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All Outputs (547)

Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study (2022)
Journal Article
Bates, J., Stanton, H., Cannings-John, R., Thomas, K. S., Leighton, P., Howells, L. M., Rodrigues, J., Howes, R., Collier, F., Harris, C., Gibbons, A., Thomas-Jones, E., Hood, K., & Ingram, J. R. (2022). Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study. BMJ Open, 12(4), Article e060815. https://doi.org/10.1136/bmjopen-2022-060815

Background Hidradenitis suppurativa (HS) is a chronic, painful, inflammatory skin disease with estimates of prevalence in the European population of 1%–2%. Despite being a relatively common condition, the evidence base for management of HS is limited... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study.

Eczema Care Online: development and qualitative optimisation of an online behavioural intervention to support self-management in young people with eczema (2022)
Journal Article
Greenwell, K., Ghio, D., Sivyer, K., Steele, M., Teasdale, E., Ridd, M. J., Roberts, A., Chalmers, J. R., Lawton, S., Langan, S., Cowdell, F., Le Roux, E., Wilczynska, S., Jones, H., Whittaker, E., Williams, H. C., Thomas, K. S., Yardley, L., Santer, M., & Muller, I. (2022). Eczema Care Online: development and qualitative optimisation of an online behavioural intervention to support self-management in young people with eczema. BMJ Open, 12(4), Article e056867. https://doi.org/10.1136/bmjopen-2021-056867

Objectives To describe the development of Eczema Care Online (ECO), an online behaviour change intervention for young people with eczema (phase I); and explore and optimise the acceptability of ECO among this target group using think-aloud interviews... Read More about Eczema Care Online: development and qualitative optimisation of an online behavioural intervention to support self-management in young people with eczema.

Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building (2022)
Journal Article
Layfield, C. P., Williams, H. C., & The UK Dermatology Clinical Trials Network. (2022). Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building. Clinical and Experimental Dermatology, 47(6), 1060-1067. https://doi.org/10.1111/ced.15132

In Part 1 of this 2-part review of the 20th anniversary of the UK Dermatology Clinical Trials Network (UK DCTN), we described its role in developing and supporting clinical trial proposals, elaborating on structure, process and clinical trials activi... Read More about Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 2: education, training and capacity building.

Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries (2022)
Journal Article
Swain, S., Kamps, A., Runhaar, J., Dell ‘Isola, A., Turkiewicz, A., Robinson, D., Strauss, V. Y., Mallen, C., Kuo, C. F., Coupland, C., Doherty, M., Sarmanova, A., Prieto Alhambra, D., Englund, M., Bierma-Zeinstra, S., & Zhang, W. (2022). Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries. BMJ Open, 12(4), Article e052816. https://doi.org/10.1136/bmjopen-2021-052816

Introduction: Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the co... Read More about Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries.

Avoidable research waste in dermatology: what are the solutions? (2022)
Journal Article
Williams, H. C. (2022). Avoidable research waste in dermatology: what are the solutions?. British Journal of Dermatology, 186(4), 599-601. https://doi.org/10.1111/bjd.20755

In the last editorial, I provided examples of research waste in dermatology and suggested that it was due to a system failure rather than just a few “bad apples”. Here, I focus on possible solutions, mainly in relation to clinical trials, building on... Read More about Avoidable research waste in dermatology: what are the solutions?.

Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls (2022)
Journal Article
Espahbodi, S., Fernandes, G., Hogervorst, E., Thanoon, A., Batt, M., Fuller, C. W., Fuller, G., Ferguson, E., Bast, T., Doherty, M., & Zhang, W. (2022). Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls. BMJ Open, 12(4), Article e054371. https://doi.org/10.1136/bmjopen-2021-054371

INTRODUCTION: Professional footballers commonly experience sports-related injury and repetitive microtrauma to the foot and ankle, placing them at risk of subsequent chronic pain and osteoarthritis (OA) of the foot and ankle. Similarly, repeated head... Read More about Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls.

