Skip to main content

Research Repository

Advanced Search

All Outputs (106)

Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain (2021)
Journal Article
Psaltis, E., Zaitoun, A. M., Neal, K. R., & Lobo, D. N. (2021). Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain. World Journal of Surgery, 45(12), 3592-3602. https://doi.org/10.1007/s00268-021-06288-w

Background
Histologically normal appendices resected for right iliac fossa pain in children demonstrate immunohistochemical markers of inflammation. We aimed to establish if subclinical inflammation was present in histologically normal appendices re... Read More about Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain.

Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020 (2021)
Journal Article
Seehra, J. K., Lewis-Lloyd, C., Koh, A., Theophilidou, E., Daliya, P., Adiamah, A., & Lobo, D. N. (2021). Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020. World Journal of Surgery, 45(11), 3266-3277. https://doi.org/10.1007/s00268-021-06268-0

Background: Presentation at academic conferences is an important marker of research productivity. However, not all accepted abstracts progress to full publication, and there is anecdotal evidence suggesting an imbalance in sex and ethnicity amongst p... Read More about Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020.

A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data (2021)
Journal Article
Bishton, M. J., Stilwell, P., Card, T. R., Lanyon, P., Ban, L., Elliss-Brookes, L., Manson, J., Nanduri, V., Earp, K., Flower, L., Amarnani, R., Rankin, J., Sen, E. S., Tattersall, R. S., Crooks, C. J., Aston, J., Siskova, V., West, J., & Bythell, M. (2021). A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data. British Journal of Haematology, 194(6), 1039-1044. https://doi.org/10.1111/bjh.17768

We assessed the validity of coded healthcare data to identify cases of haemophagocytic lymphohistiocytosis (HLH). Hospital Episode Statistics (HES) identified 127 cases within five hospital Trusts 2013–2018 using ICD-10 codes D76.1, D76.2 and D76.3.... Read More about A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data.

Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies (2021)
Journal Article
Gunn, D., Abbas, Z., Harris, H., Major, G., Hoad, C., Gowland, P., Marciani, L., Gill, S., Warren, F., Rossi, M., Remes-Troche, J., Whelan, K., & Spiller, R. (2022). Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies. Gut, 71(5), 919-927. https://doi.org/10.1136/gutjnl-2021-324784

Objective: Health promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), limiting their intake. Our aim was to test if co-administering psyllium with inulin would reduce gas... Read More about Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies.

Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection (2021)
Journal Article
Urbanowicz, R. A., Tsoleridis, T., Jackson, H. J., Cusin, L., Duncan, J. D., Chappell, J. G., Tarr, A. W., Nightingale, J., Norrish, A. R., Ikram, A., Marson, B., Craxford, S. J., Kelly, A., Aithal, G. P., Vijay, A., Tighe, P. J., Ball, J. K., Valdes, A. M., & Ollivere, B. J. (2021). Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection. Science Translational Medicine, 13(609), Article eabj0847. https://doi.org/10.1126/scitranslmed.abj0847

Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necess... Read More about Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection.

Perioperative Opioids - Reclaiming Lost Ground (2021)
Journal Article
Fawcett, W. J., Ljungqvist, O., & Lobo, D. N. (2021). Perioperative Opioids - Reclaiming Lost Ground. JAMA Surgery, 156(11), 997-998. https://doi.org/10.1001/jamasurg.2021.2858

Opium (poppy tears) has been in use since 3400 BCE, with historical writings recording its sedative, euphoric, and analgesic properties, but it was not until the 19th century that morphine was isolated, paving the way for its therapeutic use. The 20t... Read More about Perioperative Opioids - Reclaiming Lost Ground.

Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites (2021)
Journal Article
Vijay, A., Astbury, S., Panayiotis, L., Marques, F., Spector, T. D., Menni, C., & Valdes, A. M. (2021). Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites. Frontiers in Cardiovascular Medicine, 8, Article 691564. https://doi.org/10.3389/fcvm.2021.691564

Aims: The current study investigates the role of diet in mediating the gut microbiome-cardiovascular association which has not
yet been explored in humans.
Methods and results: Using a two-arm dietary intervention study in healthy participants (N=7... Read More about Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites.

Socioeconomic inequalities in the incidence of alcohol-related liver disease: A nationwide Danish study (2021)
Journal Article
Askgaard, G., Fleming, K. M., Crooks, C., Kraglund, F., Jensen, C. B., West, J., & Jepsen, P. (2021). Socioeconomic inequalities in the incidence of alcohol-related liver disease: A nationwide Danish study. Lancet Regional Health – Europe, 8, 1-9. https://doi.org/10.1016/j.lanepe.2021.100172

Background: There is socio-economic inequality in total alcohol-related harm, but knowledge of inequality in the incidence of specific alcohol-related diseases would be beneficial for prevention. Registry-based studies with nationwide coverage may re... Read More about Socioeconomic inequalities in the incidence of alcohol-related liver disease: A nationwide Danish study.

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India (2021)
Journal Article
Monaghan, T. M., Biswas, R. N., Nashine, R. R., Joshi, S. S., Mullish, B. H., Seekatz, A. M., Blanco, J. M., McDonald, J. A. K., Marchesi, J. R., Yau, T. O., Christodoulou, N., Hatziapostolou, M., Pucic-Bakovic, M., Vuckovic, F., Klicek, F., Lauc, G., Xue, N., Dottorini, T., Ambalkar, S., Satav, A., …Kashyap, R. S. (2021). Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India. Microorganisms, 9(7), Article 1485. https://doi.org/10.3390/microorganisms9071485

Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consu... Read More about Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India.

Estimating the clinical prevalence of Wilson’s disease in the UK (2021)
Journal Article
Wijayasiri, P., Hayre, J., Nicholson, E. S., Kaye, P., Wilkes, E. A., Evans, J., Aithal, G. P., Jones, G., Pearce, F., & Aravinthan, A. D. (2021). Estimating the clinical prevalence of Wilson’s disease in the UK. JHEP Reports, 3(5), Article 100329. https://doi.org/10.1016/j.jhepr.2021.100329

Background and Aim
The clinical prevalence of Wilson’s disease (WD) in the UK remains unknown. The estimated genetic prevalence in the UK, 142/million, is higher than the clinical prevalence (15/million) reported in other European studies. The aim o... Read More about Estimating the clinical prevalence of Wilson’s disease in the UK.

Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies (2021)
Journal Article
McGing, J. J., Radford, S. J., Francis, S. T., Serres, S., Greenhaff, P. L., & Moran, G. W. (2021). Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies. Alimentary Pharmacology and Therapeutics, 54(4), 368-387. https://doi.org/10.1111/apt.16465

Background: Fatigue is the inability to achieve or maintain an expected work output resulting from central or peripheral mechanisms. The prevalence of inflammatory bowel disease (IBD) fatigue can reach 86% in active disease, persisting in 50%-52% of... Read More about Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies.

Effect of intake of food hydrocolloids of bacterial origin on the glycemic response in humans: Systematic review and narrative synthesis (2021)
Journal Article
Alshammari, N. A., Taylor, M. A., Stevenson, R., Gouseti, O., Alyami, J., Muttakin, S., Bakalis, S., Lovegrove, A., Aithal, G. P., & Marciani, L. (2021). Effect of intake of food hydrocolloids of bacterial origin on the glycemic response in humans: Systematic review and narrative synthesis. Nutrients, 13(7), Article 2407. https://doi.org/10.3390/nu13072407

Diabetes mellitus is a chronic condition characterized by increased blood glucose levels from dysfunctional carbohydrate metabolism. Dietary intervention can help to prevent and manage the disease. Food hydrocolloids have been shown to have favorable... Read More about Effect of intake of food hydrocolloids of bacterial origin on the glycemic response in humans: Systematic review and narrative synthesis.

Advanced preclinical models for evaluation of drug induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [Pro-Euro-DILI-Net] (2021)
Journal Article
Fernandez-Checa, J. C., Bagnaninchi, P., Ye, H., Sancho-Bru, P., Falcon-Perez, J. M., Royo, F., Garcia-Ruiz, C., Konu, O., Miranda, J., Lunov, O., Dejneka, A., Elfick, A., McDonald, A., Sullivan, G. J., Aithal, G., Lucena, M. I., Andrade, R. J., Fromenty, B., Krannendonk, M., Cubero, F. J., & Nelson, L. J. (2021). Advanced preclinical models for evaluation of drug induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [Pro-Euro-DILI-Net]. Journal of Hepatology, 75(4), 935-959. https://doi.org/10.1016/j.jhep.2021.06.021

Drug induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies. Given the wide use of both prescribed and over the counter drugs, DILI has become a majo... Read More about Advanced preclinical models for evaluation of drug induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [Pro-Euro-DILI-Net].

