All Outputs (399)

Association of CYP2C19 Loss-of-Function Metabolizer Status With Stroke Risk Among Chinese Patients Treated With Ticagrelor-Aspirin vs Clopidogrel-Aspirin: A Prespecified Secondary Analysis of a Randomized Clinical Trial. (2023)
Journal Article
Xie, X., Johnston, S. C., Wang, A., Xu, Q., Bath, P. M., Pan, Y., …Wang, Y. (2023). Association of CYP2C19 Loss-of-Function Metabolizer Status With Stroke Risk Among Chinese Patients Treated With Ticagrelor-Aspirin vs Clopidogrel-Aspirin: A Prespecified Secondary Analysis of a Randomized Clinical Trial. JAMA Network Open, 6(6), Article e2317037. https://doi.org/10.1001/jamanetworkopen.2023.17037

Importance: The Clopidogrel With Aspirin in High-Risk Patients With Acute Nondisabling Cerebrovascular Events II (CHANCE-2) trial showed that ticagrelor-aspirin combination therapy reduced the risk of stroke compared with a clopidogrel-aspirin combi... Read More about Association of CYP2C19 Loss-of-Function Metabolizer Status With Stroke Risk Among Chinese Patients Treated With Ticagrelor-Aspirin vs Clopidogrel-Aspirin: A Prespecified Secondary Analysis of a Randomized Clinical Trial..

Care for older forensic mental health patients: A consensus guidance document (2023)
Journal Article
Tomlin, J., Walker, K., Yates, J., Dening, T., Goethals, K., Völlm, B., & Griffiths, C. (2023). Care for older forensic mental health patients: A consensus guidance document. European Psychiatry, 66(1), Article e44. https://doi.org/10.1192/j.eurpsy.2023.2413

Background
It is important to investigate the needs, experiences, and outcomes of older forensic mental health inpatients. In this consensus document, we offer practitioners working with older forensic inpatients recommendations to meet the unique o... Read More about Care for older forensic mental health patients: A consensus guidance document.

The association between the Multiple Sclerosis Screening Questionnaire and objective measures of cognition: a systematic literature review and meta-analysis (2023)
Journal Article
Tunmore, J., Kontou, E., Moghaddam, N., Hufton, L., & Das Nair, R. (2023). The association between the Multiple Sclerosis Screening Questionnaire and objective measures of cognition: a systematic literature review and meta-analysis. Journal of Clinical and Experimental Neuropsychology, 45(2), 197-217. https://doi.org/10.1080/13803395.2023.2213847

Introduction
The Multiple Sclerosis Screening Questionnaire (MSNQ) is a self-report measure used to assess cognitive difficulties in people with Multiple Sclerosis (PwMS). The aim of this systematic review was to determine the associations between t... Read More about The association between the Multiple Sclerosis Screening Questionnaire and objective measures of cognition: a systematic literature review and meta-analysis.

Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts (2023)
Journal Article
Neves, R., DeDiosPerez, B., Panek, R., Jagani, S., Wilne, S., Mahendra Bhatt, J., …Dineen, R. A. (2023). Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts. Cancer Medicine, 12(13), 14663-14673. https://doi.org/10.1002/cam4.6075

Background/Objectives: Ataxia telangiectasia (A‐T) is a multiorgan disorder with increased vulnerability to cancer. Despite this increased cancer risk, there are no widely accepted guidelines for cancer surveillance in people affected by A‐T. We aime... Read More about Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts.

Remote administration of ADHD-sensitive cognitive tasks: a pilot study (2023)
Journal Article
Sun, S., Denyer, H., Sankesara, H., Deng, Q., Ranjan, Y., Conde, P., …Kuntsi, J. (2023). Remote administration of ADHD-sensitive cognitive tasks: a pilot study. Journal of Attention Disorders, 27(9), 1040-1050. https://doi.org/10.1177/10870547231172

Objective:
We assessed the feasibility and validity of remote researcher-led administration and self-administration of modified versions of two cognitive tasks sensitive to ADHD, a four-choice reaction time task (Fast task) and a combined Continuous... Read More about Remote administration of ADHD-sensitive cognitive tasks: a pilot study.

Training for line managers should focus on primary prevention of mental ill-health at work (2023)
Journal Article
Blake, H., Hassard, J., Bartle, C., & Thomson, L. (2023). Training for line managers should focus on primary prevention of mental ill-health at work. Perspectives in Public Health, 143(3), 124-125. https://doi.org/10.1177/17579139231157528

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial (2023)
Journal Article
Wardlaw, J. M., Woodhouse, L. J., Mhlanga, I. I., Oatey, K., Heye, A. K., Bamford, J., …Bath, P. M. (2023). Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial. JAMA Neurology, 80(7), 682-692. https://doi.org/10.1001/jamaneurol.2023.1526

Importance Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), is the most common cause of vascular cognitive impairment, and impairs mobility and mood but has no specific treatment.

Objective To test the feasibili... Read More about Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.

Pregnancy-related discrimination and expectant workers' psychological well-being and work engagement: understanding the moderating role of job resources (2023)
Journal Article
Hassard, J., Wang, W., Delic, L., Gruzdyte, I., Dale-Hewitt, V., & Thomson, L. (2023). Pregnancy-related discrimination and expectant workers' psychological well-being and work engagement: understanding the moderating role of job resources. International Journal of Workplace Health Management, 16(2/3), 188-204. https://doi.org/10.1108/IJWHM-01-2022-0005

Purpose: In this paper, the authors apply the Job Demand-Resource Model to investigate the association between pregnancy-related discrimination (conceptualised as a job demand) and expectant workers' psychological well-being and work engagement, and... Read More about Pregnancy-related discrimination and expectant workers' psychological well-being and work engagement: understanding the moderating role of job resources.

Real-world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: a retrospective multicentre cohort study (2023)
Journal Article
Papathanasiou, A., Hibbert, A., Tallantyre, E., Harding, K., Selvam, A. P., Morgan, M., …Evangelou, N. (2023). Real-world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: a retrospective multicentre cohort study. Neurological Sciences, 44(10), 3629-3635. https://doi.org/10.1007/s10072-023-06838-1

Background: Annualized relapse rate (ARR) is used as an outcome measure in multiple sclerosis (MS) clinical trials. Previous studies demonstrated that ARR has reduced in placebo groups between 1990 and 2012. This study aimed to estimate real-world AR... Read More about Real-world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: a retrospective multicentre cohort study.

Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting (2023)
Journal Article
Thomas, S., Machuel, P., Foubert, J., Nafilyan, V., Bannister, N., Colvin, H., …Gordon, A. (2023). Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting. BMJ Open, 13(5), Article e067786. https://doi.org/10.1136/bmjopen-2022-067786

INTRODUCTION: Older people were at particular risk of morbidity and mortality during COVID-19. Consequently, they experienced formal (externally imposed) and informal (self-imposed) periods of social isolation and quarantine. This is hypothesised to... Read More about Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting.

Accuracy of artificial intelligence software for CT angiography in stroke (2023)
Journal Article
Mair, G., White, P., Bath, P. M., Muir, K., Martin, C., Dye, D., …for the RITeS Collaboration. (2023). Accuracy of artificial intelligence software for CT angiography in stroke. Annals of Clinical and Translational Neurology, 10(7), 1072-1082. https://doi.org/10.1002/acn3.51790

Objective: Software developed using artificial intelligence may automatically identify arterial occlusion and provide collateral vessel scoring on CT angiography (CTA) performed acutely for ischemic stroke. We aimed to assess the diagnostic accuracy... Read More about Accuracy of artificial intelligence software for CT angiography in stroke.

The impact of sleep difficulties in children with attention deficit hyperactivity disorder on the family: a thematic analysis (2023)
Journal Article
French, B., Quain, E., Kilgariff, J., Lockwood, J., & Daley, D. (2023). The impact of sleep difficulties in children with attention deficit hyperactivity disorder on the family: a thematic analysis. Journal of Clinical Sleep Medicine, 19(10), 1735-1741. https://doi.org/10.5664/jcsm.10662

Background. Attention Deficit Hyperactivity Disorder (ADHD) is a complex but common neurodevelopmental condition characterised by symptoms of inattention, hyperactivity and impulsivity associated with a significant level of academic, social and funct... Read More about The impact of sleep difficulties in children with attention deficit hyperactivity disorder on the family: a thematic analysis.

What Happens When We Hear? (2023)
Journal Article
Sumner, C. J., Akeroyd, M. A., Sollini, J., & Hart, C. (in press). What Happens When We Hear?. Frontiers for Young Minds, 11, 1072364. https://doi.org/10.3389/frym.2023.1072364

What happens when we hear? Where does the sound go when it enters our ears? Our ears sense the vibrations of the air and convert them into electrical signals the brain can process. But that is only the start. The brain uses tens of thousands of nerve... Read More about What Happens When We Hear?.

ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. (2023)
Journal Article
Jacobs, B. M., Schalk, L., Dunne, A., Scalfari, A., Nandoskar, A., Gran, B., …Dobson, R. (2023). ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. BMJ Open, 13(5), Article e071656. https://doi.org/10.1136/bmjopen-2023-071656

Purpose Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability of these findings. The gene... Read More about ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK..

The effectiveness of occupational therapy supporting return to work for people who sustain serious injuries or develop long-term (physical or mental) health conditions: A systematic review (2023)
Journal Article
De Dios Perez, B., McQueen, J., Craven, K., Radford, K., Blake, H., Smith, B., …Holmes, J. (2023). The effectiveness of occupational therapy supporting return to work for people who sustain serious injuries or develop long-term (physical or mental) health conditions: A systematic review. British Journal of Occupational Therapy, 86(7), 467-481. https://doi.org/10.1177/03080226231170996

Introduction: People with long-term conditions or recovering from serious injuries can struggle to return to work. The evidence for occupational therapy supporting return to work is limited. We aimed to identify and explain how occupational therapy i... Read More about The effectiveness of occupational therapy supporting return to work for people who sustain serious injuries or develop long-term (physical or mental) health conditions: A systematic review.

Online peer support: views and experiences of people with young onset dementia (YOD) (2023)
Journal Article
Gerritzen, E. V., McDermott, O., & Orrell, M. (2023). Online peer support: views and experiences of people with young onset dementia (YOD). Aging and Mental Health, 27(12), 2386-2394. https://doi.org/10.1080/13607863.2023.2205833

Objectives: This study explores (1) which platforms people with YOD use for online peer support, (2) reasons for using or not using online peer support, and (3) how to optimise potential benefits and accessibility. Methods: A mixed-methods online sur... Read More about Online peer support: views and experiences of people with young onset dementia (YOD).

A double-blind, sham-controlled, trial of home-administered rhythmic 10-Hz median nerve stimulation for the reduction of tics, and suppression of the urge-to-tic, in individuals with Tourette syndrome and chronic tic disorder (2023)
Journal Article
Morera Maiquez, B., Morera Maiquez, B., Smith, C., Dyke, K., Chou, C.-P., Kasbia, B., …Jackson, S. R. (2023). A double-blind, sham-controlled, trial of home-administered rhythmic 10-Hz median nerve stimulation for the reduction of tics, and suppression of the urge-to-tic, in individuals with Tourette syndrome and chronic tic disorder. Journal of Neuropsychology, 17(3), 540-563. https://doi.org/10.1111/jnp.12313

Tourette syndrome (TS) and chronic tic disorder (CTD) are neurological disorders of childhood onset characterized by the occurrence of tics; repetitive, purposeless, movements or vocalizations of short duration which can occur many times throughout a... Read More about A double-blind, sham-controlled, trial of home-administered rhythmic 10-Hz median nerve stimulation for the reduction of tics, and suppression of the urge-to-tic, in individuals with Tourette syndrome and chronic tic disorder.

Person-attuned musical interactions (PAMI) in dementia care. Complex intervention research for constructing a training manual (2023)
Journal Article
Ridder, H. M., Krøier, J. K., Anderson-Ingstrup, J., & McDermott, O. (2023). Person-attuned musical interactions (PAMI) in dementia care. Complex intervention research for constructing a training manual. Frontiers in Medicine, 10, Article 1160588. https://doi.org/10.3389/fmed.2023.1160588

Introduction: Music is of vital importance for cognition, human care, and the formation of social communities throughout life. Dementia is a neurocognitive disorder that affects cognitive domains, and in late-stage dementia, care is needed in all asp... Read More about Person-attuned musical interactions (PAMI) in dementia care. Complex intervention research for constructing a training manual.

Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke (2023)
Journal Article
Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2023). Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke. Stem Cell Reviews and Reports, 19(6), 1856-1869. https://doi.org/10.1007/s12015-023-10544-y

Ageing impairs endothelial function and predisposes the person to ischaemic stroke (IS). Endothelial progenitor cells (EPCs) repair endothelial damage and induce post-ischaemic neovascularisation. Given the prevalence of IS in older population, this... Read More about Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke.

Exploring factors influencing willingness of older adults to use assistive technologies: evidence from the cognitive function and ageing study II (2023)
Journal Article
Begde, A., Jain, M., Goodwin, M., Brayne, C., Barnes, L., Brooks, R., Green, E., Richardson, C., Dening, T., Wilcockson, T., & Hogervorst, E. (2024). Exploring factors influencing willingness of older adults to use assistive technologies: evidence from the cognitive function and ageing study II. Information, Communication and Society, 27(2), 368-385. https://doi.org/10.1080/1369118X.2023.2205915

Technology is widely promoted as a solution to greater independence and better health for the rapidly growing UK older population. If this is to be realised, we need to understand barriers and facilitators to uptake and investigate who wants this tec... Read More about Exploring factors influencing willingness of older adults to use assistive technologies: evidence from the cognitive function and ageing study II.