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All Outputs (167)

How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation (2024)
Journal Article
De Dios Pérez, B., Merchán-Baeza, J. A., Powers, K., Craven, K., Holmes, J., Phillips, J., …Radford, K. (2024). How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation. BMC Medical Research Methodology, 24(1), Article 142. https://doi.org/10.1186/s12874-024-02269-4

Background: Integrating complex interventions within healthcare settings can be challenging. Mentoring can be embedded within a randomised controlled trial (RCT) to upskill and support those delivering the intervention. This study aimed to understand... Read More about How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation.

Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial (2024)
Journal Article
Harrison, S., Ogollah, R., Hollingworth, W., Mills, N., Karantana, A., Blazeby, J., …Davis, T. (2024). Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial. Trials, 25(1), Article 398. https://doi.org/10.1186/s13063-024-08003-1

Background: Dupuytren’s contractures (DC) are fibrous cords under the skin of the hand that cause one or more fingers to curl gradually and irreversibly towards the palm. These contractures are usually painless but can cause a loss of hand function.... Read More about Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial.

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventin... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire (2024)
Journal Article
McWilliams, D., Georgopoulos, V., Patel, J., Millar, B., Smith, S., & Walsh, D. (2024). Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire. Rheumatology, https://doi.org/10.1093/rheumatology/keae342

Background Neuropathic-like pain, fatigue, cognitive difficulty, catastrophizing, anxiety, sleep disturbance, depression and widespread pain associate with a single factor in people with knee pain. We report the Central Aspects of Pain questionnai... Read More about Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire.

Orthotist involvement in early gait rehabilitation after stroke: A cross-sectional survey of orthotists in the United Kingdom (2024)
Journal Article
Golding-Day, M., Young, J., Charlton, P., Houston, B., Thomas, S., & Walker, M. (in press). Orthotist involvement in early gait rehabilitation after stroke: A cross-sectional survey of orthotists in the United Kingdom. Prosthetics and Orthotics International, https://doi.org/10.1097/pxr.0000000000000365

Background: The role of the orthotist in early gait rehabilitation after stroke in the United Kingdom is currently poorly understood. Objectives: The objective of this study was to capture current opinion and practice of orthotists on their ro... Read More about Orthotist involvement in early gait rehabilitation after stroke: A cross-sectional survey of orthotists in the United Kingdom.

Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing (2024)
Journal Article
Agbiki, T., Arm, R., Hewson, D. W., Erdody, S., Norris, A. M., Correia, R., …Morgan, S. P. (2024). Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing. BJA Open, 10, Article 100290. https://doi.org/10.1016/j.bjao.2024.100290

Introduction Leakage of orogastric secretions past the cuff of a tracheal tube is a contributory factor in ventilator-associated pneumonia. Current bench test methods specified in the International Standard for Anaesthetic and Respiratory Equipment... Read More about Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing.

Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial (2024)
Journal Article
Kouraki, A., Nogal, A., Nocun, W., Louca, P., Vijay, A., Wong, K., …Valdes, A. M. (2024). Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial. Metabolites, 14(6), Article 311. https://doi.org/10.3390/metabo14060311

Metabolomics can uncover physiological responses to prebiotic fibre and omega-3 fatty acid supplements with known health benefits and identify response-specific metabolites. We profiled 534 stool and 799 serum metabolites in 64 healthy adults followi... Read More about Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial.

A modern way to teach and practice manual therapy (2024)
Journal Article
Kerry, R., Young, K. J., Evans, D. W., Lee, E., Georgopoulos, V., Meakins, A., …Hutting, N. (2024). A modern way to teach and practice manual therapy. Chiropractic & Manual Therapies, 32(1), Article 17. https://doi.org/10.1186/s12998-024-00537-0

Background: Musculoskeletal conditions are the leading contributor to global disability and health burden. Manual therapy (MT) interventions are commonly recommended in clinical guidelines and used in the management of musculoskeletal conditions. Tra... Read More about A modern way to teach and practice manual therapy.

Social participation in the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation (2024)
Journal Article
Lorito, C. D., Pollock, K., Booth, V., Howe, L., Goldberg, S., Godfrey, M., …Lorito, C. D. (in press). Social participation in the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation. BMC Geriatrics,

Background. Interventions promoting social activity may reduce behavioural psychological symptoms and improve quality of life in people living with dementia. This study aimed to identify social benefits for participants living with dementia in the co... Read More about Social participation in the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation.

Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol (2024)
Journal Article
Chouliara, N., Cameron, T., Ballard-Ridley, S., Fisher, R. J., Kettlewell, J., Kidd, L., …Gordon, A. L. (2024). Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol. Healthcare, 12(10), Article 1027. https://doi.org/10.3390/healthcare12101027

Telerehabilitation (TR) shows promise as a method of remote service delivery, yet there is little guidance to inform implementation in the context of the National Health Service (NHS) in England. This paper presents the protocol for a realist synthes... Read More about Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol.

The influence of immobility on muscle loss in older people with frailty and fragility fractures (2024)
Journal Article
Lunt, E. K., Gordon, A. L., Greenhaff, P. L., & Gladman, J. F. R. (2024). The influence of immobility on muscle loss in older people with frailty and fragility fractures. GeroScience, https://doi.org/10.1007/s11357-024-01177-1

This longitudinal study aimed to assess muscle morphological and functional changes in older patients admitted with fragility fractures managed by immobilisation of the affected limb for at least 6 weeks. Patients aged ≥ 70 hospitalised with non-weig... Read More about The influence of immobility on muscle loss in older people with frailty and fragility fractures.

Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial (2024)
Journal Article
Bermingham, K. M., Linenberg, I., Polidori, L., Asnicar, F., Arrè, A., Wolf, J., …Berry, S. E. (2024). Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nature Medicine, https://doi.org/10.1038/s41591-024-02951-6

Large variability exists in people’s responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health... Read More about Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial.

A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications (2024)
Journal Article
Abuawwad, M., Tibude, A., Bansi, D., Idris, I., & Madhok, B. (2024). A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications. Diabetes, Obesity and Metabolism, 26(7), 2546-2553. https://doi.org/10.1111/dom.15613

Metabolic and bariatric surgeries have been shown to be the most effective strategy to induce and maintain significant weight loss for people living with severe obesity. However, ongoing concerns regarding operative risks, irreversibility and excess... Read More about A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications.

Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials (2024)
Journal Article
Balsby, I. M., Nielsen, S. M., Christensen, R., Henriksen, M., Dahl, L. U.-M., Berg, J. I., …Døssing, A. (2024). Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials. Osteoarthritis and Cartilage, 32(7), 848-857. https://doi.org/10.1016/j.joca.2024.02.947

Objective: To examine the pain relief effects of comparators (placebos and untreated control groups) in hand osteoarthritis trials and the impact of contextual factors. Methods: We systematically searched PubMed, EMBASE and CENTRAL from inception to... Read More about Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials.

Factors influencing the commissioning and implementation of health and social care interventions for people with dementia: commissioner and stakeholder perspectives (2024)
Journal Article
Tucker, R., Vickers, R., Adams, E. J., Burgon, C., Lock, J., Goldberg, S. E., …Harwood, R. H. (2024). Factors influencing the commissioning and implementation of health and social care interventions for people with dementia: commissioner and stakeholder perspectives. Archives of Public Health, 82(1), Article 54. https://doi.org/10.1186/s13690-024-01283-8

Background Despite several interventions demonstrating benefit to people living with dementia and their caregivers, few have been translated and implemented in routine clinical practice. There is limited evidence of the barriers and facilitators for... Read More about Factors influencing the commissioning and implementation of health and social care interventions for people with dementia: commissioner and stakeholder perspectives.

Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study (2024)
Journal Article
Thomas, S., Littleboy, K., Foubert, J., Nafilyan, V., Bannister, N., Routen, A., …Gordon, A. L. (2024). Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study. Age and Ageing, 53(4), Article afae071. https://doi.org/10.1093/ageing/afae071

Background: Older people with frailty are at risk of harm from immobility or isolation, yet data about how COVID-19 lockdowns affected them are limited. Falls and fractures are easily measurable adverse outcomes correlated with frailty. We investigat... Read More about Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study.

Association Between Hyperuricemia and Ultrasound-Detected Hand Synovitis (2024)
Journal Article
Jiang, T., Weng, Q., Zhang, Y., Zhang, W., Doherty, M., Sarmanova, A., …Wei, J. (2024). Association Between Hyperuricemia and Ultrasound-Detected Hand Synovitis. Arthritis Care and Research, https://doi.org/10.1002/acr.25342

Objective Although hand synovitis is prevalent in the older population, the etiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationshi... Read More about Association Between Hyperuricemia and Ultrasound-Detected Hand Synovitis.

Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies (2024)
Journal Article
Abhishek, A., Stevenson, M. D., Nakafero, G., Grainge, M. J., Evans, I., Alabas, O., …Williams, H. C. (2024). Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies. British Journal of Dermatology, 190(4), 559-564. https://doi.org/10.1093/bjd/ljad430

Background: There is no evidence base to support the use of 6-monthly monitoring blood tests for the early detection of liver, blood and renal toxicity during established anti-tumour necrosis factor alpha (TNFα) treatment. Objectives: To evaluate the... Read More about Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies.

Exploratory factor analysis and Rasch analysis to assess the structural validity of the Adult Social Care Outcomes Toolkit Proxy version (ASCOT-Proxy) completed by care home staff (2024)
Journal Article
Rand, S., Towers, A., Allan, S., Webster, L., Palmer, S., Carroll, R., …Goodman, C. (2024). Exploratory factor analysis and Rasch analysis to assess the structural validity of the Adult Social Care Outcomes Toolkit Proxy version (ASCOT-Proxy) completed by care home staff. Quality of Life Research, 33, 1555-1567. https://doi.org/10.1007/s11136-024-03631-1

Purpose. Rasch analysis and exploratory factor analysis (EFA) were used to evaluate the structural validity of the ASCOT-Proxy measures completed by staff on behalf of older adults resident in care homes, by comparison to the ASCOT-SCT4, the meas... Read More about Exploratory factor analysis and Rasch analysis to assess the structural validity of the Adult Social Care Outcomes Toolkit Proxy version (ASCOT-Proxy) completed by care home staff.