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The papillomavirus E2 DNA binding domain

de Prat-Gay, Gonzalo; Gaston, Kevin; Cicero, Daniel O.


Gonzalo de Prat-Gay

Kevin Gaston

Daniel O. Cicero


The DNA binding domain of the E2 master regulator from papillomaviruses is the primary effector for most the essential activities controlled by this protein. In this review we focus on the properties of the DNA binding domain of human papillomavirus strain 16 in solution, integrating structure, dynamics, folding, stability, conformational equilibria, and DNA binding mechanism. We discuss the relevance of these processes for the different biological activities, broadening the horizon for antiviral development. In addition, the particular fold of the DNA binding domain only shared with the Epstein-Barr nuclear antigen EBNA1, suggests a link between this unique architecture and the function of viral origin binding proteins of this kind. Finally, the E2 DNA binding domain proved to be an excellent model for addressing fundamental problems of DNA recognition mechanisms and folding of intertwined dimers.

Journal Article Type Article
Publication Date 2008-05
Journal Frontiers in Bioscience
Print ISSN 1093-9946
Publisher Frontiers in Bioscience
Peer Reviewed Peer Reviewed
Volume 13
Pages 6006-6021
APA6 Citation de Prat-Gay, G., Gaston, K., & Cicero, D. O. (2008). The papillomavirus E2 DNA binding domain. Frontiers in Bioscience, 13, 6006-6021. doi:10.2741/3132
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