Avoidable research waste in dermatology: what are the solutions? (2022)
Journal Article
Williams, H. C. (2022). Avoidable research waste in dermatology: what are the solutions?. British Journal of Dermatology, 186(4), 599-601. https://doi.org/10.1111/bjd.20755

In the last editorial, I provided examples of research waste in dermatology and suggested that it was due to a system failure rather than just a few “bad apples”. Here, I focus on possible solutions, mainly in relation to clinical trials, building on... Read More about Avoidable research waste in dermatology: what are the solutions?.

The relationship of lower extremity persistent pain and osteoarthritis on running and physical activity in recreational runners: large prospective cohort study (Running Through) (2022)
Presentation / Conference Contribution
Bullock, G. S., Stocks, J., Feakins, B., Bestwick-Stevenson, T., & Kluzek, S. (2022, April). The relationship of lower extremity persistent pain and osteoarthritis on running and physical activity in recreational runners: large prospective cohort study (Running Through). Presented at OARSI 2022 World Congress on Osteoarthritis, Berlin, Germany

Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain (2022)
Presentation / Conference Contribution
Habib, M., Smith, S., Chaplin, W., Millar, B., McWilliams, D., & Walsh, D. Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain. Presented at Osteoarthritis Research Society International (OARSI), Berlin

Purpose: Pain is the primary clinical manifestation in individuals with osteoarthritis (OA). It is an unpleasant and distressing experience, particularly during weight-bearing activities, inhibiting activity, and reducing quality of life. Two groups... Read More about Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain.

The relationship between the significant knee and hip pain and use of non-steroid medication in the middle-aged and elderly UK running population: large cohort study (2022)
Presentation / Conference Contribution
Kluzek, S., Bullock, G. S., Bestwick-Stevenson, T., & Stocks, J. (2022, March). The relationship between the significant knee and hip pain and use of non-steroid medication in the middle-aged and elderly UK running population: large cohort study. Presented at WCO-IOF-ESCEO Congress 2022. World Congress on Osteoporosis, Osteoarthritis and Musculosketal Diseases, Virtual

Objectives Oral anti-inflammatory non-steroidal drugs (NSAID) are used commonly in the general population. Association between knee osteoarthritis (OA) and early cardiovascular mortality is often linked with decreased physical activity. Both running... Read More about The relationship between the significant knee and hip pain and use of non-steroid medication in the middle-aged and elderly UK running population: large cohort study.

The HOME Core outcome set for clinical trials of atopic dermatitis (2022)
Journal Article
Williams, H. C., Schmitt, J., Thomas, K. S., Spuls, P. I., Simpson, E. L., Apfelbacher, C. J., Chalmers, J. R., Furue, M., Katoh, N., Gerbens, L. A., Leshem, Y. A., Howells, L., Singh, J. A., & Boers, M. (2022). The HOME Core outcome set for clinical trials of atopic dermatitis. Journal of Allergy and Clinical Immunology, 149(6), 1899-1911. https://doi.org/10.1016/j.jaci.2022.03.017

Core outcome sets are critically important outcomes that should be measured in clinical trials. Their absence in atopic dermatitis is a form of research waste and impedes combining evidence to inform patient care. Here, we articulate the rationale fo... Read More about The HOME Core outcome set for clinical trials of atopic dermatitis.

HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19 (2022)
Journal Article
Astbury, S., Reynolds, C. J., Butler, D. K., Munoz-Sandoval, D. C., Lin, K.-M., Pieper, F. P., Otter, A., Kouraki, A., Cusin, L., Nightingale, J., Vijay, A., Craxford, S., Aithal, G. P., Tighe, P. J., Gibbons, J. M., Pade, C., Joy, G., Maini, M., Chain, B., Semper, A., …Altmann, D. M. (2022). HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19. Immunology, 166(1), 68-77. https://doi.org/10.1111/imm.13450

SARS-CoV-2 infection results in different outcomes ranging from asymptomatic infection to mild or severe disease and death. Reasons for this diversity of outcome include differences in challenge dose, age, gender, comorbidity and host genomic variati... Read More about HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19.

Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis (2022)
Journal Article
Gwinnutt, J. M., Norton, S., Hyrich, K. L., Lunt, M., Combe, B., Rincheval, N., Ruyssen-Witrand, A., Fautrel, B., McWilliams, D. F., Walsh, D. A., Nikiphorou, E., Kiely, P., Young, A., Chipping, J. R., MacGregor, A., & Verstappen, S. M. (2022). Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis. Rheumatology, 61(12), 4687–4701. https://doi.org/10.1093/rheumatology/keac137

OBJECTIVES: To identify groups of people with RA with different disability trajectories over 10 years, despite comparable levels of inflammation. METHODS: Data for this analysis came from three European prospective cohort studies of people with RA [N... Read More about Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis.

Strategies for using topical corticosteroids in children and adults with eczema (2022)
Journal Article
Lax, S., Harvey, J., Axon, E., Howells, L., Santer, M., Ridd, M., Lawton, S., Langan, S., Roberts, A., Ahmed, A., Muller, I., Ming, L. C., Panda, S., Chernyshov, P., Carter, B., Williams, H., Thomas, K., & Chalmers, J. (2022). Strategies for using topical corticosteroids in children and adults with eczema. Cochrane Database of Systematic Reviews, 3(3), Article CD013356

Background Eczema is a common skin condition. Although topical corticosteroids (TCS) have been a first-line treatment for eczema for decades, there are uncertainties over their optimal use. Objectives To establish the effectiveness and safety of diff... Read More about Strategies for using topical corticosteroids in children and adults with eczema.

Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain (2022)
Journal Article
Gowler, P. R. W., Turnbull, J., Shahtaheri, M., Gohir, S., Kelly, T., McReynolds, C., Yang, J., Jha, R. R., Fernandes, G. S., Zhang, W., Doherty, M., Walsh, D. A., Hammock, B. D., Valdes, A. M., Barrett, D. A., & Chapman, V. (2022). Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain. Arthritis and Rheumatology, 74(4), 623-633. https://doi.org/10.1002/art.42000

Objective: Chronic pain due to osteoarthritis (OA) is a major clinical problem, and existing analgesics often have limited beneficial effects and/or adverse effects, necessitating the development of novel therapies. Epoxyeicosatrienoic acids (EETs) a... Read More about Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain.

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma (2022)
Journal Article
Lee, K. A., Thomas, A. M., Bolte, L. A., Björk, J. R., de Ruijter, L. K., Armanini, F., Asnicar, F., Blanco-Miguez, A., Board, R., Calbet-Llopart, N., Derosa, L., Dhomen, N., Brooks, K., Harland, M., Harries, M., Leeming, E. R., Lorigan, P., Manghi, P., Marais, R., Newton-Bishop, J., …Segata, N. (2022). Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma. Nature Medicine, 28(3), 535-544. https://doi.org/10.1038/s41591-022-01695-5

The composition of the gut microbiome has been associated with clinical responses to immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific microbiome characteristics linked to the clinical benefits of ICIs. We pe... Read More about Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma.

Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics (2022)
Journal Article
Bosma, A. L., Ascott, A., Iskandar, R., Farquhar, K., Matthewman, J., Langendam, M. W., Mulick, A., Abuabara, K., Williams, H. C., Spuls, P. I., Langan, S. M., & Middelkamp-Hup, M. A. (2022). Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics. Journal of the European Academy of Dermatology and Venereology, 36(6), 807-819. https://doi.org/10.1111/jdv.18008

Atopic dermatitis is a heterogeneous disease, accompanied by a wide variation in disease presentation and the potential to identify many phenotypes that may be relevant for prognosis and treatment. We aimed to systematically review previously reporte... Read More about Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.