All Outputs (1129)

Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea (2020)
Journal Article
Tserga, E., Moreno‐Paublete, R., Sarlus, H., Björn, E., Guimaraes, E., Göritz, C., …Canlon, B. (2020). Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea. FASEB Journal, 34(10), 13978-13992. https://doi.org/10.1096/fj.202001236R

The chemotherapeutic agent cisplatin is renowned for its ototoxic effects. While hair cells in the cochlea are established targets of cisplatin, less is known regarding the afferent synapse, which is an essential component in the faithful temporal tr... Read More about Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea.

The Prevalence and Severity of Misophonia in a UK Undergraduate Medical Student Population and Validation of the Amsterdam Misophonia Scale (2020)
Journal Article
Naylor, J., Caimino, C., Scutt, P., Hoare, D. J., & Baguley, D. M. (2021). The Prevalence and Severity of Misophonia in a UK Undergraduate Medical Student Population and Validation of the Amsterdam Misophonia Scale. Psychiatric Quarterly, 92(2), 609-619. https://doi.org/10.1007/s11126-020-09825-3

Misophonia is a condition of abnormal emotional responses to specific auditory stimuli. There is limited information available on the prevalence of this condition. This study aimed to estimate the prevalence of misophonia in an undergraduate medical... Read More about The Prevalence and Severity of Misophonia in a UK Undergraduate Medical Student Population and Validation of the Amsterdam Misophonia Scale.

WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry (2020)
Preprint / Working Paper
Blake, H., Somerset, S., Whittingham, K., Middleton, M., Yildirim, M., & Evans, C. WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry

Interprofessional learning (IPL) is essential to prepare healthcare trainees as the future public health workforce. WHIRL was an innovative IPL intervention that engaged multi-professional teams of volunteer healthcare trainees (n=20) to deliver heal... Read More about WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry.

Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) (2020)
Journal Article
Drummond, A., Ablewhite, J., Condon, L., das Nair, R., Jones, A., Jones, F., …Thomas, S. (2020). Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2). British Journal of Occupational Therapy, 83(11), 674-679. https://doi.org/10.1177/0308022620944797

Introduction Post-stroke fatigue is common and is one of the most distressing symptoms after stroke. It has a negative impact on physical, social and psychological functioning; it is also associated with poor outcomes and increased mortality. The... Read More about Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2).

Non-negative data-driven mapping of structural connections with application to the neonatal brain (2020)
Journal Article
Thompson, . E., Mohammadi-Nejad, A. R., Robinson, E. C., Andersson, J. L., Jbabdi, S., Glasser, M. F., …Sotiropoulos, S. N. (2020). Non-negative data-driven mapping of structural connections with application to the neonatal brain. NeuroImage, 222, Article 117273. https://doi.org/10.1016/j.neuroimage.2020.117273

© 2020 Mapping connections in the neonatal brain can provide insight into the crucial early stages of neurodevelopment that shape brain organisation and lay the foundations for cognition and behaviour. Diffusion MRI and tractography provide unique op... Read More about Non-negative data-driven mapping of structural connections with application to the neonatal brain.

Combination of dual-energy computed tomography and iterative metal artefact reduction to increase general quality of imaging for radiotherapy patients with high dense materials. Phantom study (2020)
Journal Article
Pawałowski, B., Panek, R., Szweda, H., & Piotrowski, T. (2020). Combination of dual-energy computed tomography and iterative metal artefact reduction to increase general quality of imaging for radiotherapy patients with high dense materials. Phantom study. Physica Medica, 77, 92-99. https://doi.org/10.1016/j.ejmp.2020.08.009

The Benefit of Cross-Modal Reorganization on Speech Perception in Pediatric Cochlear Implant Recipients Revealed Using Functional Near-Infrared Spectroscopy (2020)
Journal Article
Mushtaq, F., Wiggins, I. M., Kitterick, P. T., Anderson, C. A., & Hartley, D. E. H. (2020). The Benefit of Cross-Modal Reorganization on Speech Perception in Pediatric Cochlear Implant Recipients Revealed Using Functional Near-Infrared Spectroscopy. Frontiers in Human Neuroscience, 14, https://doi.org/10.3389/fnhum.2020.00308

Cochlear implants (CIs) are the most successful treatment for severe-to-profound deafness in children. However, speech outcomes with a CI often lag behind those of normally-hearing children. Some authors have attributed these deficits to the takeover... Read More about The Benefit of Cross-Modal Reorganization on Speech Perception in Pediatric Cochlear Implant Recipients Revealed Using Functional Near-Infrared Spectroscopy.

Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future (2020)
Journal Article
Mok, V. C., Pendlebury, S., Wong, A., Alladi, S., Au, L., Bath, P., …Scheltens, P. (2020). Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future. Alzheimer's and Dementia, 16(11), 1571-1581. https://doi.org/10.1002/alz.12143

We have provided an overview on the profound impact of COVID‐19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health‐care settings, including hospital, out‐pat... Read More about Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future.

Maintenance Intravenous Immunoglobulin Treatment for Multiple Sclerosis Coexisting with Ehlers-Danlos Syndrome and Muir-Torre Syndrome: A Case Study (2020)
Journal Article
Gupta, S., Suri, M., & Constantinescu, C. S. (2020). Maintenance Intravenous Immunoglobulin Treatment for Multiple Sclerosis Coexisting with Ehlers-Danlos Syndrome and Muir-Torre Syndrome: A Case Study. Neurology and Therapy, 9(2), 605–610. https://doi.org/10.1007/s40120-020-00209-0

The therapeutic options for disease modification in relapsing-remitting multiple sclerosis (RRMS) have expanded remarkably in the last 15 years. Although intravenous immunoglobulins (IVIg) have shown some therapeutic effects in multiple sclerosis, re... Read More about Maintenance Intravenous Immunoglobulin Treatment for Multiple Sclerosis Coexisting with Ehlers-Danlos Syndrome and Muir-Torre Syndrome: A Case Study.

Seasonal weight changes in laboratory ferrets (2020)
Journal Article
Jones, E. J., Poole, K. C., Sollini, J., Town, S. M., & Bizley, J. K. (2020). Seasonal weight changes in laboratory ferrets. PLoS ONE, 15(8), Article e0232733. https://doi.org/10.1371/journal.pone.0232733

Ferrets (Mustela putorius furo) are a valuable animal model used in biomedical research. Like many animals, ferrets undergo significant variation in body weight seasonally, affected by photoperiod, and these variations complicate the use weight as an... Read More about Seasonal weight changes in laboratory ferrets.

Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study (2020)
Journal Article
Maidment, D., Heyes, R., Gomez, R., Coulson, N. S., Wharrad, H., & Ferguson, M. A. (2020). Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study. JMIR mHealth and uHealth, 8(8), Article e17193. https://doi.org/10.2196/17193

© David W Maidment, Rachel Heyes, Rachel Gomez, Neil S Coulson, Heather Wharrad, Melanie A Ferguson. Background: Adults living with hearing loss have highly variable knowledge of hearing aids, resulting in suboptimal use or nonuse. This issue can be... Read More about Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study.

Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus (2020)
Journal Article
Hockley, A., Berger, J. I., Palmer, A. R., & Wallace, M. N. (2020). Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus. European Journal of Neuroscience, 52(9), 4057-4080. https://doi.org/10.1111/ejn.14913

Previous work has led to the hypothesis that, during the production of noise‐induced tinnitus, higher levels of nitric oxide (NO), in the ventral cochlear nucleus (VCN), increase the gain applied to a reduced input from the cochlea. To test this hypo... Read More about Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus.

Involving the person with dementia in crisis planning: Focus groups with crisis intervention teams (2020)
Journal Article
Bosco, A., Schneider, J., Di Lorito, C., Broome, E., Coleston-Shields, D. M., & Orrell, M. (2020). Involving the person with dementia in crisis planning: Focus groups with crisis intervention teams. International Journal of Environmental Research and Public Health, 17(15), Article 5412. https://doi.org/10.3390/ijerph17155412

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dementia leads to progressive critical situations that can escalate to a crisis episode if not adequately managed. A crisis may also resolve spontaneously, or not resolve after receiving profe... Read More about Involving the person with dementia in crisis planning: Focus groups with crisis intervention teams.

Association between Hyperacusis and Tinnitus (2020)
Journal Article
Cederroth, C. R., Lugo, A., Edvall, N. K., Lazar, A., Lopez-Escamez, J.-A., Bulla, J., …Gallus, S. (2020). Association between Hyperacusis and Tinnitus. Journal of Clinical Medicine, 9(8), Article 2412. https://doi.org/10.3390/jcm9082412

Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of... Read More about Association between Hyperacusis and Tinnitus.

Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era (2020)
Journal Article
Lawrence, R. J., O'Donoghue, G., Kitterick, P., O'Donoghue, K., Hague, R., Mitchell, L., …Hartley, D. E. (2020). Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era. Laryngoscope, 130(11), 2693-2699. https://doi.org/10.1002/lary.29014

© 2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA) Objectives/Hypothesis: The overall aim of this study was to evaluate personal protective equipment (PPE)... Read More about Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era.

Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study (2020)
Journal Article
Safavi, S., Arthofer, C., Cooper, A., Harkin, J. W., Prayle, A. P., Sovani, M. P., …Hall, I. P. (2020). Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study. European Journal of Radiology, 130, Article 109196. https://doi.org/10.1016/j.ejrad.2020.109196

Purpose The diaphragm is the most important muscle of respiration. Disorders of the diaphragm can have a deleterious impact on respiratory function. We aimed to evaluate the use of an open-configuration upright low-field MRI system to assess diaphra... Read More about Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study.

Exploring tinnitus heterogeneity (2020)
Book Chapter
Beukes, E. W., Manchaiah, V., Allen, P. M., Andersson, G., & Baguley, D. M. (2021). Exploring tinnitus heterogeneity. In Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: From Heterogeneity to Personalized Medicine (79-99). Elsevier. https://doi.org/10.1016/bs.pbr.2020.05.022

Introduction: Tinnitus experiences differ widely. A greater understanding of the core processes underlying these variations is needed. Moreover, meaningful definitions for different subgroups are required to better manage this heterogeneous populatio... Read More about Exploring tinnitus heterogeneity.

A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF) (2020)
Journal Article
Gillies, M., Ghaffar, S., Moppett, I., Docherty, A., Clarke, S., Rea, N., …Walsh, T. (2021). A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF). British Journal of Anaesthesia, 126(1), 77-86. https://doi.org/10.1016/j.bja.2020.06.048

Background The optimum transfusion strategy in patients with fractured neck of femur is uncertain, particularly if there is coexisting cardiovascular disease. Methods We conducted a prospective, single-centre, randomised feasibility trial of tw... Read More about A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF).

Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis (2020)
Journal Article
Aram, J., Frakich, N., Morandi, E., Alrouji, M., Samaraweera, A., Onion, D., …Constantinescu, C. S. (2020). Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis. Biomedicines, 8(7), Article 226. https://doi.org/10.3390/BIOMEDICINES8070226

© 2020 by the authors. Granulocyte macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine produced by immune cells. Recent evidence suggests that GM-CSF plays an important role in multiple sclerosis (MS) pathogenesis. We investi... Read More about Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis.

The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus (2020)
Journal Article
Taylor, J. A., Thompson, D. M., Hall, D. A., Walker, D., McMurran, M., Casey, A., …Hoare, D. J. (2020). The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus. International Journal of Audiology, 59(12), 905-914. https://doi.org/10.1080/14992027.2020.1788730

Objective: To develop a manualised psychological treatment for tinnitus that could enhance audiologist usual care, and to test feasibility of evaluating it in a randomised controlled trial. Design: Feasibility trial, random allocation of patients to... Read More about The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus.