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All Outputs (179)

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting (2021)
Journal Article
Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Bierma-Zeinstra, S. M., …Zhang, W. (2021). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. Rheumatology, 60(9), 4327-4339. https://doi.org/10.1093/rheumatology/keab067

OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched n... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting.

Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis (2021)
Journal Article
Lu, J., Bai, Z., Chen, Y., Li, Y., Tang, M., Wang, N., …Zhang, W. (2021). Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis. Rheumatology, 60(8), 3628-3634. https://doi.org/10.1093/rheumatology/keaa822

Objectives: Weight reduction may reduce serum uric acid (SUA). This study aimed to examine the changes of SUA before and after bariatric surgery in patients with obesity with or without hyperuricaemia and gout. Methods: This is a retrospective analys... Read More about Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis.

Investigating the barriers and facilitators to implementing mental health first aid in the workplace: a qualitative study (2020)
Journal Article
Narayanasamy, M. J., THOMSON, L., Coole, C., Nouri, F., & Drummond, A. (2021). Investigating the barriers and facilitators to implementing mental health first aid in the workplace: a qualitative study. Journal of Mental Health Training, Education and Practice, 16(2), 164-178. https://doi.org/10.1108/JMHTEP-12-2019-0064

Purpose: There has been little research into the use and efficacy of Mental Health First Aid across UK workplaces. The present study investigated the implementation of MHFA across six UK organisations, identifying key barriers and facilitators. Desi... Read More about Investigating the barriers and facilitators to implementing mental health first aid in the workplace: a qualitative study.

Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study (2020)
Journal Article
Li, X., Zhang, W., Zhang, W., Tao, K., Ni, W., Wang, K., …Lin, J. (2020). Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study. BMC Public Health, 20(1), Article 1682. https://doi.org/10.1186/s12889-020-09671-9

Background: With data from different regions accumulated, physical inactivity (PI) was found to be pandemic worldwide. Using China Health and Retirement Longitudinal Study (CHARLS), a nationwide longitudinal survey data, we aimed to delineate the pre... Read More about Level of physical activity among middle-aged and older Chinese people: evidence from the China health and retirement longitudinal study.

Occupational advice to help people return to work following lower limb arthroplasty: the OPAL intervention mapping study (2020)
Journal Article
Baker, P., COOLE, C., DRUMMOND, A., Khan, S., McDaid, C., Hewitt, C., …Rangan, A. (2020). Occupational advice to help people return to work following lower limb arthroplasty: the OPAL intervention mapping study. Health Technology Assessment, 24(45), https://doi.org/10.3310/hta24450

Background Hip and knee replacements are regularly performed for patients who work. There is little evidence about these patients’ needs and the factors influencing their return to work. There is a paucity of guidance to help patients return to wor... Read More about Occupational advice to help people return to work following lower limb arthroplasty: the OPAL intervention mapping study.

Corrigendum to: Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study (2020)
Journal Article
Sarmanova, A., Doherty, M., Kuo, C., Wei, J., Abhishek, A., Mallen, C., …Zhang, W. (2020). Corrigendum to: Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study. Rheumatology, 59(10), 3120-3120. https://doi.org/10.1093/rheumatology/keaa223

Human postprandial responses to food and potential for precision nutrition (2020)
Journal Article
Berry, S. E., Valdes, A. M., Drew, D. A., Asnicar, F., Mazidi, M., Wolf, J., Capdevila, J., Hadjigeorgiou, G., Davies, R., Al Khatib, H., Bonnett, C., Ganesh, S., Bakker, E., Hart, D., Mangino, M., Merino, J., Linenberg, I., Wyatt, P., Ordovas, J. M., Gardner, C. D., …Spector, T. D. (2020). Human postprandial responses to food and potential for precision nutrition. Nature Medicine, 26, 964-973. https://doi.org/10.1038/s41591-020-0934-0

Metabolic responses to food influence risk of cardiometabolic disease, but large-scale high-resolution studies are lacking. We recruited n = 1,002 twins and unrelated healthy adults in the United Kingdom to the PREDICT 1 study and assessed postprandi... Read More about Human postprandial responses to food and potential for precision nutrition.

Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis (2020)
Journal Article
Jin, X., Antony, B., Wang, X., Persson, M. S., McAlindon, T., Arden, N. K., …Ding, C. (2020). Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis. BMJ Open, 10(4), Article e035302. https://doi.org/10.1136/bmjopen-2019-035302

Introduction: Observational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, randomised controlled trials (RCTs) to date investigating the efficacy of vitamin D supplementation... Read More about Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis.

Anomia in people with rapidly evolving severe relapsing-remitting multiple sclerosis: both word retrieval inaccuracy and delay are common symptoms (2019)
Journal Article
De Dios Pérez, B., Cordova Luna, E., Cloutman, L., Rog, D., Preston, E., & Conroy, P. (2020). Anomia in people with rapidly evolving severe relapsing-remitting multiple sclerosis: both word retrieval inaccuracy and delay are common symptoms. Aphasiology, 34(2), 195-213. https://doi.org/10.1080/02687038.2019.1642999

Background: Multiple Sclerosis (MS) is a neurodegenerative disease that produces plaques throughout the central nervous system. MS can present in four different clinical courses. Of these, Relapsing-Remitting MS (RRMS) is the main clinical course, es... Read More about Anomia in people with rapidly evolving severe relapsing-remitting multiple sclerosis: both word retrieval inaccuracy and delay are common symptoms.

Do maladaptive beliefs delay whiplash associated disorders (WAD): A systematic review (2018)
Journal Article
Gabriela Macias, E., Georgopoulos, V., & Taylor, A. (2018). Do maladaptive beliefs delay whiplash associated disorders (WAD): A systematic review. Edorium Journal of Disability and Rehabilitation, 4(1), 1-14. https://doi.org/10.5348/100040d05em2018ra

The purpose of the study is to try to establish if maladaptive beliefs effect recovery times and poor outcomes in whiplash associated disorders (WAD). In May 2017 the following databases were searched from their inception until June 2017: SPORT Discu... Read More about Do maladaptive beliefs delay whiplash associated disorders (WAD): A systematic review.

Clinical prediction rules in the prognosis of Whiplash Associated Disorder (WAD): A systematic review (2016)
Journal Article
Georgopoulos, V., & Taylor, A. (2016). Clinical prediction rules in the prognosis of Whiplash Associated Disorder (WAD): A systematic review. Pain and Rehabilitation, 2016(41), 5-16

Objectives: To identify, evaluate and ascertain the clinical readiness of prognostic Clinical Prediction Rules (CPRs) in the prognosis of Whiplash Associated Disorder (WAD). Study design: Systematic review Background: The scientific basis for m... Read More about Clinical prediction rules in the prognosis of Whiplash Associated Disorder (WAD): A systematic review.

Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study. (2014)
Journal Article
McWilliams, D. F., Muthuri, S., Muir, K. R., Maciewicz, R. A., Zhang, W., & Doherty, M. (2014). Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study. BMC Musculoskeletal Disorders, 15(1), https://doi.org/10.1186/1471-2474-15-308

Background: Biomechanical factors may play a role in osteoarthritis (OA) development and progression. Previous biomechanical studies have indicated that types of footwear may modulate forces across the knee joint, and high heeled womens' shoes in par... Read More about Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study..

Mechanisms, impact and management of pain in rheumatoid arthritis (2014)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2014). Mechanisms, impact and management of pain in rheumatoid arthritis. Nature Reviews Rheumatology, 10(10), 581-592. https://doi.org/10.1038/nrrheum.2014.64

© 2014 Macmillan Publishers Limited. All rights reserved. People with rheumatoid arthritis (RA) identify pain as their most important symptom, one that often persists despite optimal control of inflammatory disease. RA pain arises from multiple mecha... Read More about Mechanisms, impact and management of pain in rheumatoid arthritis.

Pain in rheumatoid arthritis (2012)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2012). Pain in rheumatoid arthritis. Current Pain and Headache Reports, 16(6), 509-517. https://doi.org/10.1007/s11916-012-0303-x

Rheumatoid arthritis (RA) is an inflammatory disease of synovial joints, and pain is the predominant problem for people with RA. Pain in RA is distressing in its own right and adversely affects disability and psychosocial outcomes. RA pain may be due... Read More about Pain in rheumatoid arthritis.

Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial (2011)
Journal Article
Edmans, J., Conroy, S., Harwood, R., Lewis, S., Elliott, R. A., Logan, P., …Gladman, J. (2011). Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial. Trials, 12, Article 200. https://doi.org/10.1186/1745-6215-12-200

Background Many older people presenting to Acute Medical Units (AMU) are discharged after only a short stay (< 72 hours), yet many re-present to hospital or die within 1 year. Comprehensive Geriatric Assessment may improve patient outcomes for this... Read More about Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS): Study protocol for a randomised controlled trial.

Inflammation and angiogenesis in osteoarthritis (2003)
Journal Article
Haywood, L., McWilliams, D. F., Pearson, C. I., Gill, S. E., Ganesan, A., Wilson, D., & Walsh, D. A. (2003). Inflammation and angiogenesis in osteoarthritis. Arthritis and Rheumatism, 48(8), 2173-2177. https://doi.org/10.1002/art.11094

Objective. To quantify the relationship between inflammation and angiogenesis in synovial tissue from patients with osteoarthritis (OA). Methods. Hematoxylin and eosin staining and histologic grading for inflammation were performed for 104 patients w... Read More about Inflammation and angiogenesis in osteoarthritis.

Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling (2001)
Journal Article
McWilliams, D. F., Grimes, S., & Watson, S. A. (2001). Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling. Regulatory Peptides, 99(2-3), 157-161. https://doi.org/10.1016/S0167-0115%2801%2900245-2

Introduction: Gastrin acts to stimulate gastric acid secretion and is an acknowledged growth factor for human gastrointestinal (GI) cancer. The identity of the exact receptor type mediating the growth promoting effects of gastrin in tumours is uncert... Read More about Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling.

Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines (1998)
Journal Article
McWilliams, D. F., Watson, S. A., Crosbee, D. M., Michaeli, D., & Seth, R. (1998). Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines. Gut, 42(6), 795-798. https://doi.org/10.1136/gut.42.6.795

Background - The peptide hormone gastrin is a recognised growth factor for gastrointestinal (GI) tumour cells. Carboxyamidated gastrins bind to the cell surface gastrin/cholecystokinin B (CCK-B) receptor which can be expressed as either a normal or a... Read More about Coexpression of gastrin and gastrin receptors (CCK-B and ΔCCK-B) in gastrointestinal tumour cell lines.