All Outputs (547)

A practical guide to implementing a successful social media recruitment strategy: lessons from the Eczema Monitoring Online trial (2022)
Journal Article
Baker, A., Mitchell, E. J., & Thomas, K. S. (2022). A practical guide to implementing a successful social media recruitment strategy: lessons from the Eczema Monitoring Online trial. Trials, 23, Article 905. https://doi.org/10.1186/s13063-022-06839-z

Background: Participant recruitment into clinical trials remains challenging. The global increase in the number of social media users has accelerated the use of social media as a modality of recruitment, particularly during the COVID-19 pandemic when... Read More about A practical guide to implementing a successful social media recruitment strategy: lessons from the Eczema Monitoring Online trial.

Postprandial Responses to a Standardised Meal in Hypertension: The Mediatory Role of Visceral Fat Mass (2022)
Journal Article
Louca, P., Berry, S. E., Bermingham, K., Franks, P. W., Wolf, J., Spector, T. D., …Menni, C. (2022). Postprandial Responses to a Standardised Meal in Hypertension: The Mediatory Role of Visceral Fat Mass. Nutrients, 14(21), Article 4499. https://doi.org/10.3390/nu14214499

Postprandial insulinaemia, triglyceridaemia and measures of inflammation are thought to be more closely associated with cardiovascular risk than fasting measures. Although hypertension is associated with altered fasting metabolism, it is unknown as t... Read More about Postprandial Responses to a Standardised Meal in Hypertension: The Mediatory Role of Visceral Fat Mass.

Is vaccination against COVID-19 associated with psoriasis or eczema flare? Self-controlled case series analysis using data from the Clinical Practice Research Datalink (Aurum) (2022)
Journal Article
Adams, L., Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Van-Tam, J. S., …Abhishek, A. (2022). Is vaccination against COVID-19 associated with psoriasis or eczema flare? Self-controlled case series analysis using data from the Clinical Practice Research Datalink (Aurum). British Journal of Dermatology, 188(2), 297-299. https://doi.org/10.1093/bjd/ljac061

How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals (2022)
Journal Article
Moledina, Z., McPhee, M., Ravenscroft, J. C., Healy, E., Radley, K., Thomas, K. S., …Acne -ID Trial Development Team. (2023). How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals. Clinical and Experimental Dermatology, 48(1), 20-23. https://doi.org/10.1093/ced/llac015

We undertook a survey of UK healthcare professionals through the UKDCTN and BDNG to understand clinicians’ routine practice prescribing oral isotretinoin for treatment of acne vulgaris (acne). We also wanted to understand clinicians’ experiences and... Read More about How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals.

Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study (2022)
Journal Article
Bermingham, K. M., Linenberg, I., Hall, W. L., Kadé, K., Franks, P. W., Davies, R., …Berry, S. E. (2022). Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study. EBioMedicine, 85, Article 104303. https://doi.org/10.1016/j.ebiom.2022.104303

Background: The menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood.

Methods: The PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=5... Read More about Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study.

Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice: A Consensus Statement from the Harmonising Outcome Measures for Eczema in Clinical Practice (HOME-CP) Initiative (2022)
Journal Article
Leshem, Y. A., Chalmers, J. R., Apfelbacher, C., Katoh, N., Gerbens, L. A., Schmitt, J., …Simpson, E. L. (2022). Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice: A Consensus Statement from the Harmonising Outcome Measures for Eczema in Clinical Practice (HOME-CP) Initiative. JAMA Dermatology, 158(12), 1429-1435. https://doi.org/10.1001/jamadermatol.2022.4211

Importance: Measuring outcomes in clinical practice can aid patient care, quality improvement, and real-world evidence generation. The Harmonising Outcome Measures for Eczema (HOME) Clinical Practice initiative is developing a list of validated, feas... Read More about Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice: A Consensus Statement from the Harmonising Outcome Measures for Eczema in Clinical Practice (HOME-CP) Initiative.

International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia (2022)
Journal Article
Kundakci, B., Hall, M., Atzeni, F., Branco, J. C., Buskila, D., Clauw, D., …Taylor, A. M. (2022). International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia. Seminars in Arthritis and Rheumatism, 57, Article 152101. https://doi.org/10.1016/j.semarthrit.2022.152101

Objectives: To develop evidence-based expert recommendations for non-pharmacological treatments for pain, fatigue, sleep problems, and depression in fibromyalgia. Methods: An international, multidisciplinary Delphi exercise was conducted. Authors of... Read More about International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia.

Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD) (2022)
Journal Article
Georgopoulos, V., Smith, S., McWilliams, D. F., Steultjens, M. P. M., Williams, A., Price, A., …Walsh, D. A. (2023). Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD). Osteoarthritis and Cartilage, 31(1), 83-95. https://doi.org/10.1016/j.joca.2022.08.011

Objective: In order to facilitate data pooling between studies, we explored harmonisation of patient-reported outcome measures (PROMs) in people with knee pain due to osteoarthritis or knee trauma, using the Patient Acceptable Symptom State scores (P... Read More about Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD).

Return to performance following severe ankle, knee, and hip injuries in National Basketball Association players (2022)
Journal Article
Bullock, G. S., Ferguson, T., Arundale, A. H., Martin, C. L., Collins, G. S., & Kluzek, S. (2022). Return to performance following severe ankle, knee, and hip injuries in National Basketball Association players. PNAS Nexus, 1(4), Article pgac176. https://doi.org/10.1093/pnasnexus/pgac176

The purpose of this study was to compare basketball performancemarkers 1 y prior to initial severe lower extremity injury, including ankle, knee, and hip injuries, to 1 and 2 y following injury during the regular National Basketball Association (NBA)... Read More about Return to performance following severe ankle, knee, and hip injuries in National Basketball Association players.

Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic (2022)
Journal Article
Fuller, A., Hancox, J., Vedhara, K., Card, T., Mallen, C., Van-Tam, J. S. N., & Abhishek, A. (2022). Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic. PLoS ONE, 17(9), Article e0267769. https://doi.org/10.1371/journal.pone.0267769

Objectives To explore barriers and facilitators to COVID-19, influenza, and pneumococcal vaccine uptake in immunosuppressed adults with immune-mediated inflammatory diseases (IMIDs). Methods Recruiting through national patient charities and a local h... Read More about Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic.

Is routine laboratory testing in healthy young patients taking isotretinoin necessary – a critically appraised topic (2022)
Journal Article
Affleck, A., Jackson, D., Williams, H. C., Chavez, P., & Albrecht, J. (2022). Is routine laboratory testing in healthy young patients taking isotretinoin necessary – a critically appraised topic. British Journal of Dermatology, 187(6), 857-865. https://doi.org/10.1111/bjd.21840

Clinical question: Is monitoring of liver function, lipids and full blood count necessary in healthy people taking isotretinoin?

Background: Routine blood testing was recommended in the original licence for Roaccutane™ (isotretinoin) in 1983. In r... Read More about Is routine laboratory testing in healthy young patients taking isotretinoin necessary – a critically appraised topic.

Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study (2022)
Journal Article
Kurien, T., Kerslake, R. W., Graven‐Nielsen, T., Arendt‐Nielsen, L., Auer, D. P., Edwards, K., …Petersen, K. K. (2022). Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study. European Journal of Pain, 26(9), 1979-1989. https://doi.org/10.1002/ejp.2018

Background: A subset of osteoarthritis patients will experience chronic postoperative pain after total knee arthroplasty (TKA), but the source of pain is unclear. The aim of this exploratory study was to assess patients with and without postoperative... Read More about Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study.

Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review (2022)
Journal Article
Jones, R., Paul, L., Steultjens, M., & Smith, S. L. (2022). Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2791-2806. https://doi.org/10.1002/jcsm.13064

Lower limb muscle dysfunction is a key driver for impaired physical capacity and frailty status, both characteristics of sarcopenia. Sarcopenia is the key pathway between frailty and disability. Identifying biological markers for early diagnosis, tre... Read More about Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review.

Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon (2022)
Journal Article
Dickson, D. M., Smith, S. L., & Hendry, G. J. (2022). Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon. Rheumatology International, 42(12), 2241-2251. https://doi.org/10.1007/s00296-022-05184-3

An advanced ultrasound imaging technique, sonoelastography (SE) is used to evaluate tissue elasticity. To determine SE potential to detect pathological-related changes, and characteristics related to tendon pathology we aimed to (1) compare quadricep... Read More about Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon.

Association between Gout Flare and Subsequent Cardiovascular Events among Patients with Gout (2022)
Journal Article
Cipolletta, E., Tata, L. J., Nakafero, G., Avery, A. J., Mamas, M. A., & Abhishek, A. (2022). Association between Gout Flare and Subsequent Cardiovascular Events among Patients with Gout. Journal of the American Medical Association, 328(5), 440-450. https://doi.org/10.1001/jama.2022.11390

Importance: Gout is associated with cardiovascular diseases. The temporal association between gout flares and cardiovascular events has not been investigated. Objective: To investigate whether there is a transient increase in risk of cardiovascular e... Read More about Association between Gout Flare and Subsequent Cardiovascular Events among Patients with Gout.

Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation (2022)
Journal Article
Leighton, P. A., Dias, J., & Brearley, S. (2022). Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation. Bone & Joint Open, 3(8), 641-647. https://doi.org/10.1302/2633-1462.38.BJO-2022-0042.R1

Aims To explore individuals’ experience of a scaphoid waist fracture and its subsequent treatment. Methods A purposive sample was created, consisting of 49 participants in the Scaphoid Waist Internal Fixation for Fractures Trial of initial surgery co... Read More about Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation.

Response to Comment on: “Black Box Prediction Methods in Sports Medicine Deserve a Red Card for Reckless Practice: A Change of Tactics is Needed to Advance Athlete Care” (2022)
Journal Article
Bullock, G. S., Hughes, T., Arundale, A. H., Ward, P., Collins, G. S., & Kluzek, S. (2022). Response to Comment on: “Black Box Prediction Methods in Sports Medicine Deserve a Red Card for Reckless Practice: A Change of Tactics is Needed to Advance Athlete Care”. Sports Medicine, 52, 2799-2801. https://doi.org/10.1007/s40279-022-01737-5

Content validity of the Recap of atopic eczema (RECAP) instrument in Dutch, English and German to measure eczema control in young people with atopic eczema: a cognitive interview study (2022)
Journal Article
Gabes, M., Ragamin, A., Baker, A., Kann, G., Donhauser, T., Gabes, D., …Apfelbacher, C. (2022). Content validity of the Recap of atopic eczema (RECAP) instrument in Dutch, English and German to measure eczema control in young people with atopic eczema: a cognitive interview study. British Journal of Dermatology, 187(6), 919-926. https://doi.org/10.1111/bjd.21767

Background: Recap of atopic eczema (RECAP) is a patient-reported outcome measure assessing eczema control. This instrument has been developed and validated in the UK. There are self-reported and proxy-reported versions in English, Dutch and German. H... Read More about Content validity of the Recap of atopic eczema (RECAP) instrument in Dutch, English and German to measure eczema control in young people with atopic eczema: a cognitive interview study.

Development of Food Group Tree-Based Analysis and Its Association with Non-Alcoholic Fatty Liver Disease (NAFLD) and Co-Morbidities in a South Indian Population: A Large Case-Control Study (2022)
Journal Article
Vijay, A., Al-Awadi, A., Chalmers, J., Balakumaran, L., Grove, J. I., Valdes, A. M., Taylor, M. A., Shenoy, K. T., & Aithal, G. P. (2022). Development of Food Group Tree-Based Analysis and Its Association with Non-Alcoholic Fatty Liver Disease (NAFLD) and Co-Morbidities in a South Indian Population: A Large Case-Control Study. Nutrients, 14(14), Article 2808. https://doi.org/10.3390/nu14142808

Background: Non-alcoholic fatty liver disease (NAFLD) is a global problem growing in parallel to the epidemics of obesity and diabetes, with South Asians being particularly susceptible. Nutrition and behaviour are important modifiers of the disease,... Read More about Development of Food Group Tree-Based Analysis and Its Association with Non-Alcoholic Fatty Liver Disease (NAFLD) and Co-Morbidities in a South Indian Population: A Large Case-Control Study.

Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink (2022)
Journal Article
Abhishek, A., Cipolletta, E., Nakafero, G., Avery, A. J., Mamas, M., & Tata, L. J. (2022). Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 81(12), https://doi.org/10.1136/ard-2022-222668