All Outputs (5)

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors (2008)
Journal Article
Desjobert, C., Noy, P., Swingler, T., Williams, H., Gaston, K., & Jayaraman, P. (2009). The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors. BBA - Biomembranes, 417(1), 121-132. https://doi.org/10.1042/BJ20080872

The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a transcription factor that functions as an important regulator of vertebrate development and many other processes in the adult including haemat... Read More about The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors.

DNA wrapping and distortion by an oligomeric homeodomain protein (2008)
Journal Article
Williams, H., Jayaraman, P., & Gaston, K. (2008). DNA wrapping and distortion by an oligomeric homeodomain protein. Journal of Molecular Biology, 383, 10-23. https://doi.org/10.1016/j.jmb.2008.08.004

Many transcription factors alter DNA or chromatin structure. Changes in chromatin structure are often brought about by the recruitment of chromatin-binding proteins, chromatin-modifying proteins, or other transcription co-activator or co-repressor pr... Read More about DNA wrapping and distortion by an oligomeric homeodomain protein.

The papillomavirus E2 DNA binding domain (2008)
Journal Article
de Prat-Gay, G., Gaston, K., & Cicero, D. O. (2008). The papillomavirus E2 DNA binding domain. Frontiers in Bioscience, 13, 6006-6021. https://doi.org/10.2741/3132

The DNA binding domain of the E2 master regulator from papillomaviruses is the primary effector for most the essential activities controlled by this protein. In this review we focus on the properties of the DNA binding domain of human papillomavirus... Read More about The papillomavirus E2 DNA binding domain.

The O-linked glycosylation of secretory/shed MUC1 from an advanced breast cancer patient's serum (2008)
Journal Article
Storr, S. J., Royle, L., Chapman, C. J., Hamid, U. M. A., Robertson, J. F., Murray, A., …Rudd, P. M. (2008). The O-linked glycosylation of secretory/shed MUC1 from an advanced breast cancer patient's serum. Glycobiology, 18(6), 456-462. https://doi.org/10.1093/glycob/cwn022

MUC1 is a high molecular weight glycoprotein that is overexpressed in breast cancer. Aberrant O-linked glycosylation of MUC1 in cancer has been implicated in disease progression. We investigated the O-linked glycosylation of MUC1 purified from the se... Read More about The O-linked glycosylation of secretory/shed MUC1 from an advanced breast cancer patient's serum.

p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein (2008)
Journal Article
Brown, C., Kowalczyk, A. M., Taylor, E. R., Morgan, I. M., & Gaston, K. (2008). p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein. Virology Journal, 5, Article 5. https://doi.org/10.1186/1743-422X-5-5

Background. Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppressor protein p53. However, the mechanism through which p53 inhibits viral replication and the role that this might play in the HPV life cycle are not... Read More about p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein.