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All Outputs (1131)

Image-guided neural activity manipulation with a paramagnetic drug (2020)
Journal Article
Bricault, S., Barandov, A., Harvey, P., DeTienne, E., Hai, A., & Jasanoff, A. (2020). Image-guided neural activity manipulation with a paramagnetic drug. Nature Communications, 11(1), Article 136. https://doi.org/10.1038/s41467-019-13933-5

© 2020, The Author(s). Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of th... Read More about Image-guided neural activity manipulation with a paramagnetic drug.

Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study (2020)
Journal Article
Othman, O., Rakkar, K., Sprigg, N., Bath, P., & Bayraktutan, U. (2020). Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study. Neural Regeneration Research, 15(7), 1300-1307. https://doi.org/10.4103/1673-5374.269028

Ischemic stroke is a devastating, life altering event which can severely reduce patient quality of life. Despite years of research there have been minimal therapeutic advances. Endothelial progenitor cells (EPCs), stem cells involved in both vasculog... Read More about Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischemic stroke: protocol for an observational case-control study.

TRY plant trait database – enhanced coverage and open access (2019)
Journal Article
Kattge, J., Bönisch, G., Díaz, S., Lavorel, S., Prentice, I. C., Leadley, P., …The Nutrient Network. (2020). TRY plant trait database – enhanced coverage and open access. Global Change Biology, 26(1), 119-188. https://doi.org/10.1111/gcb.14904

© 2019 The Authors. Global Change Biology published by John Wiley & Sons Ltd Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, af... Read More about TRY plant trait database – enhanced coverage and open access.

Behavioural activation treatment for depression in individuals with neurological conditions: a systematic review (2019)
Journal Article
Oates, L. L., Moghaddam, N., Evangelou, N., & das Nair, R. (2020). Behavioural activation treatment for depression in individuals with neurological conditions: a systematic review. Clinical Rehabilitation, 34(3), 310-319. https://doi.org/10.1177/0269215519896404

© The Author(s) 2019. Objective: To evaluate the effectiveness of behavioural activation interventions for people with neurological conditions with comorbid depression, and explore content and adaptations. Data sources: PsycINFO, MEDLINE, CINAHL, AME... Read More about Behavioural activation treatment for depression in individuals with neurological conditions: a systematic review.

Looking beyond the audiogram in ototoxicity associated with platinum-based chemotherapy (2019)
Journal Article
Baguley, D. M., & Prayuenyong, P. (2020). Looking beyond the audiogram in ototoxicity associated with platinum-based chemotherapy. Cancer Chemotherapy and Pharmacology, 85(2), 245-250. https://doi.org/10.1007/s00280-019-04012-z

© 2019, The Author(s). Introduction: Ototoxicity associated with platinum-based chemotherapy is highly prevalent and can cause detrimental consequences among cancer survivors. Discussion: In this article, we highlight important aspects of the evaluat... Read More about Looking beyond the audiogram in ototoxicity associated with platinum-based chemotherapy.

Outgrowth endothelial cells form a functional cerebral barrier and restore its integrity after damage (2019)
Journal Article
Bayraktutan, U., Abdulkadir, R., Alwjwaj, M., Othman, O., & Rakkar, K. (2020). Outgrowth endothelial cells form a functional cerebral barrier and restore its integrity after damage. Neural Regeneration Research, 15(6), 1071-1078. https://doi.org/10.4103/1673-5374.269029

Breakdown of blood-brain barrier, formed mainly by brain microvascular endothelial cells (BMECs), represents the major cause of mortality during early phases of ischemic strokes. Hence, discovery of novel agents that can effectively replace dead or d... Read More about Outgrowth endothelial cells form a functional cerebral barrier and restore its integrity after damage.

Tinnitus, hearing loss and inflammatory processes in an older Portuguese population (2019)
Journal Article
Haider, H. F., Ribeiro, S. F., Martins, C., Ribeiro, D., Trigueiros, N., Szczepek, A. J., …Borrego, L.-M. (2019). Tinnitus, hearing loss and inflammatory processes in an older Portuguese population. International Journal of Audiology, 59(5), 323-332. https://doi.org/10.1080/14992027.2019.1698775

Objective: Tinnitus is associated with various conditions such as presbycusis, infectious, autoimmune and many other diseases. Our study aims to identify an association between inflammatory markers and the presence of tinnitus or hearing loss (HL).... Read More about Tinnitus, hearing loss and inflammatory processes in an older Portuguese population.

How do patients spend their time in stroke rehabilitation units in England? The REVIHR study (2019)
Journal Article
Chouliara, N., Fisher, R., Crosbie, B., Guo, B., Sprigg, N., & Walker, M. (2021). How do patients spend their time in stroke rehabilitation units in England? The REVIHR study. Disability and Rehabilitation, 43(16), 2312-2319. https://doi.org/10.1080/09638288.2019.1697764

Aim: To examine how patients spend their time in stroke rehabilitation units in England.

Methods: We recruited 144 patients within a month after stroke from four stroke rehabilitation units and observed their activity type, interactions and locati... Read More about How do patients spend their time in stroke rehabilitation units in England? The REVIHR study.

Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study (2019)
Other
Maidment, D., Heyes, R., Gomez, R., Coulson, N. S., Wharrad, H., & Ferguson, M. A. Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study

Background:
Knowledge of hearing aids in adults living with hearing loss is highly variable, resulting in suboptimal or non-use. This issue can be addressed by the provision of high-quality educational information.

Objective:
This study assesse... Read More about Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study.

Cognitive rehabilitation for attention and memory in people with multiple sclerosis: a randomized controlled trial (CRAMMS) (2019)
Journal Article
Lincoln, N., Bradshaw, L., Constantinescu, C., Day, F., Drummond, A., Fitzsimmons, D., …das Nair, R. (2020). Cognitive rehabilitation for attention and memory in people with multiple sclerosis: a randomized controlled trial (CRAMMS). Clinical Rehabilitation, 34(2), 229-241. https://doi.org/10.1177/0269215519890378

Objective: To assess the clinical and cost-effectiveness of cognitive rehabilitation for attention and memory problems in people with multiple sclerosis. Design: Multicentre, pragmatic, randomized controlled trial. Setting: Community Participants: Pe... Read More about Cognitive rehabilitation for attention and memory in people with multiple sclerosis: a randomized controlled trial (CRAMMS).

Music enhances structural maturation of emotional processing neural pathways in very preterm infants (2019)
Journal Article
Sa de Almeida, J., Lordier, L., Zollinger, B., Kunz, N., Bastiani, M., Gui, L., …Hüppi, P. S. (2020). Music enhances structural maturation of emotional processing neural pathways in very preterm infants. NeuroImage, 207, Article 116391. https://doi.org/10.1016/j.neuroimage.2019.116391

Prematurity disrupts brain maturation by exposing the developing brain to different noxious stimuli present in the neonatal intensive care unit (NICU) and depriving it from meaningful sensory inputs during a critical period of brain development, lead... Read More about Music enhances structural maturation of emotional processing neural pathways in very preterm infants.

Identifying and prioritising unanswered research questions for people with hyperacusis: James Lind Alliance Hyperacusis Priority Setting Partnership (2019)
Journal Article
Stratmann, L., Fackrell, K., Kennedy, V., MacDonald, C., Hodgson, H., Wray, N., …Hoare, D. J. (2019). Identifying and prioritising unanswered research questions for people with hyperacusis: James Lind Alliance Hyperacusis Priority Setting Partnership. BMJ Open, 9(11), Article e032178. https://doi.org/10.1136/bmjopen-2019-032178

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. OBJECTIVE: To determine research priorities in hyperacusis that key stakeholders agree are the most important. DESIGN/SETTING: A priority setting partnership usi... Read More about Identifying and prioritising unanswered research questions for people with hyperacusis: James Lind Alliance Hyperacusis Priority Setting Partnership.

Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage (2019)
Journal Article
Law, Z. K., Ali, A., Krishnan, K., Bischoff, A., Appleton, J., Scutt, P., …Sprigg, N. (2020). Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage. Stroke, 51(1), 121–128. https://doi.org/10.1161/STROKEAHA.119.026128

Background and purpose

Blend, black hole and island signs and hypodensities are reported to predict hematoma expansion in acute intracerebral hemorrhage (ICH). We explored the value of these noncontrast CT (NCCT) signs in predicting hematoma expan... Read More about Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage.

Soldiering on: a survey on the lived experience of tinnitus in aged military veterans in the UK (2019)
Journal Article
Burns-O'Connell, G., Stockdale, D., & Hoare, D. J. (2019). Soldiering on: a survey on the lived experience of tinnitus in aged military veterans in the UK. Medical Humanities, 45(4), 408-415. https://doi.org/10.1136/medhum-2019-011671

Tinnitus has long been interrogated as a medical conundrum, with little discourse between medicine and other disciplines. It involves the perception of sound in the ears or head without any external sound source, most likely a natural consequence of... Read More about Soldiering on: a survey on the lived experience of tinnitus in aged military veterans in the UK.

ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies (2019)
Preprint / Working Paper
Mutsaerts, H., Petr, J., Groot, P., Vandemaele, P., Ingala, S., Robertson, A. D., …Barkhof, F. ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies

Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of its acquisition and quantification. In a community-wide effort towards robust and reproducible cl... Read More about ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies.

Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster (2019)
Journal Article
Lewis, J. E., Monnier, C., Marshall, H., Fowler, M., Green, R., Cooper, S., …Tsintzas, K. (2020). Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster. Molecular Metabolism, 31, 45-54. https://doi.org/10.1016/j.molmet.2019.10.009

Objective
Fibroblast growth factor 21 (FGF21) has been shown to rapidly lower body weight in the Siberian hamster, a preclinical model of adiposity. This induced negative energy balance mediated by FGF21 is associated with both lowered caloric intak... Read More about Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster.

Toblerone: Surface-Based Partial Volume Estimation (2019)
Journal Article
Kirk, T. F., Coalson, T. S., Craig, M. S., & Chappell, M. A. (2020). Toblerone: Surface-Based Partial Volume Estimation. IEEE Transactions on Medical Imaging, 39(5), 1501-1510. https://doi.org/10.1109/tmi.2019.2951080

Partial volume effects (PVE) present a source of confound for the analysis of functional imaging data. Correction for PVE requires estimates of the partial volumes (PVs) present in an image. These estimates are conventionally obtained via volumetric... Read More about Toblerone: Surface-Based Partial Volume Estimation.

Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey (2019)
Journal Article
Parfitt, A., Boxell, E., Amoaku, W. M., & Bradley, C. (2019). Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey. BMJ Open Ophthalmology, 4(1), Article e000276. https://doi.org/10.1136/bmjophth-2019-000276

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objectives To investigate whether people with age-related macular degeneration (AMD) are able to self-detect... Read More about Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey.