Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3
(2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Matthews, L., Bailey, H., Ashton, D., Bendall, L., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (in press). Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3. Thorax,
All Outputs (519)
Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy (2024)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mather, M. L., Alsaleem, M., Bateman‐Price, T. D., Patke, R., Ball, G., Mongan, N. P., & Rakha, E. (2024). Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy. Journal of Microscopy, https://doi.org/10.1111/jmi.13361Breast cancer (BC) is characterised by a high level of heterogeneity, which is influenced by the interaction of neoplastic cells with the tumour microenvironment. The diagnostic and prognostic role of the tumour stroma in BC remains to be defined. Di... Read More about Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy.
Supplementary inspired oxygen fraction is a simple clinical tool that predicts clinical deterioration (2024)
Journal Article
Crooks, C. J., West, J., Morling, J. R., Juurlink, I., Briggs, S., Hammond-Pears, S., Shaw, D., Card, T. R., & Fogarty, A. W. (in press). Supplementary inspired oxygen fraction is a simple clinical tool that predicts clinical deterioration. International Journal of Tuberculosis and Lung Disease,
Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis (2024)
Journal Article
Ndzo, J., Vuyyuru, S. K., Trimble, T., Yan, K., Figueredo, G., & Moran, G. W. (in press). Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis. Journal of Crohn's and Colitis,Background & Aims:
Incidence of obesity and Crohn’s disease (CD) is increasing globally. Therefore, understanding any associations between adiposity and disease phenotype is crucial. We aimed explore the relationship between nutritional status me... Read More about Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis.
Correlation between Altmetric Attention Scores and Citation Scores across the four highest impact factor journals each in Medicine, Surgery and Anaesthesia (2024)
Journal Article
Koh, A., Lewis-Lloyd, C. A., Wong, T., & Lobo, D. N. (in press). Correlation between Altmetric Attention Scores and Citation Scores across the four highest impact factor journals each in Medicine, Surgery and Anaesthesia. British Journal of Anaesthesia,
The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study (2024)
Journal Article
McDonnell, T., Kalra, P. A., Vuilleumier, N., Cockwell, P., Wheeler, D. C., Fraser, S. D. S., Banks, R. E., & Taal, M. W. (in press). The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study. American Journal of Nephrology,
Glucagon-like peptide-1 receptor agonists – new evidence of kidney and cardiovascular protection from the FLOW and SELECT trials (2024)
Journal Article
Taal, M. W., & Selby, N. M. (2024). Glucagon-like peptide-1 receptor agonists – new evidence of kidney and cardiovascular protection from the FLOW and SELECT trials. American Journal of Kidney Diseases, https://doi.org/10.1053/j.ajkd.2024.08.002
Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society (2024)
Journal Article
El-Boghdadly, K., Levy, N. A., Fawcett, W. J., Knaggs, R. D., Laycock, H., Baird, E., Cox, F. J., Eardley, W., Kemp, H., Malpus, Z., Partridge, A., Partridge, J., Patel, A., Price, C., Robinson, J., Russon, K., Walumbe, J., & Lobo, D. N. (2024). Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society. Anaesthesia, https://doi.org/10.1111/anae.16391This is a consensus document produced by expert members of a Working Party established by the Association of Anaesthetists and the British Pain Society. It has been seen and approved by their Committee and Board respectively. It is supported by the E... Read More about Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society.
Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom (2024)
Journal Article
Al-Hadyan, K. S., Storr, S. J., Zaitoun, A. M., Lobo, D. N., & Martin, S. G. (2024). Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom. Diseases, 12(10), Article 227. https://doi.org/10.3390/diseases12100227Background: Poor survival outcomes in periampullary cancer highlight the need for improvement in biomarkers and the development of novel therapies. Redox proteins, including the thioredoxin system, play vital roles in cellular antioxidant systems. Me... Read More about Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom.
Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation (2024)
Journal Article
Portelli, M., Ketelaar, M., Bates, S., Csomor, E., Shaw, D., Emsley, J., Brightling, C., Hall, I., Affleck, K., Edwards, M., Nawijn, M., Koppelman, G., Van Oosterhout, A., & Sayers, I. (2024). Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation. Clinical and Experimental Allergy, https://doi.org/10.1111/cea.14562Introduction: The interleukin-33/interleukin-1 receptor-like-1 (IL-33/IL1RL1) signalling pathway is implicated in asthma pathogenesis, with IL1RL1 nonsynonymous genetic polymorphisms associated with disease risk. We aimed to determine these variants'... Read More about Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation.
Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia (2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Ashton, D., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (2024). Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia. Journal of Infection, 89(5), Article 106277. https://doi.org/10.1016/j.jinf.2024.106277Objectives
We aimed to determine the prevalence of and risk factors for nasopharyngeal and oral pneumococcal carriage in adults with community-acquired pneumonia (CAP), and the relationship between carried and disease-causing serotypes.
Methods... Read More about Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia.
Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task (2024)
Journal Article
Hock, R. M., Owusu-Amoah, N., Waite, L., Muir, C., Stevenson, C. W., Bonardi, C., & Cassaday, H. J. (2024). Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task. Behavioral Neuroscience, https://doi.org/10.1037/bne0000603Healthy cognition requires inhibitory modulation of associative learning; conversely, impaired inhibitory discrimination is implicated in behavioral disorders. The medial prefrontal cortex (mPFC) and its dopamine innervation are key to understanding... Read More about Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task.
Cell Division Cycle 6 (CDC6) is an Independent Prognostic Biomarker in Breast Cancer (2024)
Journal Article
Kariri, Y. A., Alsaleem, M., Alhatlani, B. Y., Al-Kawaz, A., Mongan, N. P., Green, A. R., & Rakha, E. (in press). Cell Division Cycle 6 (CDC6) is an Independent Prognostic Biomarker in Breast Cancer. Pathology,
Structuring white rice with gellan gum reduces the glycemic response in healthy humans (2024)
Journal Article
Alshammari, N. A., Riches, K., Muttakin, S., Hoad, C. L., Strkalj, L., Gouseti, O., Bakalis, S., Lovegrove, A., Spiller, R. C., Gowland, P. A., Aithal, G. P., Yakubov, G. E., Taylor, M. A., & Marciani, L. (2024). Structuring white rice with gellan gum reduces the glycemic response in healthy humans. Food Research International, 196, Article 115090. https://doi.org/10.1016/j.foodres.2024.115090White rice has a high glycemic index and its consumption has been linked to an increased risk of developing type-2 diabetes mellitus, increased diabetes associated complications and obesity. In recent in vitro studies we have shown that addition of f... Read More about Structuring white rice with gellan gum reduces the glycemic response in healthy humans.
Editorial: Emulsifiers and thickeners in our food—Do they alter gut permeability? (2024)
Journal Article
Reid, J., & Spiller, R. (2024). Editorial: Emulsifiers and thickeners in our food—Do they alter gut permeability?. Alimentary Pharmacology and Therapeutics, 60(8), 1122-1123. https://doi.org/10.1111/apt.18222
Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies (2024)
Journal Article
Jensen, M. D., West, J., Crooks, C., Morling, J. R., Kraglund, F., Card, T., Askgaard, G., & Jepsen, P. (2024). Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies. American Journal of Gastroenterology, https://doi.org/10.14309/ajg.0000000000003077Background & Aims:
Patients with alcohol-related cirrhosis (ALD cirrhosis) have an increased risk of primary liver cancer (hepatocellular carcinoma [HCC] or intrahepatic cholangiocarcinoma [iCCA]). England recommends surveillance for HCC in these... Read More about Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies.
Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium (2024)
Journal Article
Cao, Z., Wong, F., Choudhury, A. K., Kamath, P. S., Topazian, M., Torre, A., Hayes, P. C., George, J., Idilman, R., Seto, W.-K., Desalegn, H., Alvares-da-Silva, M. R., Bush, B. J., Thacker, L. R., Xie, Q., & Bajaj, J. S. (2024). Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium. The Lancet Gastroenterology & Hepatology, https://doi.org/10.1016/s2468-1253%2824%2900224-3Background
Infections have a poor prognosis in inpatients with cirrhosis. We aimed to determine regional variations in infections and their association with clinical outcomes in a global cohort of inpatients with cirrhosis.
Methods
In this prospec... Read More about Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium.
Kidney Beam - a cost-effective digital intervention to improve mental health (2024)
Journal Article
Greenwood, S. A., Briggs, J., Walklin, C., Mangahis, E., Young, H. M., Castle, E. M., Billany, R. E., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J. O., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M. P., Haggis, L., Hamilton, A., Jesky, M., …Macdonald, J. (2024). Kidney Beam - a cost-effective digital intervention to improve mental health. Kidney International Reports, https://doi.org/10.1016/j.ekir.2024.08.030Background: There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health interv... Read More about Kidney Beam - a cost-effective digital intervention to improve mental health.
Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (in press). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut,Background
Colonic motility in constipation can be assessed non-invasively using MRI
Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.
Design
Part 1: 44 healthy volunteers (HV), 43 p... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.
The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes (2024)
Journal Article
Ghannam, S. F., Makhlouf, S., Alsaleem, M., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2024). The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes. Modern Pathology, 37(12), Article 100607. https://doi.org/10.1016/j.modpat.2024.100607The tumor microenvironment plays a key role in tumor progression. The proportion of the stroma-to-tumor cells (stroma-tumor ratio [STR]) has a variable prognostic significance in breast cancer (BC) molecular classes. In this study, we evaluated the m... Read More about The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes.