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All Outputs (178)

Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – findings from the ADVANCE study (2024)
Journal Article
O’Sullivan, O., Stocks, J., Schofield, S., Bilzon, J., Boos, C. J., Bull, A. M. J., Fear, N. T., Watt, F. E., Bennett, A. N., Kluzek, S., & Valdes, A. M. (online). Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – findings from the ADVANCE study. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.07.016

Objective The ArmeD SerVices TrAuma RehabilitatioN OutComE (ADVANCE) study is investigating long-term combat-injury outcomes; this sub-study aims to understand the association of osteoarthritis (OA) biomarkers with knee radiographic OA (rOA), pain... Read More about Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – findings from the ADVANCE study.

Impact of COVID-19 on home care provision: A qualitative study (2024)
Journal Article
Darby, J., Allen, F., Bennett, C., Logan, P., & Kasonde, C. (in press). Impact of COVID-19 on home care provision: A qualitative study. Journal of Social Work, https://doi.org/10.1177/14680173241258900

Summary The COVID-19 pandemic and subsequent public health restrictions caused an unprecedented impact on long-term care services in the United Kingdom (UK). A qualitative study was conducted in the East Midlands, UK, to explore how home care provisi... Read More about Impact of COVID-19 on home care provision: A qualitative study.

Social participation in the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation (2024)
Journal Article
Lorito, C. D., Pollock, K., Booth, V., Howe, L., Goldberg, S., Godfrey, M., Dunlop, M., Harwood, R. H., Van Der Wardt, V., & Lorito, C. D. (2024). Social participation in the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation. BMC Geriatrics, 24(1), Article 615. https://doi.org/10.1186/s12877-024-05086-y

Background. Interventions promoting social activity may reduce behavioural psychological symptoms and improve quality of life in people living with dementia. This study aimed to identify social benefits for participants living with dementia in the co... Read More about Social participation in the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation.

Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach (2024)
Journal Article
Radford, K., Kettlewell, J., das Nair, R., Morriss, R., Holmes, J., Kellezi, B., Timmons, S., Jones, T., Tressider, H., Andrews, I., Bridger, K., Patel, P., Lindley, R., De Dios Perez, B., Statham, A., Jones, T., Hoffman, K., James, M., Kendrick, D., & ROWTATE study team. (in press). Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach. BMJ Open,

Objectives: Major trauma centres save lives but rehabilitation to support return-to-work (RTW) is lacking. This paper describes development of a vocational rehabilitation intervention (the ROWTATE intervention) to support RTW following traumatic inju... Read More about Development of a Vocational Rehabilitation Intervention to support Return to Work and Wellbeing following Major Trauma: A Person-Based Approach.

How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation (2024)
Journal Article
De Dios Pérez, B., Merchán-Baeza, J. A., Powers, K., Craven, K., Holmes, J., Phillips, J., Tyerman, R., & Radford, K. (2024). How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation. BMC Medical Research Methodology, 24(1), Article 142. https://doi.org/10.1186/s12874-024-02269-4

Background: Integrating complex interventions within healthcare settings can be challenging. Mentoring can be embedded within a randomised controlled trial (RCT) to upskill and support those delivering the intervention. This study aimed to understand... Read More about How does mentoring occupational therapists improve intervention fidelity in a randomised controlled trial? A realist evaluation.

Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial (2024)
Journal Article
Harrison, S., Ogollah, R., Hollingworth, W., Mills, N., Karantana, A., Blazeby, J., …Davis, T. (2024). Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial. Trials, 25(1), Article 398. https://doi.org/10.1186/s13063-024-08003-1

Background: Dupuytren’s contractures (DC) are fibrous cords under the skin of the hand that cause one or more fingers to curl gradually and irreversibly towards the palm. These contractures are usually painless but can cause a loss of hand function.... Read More about Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers (Hand-2): study protocol for a randomised controlled trial.

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventin... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire (2024)
Journal Article
McWilliams, D., Georgopoulos, V., Patel, J., Millar, B., Smith, S., & Walsh, D. (2024). Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire. Rheumatology, https://doi.org/10.1093/rheumatology/keae342

Background Neuropathic-like pain, fatigue, cognitive difficulty, catastrophizing, anxiety, sleep disturbance, depression and widespread pain associate with a single factor in people with knee pain. We report the Central Aspects of Pain questionnai... Read More about Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire.

Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse (2024)
Journal Article
Khoshkerdar, A., Eid, N., Batra, V., Baker, N., Holmes, N., Henson, S., Sang, F., Wright, V., McLaren, J., Shakesheff, K., Woad, K. J., Morgan, H. L., & Watkins, A. J. (2024). Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse. Nutrients, 16(12), Article 1879. https://doi.org/10.3390/nu16121879

Pregnancy represents a stage during which maternal physiology and homeostatic regulation undergo dramatic change and adaptation. The fundamental purpose of these adaptations is to ensure the survival of her offspring through adequate nutrient provisi... Read More about Sub-optimal paternal diet at the time of mating disrupts maternal adaptations to pregnancy in the late gestation mouse.

Orthotist involvement in early gait rehabilitation after stroke: A cross-sectional survey of orthotists in the United Kingdom (2024)
Journal Article
Golding-Day, M., Young, J., Charlton, P., Houston, B., Thomas, S., & Walker, M. (in press). Orthotist involvement in early gait rehabilitation after stroke: A cross-sectional survey of orthotists in the United Kingdom. Prosthetics and Orthotics International, https://doi.org/10.1097/pxr.0000000000000365

Background: The role of the orthotist in early gait rehabilitation after stroke in the United Kingdom is currently poorly understood. Objectives: The objective of this study was to capture current opinion and practice of orthotists on their ro... Read More about Orthotist involvement in early gait rehabilitation after stroke: A cross-sectional survey of orthotists in the United Kingdom.

Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing (2024)
Journal Article
Agbiki, T., Arm, R., Hewson, D. W., Erdody, S., Norris, A. M., Correia, R., …Morgan, S. P. (2024). Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing. BJA Open, 10, Article 100290. https://doi.org/10.1016/j.bjao.2024.100290

Introduction Leakage of orogastric secretions past the cuff of a tracheal tube is a contributory factor in ventilator-associated pneumonia. Current bench test methods specified in the International Standard for Anaesthetic and Respiratory Equipment... Read More about Fabrication and assessment of a bio-inspired synthetic tracheal tissue model for tracheal tube cuff leakage testing.

Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain (2024)
Journal Article
Franks, S. J., Gowler, P. R., Dunster, J. L., Turnbull, J., Gohir, S. A., Kelly, A., Valdes, A. M., King, J. R., Barrett, D. A., Chapman, V., & Preston, S. (2024). Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain. Mathematical Biosciences, 374, Article 109228. https://doi.org/10.1016/j.mbs.2024.109228

Chronic pain is a major cause of disability and suffering in osteoarthritis (OA) patients. Endogenous specialised pro-resolving molecules (SPMs) curtail pro-inflammatory responses. One of the SPM intermediate oxylipins, 17-hydroxydocasahexaenoic acid... Read More about Modelling the role of enzymatic pathways in the metabolism of docosahexaenoic acid by monocytes and its association with osteoarthritic pain.

2023 EULAR classification criteria for hand osteoarthritis (2024)
Journal Article
Haugen, I. K., Felson, D. T., Abhishek, A., Berenbaum, F., Bierma-Zeinstra, S., Dziedzic, K. S., Edwards, J. J., Englund, M., Hermann-Eriksen, M., Herrero-Beaumont, G., Hill, C., Ishimori, M. L., Jonsson, H., Karjalainen, T., Leung, Y. Y., Maheu, E., Mallen, C. D., Marshall, M., Moe, R. H., Ramonda, R., …Kloppenburg, M. (2024). 2023 EULAR classification criteria for hand osteoarthritis. Annals of the Rheumatic Diseases, https://doi.org/10.1136/ard-2023-225073

The objective of this study is to develop classification criteria for overall hand osteoarthritis (OA), interphalangeal OA and thumb base OA based on self-reported data and radiographic features. The classification criteria sets were developed in thr... Read More about 2023 EULAR classification criteria for hand osteoarthritis.

Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial (2024)
Journal Article
Kouraki, A., Nogal, A., Nocun, W., Louca, P., Vijay, A., Wong, K., Michelotti, G. A., Menni, C., & Valdes, A. M. (2024). Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial. Metabolites, 14(6), Article 311. https://doi.org/10.3390/metabo14060311

Metabolomics can uncover physiological responses to prebiotic fibre and omega-3 fatty acid supplements with known health benefits and identify response-specific metabolites. We profiled 534 stool and 799 serum metabolites in 64 healthy adults followi... Read More about Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial.

Pre- and post-operative voice therapy for benign vocal fold lesions: protocol for a non-randomised, multicentre feasibility trial with embedded process evaluation (2024)
Journal Article
White, A., Carding, P., Booth, V., McGlashan, J., Van Stan, J., Logan, P., & Awad, R. (2024). Pre- and post-operative voice therapy for benign vocal fold lesions: protocol for a non-randomised, multicentre feasibility trial with embedded process evaluation. Pilot and Feasibility Studies, 10, Article 84. https://doi.org/10.1186/s40814-024-01508-1

Background: Management of benign vocal fold lesions (BVFLs) is variable with individuals receiving surgery, voice therapy, or a combination of these approaches. Some evidence suggests that the best outcomes may be achieved when patients are offered p... Read More about Pre- and post-operative voice therapy for benign vocal fold lesions: protocol for a non-randomised, multicentre feasibility trial with embedded process evaluation.

A modern way to teach and practice manual therapy (2024)
Journal Article
Kerry, R., Young, K. J., Evans, D. W., Lee, E., Georgopoulos, V., Meakins, A., …Hutting, N. (2024). A modern way to teach and practice manual therapy. Chiropractic & Manual Therapies, 32(1), Article 17. https://doi.org/10.1186/s12998-024-00537-0

Background: Musculoskeletal conditions are the leading contributor to global disability and health burden. Manual therapy (MT) interventions are commonly recommended in clinical guidelines and used in the management of musculoskeletal conditions. Tra... Read More about A modern way to teach and practice manual therapy.

Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol (2024)
Journal Article
Chouliara, N., Cameron, T., Ballard-Ridley, S., Fisher, R. J., Kettlewell, J., Kidd, L., …Gordon, A. L. (2024). Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol. Healthcare, 12(10), Article 1027. https://doi.org/10.3390/healthcare12101027

Telerehabilitation (TR) shows promise as a method of remote service delivery, yet there is little guidance to inform implementation in the context of the National Health Service (NHS) in England. This paper presents the protocol for a realist synthes... Read More about Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol.

The influence of immobility on muscle loss in older people with frailty and fragility fractures (2024)
Journal Article
Lunt, E. K., Gordon, A. L., Greenhaff, P. L., & Gladman, J. F. R. (2024). The influence of immobility on muscle loss in older people with frailty and fragility fractures. GeroScience, https://doi.org/10.1007/s11357-024-01177-1

This longitudinal study aimed to assess muscle morphological and functional changes in older patients admitted with fragility fractures managed by immobilisation of the affected limb for at least 6 weeks. Patients aged ≥ 70 hospitalised with non-weig... Read More about The influence of immobility on muscle loss in older people with frailty and fragility fractures.

Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial (2024)
Journal Article
Bermingham, K. M., Linenberg, I., Polidori, L., Asnicar, F., Arrè, A., Wolf, J., Badri, F., Bernard, H., Capdevila, J., Bulsiewicz, W. J., Gardner, C. D., Ordovas, J. M., Davies, R., Hadjigeorgiou, G., Hall, W. L., Delahanty, L. M., Valdes, A. M., Segata, N., Spector, T. D., & Berry, S. E. (2024). Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nature Medicine, 30, 1888-1897. https://doi.org/10.1038/s41591-024-02951-6

Large variability exists in people’s responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health... Read More about Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial.