How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals

Moledina, Zahra; McPhee, Margaret; Ravenscroft, Jane C.; Healy, Eugene; Radley, Kathy; Thomas, Kim S.; Burden-Teh, Esther; Acne -ID Trial Development Team

Abstract

We undertook a survey of UK healthcare professionals through the UKDCTN and BDNG to understand clinicians’ routine practice prescribing oral isotretinoin for treatment of acne vulgaris (acne). We also wanted to understand clinicians’ experiences and views on prescribing low daily dose regimens. Overall, the survey showed that clinicians adopted a patient-centred approach when deciding isotretinoin dosing. The rationale for using a low-dose regimen varied, but was focused on patient wellbeing during treatment. Some clinicians were concerned that use of a low-dose regimen could be less effective and lead to longer treatment durations. The survey results will be useful to inform a clinical trial investigating the effectiveness and safety of low daily dose isotretinoin for the treatment of acne.

Citation

Moledina, Z., McPhee, M., Ravenscroft, J. C., Healy, E., Radley, K., Thomas, K. S., …Acne -ID Trial Development Team. (2023). How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals. Clinical and Experimental Dermatology, 48(1), 20-23. https://doi.org/10.1093/ced/llac015

• Journal Article Type: Article
• Acceptance Date: Sep 15, 2022
• Online Publication Date: Oct 20, 2022
• Publication Date: Jan 20, 2023
• Deposit Date: Oct 7, 2022
• Publicly Available Date: Oct 21, 2023
• Journal: Clinical and Experimental Dermatology
• Print ISSN: 0307-6938
• Electronic ISSN: 1365-2230
• Peer Reviewed: Peer Reviewed
• Volume: 48
• Issue: 1
• Pages: 20-23
• DOI: https://doi.org/10.1093/ced/llac015
• Keywords: Dermatology
• Public URL: https://nottingham-repository.worktribe.com/output/12034651
• Publisher URL: https://academic.oup.com/ced/article/48/1/20/6764863
• Additional Information: This is the peer reviewed version of the following article: Zahra Moledina, Margaret McPhee, Jane C Ravenscroft, Eugene Healy, Kathy Radley, Kim S Thomas, Esther Burden-Teh, Acne-ID Trial Development Team, How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals, Clinical and Experimental Dermatology, Volume 48, Issue 1, January 2023, Pages 20–23, which has been published in final form at https://doi.org/10.1093/ced/llac015]. The article must be linked to Wiley’s version of record on Wiley Online Library.