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Wnt/GSK‐3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon (2024)
Journal Article
Almozyan, S., Babaei‐Jadidi, R., Aljohani, A., Youssefi, S., Dalleywater, W., Kadam, P., Spencer‐Dene, B., Rakha, E., Ilyas, M., & Shams Nateri, A. (2024). Wnt/GSK‐3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon. Cancer Communications, https://doi.org/10.1002/cac2.12625

Hydroxyacid oxidase 1, a glutamine metabolism-associated protein, predicts poor patient outcome in luminal breast cancer (2024)
Journal Article
Erkan, B., MacIntyre, S., Brown, C., Fakroun, A., Lashen, A. G., Mongan, N. P., Ellis, I. O., Rakha, E. A., & Green, A. R. (2024). Hydroxyacid oxidase 1, a glutamine metabolism-associated protein, predicts poor patient outcome in luminal breast cancer. International Journal of Molecular Sciences, 25(21), Article 11572. https://doi.org/10.3390/ijms252111572

Background
Breast cancer (BC), which remains the most prevalent malignancy among women, is characterised by significant heterogeneity across its molecular subtypes. Oestrogen Receptor-positive (ER+) (luminal) BC represents approximately 75% cases an... Read More about Hydroxyacid oxidase 1, a glutamine metabolism-associated protein, predicts poor patient outcome in luminal breast cancer.

Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma (2024)
Journal Article
Serra, R., Smith, S. J., Rowlinson, J., Gorelick, N., Moloney, C., McCrorie, P., Veal, G. J., Berry, P., Chalmers, A. J., Suk, I., Shakesheff, K. M., Alexander, C., Grundy, R. G., Brem, H., Tyler, B. M., & Rahman, R. (2024). Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma. British Journal of Cancer, https://doi.org/10.1038/s41416-024-02878-2

Background: There is increased pan-cancer specific interest in repurposing the poly adenosine diphosphate-ribose polymerase-1 (PARP-1) inhibitor, olaparib, for newly diagnosed or recurrent isocitrate dehydrogenase wild type glioblastoma. We explore w... Read More about Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma.

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., Marciani, L., Atkinson, D., Sansone, S., Zdanaviciene, A., Coupland, C., Knowles, C. H., Dinning, P., Taylor, S. A., Gowland, P., Hoad, C. L., Corsetti, M., & Spiller, R. C. (2024). Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut, https://doi.org/10.1136/gutjnl-2024-332755

Background: Colonic motility in constipation can be assessed non-invasively using MRI.

Objective: To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design: Part 1: 44 healthy volunteers (HVs), 43 pa... Read More about Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.

Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance (2024)
Journal Article
Malhotra, P., & Rahman, R. (2024). Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance. Onco, 4(4), 349-358. https://doi.org/10.3390/onco4040024

Isocitrate dehydrogenase wild-type glioblastoma, a Grade 4 malignant brain neoplasm, remains resistant to multimodal treatment, with a median survival of 16 months from diagnosis with no geographical bias. Despite increasing appreciation of intra-tum... Read More about Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance.

Functional variation in human CAZyme genes in relation to the efficacy of a carbohydrate-restricted diet in IBS patients (2024)
Journal Article
Zamfir-Taranu, A., Löscher, B.-S., Carbone, F., Hoter, A., Blanco, C. E., Bozzarelli, I., Torices, L., Routhiaux, K., Van den Houte, K., Bonfiglio, F., Mayr, G., Corsetti, M., Naim, H. Y., Franke, A., Tack, J., & D’Amato, M. (2024). Functional variation in human CAZyme genes in relation to the efficacy of a carbohydrate-restricted diet in IBS patients. Clinical Gastroenterology and Hepatology, https://doi.org/10.1016/j.cgh.2024.09.004

Background and aims
Limiting the dietary intake of certain carbohydrates has therapeutic effects in some but not all irritable bowel syndrome (IBS) patients. We investigated genetic variation in human Carbohydrate-Active enZYmes (hCAZymes) genes in... Read More about Functional variation in human CAZyme genes in relation to the efficacy of a carbohydrate-restricted diet in IBS patients.

Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment (2024)
Journal Article
Milborne, B., Arjuna, A., Islam, T., Arafat, A., Layfield, R., Thompson, A., & Ahmed, I. (in press). Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment. Journal of the American Chemical Society,

This study presents the development and characterisation of high yttrium-content phosphate-based glass-ceramic microspheres for potential applications in bone cancer radiotherapy treatment. The microspheres produced via flame spheroidisa-tion, follow... Read More about Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment.

Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3 (2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Matthews, L., Bailey, H., Ashton, D., Bendall, L., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (in press). Pneumococcal pneumonia trends in adults hospitalised with community-acquired pneumonia over 10 years (2013-2023), and the role of serotype 3. Thorax,

Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing (2024)
Journal Article
van Bree, N., Oppelt, A.-S., Lindström, S., Zhou, L., Boutin, L., Coyle, B., Swartling, F. J., Johnsen, J. I., Bräutigam, L., & Wilhelm, M. (2024). Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing. Neuro-Oncology, https://doi.org/10.1093/neuonc/noae210

Background

Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Current preclinical in vivo model systems for MB have increased our understanding of molecular mechanisms regulating MB development. However, they may no... Read More about Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing.

The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study (2024)
Journal Article
McDonnell, T., Kalra, P. A., Vuilleumier, N., Cockwell, P., Wheeler, D. C., Fraser, S. D., Banks, R. E., & Taal, M. W. (2024). The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study. American Journal of Nephrology, 1-12. https://doi.org/10.1159/000541770

Introduction: The definition of CKD is broad, which neglects the heterogeneity of risk across primary renal diseases.

Methods: The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD is an ongoing UK, prospective multicenter coh... Read More about The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study.

Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy (2024)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mather, M. L., Alsaleem, M., Bateman-Price, T. D., Patke, R., Ball, G., Mongan, N. P., & Rakha, E. (2024). Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy. Journal of Microscopy, https://doi.org/10.1111/jmi.13361

Breast cancer (BC) is characterised by a high level of heterogeneity, which is influenced by the interaction of neoplastic cells with the tumour microenvironment. The diagnostic and prognostic role of the tumour stroma in BC remains to be defined. Di... Read More about Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy.

Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis (2024)
Journal Article
Ndzo, J., Vuyyuru, S. K., Trimble, T., Yan, K., Figueredo, G., & Moran, G. W. (in press). Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis. Journal of Crohn's and Colitis,

Background & Aims:

Incidence of obesity and Crohn’s disease (CD) is increasing globally. Therefore, understanding any associations between adiposity and disease phenotype is crucial. We aimed explore the relationship between nutritional status me... Read More about Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis.

Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society (2024)
Journal Article
El-Boghdadly, K., Levy, N. A., Fawcett, W. J., Knaggs, R. D., Laycock, H., Baird, E., Cox, F. J., Eardley, W., Kemp, H., Malpus, Z., Partridge, A., Partridge, J., Patel, A., Price, C., Robinson, J., Russon, K., Walumbe, J., & Lobo, D. N. (2024). Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society. Anaesthesia, 79(11), 1220-1236. https://doi.org/10.1111/anae.16391

This is a consensus document produced by expert members of a Working Party established by the Association of Anaesthetists and the British Pain Society. It has been seen and approved by their Committee and Board respectively. It is supported by the E... Read More about Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society.

Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom (2024)
Journal Article
Al-Hadyan, K. S., Storr, S. J., Zaitoun, A. M., Lobo, D. N., & Martin, S. G. (2024). Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom. Diseases, 12(10), Article 227. https://doi.org/10.3390/diseases12100227

Background: Poor survival outcomes in periampullary cancer highlight the need for improvement in biomarkers and the development of novel therapies. Redox proteins, including the thioredoxin system, play vital roles in cellular antioxidant systems. Me... Read More about Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom.

Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation (2024)
Journal Article
Portelli, M., Ketelaar, M., Bates, S., Csomor, E., Shaw, D., Emsley, J., Brightling, C., Hall, I., Affleck, K., Edwards, M., Nawijn, M., Koppelman, G., Van Oosterhout, A., & Sayers, I. (2024). Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation. Clinical and Experimental Allergy, https://doi.org/10.1111/cea.14562

Introduction: The interleukin-33/interleukin-1 receptor-like-1 (IL-33/IL1RL1) signalling pathway is implicated in asthma pathogenesis, with IL1RL1 nonsynonymous genetic polymorphisms associated with disease risk. We aimed to determine these variants'... Read More about Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation.

Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task (2024)
Journal Article
Hock, R. M., Owusu-Amoah, N., Waite, L., Muir, C., Stevenson, C. W., Bonardi, C., & Cassaday, H. J. (2024). Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task. Behavioral Neuroscience, https://doi.org/10.1037/bne0000603

Healthy cognition requires inhibitory modulation of associative learning; conversely, impaired inhibitory discrimination is implicated in behavioral disorders. The medial prefrontal cortex (mPFC) and its dopamine innervation are key to understanding... Read More about Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task.