Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline

Shur, N. F.; Creedon, L.; Skirrow, S.; Atherton, P. J.; MacDonald, I. A.; Lund, J.; Greenhaff, P. L.

doi:10.1016/j.arr.2021.101344

FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study (2021)
Preprint / Working Paper
Urwin, S. G., Lendrem, B. C., Suklan, J., Green, K., Graziadio, S., Buckle, P., Dark, P. M., Gordon, A. L., Lasserson, D. S., Nicholson, B., Price, D. A., Reynard, C., Wilcox, M. H., Prestwich, G., Tate, V., Clark, T. W., Reddy, R. V., Body, R., & Allen, A. J. FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study

Background: Point-of-care (POC) tests for COVID-19 could relieve pressure on isolation resource, support infection prevention and control, and help commence more timely and appropriate treatment. We aimed to undertake a systematic review and pooled d... Read More about FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study.

HEARTS, minds and souls—it is time for geriatricians to bring more to continence management (2021)
Journal Article
Schlögl, M., & Gordon, A. (2021). HEARTS, minds and souls—it is time for geriatricians to bring more to continence management. Age and Ageing, 50(5), 1508-1511. https://doi.org/10.1093/ageing/afab088

Urinary incontinence (UI), the involuntary loss of urine, is a common health condition that may decrease the quality of life and which increases in incidence and prevalence with age. Recent epidemiologic data suggest an overall prevalence of 38% in w... Read More about HEARTS, minds and souls—it is time for geriatricians to bring more to continence management.

Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential (2021)
Journal Article
Farrash, W. F., Phillips, B. E., Britton, S. L., Qi, N., Koch, L. G., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2021). Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential. Frontiers in Endocrinology, 12, 1-10. https://doi.org/10.3389/fendo.2021.645881

Introduction: Assuming myokines underlie some of the health benefits of exercise, we hypothesised that ‘high responder trainer’ (HRT) rats would exhibit distinct myokine profiles to ‘low responder trainers’ (LRT), reflecting distinct health and adapt... Read More about Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential.

The physiological impact of high‐intensity interval training in octogenarians with comorbidities (2021)
Journal Article
Blackwell, J. E., Gharahdaghi, N., Brook, M. S., Watanabe, S., Boereboom, C. L., Doleman, B., Lund, J. N., Wilkinson, D. J., Smith, K., Atherton, P. J., Williams, J. P., & Phillips, B. E. (2021). The physiological impact of high‐intensity interval training in octogenarians with comorbidities. Journal of Cachexia, Sarcopenia and Muscle, 12(4), 866-879. https://doi.org/10.1002/jcsm.12724

Background
Declines in cardiorespiratory fitness (CRF) and fat-free mass (FFM) with age are linked to mortality, morbidity and poor quality of life. High-intensity interval training (HIIT) has been shown to improve CRF and FFM in many groups, but it... Read More about The physiological impact of high‐intensity interval training in octogenarians with comorbidities.

Diagnostic accuracy of the Dysphagia Trained Nurse Assessment tool in acute stroke (2021)
Journal Article
Benfield, J. K., Wilkinson, G., Everton, L. F., Bath, P. M., & England, T. J. (2021). Diagnostic accuracy of the Dysphagia Trained Nurse Assessment tool in acute stroke. European Journal of Neurology, 28(8), 2766-2774. https://doi.org/10.1111/ene.14900

Background and purpose
Comprehensive swallow screening assessments to identify dysphagia and make early eating and drinking recommendations can be used by trained nurses. This study aimed to validate the Dysphagia Trained Nurse Assessment (DTNAx) to... Read More about Diagnostic accuracy of the Dysphagia Trained Nurse Assessment tool in acute stroke.

A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo (2021)
Journal Article
Civil, R., Brook, M. S., Elliott-Sale, K. J., Santos, L., Varley, I., Lensu, S., Kainulainen, H., Koch, L. G., Britton, S. L., Wilkinson, D. J., Smith, K., Sale, C., & Atherton, P. J. (2021). A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo. Physiological Reports, 9(10), Article e14799. https://doi.org/10.14814/phy2.14799

Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach (2021)
Journal Article
Cegielski, J., Wilkinson, D. J., Brook, M. S., Boereboom, C., Phillips, B. E., Gladman, J. F. R., Smith, K., & Atherton, P. J. (2021). Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach. GeroScience, 43(6), 2653-2665. https://doi.org/10.1007/s11357-021-00386-2

Optimising approaches for measuring skeletal muscle mass and turnover that are widely applicable, minimally invasive and cost effective is crucial in furthering research into sarcopenia and cachexia. Traditional approaches for measurement of muscle p... Read More about Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach.

Childhood pet ownership and multiple sclerosis: A systematic review and meta-analysis (2021)
Journal Article
Edwards, L., & Tench, C. (2021). Childhood pet ownership and multiple sclerosis: A systematic review and meta-analysis. Multiple Sclerosis and Related Disorders, 53, Article 103046. https://doi.org/10.1016/j.msard.2021.103046

Background

Many studies have been conducted investigating a range of environmental factors which have been implicated in the pathogenesis of multiple sclerosis (MS). We collated available data about exposure to domestic animals before symptom onse... Read More about Childhood pet ownership and multiple sclerosis: A systematic review and meta-analysis.

Optimal management of older people with frailty non-weight bearing after lower limb fracture: a scoping review (2021)
Journal Article
Aloraibi, S., Booth, V., Robinson, K., Lunt, E. K., Godfrey, D., Caswell, A., Kerr, M., Ollivere, B., Gordon, A. L., & Gladman, J. (2021). Optimal management of older people with frailty non-weight bearing after lower limb fracture: a scoping review. Age and Ageing, 50(4), 1129–1136. https://doi.org/10.1093/ageing/afab071

Background

Patients with lower limb fractures who are non-weight bearing are at risk of the complications of the associated immobility and disability, particularly people with frailty, but there is lack of clarity about what constitutes optimal ca... Read More about Optimal management of older people with frailty non-weight bearing after lower limb fracture: a scoping review.

Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG) (2021)
Journal Article
Biganzoli, L., Battisti, N. . M. L., Wildiers, H., McCartney, A., Colloca, G., Kunkler, I. H., Cardoso, M. J., Cheung, K. L., de Glas, N. A., Trimboli, R. M., Korc-Grodzicki, B., Soto-Perez-de-Celis, E., Ponti, A., Tsang, J., Marotti, L., Benn, K., Aapro, M. S., & Brain, E. G. (2021). Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG). Lancet Oncology, 22(7), e327-e340. https://doi.org/10.1016/S1470-2045%2820%2930741-5

Breast cancer is increasingly prevalent in older adults and is a substantial part of routine oncology practice. However, management of breast cancer in this population is challenging because the disease is highly heterogeneous and there is insufficie... Read More about Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).

COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice? (2021)
Journal Article
Buckle, P., Micocci, M., Tulloch, J., Kierkegaard, P., Parvulescu, P., Thompson, C., Spilsbury, K., Allen, A. J., Body, R., Hayward, G., Buchan, I., & Gordon, A. L. (2021). COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice?. Age and Ageing, 50(5), 1442-1444. https://doi.org/10.1093/ageing/afab101

COVID-19 has devastated care homes. Point of care tests (POCTs), mainly using Lateral Flow Devices (LFDs), have been deployed hurriedly without much consideration of their usability or impact on care workflow. Even after the pandemic POCTs, particula... Read More about COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice?.

Lower risk of hospitalization for heart failure, kidney disease and death with sodium-glucose co-transporter-2 inhibitors compared with dipeptidyl peptidase-4 inhibitors in type 2 diabetes regardless of prior cardiovascular or kidney disease: A retrospective cohort study in UK primary care (2021)
Journal Article
Idris, I., Zhang, R., Mamza, J. B., Ford, M., Morris, T., Banerjee, A., Khunti, K., Tulip, J., & Greener, M. (2021). Lower risk of hospitalization for heart failure, kidney disease and death with sodium-glucose co-transporter-2 inhibitors compared with dipeptidyl peptidase-4 inhibitors in type 2 diabetes regardless of prior cardiovascular or kidney disease: A retrospective cohort study in UK primary care. Diabetes, Obesity and Metabolism, 23(10), 2207-2214. https://doi.org/10.1111/dom.14437

Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer (2021)
Journal Article
Ring, A., Battisti, N. M. L., Reed, M. W. R., Herbert, E., Morgan, J. L., Bradburn, M., Walters, S. J., Collins, K. A., Ward, S. E., Holmes, G. R., Burton, M., Lifford, K., Edwards, A., Robinson, T. G., Martin, C., Chater, T., Pemberton, K. J., Brennan, A., Cheung, K. L., Todd, A., …on behalf of the Age Gap TMG. (2021). Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer. British Journal of Cancer, 125, 209-219. https://doi.org/10.1038/s41416-021-01388-9

Background: Chemotherapy improves outcomes for high risk early breast cancer (EBC) patients but is infrequently offered to older individuals. This study determined if there are fit older patients with high-risk disease who may benefit from chemothera... Read More about Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer.

A pilot of the feasibility and usefulness of an aged obese model for use in stroke research (2021)
Journal Article
Learoyd, A. E., Calmus, R., Cunningham, C. N., England, T. J., Farr, T. D., Fone, K. C., Kendall, D. A., O’Sullivan, S. E., & Trueman, R. C. (2021). A pilot of the feasibility and usefulness of an aged obese model for use in stroke research. Wellcome Open Research, 6, Article 104. https://doi.org/10.12688/wellcomeopenres.16592.1

Background: Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a combined aged and high-fat diet model,... Read More about A pilot of the feasibility and usefulness of an aged obese model for use in stroke research.

Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy (2021)
Journal Article
Ellwood, R. A., Piasecki, M., & Szewczyk, N. J. (2021). Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy. International Journal of Molecular Sciences, 22(9), Article 4891. https://doi.org/10.3390/ijms22094891

The nematode worm Caenorhabditis elegans has been used extensively to enhance our understanding of the human neuromuscular disorder Duchenne Muscular Dystrophy (DMD). With new arising clinically relevant models, technologies and treatments, there is... Read More about Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy.

Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy (2021)
Journal Article
Hardy, E., Inns, T., Wilkinson, D., Piasecki, M., Atherton, P., Phillips, B., Bass, J. J., Morris, R., Spicer, A., Sale, C., & Smith, K. (2021). Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy. Frontiers in Psychology, 12, Article 653060. https://doi.org/10.3389/fphys.2021.653060

Objective: Disuse atrophy (DA) describes inactivity-induced skeletal muscle loss, through incompletely defined mechanisms. An intriguing observation is that individual muscles exhibit differing degrees of atrophy, despite exhibiting similar anatomica... Read More about Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy.

Point of Care Testing using rapid automated Antigen Testing for SARS- COV-2 in Care Homes -an exploratory safety, usability and diagnostic agreement evaluation (2021)
Preprint / Working Paper
Micocci, M., Buckle, P., Hayward, G., Allen, A. J., Davies, K., Kierkegaard, P., Spilsbury, K., Thompson, C., Astle, A., Heath, R., Sharpe, C., Akrill, C., Lasserson, D., Perera, R., Body, R., & Gordon, A. L. Point of Care Testing using rapid automated Antigen Testing for SARS- COV-2 in Care Homes -an exploratory safety, usability and diagnostic agreement evaluation

Is point-of-care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of a point-of-care polymerase chain reaction test for SARS-CoV-2 (2021)
Journal Article
Micocci, M., Gordon, A. L., Kelly Seo, M., Joy Allen, A., Davies, K., Hayward, G., Lasserson, D., Thompson, C., Spilsbury, K., Akrill, C., Heath, R., Astle, A., Perera, R., Sharpe, C., & Buckle, P. (2021). Is point-of-care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of a point-of-care polymerase chain reaction test for SARS-CoV-2. Age and Ageing, 50(5), 1464-1472. https://doi.org/10.1093/ageing/afab072

Introduction:
Reliable rapid testing for COVID-19 is needed in care homes to reduce the risk of outbreaks and enable timely care. This study aimed to examine the usability and test performance of a point of care polymerase chain reaction (PCR) test... Read More about Is point-of-care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of a point-of-care polymerase chain reaction test for SARS-CoV-2.

Feeding during neonatal therapeutic hypothermia, assessed using routinely collected National Neonatal Research Database data: a retrospective, UK population-based cohort study (2021)
Journal Article
Gale, C., Longford, N. T., Jeyakumaran, D., Ougham, K., Battersby, C., Ojha, S., & Dorling, J. (2021). Feeding during neonatal therapeutic hypothermia, assessed using routinely collected National Neonatal Research Database data: a retrospective, UK population-based cohort study. Lancet Child and Adolescent Health, 5(6), 408-416. https://doi.org/10.1016/S2352-4642%2821%2900026-2

Background: Therapeutic hypothermia is standard of care in high-income countries for babies born with signs of hypoxic ischaemic encephalopathy, but optimal feeding during treatment is uncertain and practice is variable. This study aimed to assess th... Read More about Feeding during neonatal therapeutic hypothermia, assessed using routinely collected National Neonatal Research Database data: a retrospective, UK population-based cohort study.

Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline (2021)
Journal Article
Shur, N. F., Creedon, L., Skirrow, S., Atherton, P. J., MacDonald, I. A., Lund, J., & Greenhaff, P. L. (2021). Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline. Ageing Research Reviews, 68, Article 101344. https://doi.org/10.1016/j.arr.2021.101344

In the United Kingdom (UK), it is projected that by 2035 people aged >65 years will make up 23 % of the population, with those aged >85 years accounting for 5% of the total population. Ageing is associated with progressive changes in muscle metabolis... Read More about Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline.

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