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Response assessment in paediatric high-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group (2020)
Journal Article
Erker, C., Tamrazi, B., Poussaint, T. Y., Mueller, S., Mata-Mbemba, D., Franceschi, E., …Warren, K. E. (2020). Response assessment in paediatric high-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncology, 21(6), e317-e329. https://doi.org/10.1016/s1470-2045%2820%2930173-x

Response criteria for paediatric high-grade glioma vary historically and across different cooperative groups. The Response Assessment in Neuro-Oncology working group developed response criteria for adult high-grade glioma, but these were not created... Read More about Response assessment in paediatric high-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group.

Confound modelling in UK Biobank brain imaging (2020)
Journal Article
Alfaro-Almagro, F., McCarthy, P., Afyouni, S., Andersson, J. L., Bastiani, M., Miller, K. L., …Smith, S. M. (2021). Confound modelling in UK Biobank brain imaging. NeuroImage, 224, Article 117002. https://doi.org/10.1016/j.neuroimage.2020.117002

© 2020 Dealing with confounds is an essential step in large cohort studies to address problems such as unexplained variance and spurious correlations. UK Biobank is a powerful resource for studying associations between imaging and non-imaging measure... Read More about Confound modelling in UK Biobank brain imaging.

Clinical implications of chloroquine and hydroxychloroquine ototoxicity for COVID-19 treatment: A mini-review (2020)
Journal Article
Kasbekar, A. V., Prayuenyong, P., & Baguley, D. M. (2020). Clinical implications of chloroquine and hydroxychloroquine ototoxicity for COVID-19 treatment: A mini-review. Frontiers in Public Health, 8, Article 252. https://doi.org/10.3389/fpubh.2020.00252

At this time of the COVID-19 pandemic, potentially effective treatments are currently under urgent investigation. Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underw... Read More about Clinical implications of chloroquine and hydroxychloroquine ototoxicity for COVID-19 treatment: A mini-review.

Strategies in Translating the Therapeutic Potentials of Host Defense Peptides (2020)
Journal Article
Ting, D. S. J., Beuerman, R. W., Dua, H. S., Lakshminarayanan, R., & Mohammed, I. (2020). Strategies in Translating the Therapeutic Potentials of Host Defense Peptides. Frontiers in Immunology, 11, Article 983. https://doi.org/10.3389/fimmu.2020.00983

The golden era of antibiotics, heralded by the discovery of penicillin, has long been challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides (HDPs), previously known as antimicrobial peptides, are emerging as a group of... Read More about Strategies in Translating the Therapeutic Potentials of Host Defense Peptides.

Associations Between Subjective Tinnitus and Cognitive Performance: Systematic Review and Meta-Analyses (2020)
Journal Article
Clarke, N. A., Henshaw, H., Akeroyd, M. A., Adams, B., & Hoare, D. J. (2020). Associations Between Subjective Tinnitus and Cognitive Performance: Systematic Review and Meta-Analyses. Trends in Hearing, 24, Article 233121652091841. https://doi.org/10.1177/2331216520918416

Tinnitus is the perception of sound in the absence of a corresponding external sound source, and bothersome tinnitus has been linked to poorer cognitive performance. This review comprehensively quantifies the association between tinnitus and differen... Read More about Associations Between Subjective Tinnitus and Cognitive Performance: Systematic Review and Meta-Analyses.

Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity (2020)
Journal Article
Prayuenyong, P., Kasbekar, A. V., Hall, D. A., & Baguley, D. M. (2020). Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity. European Archives of Oto-Rhino-Laryngology, 277, 3283–3293. https://doi.org/10.1007/s00405-020-06033-4

Purpose Vestibulotoxicity associated with cisplatin chemotherapy is known to exist, but the extent, severity, and impact is unclear from the literature. This study explored knowledge, experiences, and opinions of audiovestibular professionals abou... Read More about Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity.

The Landscape of Videofluoroscopy in the UK: A Web-Based Survey (2020)
Journal Article
Benfield, J. K., Michou, E., Everton, L. F., Mills, C., Hamdy, S., Bath, P. M., & England, T. J. (2020). The Landscape of Videofluoroscopy in the UK: A Web-Based Survey. Dysphagia, https://doi.org/10.1007/s00455-020-10130-1

Videofluoroscopy (VFS) is considered one of the gold-standard assessments of swallowing. Whilst guidelines for the application and conduct of VFS exist, their translation into clinical practice remain challenging. To build a greater understanding on... Read More about The Landscape of Videofluoroscopy in the UK: A Web-Based Survey.

Daily-Life Fatigue in Mild to Moderate Hearing Impairment: An Ecological Momentary Assessment Study (2020)
Journal Article
Burke, L. A., & Naylor, G. (2020). Daily-Life Fatigue in Mild to Moderate Hearing Impairment: An Ecological Momentary Assessment Study. Ear and Hearing, 41(6), 1518-1532. https://doi.org/10.1097/aud.0000000000000888

Objectives: Previous research has indicated an association between hearing impairment (HI) and daily-life fatigue. However, the temporal and contextual correlates of such fatigue are largely unexplored. The present study used ecological momentary... Read More about Daily-Life Fatigue in Mild to Moderate Hearing Impairment: An Ecological Momentary Assessment Study.

The spatial percept of tinnitus is associated with hearing asymmetry: subgroup comparisons (2020)
Preprint / Working Paper
Genitsaridi, E., Kypraios, T., Edvall, N. K., Trpchevska, N., Canlon, B., Hoare, D. J., …Hall, D. A. The spatial percept of tinnitus is associated with hearing asymmetry: subgroup comparisons

The spatial percept of tinnitus is hypothesized as an important variable for tinnitus subtyping. Hearing asymmetry often associates with tinnitus laterality, but not always. One of the methodological limitations for cross-study comparisons is how the... Read More about The spatial percept of tinnitus is associated with hearing asymmetry: subgroup comparisons.

Rapid event-related, BOLD fMRI, non-human primates (NHP): choose two out of three (2020)
Journal Article
Joly, O., Pelekanos, V., Kyriazis, D., Mok, R. M., Kriegeskorte, N., Ainsworth, M., …Kelly, M. G. (2020). Rapid event-related, BOLD fMRI, non-human primates (NHP): choose two out of three. Scientific Reports, 10, Article 7485. https://doi.org/10.1038/s41598-020-64376-8

Human functional magnetic resonance imaging (fMRI) typically employs the blood-oxygen-level-dependent (BOLD) contrast mechanism. In non-human primates (NHP), contrast enhancement is possible using monocrystalline iron-oxide nanoparticles (MION) contr... Read More about Rapid event-related, BOLD fMRI, non-human primates (NHP): choose two out of three.

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo (2020)
Journal Article
Rostam, H. M., Fisher, L. E., Hook, A. L., Burroughs, L., Luckett, J. C., Figueredo, G. P., …Ghaemmaghami, A. M. (2020). Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo. Matter, 2(6), 1564-1581. https://doi.org/10.1016/j.matt.2020.03.018

© 2020 The Author(s) Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive pro... Read More about Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo.

Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients (2020)
Journal Article
Everton, L. F., Benfield, J. K., Hedstrom, A., Wilkinson, G., Michou, E., England, T. J., …Hamdy, S. (2020). Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients. Scientific Reports, 10, Article 7268. https://doi.org/10.1038/s41598-020-64208-9

Post stroke dysphagia (PSD) is common and associated with poor outcome. The Dysphagia Severity Rating Scale (DSRS), which grades how severe dysphagia is based on fluid and diet modification and supervision requirements for feeding, is used for clinic... Read More about Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients.

Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations (2020)
Journal Article
Zouache, M. A., Silvestri, G., Amoaku, W. M., Silvestri, V., Hubbard, W. C., Pappas, C., …Hageman, G. S. (2020). Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations. Translational Vision Science & Technology, 9(5), Article 24. https://doi.org/10.1167/tvst.9.5.24

Purpose: The purpose of this study was to characterize foveal pit morphology in an African (Ghanaian) population, to compare it to that of a Caucasian group and to determine if it varied with age in the two populations. Methods: The depth, diamet... Read More about Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations.

Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan (2020)
Journal Article
Mair, G., Chappell, F., Martin, C., Dye, D., Bath, P. M., Muir, K. W., …Wardlaw, J. M. (2020). Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan. AMRC Open Research, 2, Article 20. https://doi.org/10.12688/amrcopenres.12904.1

Background: Artificial intelligence-based software may automatically detect ischaemic stroke lesions and provide an Alberta Stroke Program Early CT score (ASPECTS) on CT, and identify arterial occlusion and provide a collateral score on CTA. Large-sc... Read More about Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan.

Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching (2020)
Journal Article
Morgan, L., McKeever, T. M., Nightingale, J., Deakin, D. E., & Moppett, I. K. (2020). Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching. Anaesthesia, 75(9), 1173-1179. https://doi.org/10.1111/anae.15042

Around 76,000 people fracture their hip annually in the UK at a considerable personal, social and financial cost. Despite longstanding debate, the optimal mode of anaesthesia (general or spinal) remains unclear. Our aim was to assess whether there is... Read More about Spinal or general anaesthesia for surgical repair of hip fracture and subsequent risk of mortality and morbidity: a database analysis using propensity score‐matching.

Utility of Driving Pressure and Mechanical Power to Guide Protective Ventilator Settings in Two Cohorts of Adult and Pediatric Patients With Acute Respiratory Distress Syndrome: A Computational Investigation (2020)
Journal Article
Yehya, N., Saffaran, S., Das, A., Hardman, J. G., Laffey, J. G., & Bates, D. G. (2020). Utility of Driving Pressure and Mechanical Power to Guide Protective Ventilator Settings in Two Cohorts of Adult and Pediatric Patients With Acute Respiratory Distress Syndrome: A Computational Investigation. Critical Care Medicine, https://doi.org/10.1097/ccm.0000000000004372

Objectives: Mechanical power and driving pressure have been proposed as indicators, and possibly drivers, of ventilator-induced lung injury. We tested the utility of these different measures as targets to derive maximally protective ventilator sett... Read More about Utility of Driving Pressure and Mechanical Power to Guide Protective Ventilator Settings in Two Cohorts of Adult and Pediatric Patients With Acute Respiratory Distress Syndrome: A Computational Investigation.

Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease (2020)
Journal Article
Wardlaw, J., Bath, P. M., Doubal, F., Heye, A., Sprigg, N., Woodhouse, L. J., …The LACI-2 Trial Investigators. (2020). Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease. European Stroke Journal, 5(3), 297-308. https://doi.org/10.1177/2396987320920110

Background Small vessel disease causes a quarter of ischaemic strokes (lacunar subtype), up to 45% of dementia either as vascular or mixed types, cognitive impairment and physical frailty. However, there is no specific treatment to prevent progressi... Read More about Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease.

Regulation of auditory plasticity during critical periods and following hearing loss (2020)
Journal Article
Persic, D., Thomas, M. E., Pelekanos, V., Ryugo, D. K., Takesian, A. E., Krumbholz, K., & Pyott, S. J. (2020). Regulation of auditory plasticity during critical periods and following hearing loss. Hearing Research, 397, Article 107976. https://doi.org/10.1016/j.heares.2020.107976

Sensory input has profound effects on neuronal organization and sensory maps in the brain. The mechanisms regulating plasticity of the auditory pathway have been revealed by examining the consequences of altered auditory input during both development... Read More about Regulation of auditory plasticity during critical periods and following hearing loss.

Applications of qualitative grounded theory methodology to investigate hearing loss: protocol for a qualitative systematic review (2020)
Journal Article
Ali, Y. H., Wright, N., Charnock, D., Henshaw, H., & Hoare, D. (2020). Applications of qualitative grounded theory methodology to investigate hearing loss: protocol for a qualitative systematic review. BMJ Open, 10(4), Article e033537. https://doi.org/10.1136/bmjopen-2019-033537

Introduction Hearing loss is a chronic condition affecting 12 million individuals in the UK. People with hearing loss regularly experience difficulties interacting in everyday conversations. These difficulties in communication can result in a person... Read More about Applications of qualitative grounded theory methodology to investigate hearing loss: protocol for a qualitative systematic review.