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All Outputs (547)

Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model (2020)
Journal Article
Gorelick, N. L., Serra, R., Iyer, R., Um, R., Grewal, A., Monroe, A., Antoine, H., Beharry, K., Cecia, A., Kroll, F., Ishida, W., Perdomo-Pantoja, A., Xu, R., Loth, F., Ye, X., Suk, I., Tyler, B., Bayston, R., & Luciano, M. G. (2020). Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model. Neurosurgery, 87(5), 1046-1054. https://doi.org/10.1093/neuros/nyaa203

BACKGROUND

Hydrocephalus is managed by surgically implanting flow-diversion technologies such as differential pressure valves and antisiphoning devices; however, such hardware is prone to failure. Extensive research has tested them in flow-control... Read More about Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model.

Development of dual anti-biofilm and anti-bacterial medical devices (2020)
Journal Article
Burroughs, L., Singh, S., Ashraf, W., Martinez-Pomares, L., Bayston, R., & Hook, A. L. (2020). Development of dual anti-biofilm and anti-bacterial medical devices. Biomaterials Science, 8(14), 3926-3934. https://doi.org/10.1039/d0bm00709a

The rising occurrence of antimicrobial resistance demands new strategies for delivering antibiotics to ensure their effective use. In this study, a multi-functional strategy to address medical device associated infections is explored whereby an anti-... Read More about Development of dual anti-biofilm and anti-bacterial medical devices.

Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial (2020)
Journal Article
Bradshaw, L., Montgomery, A. A., Williams, H. C., Chalmers, J., & Haines, R. (2020). Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial. Trials, 21, Article 529. https://doi.org/10.1186/s13063-020-04373-4

Background
Failure to collect outcome data in randomised trials can result in bias and loss of statistical power. Further evaluations of strategies to increase retention are required. We assessed the effectiveness of two strategies for retention in... Read More about Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial.

Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies (2020)
Journal Article
Swain, S., Sarmanova, A., Coupland, C., Doherty, M., & Zhang, W. (2020). Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies. Arthritis Care and Research, 72(7), 991-1000. https://doi.org/10.1002/acr.24008

Objectives

Osteoarthritis (OA) is a common chronic condition in older people but its association with other chronic conditions is largely unknown. This study aimed to systematically review the literature on comorbidities in people with OA compared... Read More about Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies.

Conservative management of fifth metacarpal head fracture in a professional cricketer: A case study and literature review (2020)
Journal Article
Pandya, T., Dale, S., Donnison, E., & Kluzek, S. (2020). Conservative management of fifth metacarpal head fracture in a professional cricketer: A case study and literature review. Clinical Case Reports, 8(9), 1682-1685. https://doi.org/10.1002/ccr3.2960

Diagnosis of fifth metacarpal head fracture with collateral ligament injuries can be difficult. We present a case of a professional cricketer with a fifth metacarpal head fracture. who played a match before pain made the injury obvious. Following im... Read More about Conservative management of fifth metacarpal head fracture in a professional cricketer: A case study and literature review.

Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats (2020)
Journal Article
Aso, K., Shahtaheri, S. M., Hill, R., Wilson, D., McWilliams, D. F., Nwosu, L. N., Chapman, V., & Walsh, D. A. (2020). Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2020.05.010

© 2020 Osteoarthritis Research Society International Objectives: Subchondral bone may contribute to knee osteoarthritis (OA) pain. Nerve growth factor (NGF) can stimulate nerve growth through TrkA. We aimed to identify how sensory nerve growth at the... Read More about Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats.

Prevention of Atopic Dermatitis (2020)
Journal Article
Williams, H. C., & Chalmers, J. (2020). Prevention of Atopic Dermatitis. Acta Dermato-Venereologica, 100, 380-388. https://doi.org/10.2340/00015555-3516

Despite advances in atopic dermatitis (AD) treatments, research into AD prevention has been slow. Systematic reviews of prevention strategies promoting exclusive and prolonged breastfeeding, or interventions that reduce ingested or airborne allergens... Read More about Prevention of Atopic Dermatitis.

Real-time tracking of self-reported symptoms to predict potential COVID-19 (2020)
Journal Article
Menni, C., Valdes, A. M., Freidin, M. B., Sudre, C. H., Nguyen, L. H., Drew, D. A., Ganesh, S., Varsavsky, T., Cardoso, M. J., El-Sayed Moustafa, J. S., Visconti, A., Hysi, P., Bowyer, R. C. E., Mangino, M., Falchi, M., Wolf, J., Ourselin, S., Chan, A. T., Steves, C. J., & Spector, T. D. (2020). Real-time tracking of self-reported symptoms to predict potential COVID-19. Nature Medicine, 26, 1037-1040. https://doi.org/10.1038/s41591-020-0916-2

A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion of participants who reported loss of smell and taste was higher in those w... Read More about Real-time tracking of self-reported symptoms to predict potential COVID-19.

Pain distant from the index site and sensitization in people with knee pain and low back pain (2020)
Presentation / Conference Contribution
Akin-Akinyosoye, K., Georgopoulos, V., Frowd, N., Swaithes, L., Stocks, J., Fernandes, G. S., Valdes, A., McWilliams, D., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. (2020, April). Pain distant from the index site and sensitization in people with knee pain and low back pain. Presented at OARSI 2020 World Congress, Vienna, Austria

Mediators of the predictive relationship between a self-report measure of central mechanisms and future knee pain outcomes in the knee pain in the community (KPIC) cohort (2020)
Presentation / Conference Contribution
Matthews, R., Akin-Akinyosoye, K., Frowd, N., Swaithes, L., Stocks, J., Sarmanova, A., Fernandes, G. S., Valdes, A., McWilliams, D. F., Zhang, W., Doherty, M., Ferguson, E., & Walsh, D. A. (2020, April). Mediators of the predictive relationship between a self-report measure of central mechanisms and future knee pain outcomes in the knee pain in the community (KPIC) cohort. Presented at OARSI 2020 World Congress, Vienna, Austria

Assessment of Evidence About Common Infant Symptoms and Cow’s Milk Allergy (2020)
Journal Article
Munblit, D., Perkin, M. R., Palmer, D. J., Allen, K. J., & Boyle, R. J. (2020). Assessment of Evidence About Common Infant Symptoms and Cow’s Milk Allergy. JAMA Pediatrics, 174(6), 599-608. https://doi.org/10.1001/jamapediatrics.2020.0153

Importance Sales of specialized formula for managing cow’s milk allergy (CMA) have increased, triggering concern that attribution of common infant symptoms, such as crying, vomiting, and rashes, to CMA may be leading to overdiagnosis, which could un... Read More about Assessment of Evidence About Common Infant Symptoms and Cow’s Milk Allergy.

Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials (2020)
Journal Article
Persson, M. S., Stocks, J., Varadi, G., Hashempur, M. H., van Middelkoop, M., Bierma-Zeinstra, S., Walsh, D. A., Doherty, M., & Zhang, W. (2020). Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials. Rheumatology, 59(9), 2207-2216. https://doi.org/10.1093/rheumatology/keaa113

© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology.

OBJECTIVES: To identify predictors of the specific (difference between treatment and placebo) and overall (change from baseline in treat... Read More about Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials.

Investigating musculoskeletal health and wellbeing; A cohort study protocol (2020)
Journal Article
Millar, B., McWilliams, D. F., Abhishek, A., Akin-Akinyosoye, K., Auer, D. P., Chapman, V., Doherty, M., Ferguson, E., Gladman, J. R., Greenhaff, P., Stocks, J., Valdes, A. M., & Walsh, D. A. (2020). Investigating musculoskeletal health and wellbeing; A cohort study protocol. BMC Musculoskeletal Disorders, 21(1), Article 182. https://doi.org/10.1186/s12891-020-03195-4

© 2020 The Author(s). Background: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal Heal... Read More about Investigating musculoskeletal health and wellbeing; A cohort study protocol.

Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD) (2020)
Journal Article
Swain, S., Sarmanova, A., Mallen, C., Kuo, C. F., Coupland, C., Doherty, M., & Zhang, W. (2020). Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis and Cartilage, 28(6), 792-801. https://doi.org/10.1016/j.joca.2020.03.004

© 2020 The Authors Objective: This study aimed to explore the incidence and prevalence of OA in the UK in 2017 and their trends from 1997 to 2017 using a large nationally representative primary care database. Design: The UK Clinical Practice Research... Read More about Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD).

Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem (2020)
Journal Article
Craig, J. C., Ravaud, P., Créquit, P., Williams, H. C., Meerpohl, J., & Boutron, I. (2020). Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem. Journal of Clinical Epidemiology, 123, 153-161. https://doi.org/10.1016/j.jclinepi.2020.01.027

The “one-off” approach of systematic reviews is no longer sustainable; we need to move toward producing “living” evidence syntheses (i.e., comprehensive, based on rigorous methods, and up-to-date). This implies rethinking the evidence synthesis ecosy... Read More about Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem.

A process for prioritising systematic reviews in tinnitus (2020)
Journal Article
Sereda, M., McFerran, D., Axon, E., Baguley, D. M., Hall, D. A., Potgieter, I., Cima, R., Cox, S., & Hoare, D. J. (2020). A process for prioritising systematic reviews in tinnitus. International Journal of Audiology, 59(8), 640-646. https://doi.org/10.1080/14992027.2020.1733677

© 2020 British Society of Audiology, International Society of Audiology, and Nordic Audiological Society. Objective: To develop an innovative prioritisation process to identify topics for new or updated systematic reviews of tinnitus research. Design... Read More about A process for prioritising systematic reviews in tinnitus.