All Outputs (1077)

Achieving Quality and Effectiveness in Dementia Using Crisis Teams (AQUEDUCT): a randomised controlled trial evaluating the impact of a best practice Resource Kit used by teams managing crisis in dementia (2025)
Journal Article
Orrell, M., O’Raw, L., Coleston, D., Opazo Breton, M., Guo, B., Dening, T., Hoe, J., Lloyd-Evans, B., Moniz-Cook, E., Poland, F., Redley, M., Worden, A., & Challis, D. (2025). Achieving Quality and Effectiveness in Dementia Using Crisis Teams (AQUEDUCT): a randomised controlled trial evaluating the impact of a best practice Resource Kit used by teams managing crisis in dementia. Nature Communications, 16, Article 6414. https://doi.org/10.1038/s41467-025-61537-z

People with dementia frequently experience mental health crisis requiring psychiatric hospital admission. In the UK, Teams Managing Crisis in Dementia (TMCDs) vary in structure and practice due to the absence of a standardized model. A pragmatic, ran... Read More about Achieving Quality and Effectiveness in Dementia Using Crisis Teams (AQUEDUCT): a randomised controlled trial evaluating the impact of a best practice Resource Kit used by teams managing crisis in dementia.

Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD (2025)
Journal Article
Forbes, E. J., Tiego, J., Langmead, J., Unruh, K. E., Mosconi, M. W., Finlay, A., Kallady, K., Maclachlan, L., Moses, M., Cappel, K., Knott, R., Chau, T., Sindhu, V. P. M., Bellato, A., Groom, M. J., Kerestes, R., Bellgrove, M. A., & Johnson, B. P. (2025). Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD. Journal of Autism and Developmental Disorders, https://doi.org/10.1007/s10803-024-06718-3

Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics... Read More about Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD.

Exploring the Impact of Different Approaches to Healthcare Support for Older Care Home Residents in Greater Manchester on Ambulance Services and Unplanned Hospital Admissions (2024)
Journal Article
Hargreaves, C., Tucker, S., Hughes, J., Hothersall, G., Patterson, M., Gillan, V., & Challis, D. (2024). Exploring the Impact of Different Approaches to Healthcare Support for Older Care Home Residents in Greater Manchester on Ambulance Services and Unplanned Hospital Admissions. Journal of Long-Term Care, 2024, 489-499. https://doi.org/10.31389/jltc.339

Context:

Meeting the healthcare needs of care home residents is an international concern. In England, three approaches to enhance usual care provided by primary care general practitioners have been identified: additional direct (face-to-face) sup... Read More about Exploring the Impact of Different Approaches to Healthcare Support for Older Care Home Residents in Greater Manchester on Ambulance Services and Unplanned Hospital Admissions.

Organizations offering line manager training in mental health and presenteeism: A secondary data analysis of organizational-level data (2024)
Journal Article
Dulal-Arthur, T., Hassard, J., Bourke, J., Wishart, M., Bartle, C., Roper, S., Belt, V., Leka, S., Pahl, N., Thomson, L., & Blake, H. (2025). Organizations offering line manager training in mental health and presenteeism: A secondary data analysis of organizational-level data. Journal of Occupational and Organizational Psychology, 98(1), Article e12552. https://doi.org/10.1111/joop.12552

Presenteeism (working while ill) due to mental ill-health is estimated to be one of the largest economic costs to employers. We seek to investigate the relationship between line manager training in mental health (MH) and presenteeism trends at work.... Read More about Organizations offering line manager training in mental health and presenteeism: A secondary data analysis of organizational-level data.

Providing emotional support during the process of multiple sclerosis diagnosis (PrEliMS): A feasibility randomised controlled trial (2024)
Journal Article
Das Nair, R., Mhizha-Murira, J. R., Topcu, G., Tindall, T., Bale, C., Moghaddam, N., Scheffler-Ansari, G., Drummond, A., Fitzsimmons, D., & Evangelou, N. (2024). Providing emotional support during the process of multiple sclerosis diagnosis (PrEliMS): A feasibility randomised controlled trial. Clinical Rehabilitation, 38(11), 1506-1520. https://doi.org/10.1177/02692155241284781

Objectives
To evaluate the feasibility and acceptability of an emotional support programme for newly diagnosed people with multiple sclerosis.

Design
Three-arm, mixed methods, randomised controlled trial comparing usual care, versus usual care p... Read More about Providing emotional support during the process of multiple sclerosis diagnosis (PrEliMS): A feasibility randomised controlled trial.

The Mechanisms of Persisting Disability in Schizophrenia: Imprecise Predictive Coding via Corticostriatothalamic-Cortical Loop Dysfunction (2024)
Journal Article
Liddle, P. F., & Sami, M. B. (2024). The Mechanisms of Persisting Disability in Schizophrenia: Imprecise Predictive Coding via Corticostriatothalamic-Cortical Loop Dysfunction. Biological Psychiatry, https://doi.org/10.1016/j.biopsych.2024.08.007

Persisting symptoms and disability remain a problem for an appreciable proportion of people with schizophrenia despite treatment with antipsychotic medication. Improving outcomes requires an understanding of the nature and mechanisms of the pathologi... Read More about The Mechanisms of Persisting Disability in Schizophrenia: Imprecise Predictive Coding via Corticostriatothalamic-Cortical Loop Dysfunction.

Trajectories of improvement with repetitive transcranial magnetic stimulation for treatment-resistant major depression in the BRIGhTMIND trial (2024)
Journal Article
Briley, P., Webster, L., Lankappa, S., Pszczolkowski, S., H. McAllister-Williams, R., Liddle, P., Auer, D., & Morriss, R. (2024). Trajectories of improvement with repetitive transcranial magnetic stimulation for treatment-resistant major depression in the BRIGhTMIND trial. npj Mental Health Research, 3, Article 32. https://doi.org/10.1038/s44184-024-00077-8

Repetitive transcranial magnetic stimulation (rTMS) is an established non-invasive brain stimulation treatment for major depressive disorder, but there is marked inter-individual variability in response. Using latent class growth analysis with sessio... Read More about Trajectories of improvement with repetitive transcranial magnetic stimulation for treatment-resistant major depression in the BRIGhTMIND trial.

Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences (2024)
Preprint / Working Paper
Deakin, B., Liddle, E., Rathnaiah, M., Gregory, C., Katshu, M., Wiliams, G., Conen, S., Smallman, R., Koelewijn, L. C., Anton, A., Kumar, J., Gasgoyne, L. E., Chen, C., Nikkheslat, N., Evans, J., Lanz, B., Walters, J., Talbot, P., Palaniyappan, L., Singh, K. D., …Liddle, P. F. Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences

It is widely thought that the onset of psychotic symptoms in schizophrenia may arise from an early neurotoxic phase, possibly related to oxidative stress or inflammation, and a late residual damage phase associated with persistent negative symptoms.... Read More about Defining the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences.

Magnetic resonance imaging connectivity features associated with response to transcranial magnetic stimulation in major depressive disorder (2024)
Journal Article
Briley, P., Webster, L., Boutry, C., Oh, H., Auer, D., Liddle, P., & Morriss, R. (2024). Magnetic resonance imaging connectivity features associated with response to transcranial magnetic stimulation in major depressive disorder. Psychiatry Research: Neuroimaging, 342, Article 111846. https://doi.org/10.1016/j.pscychresns.2024.111846

Transcranial magnetic stimulation (TMS) is an FDA-approved neuromodulation treatment for major depressive disorder (MDD), thought to work by altering dysfunctional brain connectivity pathways, or by indirectly modulating the activity of subcortical b... Read More about Magnetic resonance imaging connectivity features associated with response to transcranial magnetic stimulation in major depressive disorder.

Tracking subjects' strategies in behavioural choice experiments at trial resolution. (2024)
Journal Article
Maggi, S., Hock, R. M., O'Neill, M., Buckley, M. J., Moran, P. M., Bast, T., Sami, M., & Humphries, M. D. (2024). Tracking subjects' strategies in behavioural choice experiments at trial resolution. eLife, 13, Article e86491. https://doi.org/10.7554/eLife.86491

Investigating how, when, and what subjects learn during decision-making tasks requires tracking their choice strategies on a trial-by-trial basis. Here we present a simple but effective probabilistic approach to tracking choice strategies at trial re... Read More about Tracking subjects' strategies in behavioural choice experiments at trial resolution..

Realist Evaluation Comparison of Dementia-Friendly Communities in England and the Netherlands (2024)
Journal Article
Chadborn, N. H., Thijssen, M., Logan, P., Radford, K., & Graff, M. (2024). Realist Evaluation Comparison of Dementia-Friendly Communities in England and the Netherlands. Health and Social Care in the Community, 2024, Article 5576029. https://doi.org/10.1155/2024/5576029

Introduction. Dementia-friendly communities coordinate activities and events which offer social inclusion and participation of people with dementia. Initiatives can include memory cafés, sports, and tourist and heritage visits. This study explored ho... Read More about Realist Evaluation Comparison of Dementia-Friendly Communities in England and the Netherlands.

Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial (2024)
Journal Article
Morriss, R., Briley, P. M., Webster, L., Abdelghani, M., Barber, S., Bates, P., Brookes, C., Hall, B., Ingram, L., Kurkar, M., Lankappa, S., Liddle, P. F., McAllister-Williams, R. H., O’Neil-Kerr, A., Pszczolkowski, S., Suazo Di Paola, A., Walters, Y., & Auer, D. P. (2024). Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial. Nature Medicine, 30(2), 403–413. https://doi.org/10.1038/s41591-023-02764-z

Disruption in reciprocal connectivity between the right anterior insula and the left dorsolateral prefrontal cortex is associated with depression and may be a target for neuromodulation. In a five-center, parallel, double-blind, randomized controlled... Read More about Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial.

Online Remote Behavioural Intervention for Tics in 9 to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation (2023)
Journal Article
Hollis, C., Hall, C. L., Khan, K., Le Novere, M., Marston, L., Jones, R., Hunter, R., Brown, B. J., Sanderson, C., Andrén, P., Bennett, S. D., Chamberlain, L. R., Bethan Davies, E., Evans, A., Kouzoupi, N., McKenzie, C., Heyman, I., Kilgariff, J., Glazebrook, C., Mataix-Cols, D., …Murphy, T. (2023). Online Remote Behavioural Intervention for Tics in 9 to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation. Health Technology Assessment, 27(18), 1-120. https://doi.org/10.3310/cpms3211

Background:

Behavioural therapy for tics is difficult to access, and little is known about its effectiveness when delivered online.

Objective:

To investigate the clinical and cost-effectiveness of an online-delivered, therapist and parent-... Read More about Online Remote Behavioural Intervention for Tics in 9 to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation.

Relationship Between Occupational Safety and Health Policy Principles, Organizational Action on Work-related Stress and the Psychosocial Work Environment in Italy (2023)
Journal Article
Leka, S., Torres, L., Jain, A., Di Tecco, C., Russo, S., & Iavicoli, S. (2023). Relationship Between Occupational Safety and Health Policy Principles, Organizational Action on Work-related Stress and the Psychosocial Work Environment in Italy. Safety and Health at Work, 14(4), 425-430. https://doi.org/10.1016/j.shaw.2023.10.001

Background: It is acknowledged that legislation acts as a motivator for organizational action on psychosocial risks. Our study aims to provide evidence on the relationship between key occupational safety and health (OSH) policy principles and organiz... Read More about Relationship Between Occupational Safety and Health Policy Principles, Organizational Action on Work-related Stress and the Psychosocial Work Environment in Italy.

