All Outputs (578)

Communication during the COVID-19 Pandemic: Evaluation-Study on Self-Perceived Competences and Views of Health Care Professionals (2021)
Journal Article
Schlögl, M., Singler, K., Martinez-Velilla, N., Jan, S., Bischoff-Ferrari, H. A., Roller-Wirnsberger, R. E., Attier-Zmudka, J., Jones, C. A., Miot, S., & Gordon, A. L. (2021). Communication during the COVID-19 Pandemic: Evaluation-Study on Self-Perceived Competences and Views of Health Care Professionals. European Geriatric Medicine, 12(6), 1181-1190. https://doi.org/10.1007/s41999-021-00532-1

Purpose
The aims of this study were to describe communication experiences while wearing a mask during COVID-19 pandemic in 2020, in order to identify possible mask-related barriers to COVID-19-adapted communications and to investigate whether the AB... Read More about Communication during the COVID-19 Pandemic: Evaluation-Study on Self-Perceived Competences and Views of Health Care Professionals.

Research into ageing and frailty (2021)
Journal Article
Gordon, A. L., Witham, M. D., Henderson, E. J., Harwood, R. H., & Masud, T. (2021). Research into ageing and frailty. Future Healthcare Journal, 8(2), e237-e242. https://doi.org/10.7861/fhj.2021-0088

Research into ageing covers opportunities and challenges posed by an older population, and research to understand the ageing processes across the lifespan. The evidence base for Comprehensive Geriatric Assessment (CGA) is well established and efforts... Read More about Research into ageing and frailty.

Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males (2021)
Journal Article
Quinlan, J. I., Franchi, M. V., Gharahdaghi, N., Badiali, F., Francis, S., Hale, A., Phillips, B. E., Szewczyk, N., Greenhaff, P. L., Smith, K., Maganaris, C., Atherton, P. J., & Narici, M. V. (2021). Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males. GeroScience, 43(4), 1567-1584. https://doi.org/10.1007/s11357-021-00396-0

Resistance exercise training (RET) is well-known to counteract negative age-related changes in both muscle and tendon tissue. Traditional RET consists of both concentric (CON) and eccentric (ECC) contractions; nevertheless, isolated ECC contractions... Read More about Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males.

Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers (2021)
Journal Article
Deane, C. S., Gates, A., Traviss-Turner, G. D., Wilkinson, D. J., Smith, K., Atherton, P. J., & Phillips, B. E. (2021). Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers. Applied Physiology, Nutrition, and Metabolism, 46(9), 1147-1151. https://doi.org/10.1139/apnm-2021-0204

We explored the views of older (≥65 years) past and potential volunteers in regard to participating in physiology research during the COVID-19 pandemic. Using an online questionnaire and focus groups, we found that past volunteers (n=55) were more li... Read More about Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers.

Biology of primary breast cancer in older women beyond routine biomarkers (2021)
Journal Article
Parks, R. M., Alfarsi, L. H., Green, A. R., & Cheung, K. L. (2021). Biology of primary breast cancer in older women beyond routine biomarkers. Breast Cancer, 28(5), 991-1001. https://doi.org/10.1007/s12282-021-01266-5

Purpose: There are numerous biomarkers which may have potential predictive and prognostic significance in breast cancer. This is extremely important in older adults, who may opt for less aggressive therapy. This work outlines the literature on biolog... Read More about Biology of primary breast cancer in older women beyond routine biomarkers.

Parents, healthcare professionals and other stakeholders’ experiences of caring for babies born too soon in a low resource setting: A qualitative study of essential newborn care for preterm infants in Kenya (2021)
Journal Article
Mitchell, E. J., Pallotti, P., Qureshi, Z., Daniels, J. P., Oliver, M., Were, F., Osoti, A., Gwako, G., Kimani, V., Opira, J., & Ojha, S. (2021). Parents, healthcare professionals and other stakeholders’ experiences of caring for babies born too soon in a low resource setting: A qualitative study of essential newborn care for preterm infants in Kenya. BMJ Open, 11(6), Article e043802. https://doi.org/10.1136/bmjopen-2020-043802

Objectives: Prematurity is the leading cause of global neonatal and infant mortality. Many babies could survive by the provision of essential newborn care. This qualitative study was conducted in order to understand, from a family and professional pe... Read More about Parents, healthcare professionals and other stakeholders’ experiences of caring for babies born too soon in a low resource setting: A qualitative study of essential newborn care for preterm infants in Kenya.

Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality (2021)
Journal Article
Battisti, N. M. L., Hatton, M. Q., Reed, M. W., Herbert, E., Morgan, J. L., Bradburn, M., Simcock, R., Walters, S. J., Collins, K. A., Ward, S. E., Holmes, G. R., Burton, M., Lifford, K. J., Edwards, A., Robinson, T. G., Martin, C., Chater, T., Pemberton, K. J., Brennan, A., Leung Cheung, K., …Ring, A. (2021). Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality. Radiotherapy and Oncology, 161, 166-176. https://doi.org/10.1016/j.radonc.2021.06.021

Background: Radiotherapy reduces in-breast recurrence risk in early breast cancer (EBC) in older women. This benefit may be small and should be balanced against treatment effect and holistic patient assessment. This study described treatment patterns... Read More about Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality.

FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study (2021)
Preprint / Working Paper
Urwin, S. G., Lendrem, B. C., Suklan, J., Green, K., Graziadio, S., Buckle, P., Dark, P. M., Gordon, A. L., Lasserson, D. S., Nicholson, B., Price, D. A., Reynard, C., Wilcox, M. H., Prestwich, G., Tate, V., Clark, T. W., Reddy, R. V., Body, R., & Allen, A. J. FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study

Background: Point-of-care (POC) tests for COVID-19 could relieve pressure on isolation resource, support infection prevention and control, and help commence more timely and appropriate treatment. We aimed to undertake a systematic review and pooled d... Read More about FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study.

Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential (2021)
Journal Article
Farrash, W. F., Phillips, B. E., Britton, S. L., Qi, N., Koch, L. G., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2021). Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential. Frontiers in Endocrinology, 12, 1-10. https://doi.org/10.3389/fendo.2021.645881

Introduction: Assuming myokines underlie some of the health benefits of exercise, we hypothesised that ‘high responder trainer’ (HRT) rats would exhibit distinct myokine profiles to ‘low responder trainers’ (LRT), reflecting distinct health and adapt... Read More about Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential.

HEARTS, minds and souls—it is time for geriatricians to bring more to continence management (2021)
Journal Article
Schlögl, M., & Gordon, A. (2021). HEARTS, minds and souls—it is time for geriatricians to bring more to continence management. Age and Ageing, 50(5), 1508-1511. https://doi.org/10.1093/ageing/afab088

Urinary incontinence (UI), the involuntary loss of urine, is a common health condition that may decrease the quality of life and which increases in incidence and prevalence with age. Recent epidemiologic data suggest an overall prevalence of 38% in w... Read More about HEARTS, minds and souls—it is time for geriatricians to bring more to continence management.

The physiological impact of high‐intensity interval training in octogenarians with comorbidities (2021)
Journal Article
Blackwell, J. E., Gharahdaghi, N., Brook, M. S., Watanabe, S., Boereboom, C. L., Doleman, B., Lund, J. N., Wilkinson, D. J., Smith, K., Atherton, P. J., Williams, J. P., & Phillips, B. E. (2021). The physiological impact of high‐intensity interval training in octogenarians with comorbidities. Journal of Cachexia, Sarcopenia and Muscle, 12(4), 866-879. https://doi.org/10.1002/jcsm.12724

Background
Declines in cardiorespiratory fitness (CRF) and fat-free mass (FFM) with age are linked to mortality, morbidity and poor quality of life. High-intensity interval training (HIIT) has been shown to improve CRF and FFM in many groups, but it... Read More about The physiological impact of high‐intensity interval training in octogenarians with comorbidities.

Diagnostic accuracy of the Dysphagia Trained Nurse Assessment tool in acute stroke (2021)
Journal Article
Benfield, J. K., Wilkinson, G., Everton, L. F., Bath, P. M., & England, T. J. (2021). Diagnostic accuracy of the Dysphagia Trained Nurse Assessment tool in acute stroke. European Journal of Neurology, 28(8), 2766-2774. https://doi.org/10.1111/ene.14900

Background and purpose
Comprehensive swallow screening assessments to identify dysphagia and make early eating and drinking recommendations can be used by trained nurses. This study aimed to validate the Dysphagia Trained Nurse Assessment (DTNAx) to... Read More about Diagnostic accuracy of the Dysphagia Trained Nurse Assessment tool in acute stroke.

A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo (2021)
Journal Article
Civil, R., Brook, M. S., Elliott-Sale, K. J., Santos, L., Varley, I., Lensu, S., Kainulainen, H., Koch, L. G., Britton, S. L., Wilkinson, D. J., Smith, K., Sale, C., & Atherton, P. J. (2021). A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo. Physiological Reports, 9(10), Article e14799. https://doi.org/10.14814/phy2.14799

The development of safe and practical strategies to prevent weakening of bone tissue is vital, yet attempts to achieve this have been hindered by a lack of understanding of the short-term (days-weeks) physiology of bone collagen turnover. To address... Read More about A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo.

Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach (2021)
Journal Article
Cegielski, J., Wilkinson, D. J., Brook, M. S., Boereboom, C., Phillips, B. E., Gladman, J. F. R., Smith, K., & Atherton, P. J. (2021). Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach. GeroScience, 43(6), 2653-2665. https://doi.org/10.1007/s11357-021-00386-2

Optimising approaches for measuring skeletal muscle mass and turnover that are widely applicable, minimally invasive and cost effective is crucial in furthering research into sarcopenia and cachexia. Traditional approaches for measurement of muscle p... Read More about Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach.

Childhood pet ownership and multiple sclerosis: A systematic review and meta-analysis (2021)
Journal Article
Edwards, L., & Tench, C. (2021). Childhood pet ownership and multiple sclerosis: A systematic review and meta-analysis. Multiple Sclerosis and Related Disorders, 53, Article 103046. https://doi.org/10.1016/j.msard.2021.103046

Background

Many studies have been conducted investigating a range of environmental factors which have been implicated in the pathogenesis of multiple sclerosis (MS). We collated available data about exposure to domestic animals before symptom onse... Read More about Childhood pet ownership and multiple sclerosis: A systematic review and meta-analysis.

Optimal management of older people with frailty non-weight bearing after lower limb fracture: a scoping review (2021)
Journal Article
Aloraibi, S., Booth, V., Robinson, K., Lunt, E. K., Godfrey, D., Caswell, A., Kerr, M., Ollivere, B., Gordon, A. L., & Gladman, J. (2021). Optimal management of older people with frailty non-weight bearing after lower limb fracture: a scoping review. Age and Ageing, 50(4), 1129–1136. https://doi.org/10.1093/ageing/afab071

Background

Patients with lower limb fractures who are non-weight bearing are at risk of the complications of the associated immobility and disability, particularly people with frailty, but there is lack of clarity about what constitutes optimal ca... Read More about Optimal management of older people with frailty non-weight bearing after lower limb fracture: a scoping review.

Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG) (2021)
Journal Article
Biganzoli, L., Battisti, N. . M. L., Wildiers, H., McCartney, A., Colloca, G., Kunkler, I. H., Cardoso, M. J., Cheung, K. L., de Glas, N. A., Trimboli, R. M., Korc-Grodzicki, B., Soto-Perez-de-Celis, E., Ponti, A., Tsang, J., Marotti, L., Benn, K., Aapro, M. S., & Brain, E. G. (2021). Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG). Lancet Oncology, 22(7), e327-e340. https://doi.org/10.1016/S1470-2045%2820%2930741-5

Breast cancer is increasingly prevalent in older adults and is a substantial part of routine oncology practice. However, management of breast cancer in this population is challenging because the disease is highly heterogeneous and there is insufficie... Read More about Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).

COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice? (2021)
Journal Article
Buckle, P., Micocci, M., Tulloch, J., Kierkegaard, P., Parvulescu, P., Thompson, C., Spilsbury, K., Allen, A. J., Body, R., Hayward, G., Buchan, I., & Gordon, A. L. (2021). COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice?. Age and Ageing, 50(5), 1442-1444. https://doi.org/10.1093/ageing/afab101

COVID-19 has devastated care homes. Point of care tests (POCTs), mainly using Lateral Flow Devices (LFDs), have been deployed hurriedly without much consideration of their usability or impact on care workflow. Even after the pandemic POCTs, particula... Read More about COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice?.

Lower risk of hospitalization for heart failure, kidney disease and death with sodium-glucose co-transporter-2 inhibitors compared with dipeptidyl peptidase-4 inhibitors in type 2 diabetes regardless of prior cardiovascular or kidney disease: A retrospective cohort study in UK primary care (2021)
Journal Article
Idris, I., Zhang, R., Mamza, J. B., Ford, M., Morris, T., Banerjee, A., Khunti, K., Tulip, J., & Greener, M. (2021). Lower risk of hospitalization for heart failure, kidney disease and death with sodium-glucose co-transporter-2 inhibitors compared with dipeptidyl peptidase-4 inhibitors in type 2 diabetes regardless of prior cardiovascular or kidney disease: A retrospective cohort study in UK primary care. Diabetes, Obesity and Metabolism, 23(10), 2207-2214. https://doi.org/10.1111/dom.14437

Aim: To assess if sodium-glucose co-transporter-2 inhibitors (SGLT2is) reduce the risk of all-cause mortality, cardiovascular death and hospitalization for heart failure (HF) or chronic kidney disease (CKD) to a greater extent than dipeptidyl peptida... Read More about Lower risk of hospitalization for heart failure, kidney disease and death with sodium-glucose co-transporter-2 inhibitors compared with dipeptidyl peptidase-4 inhibitors in type 2 diabetes regardless of prior cardiovascular or kidney disease: A retrospective cohort study in UK primary care.

Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer (2021)
Journal Article
Ring, A., Battisti, N. M. L., Reed, M. W. R., Herbert, E., Morgan, J. L., Bradburn, M., Walters, S. J., Collins, K. A., Ward, S. E., Holmes, G. R., Burton, M., Lifford, K., Edwards, A., Robinson, T. G., Martin, C., Chater, T., Pemberton, K. J., Brennan, A., Cheung, K. L., Todd, A., …on behalf of the Age Gap TMG. (2021). Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer. British Journal of Cancer, 125, 209-219. https://doi.org/10.1038/s41416-021-01388-9

Background: Chemotherapy improves outcomes for high risk early breast cancer (EBC) patients but is infrequently offered to older individuals. This study determined if there are fit older patients with high-risk disease who may benefit from chemothera... Read More about Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer.