All Outputs (220)

Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function (2023)
Journal Article
Piasecki, J., Guo, Y., Jones, E. J., Phillips, B. E., Stashuk, D. W., Atherton, P. J., & Piasecki, M. (2023). Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function. Sports Medicine - Open, 9, Article 97. https://doi.org/10.1186/s40798-023-00639-8

Background: Estrogen and progesterone are the primary female sex hormones and have net excitatory and inhibitory effects, respectively, on neuronal function. Fluctuating concentrations across the menstrual cycle has led to several lines of research i... Read More about Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function.

Identifying and Managing Frailty: A Survey of UK Healthcare Professionals (2023)
Journal Article
Frost, R., Robinson, K., Gordon, A., Caldeira de Melo, R., Villas-Boas, P. J. F., Azevedo, P. S., …Gavin, J. P. (2024). Identifying and Managing Frailty: A Survey of UK Healthcare Professionals. Journal of Applied Gerontology, 43(4), 402-412. https://doi.org/10.1177/07334648231206321

Frailty is a common condition that leads to multiple adverse outcomes. Frailty should be identified and managed in a holistic, evidence-based and patient-centered way. We aimed to understand how UK healthcare professionals (HCPs) identify and manage... Read More about Identifying and Managing Frailty: A Survey of UK Healthcare Professionals.

Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women (2023)
Journal Article
MALLINSON, J., WARDLE, S., O'LEARY, T., GREEVES, J., CEGIELSKI, J., BASS, J., …GREENHAFF, P. (2023). Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women. Scandinavian Journal of Medicine and Science in Sports, 33(12), 2470-2481. https://doi.org/10.1111/sms.14506

Studies examining the effect of protein (PRO) feeding on post resistance exercise (RE) muscle protein synthesis (MPS) have primarily been performed in men, and little evidence is available regarding the quantity of PRO required to maximally stimulate... Read More about Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women.

The student patient alliance: development and formative evaluation of an initiative to support collaborations between patient and public involvement partners and doctoral students (2023)
Journal Article
Simons, G., Birch, R., Stocks, J., Insch, E., Rijckborst, R., Neag, G., …Falahee, M. (2023). The student patient alliance: development and formative evaluation of an initiative to support collaborations between patient and public involvement partners and doctoral students. BMC Rheumatology, 7(1), Article 36. https://doi.org/10.1186/s41927-023-00359-2

Background
While the integration of patient and public involvement (PPI) in clinical research is now widespread and recommended as standard practice, meaningful PPI in pre-clinical, discovery science research is more difficult to achieve. One potent... Read More about The student patient alliance: development and formative evaluation of an initiative to support collaborations between patient and public involvement partners and doctoral students.

ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial (2023)
Journal Article
Rossios, C., Bashir, T., Achison, M., Adamson, S., Akpan, A., Aspray, T., …Kemp, P. R. (2023). ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial. PLoS ONE, 18(10), Article e0292402. https://doi.org/10.1371/journal.pone.0292402

Background: Angiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as a method to inhibit muscle loss. The LACE clinical trial was designed... Read More about ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial.

Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study (2023)
Journal Article
Bishop, S., Narayanasamy, M. J., Paskins, Z., Corp, N., Bastounis, A., Griffin, J., …Sahota, O. (2023). Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study. BMC Musculoskeletal Disorders, 24, Article 770. https://doi.org/10.1186/s12891-023-06865-1

Background Bisphosphonate medications, including alendronate, ibandronate and risedronate administered orally and zoledronate, administered intravenously, are commonly prescribed for the treatment of osteoporosis based on evidence that, correctly tak... Read More about Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study.

Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort (2023)
Journal Article
McWilliams, D. F., Yue, B., Smith, S. L., Stocks, J., Doherty, M., Valdes, A. M., …Walsh, D. A. (2023). Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort. Journal of Personalized Medicine, 13(10), Article 1450. https://doi.org/10.3390/jpm13101450

Knee pain is associated with lower muscle strength, and both contribute to disability. Peripheral and central neurological mechanisms contribute to OA pain. Understanding the relative contributions of pain mechanisms to muscle strength might help fut... Read More about Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.

Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study (2023)
Journal Article
Sokhal, B. S., Matetić, A., Abhishek, A., Banerjee, A., Partington, R., Roddy, E., Rashid, M., Mallen, C. D., & Mamas, M. A. (2023). Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study. American Journal of Cardiology, 206, 210-218. https://doi.org/10.1016/j.amjcard.2023.08.138

Data are limited on whether the causes of emergency department (ED) encounters for cardiovascular diseases (CVDs) and associated clinical outcomes vary by frailty status. Using the United States Nationwide ED Sample, selected CVD encounters (acute my... Read More about Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study.

A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts (2023)
Journal Article
Nogal, A., Tettamanzi, F., Dong, Q., Louca, P., Visconti, A., Christiansen, C., …Menni, C. (2023). A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts. Diabetes, 72(12), 1870–1880. https://doi.org/10.2337/db23-0170

Prediabetes is a metabolic condition associated with gut microbiome composition, though mechanisms remain elusive. We searched for faecal metabolites, a readout of gut microbiome function, associated with impaired fasting glucose (IFG) in 142 individ... Read More about A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts.

Promoting Activity, Independence and Stability in early dementia and mild cognitive impairment (PrAISED): randomised controlled trial (2023)
Journal Article
Harwood, R. H., Goldberg, S. E., Brand, A., van Der Wardt, V., Booth, V., Di Lorito, C., …Adams, E. (2023). Promoting Activity, Independence and Stability in early dementia and mild cognitive impairment (PrAISED): randomised controlled trial. BMJ, 382, Article e074787. https://doi.org/10.1136/bmj-2023-074787

Objective: To determine the effectiveness of an exercise and functional activity therapy intervention in adults with early dementia or mild cognitive impairment compared with usual care.

Design: Randomised controlled trial.

Setting: Participant... Read More about Promoting Activity, Independence and Stability in early dementia and mild cognitive impairment (PrAISED): randomised controlled trial.

Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial (2023)
Journal Article
Harwood, R. H., Goldberg, S. E., Brand, A., van Der Wardt, V., Booth, V., Di Lorito, C., Hoare, Z., Hancox, J., Bajwa, R., Burgon, C., Howe, L., Cowley, A., Bramley, T., Long, A., Lock, J., Tucker, R., Adams, E. J., O’Brien, R., Kearney, F., Kowalewska, K., …Masud, T. (2023). Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial. BMJ, 382, Article e074787. https://doi.org/10.1136/bmj-2023-074787

Objective To determine the effectiveness of an exercise and functional activity therapy intervention in adults with early dementia or mild cognitive impairment compared with usual care.

Design Randomised controlled trial.

Setting Participants’... Read More about Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial.

The facilitators and barriers to improving functional activity and wellbeing in people with dementia: A qualitative study from the Process Evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED) (2023)
Journal Article
Lorito, C. D., Van Der Wardt, V., Pollock, K., Howe, L., Booth, V., Logan, P., …Harwood, R. H. (2023). The facilitators and barriers to improving functional activity and wellbeing in people with dementia: A qualitative study from the Process Evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED). Age and Ageing, 52(8), Article afad166. https://doi.org/10.1093/ageing/afad166

Background. The PRomoting Activity, Independence and Stability in Early Dementia (PrAISED) study delivered an exercise and functional activity programme to participants living with dementia. A Randomised Controlled Trial (RCT) showed no measurable be... Read More about The facilitators and barriers to improving functional activity and wellbeing in people with dementia: A qualitative study from the Process Evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED).

The impact of ageing on adults with cerebral palsy (2023)
Journal Article
Bell, B., Shah, S., Coulson, N., McLaughlin, J., Logan, P., Luke, R., & Avery, A. J. (2023). The impact of ageing on adults with cerebral palsy. British Journal of General Practice Open, 7(4), Article 0028. https://doi.org/10.3399/BJGPO.2023.0028

Background Cerebral palsy (CP) is one of the most common neurological disorders in children and results in lifelong physical impairments. Adults with CP have approximately the same life expectancy as their non-disabled peers, so helping them to stay... Read More about The impact of ageing on adults with cerebral palsy.

The use of non‐invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta‐analysis (2023)
Journal Article
Alhindi, Y. A., Khalifa, N., Al-Khyatt, W., & Idris, I. (2023). The use of non‐invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta‐analysis. Clinical Obesity, 13(6), Article e12611. https://doi.org/10.1111/cob.12611

Several studies demonstrated non‐invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are safe and simple techniques that can reduce body weight, food cravings... Read More about The use of non‐invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta‐analysis.

Barriers and facilitators in providing home-based rehabilitation for stroke survivors with severe disability in the UK: an online focus group study with multidisciplinary rehabilitation teams (2023)
Journal Article
Fisher, R., Russell, L., Riley-Bennett, F., Cameron, T., Walker, M., & Sackley, C. (2023). Barriers and facilitators in providing home-based rehabilitation for stroke survivors with severe disability in the UK: an online focus group study with multidisciplinary rehabilitation teams. BMJ Open, 13(8), Article e071217. https://doi.org/10.1136/bmjopen-2022-071217

Objectives: In the UK, over 20% of stroke survivors leave hospital with severe disability. Limited evidence-based clinical guidance is available to support the rehabilitation of these individuals. Our previous research has focussed on establishing co... Read More about Barriers and facilitators in providing home-based rehabilitation for stroke survivors with severe disability in the UK: an online focus group study with multidisciplinary rehabilitation teams.

Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review (2023)
Journal Article
O’Sullivan, O., Ladlow, P., Steiner, K., Kuyser, D., Ali, O., Stocks, J., …Kluzek, S. (2023). Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review. Osteoarthritis and Cartilage Open, 5(3), Article 100385. https://doi.org/10.1016/j.ocarto.2023.100385

Introduction
Osteoarthritis (OA) results from various aetiologies, including joint morphology, biomechanics, inflammation, and injury. The latter is implicated in post-traumatic OA, which offers a paradigm to identify potential biomarkers enabling e... Read More about Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review.

The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease (2023)
Journal Article
Abhishek, A., Tedeschi, S. K., Pascart, T., Latourte, A., Dalbeth, N., Neogi, T., …Choi, H. K. (2023). The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease. Annals of the Rheumatic Diseases, 82(10), 1248-1257. https://doi.org/10.1136/ard-2023-224575

Objective Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have develop... Read More about The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease.

The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease (2023)
Journal Article
Abhishek, A., Tedeschi, S. K., Pascart, T., Latourte, A., Dalbeth, N., Neogi, T., …Choi, H. K. (2023). The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease. Arthritis and Rheumatology, 75(10), 1703-1713. https://doi.org/10.1002/art.42619

Objective

Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have deve... Read More about The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease.

The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease (2023)
Journal Article
Abhishek, A., Tedeschi, S. K., Pascart, T., Latourte, A., Dalbeth, N., Neogi, T., …Choi, H. K. (2023). The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease. Arthritis and Rheumatology, 75(10), 1703-1713. https://doi.org/10.1002/art.42619

Objective
Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have develo... Read More about The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease.

Osteoarthritis in the UK Armed Forces: a review of its impact, treatment and future research (2023)
Journal Article
O'Sullivan, O., Behan, F. P., Coppack, R. J., Stocks, J., Kluzek, S., Valdes, A. M., & Bennett, A. N. (2024). Osteoarthritis in the UK Armed Forces: a review of its impact, treatment and future research. BMJ Military Health, 170(4), 359-364. https://doi.org/10.1136/military-2023-002390

Within the UK Armed Forces, musculoskeletal injuries account for over half of all medical downgrades and discharges. Data from other Armed Forces show that osteoarthritis (OA), more common in military personnel, is likely to contribute to this, both... Read More about Osteoarthritis in the UK Armed Forces: a review of its impact, treatment and future research.