Measurement of brain glutathione with magnetic Resonance spectroscopy in Schizophrenia-Spectrum disorders - A systematic review and Meta-Analysis. (2023)
Journal Article
Murray, A. J., Humpston, C. S., Wilson, M., Rogers, J. C., Zia Ul Haq Katshu, M., Liddle, P. F., & Upthegrove, R. (2024). Measurement of brain glutathione with magnetic Resonance spectroscopy in Schizophrenia-Spectrum disorders - A systematic review and Meta-Analysis. Brain, Behavior, and Immunity, 115, 3-12. https://doi.org/10.1016/j.bbi.2023.09.017

Oxidative stress may contribute to declining course and poor outcomes in psychosis. However, in vivo Magnetic Resonance Spectroscopy studies yield disparate results due to clinical stage, sample demographics, neuroanatomical focus, sample size, and a... Read More about Measurement of brain glutathione with magnetic Resonance spectroscopy in Schizophrenia-Spectrum disorders - A systematic review and Meta-Analysis..

Training for line managers should focus on primary prevention of mental ill-health at work (2023)
Journal Article
Blake, H., Hassard, J., Bartle, C., & Thomson, L. (2023). Training for line managers should focus on primary prevention of mental ill-health at work. Perspectives in Public Health, 143(3), 124-125. https://doi.org/10.1177/17579139231157528

The potential of responsible business to promote sustainable work – An analysis of CSR/ESG instruments (2023)
Journal Article
Torres, L., Ripa, D., Jain, A., Herrero, J., & Leka, S. (2023). The potential of responsible business to promote sustainable work – An analysis of CSR/ESG instruments. Safety Science, 164, Article 106151. https://doi.org/10.1016/j.ssci.2023.106151

In the last few years important efforts have been made to rationalise the growing corporate sustainability or CSR/ESG standards field aiming at achieving some degree of harmonisation. Yet, these efforts might be unable to capture the diversity of CSR... Read More about The potential of responsible business to promote sustainable work – An analysis of CSR/ESG instruments.

How are adverse events identified and categorised in trials of digital mental health interventions? A narrative scoping review of trials in the ISRCTN registry (2023)
Journal Article
Bergin, A. D. G., Valentine, A. Z., Rennick Egglestone, S., Slade, M., Hollis, C., & Hall, C. L. (2023). How are adverse events identified and categorised in trials of digital mental health interventions? A narrative scoping review of trials in the ISRCTN registry. JMIR Mental Health, 10, Article e42501. https://doi.org/10.2196/42501

Background: To contextualize the benefits of an intervention, it is important that adverse events (AEs) are reported. This is potentially difficult in trials of digital mental health interventions, where delivery may be remote and the mechanisms of a... Read More about How are adverse events identified and categorised in trials of digital mental health interventions? A narrative scoping review of trials in the ISRCTN registry.

Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study (2023)
Journal Article
Tindall, T., Topcu, G., Thomas, S., Bale, C., Evangelou, N., Drummond, A., & das Nair, R. (2023). Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study. Health Expectations, 26(2), 858-868. https://doi.org/10.1111/hex.13711

Background: Diagnosing multiple sclerosis (MS) can be a lengthy process, which can impact psychological wellbeing, condition management, and future engagement with health services. Therefore, providing timely and appropriate emotional support may imp... Read More about Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study.

Understanding the Impact of Home Confinement on Children and Young People with ADHD and ASD During the COVID-19 Pandemic (2023)
Journal Article
Hall, C. L., Partlett, C., Valentine, A. Z., Pearcey, S., & Sayal, K. (2023). Understanding the Impact of Home Confinement on Children and Young People with ADHD and ASD During the COVID-19 Pandemic. Child Psychiatry and Human Development, 55(5), 1279-1293. https://doi.org/10.1007/s10578-022-01490-w

To understand whether the mental health of children and young people (CYP) with and without attention-deficit/hyperactivity disorder (ADHD) and/or autism spectrum disorder (ASD) were differentially affected by COVID-19. We analysed data (n = 6507) fr... Read More about Understanding the Impact of Home Confinement on Children and Young People with ADHD and ASD During the COVID-19 Pandemic.