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Mathematical Modelling of Carbohydrate and Protein Metabolism in Muscle (2025)
Journal Article
Alharbi, B. M., Williams, H. E., Parr, T., Brameld, J., Fallaize, C., & Wattis, J. A. D. (in press). Mathematical Modelling of Carbohydrate and Protein Metabolism in Muscle. Mathematical Biosciences,

We propose a mathematical model based on coupled ordinary differential equations (ODEs) for metabolite concentrations with the aim of investigating how modifications to the rates affects outputs from a regulatory network. Our aim is to model the rela... Read More about Mathematical Modelling of Carbohydrate and Protein Metabolism in Muscle.

TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells (2025)
Preprint / Working Paper
Riley, S., Nguyen, V., Bhattacharjee, R., Ng, P. Q., Ritchie, T., Fisk, I., Gecz, J., Kumar, R., & Searle, I. R. (2025). TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells

β-Cyano-L-alanine (BCA) and γ-glutamyl-β-cyano-L-alanine (GBCA) are the primary antinutritional compounds present within the seeds of the high protein and drought tolerant orphan legume Vicia sativa. Evidence of neurotoxicity is limited to symptom an... Read More about TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells.

Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review (2025)
Journal Article
AlMutairi, H., Mccullough, F., Siddiqui, K., Ghemlas, I., AlHarbi, M., Grundy, R., & Dandapani, M. (2025). Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review. Journal of Nutrition and Metabolism, https://doi.org/10.1155/jnme/7935879

Background: Evidence suggests the positive effects of ketogenic diet (KD) on cancers by limiting glucose availability to cancer cells. This systematic review aimed to explore the safety, feasibility, and effectiveness of KD in children with brain tum... Read More about Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients With Brain Tumors: A Systematic Review.

Octopamine alters yellow mealworm body composition (2025)
Journal Article
Hill, V., Williams, L., Salter, A., Brameld, J., & Parr, T. (2025). Octopamine alters yellow mealworm body composition. Animal, 19(5), Article 101490. https://doi.org/10.1016/j.animal.2025.101490

There is the potential to increase the production yield within the emerging insect industry in order to produce high-quality, sustainable protein. In invertebrates, the monoamine, octopamine (OA), has a similar role to that of noradrenaline in mammal... Read More about Octopamine alters yellow mealworm body composition.

Food insecurity amongst universal credit claimants: the benefits and nutrition study (BEANS), a cross-sectional online study (2025)
Journal Article
Thomas, M., Rose, P., Coneyworth, L., Harvey, J., Goulding, J., Stone, J., Padley, M., O’Reilly, P., & Welham, S. (2025). Food insecurity amongst universal credit claimants: the benefits and nutrition study (BEANS), a cross-sectional online study. European Journal of Nutrition, 64, Article 115. https://doi.org/10.1007/s00394-025-03596-y

Purpose
Increasing food insecurity (FIS) in the UK presents a major challenge to public health. Universal Credit (UC) claimants are disproportionately impacted by FIS but research on socio-demographic factors and consequent nutritional security is... Read More about Food insecurity amongst universal credit claimants: the benefits and nutrition study (BEANS), a cross-sectional online study.

The anti-inflammatory effects of vitamin D on offspring brain development during pregnancy: critical review (2025)
Journal Article
Kozhevnikova, S. V., Elmes, M. J., Brameld, J. M., & Jethwa, P. H. (in press). The anti-inflammatory effects of vitamin D on offspring brain development during pregnancy: critical review. Academia, Nutrition and Dietetics, 2(1), Article 7573. https://doi.org/10.20935/acadnutr7573

Vitamin D (VD) plays a pivotal role in fetal brain development by regulating essential processes such as neuronal proliferation, differentiation, and apoptosis. Despite the critical role of VD in maternal and fetal health, studies have shown that alm... Read More about The anti-inflammatory effects of vitamin D on offspring brain development during pregnancy: critical review.

Enzymatic Synthesis of Functional PEGylated Adipate Copolymers (2025)
Journal Article
Axioti, E., Dixon, E. G., Jepras, T., Tin He, F., Hartman, P. J., Hopkins, B., Di Bari, V., Suksiriworapong, J., Cuzzucoli Crucitti, V., Galantini, L., Francolini, I., Cavanagh, R. J., & Taresco, V. (2025). Enzymatic Synthesis of Functional PEGylated Adipate Copolymers. ChemPlusChem, https://doi.org/10.1002/cplu.202400668

Many new active pharmaceutical ingredients (APIs) demonstrate high hydrophobicity and low water-solubility issues. In this regard, polymeric nanoparticles (NPs) have been extensively used as drug delivery carriers for the encapsulation of such APIs.... Read More about Enzymatic Synthesis of Functional PEGylated Adipate Copolymers.

Machine learning on national shopping data reliably estimates childhood obesity prevalence and socio-economic deprivation (2025)
Journal Article
Long, G., Nica-Avram, G., Harvey, J., Lukinova, E., Mansilla, R., Welham, S., Engelmann, G., Dolan, E., Makokoro, K., Thomas, M., Powell, E., & Goulding, J. (2025). Machine learning on national shopping data reliably estimates childhood obesity prevalence and socio-economic deprivation. Food Policy, 131, Article 102826. https://doi.org/10.1016/j.foodpol.2025.102826

Deprivation pushes people to choose cheap, calorie-dense foods instead of nutritious but expensive alternatives. Diseases, such as obesity, cardiovascu-lar disease, and diabetes, resulting from these poor dietary choices place a significant burden on... Read More about Machine learning on national shopping data reliably estimates childhood obesity prevalence and socio-economic deprivation.

Wet spinning of sodium carboxymethyl cellulose-sodium caseinate hydrogel fibres: relationship between rheology and spinnability (2025)
Journal Article
Vaniyan, L., Borah, P. K., Pavlovskaya, G. E., Terrill, N., Reid, J. E., Boehm, M., Prochasson, P., Nicholson, R. A., Baier, S., & Yakubov, G. E. (2025). Wet spinning of sodium carboxymethyl cellulose-sodium caseinate hydrogel fibres: relationship between rheology and spinnability. Soft Matter, https://doi.org/10.1039/d4sm00705k

Mimicking the fibrous structures of meat is a significant challenge as natural plant protein assemblies lack the fibrous organisation ubiquitous in mammalian muscle tissues. In this work, wet-spun hydrogel fibres resembling the anisotropic fibrous mi... Read More about Wet spinning of sodium carboxymethyl cellulose-sodium caseinate hydrogel fibres: relationship between rheology and spinnability.

Gaussian mixture model clustering allows accurate semantic image segmentation of wheat kernels from near-infrared hyperspectral images (2025)
Journal Article
Kartakoullis, A., Caporaso, N., Whitworth, M. B., & Fisk, I. D. (2025). Gaussian mixture model clustering allows accurate semantic image segmentation of wheat kernels from near-infrared hyperspectral images. Chemometrics and Intelligent Laboratory Systems, 259, Article 105341. https://doi.org/10.1016/j.chemolab.2025.105341

In this study, an ad-hoc image processing pipeline has been developed and proposed for the purpose of semantically segmenting wheat kernel data acquired through near-infrared hyperspectral imaging (HSI). The Gaussian Mixture Model (GMM), characterize... Read More about Gaussian mixture model clustering allows accurate semantic image segmentation of wheat kernels from near-infrared hyperspectral images.

It tastes sweeter when melted: Exploring the impact of food temperature on tongue temperature and perceived sweetness/vanilla (2025)
Journal Article
McNeill, H., Ford, R., Fisk, I., Thibodeau, M., Liu, G., Doyennette, M., & Yang, Q. (2025). It tastes sweeter when melted: Exploring the impact of food temperature on tongue temperature and perceived sweetness/vanilla. Science Talks, 13, Article 100424. https://doi.org/10.1016/j.sctalk.2025.100424

The relationship between perceived sweetness intensity and temperature of food is complex. Previous research on the effect of temperature on sweetness perception primarily focused on single solutions. This study aimed to address the gap by using an i... Read More about It tastes sweeter when melted: Exploring the impact of food temperature on tongue temperature and perceived sweetness/vanilla.

Effects of feed nutrients on growth, development and the deposition of protein and fat in Tenebrio molitor larvae (2025)
Journal Article
Tamim, B., Salter, A., Parr, T., & Brameld, J. (2025). Effects of feed nutrients on growth, development and the deposition of protein and fat in Tenebrio molitor larvae. Journal of Insects as Food and Feed, 1-14. https://doi.org/10.1163/23524588-00001331

An understanding of the impact of dietary nutritional composition on growth, development and composition of Tenebrio molitor larvae (mealworms) could help optimise production systems. Replicate containers of mealworms fed for 24 days on synthetic cel... Read More about Effects of feed nutrients on growth, development and the deposition of protein and fat in Tenebrio molitor larvae.

Freeze-thaw stability of oilseed rape oleosome emulsions (2025)
Journal Article
Bramante, F., di Bari, V., Adams, G., Beaudoin, F., Waschatko, G., Jakobi, R., Billecke, N., & Gray, D. (2025). Freeze-thaw stability of oilseed rape oleosome emulsions. Journal of Food Engineering, 392, Article 112471. https://doi.org/10.1016/j.jfoodeng.2025.112471

This work investigated the stability of natural oleosome emulsions on freeze-thawing. Oleosomes were recovered from oilseed rape seeds following an aqueous extraction process using sodium bicarbonate (0.1 M). The final emulsions pH was adjusted to 9,... Read More about Freeze-thaw stability of oilseed rape oleosome emulsions.

Assessing Water Content of the Human Colonic Chyme Using the MRI Parameter T1: A Key Biomarker of Colonic Function (2025)
Journal Article
Dellschaft, N., Murray, K., Ren, Y., Marciani, L., Gowland, P., Spiller, R., & Hoad, C. (2025). Assessing Water Content of the Human Colonic Chyme Using the MRI Parameter T1: A Key Biomarker of Colonic Function. Neurogastroenterology and Motility, https://doi.org/10.1111/nmo.14999

Background
The human colon receives 2 L of fluid daily. Small changes in the efficacy of absorption can lead to altered stool consistency with diarrhea or constipation. Drugs and formulations can also alter colonic water, which can be assessed using... Read More about Assessing Water Content of the Human Colonic Chyme Using the MRI Parameter T1: A Key Biomarker of Colonic Function.

Diet Quality and Caloric Accuracy in AI-Generated Diet Plans: A Comparative Study Across Chatbots (2025)
Journal Article
Kaya Kaçar, H., Kaçar, Ö. F., & Avery, A. (2025). Diet Quality and Caloric Accuracy in AI-Generated Diet Plans: A Comparative Study Across Chatbots. Nutrients, 17(2), Article 206. https://doi.org/10.3390/nu17020206

Background/Objectives: With the rise of artificial intelligence (AI) in nutrition and healthcare, AI-driven chatbots are increasingly recognised as potential tools for generating personalised diet plans. This study aimed to evaluate the capabilities... Read More about Diet Quality and Caloric Accuracy in AI-Generated Diet Plans: A Comparative Study Across Chatbots.

Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers (2024)
Journal Article
Alhasani, A., Modasia, A., Anodiyil, M., Corsetti, M., Aliyu, A., Crooks, C., MARCIANI, L., Reid, J., Yakubov, G., Avery, A., Harris, H., Warren, F., & Spiller, R. (2025). Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers. Journal of Nutrition, 155(3), 839-848. https://doi.org/10.1016/j.tjnut.2024.12.017

Background
Recent studies show that the increase in breath hydrogen (BH2) and symptoms after ingestion of inulin are reduced by coadministering psyllium (PI).

Objectives
To determine if slowing delivery of inulin to the colon by administering it... Read More about Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.

Mineral Supplements in Ageing (2024)
Book Chapter
Welham, S., Rose, P., Kirk, C., Coneyworth, L., & Avery, A. (2024). Mineral Supplements in Ageing. In V. I. Korolchuk, & J. R. Harris (Eds.), Biochemistry and Cell Biology of Ageing: Part V, Anti-Ageing Interventions (269-306). Springer. https://doi.org/10.1007/978-3-031-66768-8_13

With advancing age, achievement of dietary adequacy for all nutrients is increasingly difficult and this is particularly so for minerals. Various factors impede mineral acquisition and absorption including reduced appetite, depressed gastric acid pro... Read More about Mineral Supplements in Ageing.

Mineral Supplements in Aging (2024)
Book Chapter
Welham, S., Rose, P., Coneyworth, L., Avery, A., & Kirk, C. (2024). Mineral Supplements in Aging. In V. I. Korolchuk, & J. R. Harris (Eds.), Biochemistry and Cell Biology of Ageing: Part V, Anti-ageing Interventions (269-306). Springer Nature

With advancing age, achievement of dietary adequacy for all nutrients is increasingly difficult and this is particularly so for minerals. Various factors impede mineral acquisition and absorption including reduced appetite, depressed gastric acid pro... Read More about Mineral Supplements in Aging.

Sustainable fertiliser mesh, ‘4D’-precision engineered by flow chemistry: minimising agrochemical pollution (2024)
Journal Article
Le, T. N. Q., Lim, C. N., Fisk, I., Tran, N. N., Hessel, V., & Robertson, K. (2025). Sustainable fertiliser mesh, ‘4D’-precision engineered by flow chemistry: minimising agrochemical pollution. Green Chemistry, 27(3), 696-715. https://doi.org/10.1039/d4gc04833d

Flow chemistry is best when opening “novel process windows”, and one of six NPW paths is “new chemical transformations”. Flow chemistry has a large impact on syntheses which are particularly mixing-sensitive. Here we exploit the NPW offered by flow c... Read More about Sustainable fertiliser mesh, ‘4D’-precision engineered by flow chemistry: minimising agrochemical pollution.