwin, M., Batt, M., Fuller, C. W., Fuller, G., Ferguson, E., Bast, T., Doherty, M., & Zhang, W. (2023). Cognitive Impairment and Self-Reported Dementia in UK Retired Professional Soccer Players: A Cross Sectional Comparative Study. Sports Medicine - Open, 9, Article 43. https://doi.org/10.1186/s40798-023-00588-2

Background
Previous studies based on death certificates have found professional soccer players were more likely to die with neurodegenerative diseases, including dementia. Therefore, this study aimed to investigate whether retired professional male... Read More about Cognitive Impairment and Self-Reported Dementia in UK Retired Professional Soccer Players: A Cross Sectional Comparative Study.

"Crack on": a qualitative study of care home managers experiences and responses to system-led setbacks during the crisis of the COVID- 19 Pandemic in England (2023)
Journal Article
Marshall, F., Gordon, A. L., Gladman, J. R., & Bishop, S. (2023). "Crack on": a qualitative study of care home managers experiences and responses to system-led setbacks during the crisis of the COVID- 19 Pandemic in England. European Geriatric Medicine, 14(4), 811-821. https://doi.org/10.1007/s41999-023-00804-y

Objectives: To explore care home managers’ experiences of systems working with various organisations, including statutory, third sector and private, during the second wave of the COVID-19 pandemic from Sept 2020 to April 2021 Design: An exploratory q... Read More about "Crack on": a qualitative study of care home managers experiences and responses to system-led setbacks during the crisis of the COVID- 19 Pandemic in England.

Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts (2023)
Journal Article
Neves, R., DeDiosPerez, B., Panek, R., Jagani, S., Wilne, S., Mahendra Bhatt, J., Caputi, C., Cirillo, E., Coman, D. J., Dückers, G., Gilbert, D. L., Koenig, M. K., Mansour, L., McDermott, E., Pauni, M., Pignata, C., Perlman, S. L., Porras, O., Porto, M. B., Schon, K., …Dineen, R. A. (2023). Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts. Cancer Medicine, 12(13), 14663-14673. https://doi.org/10.1002/cam4.6075

Background/Objectives: Ataxia telangiectasia (A‐T) is a multiorgan disorder with increased vulnerability to cancer. Despite this increased cancer risk, there are no widely accepted guidelines for cancer surveillance in people affected by A‐T. We aime... Read More about Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts.

Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK (2023)
Journal Article
Nakafero, G., Grainge, M. J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., van der Windt, D. A., Stevenson, M. D., Riley, R. D., & Abhishek, A. (2023). Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK. BMJ, 381, Article e074678. https://doi.org/10.1136/bmj-2022-074678

OBJECTIVE: To develop and validate a prognostic model to inform risk stratified decisions on frequency of monitoring blood tests during long term methotrexate treatment. DESIGN: Retrospective cohort study. SETTING: Electronic health records within th... Read More about Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK.

Implementation of the PrAISED (Promoting Activity, Independence and Stability in Early Dementia) intervention in practice: a mixed methods study (2023)
Preprint / Working Paper
Adams, E. J., Burgon, C., Lock, J., Smith, H., Vickers, R., Tucker, R., Timmons, S., Orton, E., Goldberg, S. E., Gladman, J., Masud, T., & Harwood, R. H. (in press). Implementation of the PrAISED (Promoting Activity, Independence and Stability in Early Dementia) intervention in practice: a mixed methods study

There is a paucity of evidence relating to the implementation of dementia care. The Promoting Activity, Independence and Stability in Early Dementia (PrAISED) intervention is a newly developed 12-month, home-based, individually tailored rehabilitatio... Read More about Implementation of the PrAISED (Promoting Activity, Independence and Stability in Early Dementia) intervention in practice: a mixed methods study.

Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting (2023)
Journal Article
Thomas, S., Machuel, P., Foubert, J., Nafilyan, V., Bannister, N., Colvin, H., Routen, A., Morriss, R., Khunti, K., Farooqi, A., Armstrong, N., Gray, L. J., & Gordon, A. (2023). Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting. BMJ Open, 13(5), Article e067786. https://doi.org/10.1136/bmjopen-2022-067786

INTRODUCTION: Older people were at particular risk of morbidity and mortality during COVID-19. Consequently, they experienced formal (externally imposed) and informal (self-imposed) periods of social isolation and quarantine. This is hypothesised to... Read More about Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting.

The effectiveness of occupational therapy supporting return to work for people who sustain serious injuries or develop long-term (physical or mental) health conditions: A systematic review (2023)
Journal Article
De Dios Perez, B., McQueen, J., Craven, K., Radford, K., Blake, H., Smith, B., Thomson, L., & Holmes, J. (2023). The effectiveness of occupational therapy supporting return to work for people who sustain serious injuries or develop long-term (physical or mental) health conditions: A systematic review. British Journal of Occupational Therapy, 86(7), 467-481. https://doi.org/10.1177/03080226231170996

Introduction: People with long-term conditions or recovering from serious injuries can struggle to return to work. The evidence for occupational therapy supporting return to work is limited. We aimed to identify and explain how occupational therapy i... Read More about The effectiveness of occupational therapy supporting return to work for people who sustain serious injuries or develop long-term (physical or mental) health conditions: A systematic review.

‘It’s just a finger isn’t it…’: patients’ perspectives of recovery following finger fractures and participation in surgical trials – a qualitative interview study (2023)
Journal Article
Mousoulis, C., Karantana, A., Trickett, R. W., Thomas, K. S., & Leighton, P. (2023). ‘It’s just a finger isn’t it…’: patients’ perspectives of recovery following finger fractures and participation in surgical trials – a qualitative interview study. BMJ Open, 13(5), Article e065185. https://doi.org/10.1136/bmjopen-2022-065185

Objectives: To (1) generate detailed, person-centred data about the experience of finger injury and treatment and (2) understand the patients’ perspectives of research involvement with a view to informing better designed future studies in hand injury... Read More about ‘It’s just a finger isn’t it…’: patients’ perspectives of recovery following finger fractures and participation in surgical trials – a qualitative interview study.

The bidirectional relationship between chronic joint pain and frailty: data from the Investigating Musculoskeletal Health and Wellbeing cohort (2023)
Journal Article
Chaplin, W. J., McWilliams, D. F., Millar, B. S., Gladman, J. R. F., & Walsh, D. A. (2023). The bidirectional relationship between chronic joint pain and frailty: data from the Investigating Musculoskeletal Health and Wellbeing cohort. BMC Geriatrics, 23(1), Article 273. https://doi.org/10.1186/s12877-023-03949-4

Background: Pain and frailty are associated, but this relationship is insufficiently understood. We aimed to test whether there is a unidirectional or bidirectional relationship between joint pain and frailty. Methods: Data were from Investigating Mu... Read More about The bidirectional relationship between chronic joint pain and frailty: data from the Investigating Musculoskeletal Health and Wellbeing cohort.

Peri- and Postoperative Outcomes for Obstructive Sleep Apnoea Patients after Bariatric Surgery—a Systematic Review and Meta-analysis (2023)
Journal Article
Katasani, T., Holt, G., Al-Khyatt, W., & Idris, I. (2023). Peri- and Postoperative Outcomes for Obstructive Sleep Apnoea Patients after Bariatric Surgery—a Systematic Review and Meta-analysis. Obesity Surgery, 33, 2016-2024. https://doi.org/10.1007/s11695-023-06557-8

Background
Obstructive sleep apnoea (OSA) is prevalent among patients undergoing bariatric surgery. Previous studies have reported a higher risk of complications, ICU admission and longer length of stay in patients with OSA following surgery. Howeve... Read More about Peri- and Postoperative Outcomes for Obstructive Sleep Apnoea Patients after Bariatric Surgery—a Systematic Review and Meta-analysis.

Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation (2023)
Journal Article
Goodwin, A. T., John, A. E., Joseph, C., Habgood, A., Tatler, A. L., Susztak, K., Palmer, M., Offermanns, S., Henderson, N. C., & Jenkins, R. G. (2023). Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation. Development, 150(9), https://doi.org/10.1242/dev.201046

Alveolar development and repair require tight spatiotemporal regulation of numerous signalling pathways that are influenced by chemical and mechanical stimuli. Mesenchymal cells play key roles in numerous developmental processes. Transforming growth... Read More about Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.

Regional analgesia for total hip arthroplasty and Schwartz's paradox (2023)
Journal Article
HEWSON, D., Macfarlane, A., & Scott, C. (2023). Regional analgesia for total hip arthroplasty and Schwartz's paradox. British Journal of Anaesthesia, 130(6), 650-654

Enhanced recovery after total hip arthroplasty aims to facilitate return to function and early hospital discharge, but the role of novel fascial plane block techniques in such pathways is uncertain. A randomised trial by Kukreja and colleagues descri... Read More about Regional analgesia for total hip arthroplasty and Schwartz's paradox.

P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis (2023)
Presentation / Conference Contribution
Abd Elkhabir, A. A., McWilliams, D. F., Smith, S., Chaplin, W., Salimian, M., Georgopoulos, V., Kouraki, A., & Walsh, D. A. (2023, April). P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis. Presented at British Society for Rheumatology Annual Conference 2023, Manchester

Background/Aims

Exercise has shown a promising effect in reducing central sensitisation (CS), but it is unknown which exercise type is the most effective. This review aimed to rank and compare the effectiveness of different exercise interventions... Read More about P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis.

Non-invasive imaging of functional pancreatic islet beta-cell mass in people with type 1 diabetes mellitus (2023)
Journal Article
Joshi, S. S., Singh, T., Kershaw, L. E., Gibb, F. W., Dweck, M. R., Williams, M., Idris, I., Semple, S., Forbes, S., Newby, D. E., & Reynolds, R. M. (2023). Non-invasive imaging of functional pancreatic islet beta-cell mass in people with type 1 diabetes mellitus. Diabetic Medicine, 40(10), Article e15111. https://doi.org/10.1111/dme.15111

To investigate whether manganese-enhanced magnetic resonance imaging can assess functional pancreatic beta-cell mass in people with type 1 diabetes mellitus. In a prospective case-control study, 20 people with type 1 diabetes mellitus (10 with low (≥... Read More about Non-invasive imaging of functional pancreatic islet beta-cell mass in people with type 1 diabetes mellitus.

The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery (2023)
Journal Article
Louca, P., Meijnikman, A. S., Nogal, A., Asnicar, F., Attaye, I., Vijay, A., Kouraki, A., Visconti, A., Wong, K., Berry, S. E., Leeming, E. R., Mompeo, O., Tettamanzi, F., Baleanu, A. F., Falchi, M., Hadjigeorgiou, G., Wolf, J., Acherman, Y. I., Van de Laar, A. W., Gerdes, V. E., …Menni, C. (2023). The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery. Cell Reports Medicine, 4(4), Article 100993. https://doi.org/10.1016/j.xcrm.2023.100993

Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 s... Read More about The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery.

Acute adaptation of central and peripheral motor unit features to exercise‐induced fatigue differs with concentric and eccentric loading (2023)
Journal Article
Jones, E. J., Guo, Y., Martinez‐Valdes, E., Negro, F., Stashuk, D. W., Atherton, P. J., Phillips, B. E., & Piasecki, M. (2023). Acute adaptation of central and peripheral motor unit features to exercise‐induced fatigue differs with concentric and eccentric loading. Experimental Physiology, 108(6), 827-837. https://doi.org/10.1113/EP091058

New Findings: What is the central question of this study? Conflicting evidence exists on motor unit (MU) firing rate in response to exercise‐induced fatigue, possibly due to the contraction modality used: Do MU properties adapt similarly following co... Read More about Acute adaptation of central and peripheral motor unit features to exercise‐induced fatigue differs with concentric and eccentric loading.

Understanding the burden of chronic back pain: a spatial microsimulation of chronic back pain at small area level across England (2023)
Journal Article
Smalley, H., & Edwards, K. (2023). Understanding the burden of chronic back pain: a spatial microsimulation of chronic back pain at small area level across England. European Spine Journal, https://doi.org/10.1007/s00586-023-07584-w

Purpose: Chronic back pain (CBP)carries a significant burden. Understanding how and why CBP prevalence varies spatially, as well as the potential impact of policies to decrease CBP would prove valuable for public health planning. This study aims to s... Read More about Understanding the burden of chronic back pain: a spatial microsimulation of chronic back pain at small area level across England.