The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome (2021)
Journal Article
Mohr, S., Fritz, N., Hammer, C., Martínez, C., Berens, S., Schmitteckert, S., Wahl, V., Schmidt, M., Houghton, L. A., Goebel‐Stengel, M., Kabisch, M., Götze, D., Milovač, I., D’Amato, M., Zheng, T., Röth, R., Mönnikes, H., Engel, F., Gauss, A., Tesarz, J., …Niesler, B. (2021). The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome. Journal of Cellular and Molecular Medicine, 25(16), 8047-8061. https://doi.org/10.1111/jcmm.16736

Irritable bowel syndrome (IBS) is a gut-brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying genetic mechanism... Read More about The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome.

Clinical Utility of small bowel ultrasound assessment of Crohn’s Disease in Adults: A systematic scoping review (2021)
Journal Article
Radford, S. J., Clarke, C. G., Shinkins, B., Leighton, P., Taylor, S. A., & Moran, G. W. (2022). Clinical Utility of small bowel ultrasound assessment of Crohn’s Disease in Adults: A systematic scoping review. Frontline Gastroenterology, 13(4), 280-286. https://doi.org/10.1136/flgastro-2021-101897

Background: Ultrasound is an alternative to Magnetic Resonance Enterography, and has the potential to significantly reduce waiting times, expedite clinical decision making and improve patient experience. Point of care ultrasound is an advantage of th... Read More about Clinical Utility of small bowel ultrasound assessment of Crohn’s Disease in Adults: A systematic scoping review.

Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging (2021)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C. L., Marciani, L., Ban, L., Prayle, A. P., Barr, H. L., Jaudszus, A., Mainz, J. G., Spiller, R., Gowland, P., Major, G., & Smyth, A. R. (2021). Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging. Journal of Cystic Fibrosis, 20(4), 591-597. https://doi.org/10.1016/j.jcf.2020.06.004

Background: Cystic fibrosis (CF) is a multi-system genetic disorder affecting >72,000 people worldwide. Most CF patients experience gastrointestinal symptoms and can develop complications. However, the mechanisms of CF gut disease are not well unders... Read More about Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging.

Planned surgery in the COVID-19 pandemic: a prospective cohort study from Nottingham (2021)
Journal Article
Catton, J., Banerjea, A., Gregory, S., Hall, C., Crooks, C., Lewis-Lloyd, C., Marshall, A., & Humes, D. (2021). Planned surgery in the COVID-19 pandemic: a prospective cohort study from Nottingham. Langenbeck's Archives of Surgery, 406, 2469-2477. https://doi.org/10.1007/s00423-021-02207-8

Purpose
Globally planned surgical procedures have been deferred during the current COVID-19 pandemic. The study aimed to report the outcomes of planned urgent and cancer cases during the current pandemic using a multi-disciplinary prioritisation gro... Read More about Planned surgery in the COVID-19 pandemic: a prospective cohort study from Nottingham.

External validation of a model to predict women most at risk of postpartum venous thromboembolism: Maternity clot risk (2021)
Journal Article
Ban, L., Abdul Sultan, A., West, J., Tata, L. J., Riley, R. D., Nelson-Piercy, C., & Grainge, M. J. (2021). External validation of a model to predict women most at risk of postpartum venous thromboembolism: Maternity clot risk. Thrombosis Research, 208, 202-210. https://doi.org/10.1016/j.thromres.2021.05.020

Introduction: Venous thromboembolism (VTE) is the leading cause of direct maternal mortality in high-income countries. We previously developed a risk prediction score for postpartum venous thromboembolism (VTE) in women without a previous VTE. In thi... Read More about External validation of a model to predict women most at risk of postpartum venous thromboembolism: Maternity clot risk.

Determining a healthy reference range and factors potentially influencing PRO-C3 – A biomarker of liver fibrosis (2021)
Journal Article
Erhardtsen, E., Rasmussen, D. G., Frederiksen, P., Leeming, D. J., Shevell, D., Gluud, L. L., Karsdal, M. A., Aithal, G. P., & Schattenberg, J. M. (2021). Determining a healthy reference range and factors potentially influencing PRO-C3 – A biomarker of liver fibrosis. JHEP Reports, 3(4), Article 100317. https://doi.org/10.1016/j.jhepr.2021.100317

Background & Aims
Progressive fibrosis has been identified as the major predictor of mortality in patients with non-alcoholic fatty liver disease (NAFLD). Several biomarkers are currently being evaluated for their ability to substitute the liver bio... Read More about Determining a healthy reference range and factors potentially influencing PRO-C3 – A biomarker of liver fibrosis.