All Outputs (553)

Development of an Early Warning Track and Trigger system for preterm or low-birth weight infants in a low resource setting: results of a mixed-methods study at a national referral hospital in Kenya (2020)
Journal Article
Mitchell, E., Qureshi, Z., Were, F., Daniels, J., Gwako, G., Osoti, A., …Ojha, S. (2020). Development of an Early Warning Track and Trigger system for preterm or low-birth weight infants in a low resource setting: results of a mixed-methods study at a national referral hospital in Kenya. BMJ Global Health, 10(10), Article e039061. https://doi.org/10.1136/bmjopen-2020-039061

Introduction: Fifteen million babies are born prematurely, before 37 weeks gestational age, globally. More than 80% of these are in sub-Saharan Africa and Asia. 35% of all deaths in the first month of life are due to prematurity and the neonatal mort... Read More about Development of an Early Warning Track and Trigger system for preterm or low-birth weight infants in a low resource setting: results of a mixed-methods study at a national referral hospital in Kenya.

Feasibility of using an Early Warning Score for preterm or low birthweight infants in a low-resource setting: Results of a mixed-methods study at a national referral hospital in Kenya (2020)
Journal Article
Mitchell, E. J., Qureshi, Z., Were, F., Daniels, J., Gwako, G., Osoti, A., …Ojha, S. (2020). Feasibility of using an Early Warning Score for preterm or low birthweight infants in a low-resource setting: Results of a mixed-methods study at a national referral hospital in Kenya. BMJ Open, 10(10), Article e039061. https://doi.org/10.1136/bmjopen-2020-039061

© 2020 BMJ Publishing Group. All rights reserved. Introduction Fifteen million babies are born prematurely, before 37 weeks gestational age, globally. More than 80% of these are in sub-Saharan Africa and Asia. 35% of all deaths in the first month o... Read More about Feasibility of using an Early Warning Score for preterm or low birthweight infants in a low-resource setting: Results of a mixed-methods study at a national referral hospital in Kenya.

The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer (2020)
Journal Article
Chan, W. L., Ma, T., Cheung, K. L., Choi, H., Wong, J., Lam, K. O., …Kwong, D. (2021). The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer. Journal of Geriatric Oncology, 12(4), 557-562. https://doi.org/10.1016/j.jgo.2020.10.013

Introduction: Older patients experience a higher risk of treatment-related toxicity (TRT). The G8 screening tool was developed to separate cancer older patients fit to receive standard treatment from those who are frail and experiencing functional de... Read More about The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer.

Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women: The Age Gap Trial (2020)
Journal Article
Todd, A., Martin, C., Morgan, J., Herbert, E., Bradburn, M., Burton, M., …Wyld, L. (2021). Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women: The Age Gap Trial. Journal of Geriatric Oncology, 12(5), 714-723. https://doi.org/10.1016/j.jgo.2020.10.015

Introduction Recruitment and retention are two of the most important factors in successfully running clinical trials. Many trials encounter problems with both, causing delays or preventing study progress. These issues are greater in older adults and... Read More about Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women: The Age Gap Trial.

Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis (2020)
Journal Article
Hope, C., Reilly, J.-J., Griffiths, G., Lund, J., & Humes, D. (2021). Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis. World Journal of Surgery, 45, 429-442

Background Attrition within surgical training is a challenge. In the USA, attrition rates are as high as 20-26%. The factors predicting attrition are not well known. The aim of this systematic review is to identify factors that influence attrition or... Read More about Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis.

Influence of sex on the age‐related adaptations of neuromuscular function and motor unit properties in elite masters athletes (2020)
Journal Article
Piasecki, J., Inns, T. B., Bass, J. J., Scott, R., Stashuk, D. W., Phillips, B. E., …Piasecki, M. (2021). Influence of sex on the age‐related adaptations of neuromuscular function and motor unit properties in elite masters athletes. Journal of Physiology, 599(1), 193-205. https://doi.org/10.1113/jp280679

Motor unit (MU) remodelling acts to minimise loss of muscle fibres following denervation in older age, which may be more successful in masters athletes. Evidence suggests performance and neuromuscular function decline with age in this population, alt... Read More about Influence of sex on the age‐related adaptations of neuromuscular function and motor unit properties in elite masters athletes.

Ion channels as therapeutic targets in high grade gliomas (2020)
Journal Article
Griffin, M., Khan, R., Basu, S., & Smith, S. (2020). Ion channels as therapeutic targets in high grade gliomas. Cancers, 12(10), Article 3068. https://doi.org/10.3390/cancers12103068

Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15 months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS cancer-related death in children and adults due to the aggressive nature of t... Read More about Ion channels as therapeutic targets in high grade gliomas.

Ion channels as therapeutic targets in high grade gliomas (2020)
Journal Article
Smith, S., Griffin, M., & Khan, R. (2020). Ion channels as therapeutic targets in high grade gliomas. Cancers, 12(10), Article 3068. https://doi.org/10.3390/cancers12103068

Abstract: Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15 months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS cancer-related death in children and adults due to the aggressive n... Read More about Ion channels as therapeutic targets in high grade gliomas.

Time-efficient physical activity interventions to reduce blood pressure in older adults: a randomized controlled trial (2020)
Journal Article
Herrod, P., Lund, J., & Phillips, B. (2021). Time-efficient physical activity interventions to reduce blood pressure in older adults: a randomized controlled trial. Age and Ageing, 50(3), 980-984. https://doi.org/10.1093/ageing/afaa211

Background Hypertension is a risk factor for both cardiovascular and cerebrovascular disease, with an increasing incidence with advancing patient age. Exercise interventions have the potential to reduce blood pressure in older adults, however, rates... Read More about Time-efficient physical activity interventions to reduce blood pressure in older adults: a randomized controlled trial.

Improving the Quality of Care in Care Homes Using the Quality Improvement Collaborative Approach: Lessons Learnt from Six Projects Conducted in the UK and The Netherlands (2020)
Journal Article
Devi, R., Martin, G., Banerjee, J., Butler, L., Pattison, T., Cruickshank, L., …Gordon, A. L. (2020). Improving the Quality of Care in Care Homes Using the Quality Improvement Collaborative Approach: Lessons Learnt from Six Projects Conducted in the UK and The Netherlands. International Journal of Environmental Research and Public Health, 17(20), Article 7601. https://doi.org/10.3390/ijerph17207601

The Breakthrough Series Quality Improvement Collaborative (QIC) initiative is a well-developed and widely used approach, but most of what we know about it has come from healthcare settings. In this article, those leading QICs to improve care in care... Read More about Improving the Quality of Care in Care Homes Using the Quality Improvement Collaborative Approach: Lessons Learnt from Six Projects Conducted in the UK and The Netherlands.

Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age (2020)
Journal Article
Sayda, M. H., Phillips, B. E., Williams, J. P., Greenhaff, P. L., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2020). Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age. Nutrients, 12(10), Article 3029. https://doi.org/10.3390/nu12103029

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support and regulation of tissue protein regulation and also as energy substrates. However, p... Read More about Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age.

Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer (2020)
Journal Article
Morgan, J. L., Holmes, G., Ward, S., Martin, C., Burton, M., Walters, S. J., …Parmeshwar, R. (2021). Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer. EJSO - European Journal of Surgical Oncology, 47(2), 261-268. https://doi.org/10.1016/j.ejso.2020.09.029

© 2020 The Authors Background: In the UK there is variation in the treatment of older women with breast cancer, with up to 40% receiving primary endocrine therapy (PET), which is associated with inferior survival. Case mix and patient choice may expl... Read More about Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer.

Symptom-burden in people living with frailty and chronic kidney disease (2020)
Journal Article
Nixon, A. C., Wilkinson, T. J., Young, H. M. L., Taal, M. W., Pendleton, N., Mitra, S., …Smith, A. C. (2020). Symptom-burden in people living with frailty and chronic kidney disease. BMC Nephrology, 21, Article 411. https://doi.org/10.1186/s12882-020-02063-6

Background: Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This... Read More about Symptom-burden in people living with frailty and chronic kidney disease.

The care of older cancer patients in the United Kingdom (2020)
Journal Article
Gomes, F., Lewis, A., Morris, R., Parks, R., Kalsi, T., Babic-Illamn, G., …Simcock, R. (2020). The care of older cancer patients in the United Kingdom. ecancermedicalscience, 14, Article 1101. https://doi.org/10.3332/ECANCER.2020.1101

The ageing population poses new challenges globally. Cancer care for older patients is one of these challenges, and it has a significant impact on societies. In the United Kingdom (UK), as the number of older cancer patients increases, the management... Read More about The care of older cancer patients in the United Kingdom.

Seeking Answers for Care Homes during the COVID-19 pandemic (COVID SEARCH) (2020)
Journal Article
Spilsbury, K., Devi, R., Griffiths, A., Akrill, C., Astle, A., Goodman, C., …Thompson, C. (2021). Seeking Answers for Care Homes during the COVID-19 pandemic (COVID SEARCH). Age and Ageing, 50(2), 335–340. https://doi.org/10.1093/ageing/afaa201

The care and support of older people residing in long-term care facilities during the COVID-19 pandemic has created new and unanticipated uncertainties for staff. In this short report, we present our analyses of the uncertainties of care home manager... Read More about Seeking Answers for Care Homes during the COVID-19 pandemic (COVID SEARCH).

Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease (2020)
Journal Article
Viramontes-Hörner, D., & Taal, M. W. (2020). Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease. Current Opinion in Nephrology and Hypertension, 29(6), 547-554. https://doi.org/10.1097/MNH.0000000000000651

Purpose of review: Malnutrition is a frequent complication and risk factor for adverse outcomes in the dialysis population that is often underrecognized and neglected. This article reviews published literature on the associations between malnutrition... Read More about Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease.

The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial (2020)
Journal Article
Greenwood, S. A., Koufaki, P., Macdonald, J., Bhandari, S., Burton, J., Dasgupta, I., …Mercer, T. H. (2021). The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial. Clinical Kidney Journal, 14(5), 1345–1355. https://doi.org/10.1093/ckj/sfaa107

Background Exercise interventions designed to improve physical function and reduce sedentary behaviour in haemodialysis (HD) patients might improve exercise capacity, reduce fatigue and lead to improved quality of life (QOL). The PrEscription of int... Read More about The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial.

Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial (2020)
Journal Article
Kang Law, Z., Dineen, R., England, T. J., Cala, L., Mistri, A. K., Appleton, J. P., …TICH-2 investigators. (2021). Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial. Translational Stroke Research, 12, 275-283. https://doi.org/10.1007/s12975-020-00845-6

Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexa... Read More about Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial.

Quality improvement in long-term care settings: a scoping review of effective strategies used in care homes (2020)
Journal Article
Chadborn, N. H., Devi, R., Hinsliff-Smith, K., Banerjee, J., & Gordon, A. L. (2021). Quality improvement in long-term care settings: a scoping review of effective strategies used in care homes. European Geriatric Medicine, 12, 17-26. https://doi.org/10.1007/s41999-020-00389-w

Purpose We conducted a scoping review of quality improvement in care homes. We aimed to identify participating occupational groups and methods for evaluation. Secondly, we aimed to describe resident-level interventions and which outcomes were measur... Read More about Quality improvement in long-term care settings: a scoping review of effective strategies used in care homes.

Development of a Malaysian Undergraduate Geriatric Medicine Curriculum (2020)
Journal Article
Sallehuddin, H., Tan, M. P., Blundell, A., Gordon, A. L., & Masud, T. (2020). Development of a Malaysian Undergraduate Geriatric Medicine Curriculum. Aging Medicine and Healthcare, 11(3), 82-88. https://doi.org/10.33879/AMH.113.2020.05015

Objective: Malaysia is only beginning to age in 2020, but is expected to do this at an unprecedented rate in the next two decades. We aim to develop a national curriculum for undergraduate geriatric medicine in Malaysia to ensure future doctors are a... Read More about Development of a Malaysian Undergraduate Geriatric Medicine Curriculum.