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Tinnitus, hearing loss and inflammatory processes in an older Portuguese population

Haider, Ha�la F.; Ribeiro, Sara F.; Martins, Catarina; Ribeiro, Diogo; Trigueiros, Nuno; Szczepek, Agnieszka J.; Caria, Helena; Hoare, Derek J.; Pa�o, Jo�o; Borrego, Lu�s-Miguel

Tinnitus, hearing loss and inflammatory processes in an older Portuguese population Thumbnail


Authors

Ha�la F. Haider

Sara F. Ribeiro

Catarina Martins

Diogo Ribeiro

Nuno Trigueiros

Agnieszka J. Szczepek

Helena Caria

DEREK HOARE derek.hoare@nottingham.ac.uk
Associate Professor in Hearing Sciences

Jo�o Pa�o

Lu�s-Miguel Borrego



Abstract

Objective: Tinnitus is associated with various conditions such as presbycusis, infectious, autoimmune and many other diseases. Our study aims to identify an association between inflammatory markers and the presence of tinnitus or hearing loss (HL).

Design: Exploratory study including a structured interview, complete ENT observation, audiological and inflammatory markers evaluation.
Study Sample: Sixty women and 54 men (55 to 75 years) from the Portuguese population, with or without sensory presbycusis and/or tinnitus.

Results: IL10 levels were significantly lower in participants with tinnitus than in those without tinnitus. Moreover, TGF-β was lower in older participants (p = 0.034), IL1α was higher in participants with tonal tinnitus (p = 0.033), and IL2 was lower in participants who reported partial or complete residual inhibition (p = 0.019). Additionally, we observed a negative correlation between tinnitus duration and IL10 levels (r= −.281), and between HSP70 levels and tinnitus loudness (r= −.377). TNF-α and HSP70 levels appears to be sensitive to the time when samples were collected (morning or afternoon).

Conclusions: The results of our study showing fluctuations in inflammatory markers along the hearing loss process, reinforce the idea that inflammatory mechanisms are involved in hearing loss pathogenesis but also in tinnitus. IL10 levels appear significantly altered in tinnitus but not in hearing loss.

Citation

Haider, H. F., Ribeiro, S. F., Martins, C., Ribeiro, D., Trigueiros, N., Szczepek, A. J., …Borrego, L. (2019). Tinnitus, hearing loss and inflammatory processes in an older Portuguese population. International Journal of Audiology, 59(5), 323-332. https://doi.org/10.1080/14992027.2019.1698775

Journal Article Type Article
Acceptance Date Nov 8, 2019
Online Publication Date Dec 12, 2019
Publication Date Dec 12, 2019
Deposit Date Dec 21, 2019
Publicly Available Date Mar 28, 2024
Journal International Journal of Audiology
Print ISSN 1499-2027
Electronic ISSN 1708-8186
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Volume 59
Issue 5
Pages 323-332
DOI https://doi.org/10.1080/14992027.2019.1698775
Keywords Tinnitus, Inflammatory biomarkers, ARHL (age-related hearing loss), Oxidative stress
Public URL https://nottingham-repository.worktribe.com/output/3610504
Publisher URL https://www.tandfonline.com/doi/full/10.1080/14992027.2019.1698775
Additional Information This is an Accepted Manuscript of an article published by Taylor & Francis in International Journal of Audiology on 12/12/2019, available online: http://www.tandfonline.com/10.1080/14992027.2019.1698775

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