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The just-noticeable difference in speech-to-noise ratio (2015)
Journal Article
McShefferty, D., Whitmer, W. M., & Akeroyd, M. A. (2015). The just-noticeable difference in speech-to-noise ratio. Trends in Hearing, 19(1), https://doi.org/10.1177/2331216515572316

Just-noticeable differences (JNDs) have been measured for various features of sounds, but despite its importance to communication, there is no benchmark for what is a just-noticeable—and possibly meaningful—difference in speech-to-noise ratio (SNR).... Read More about The just-noticeable difference in speech-to-noise ratio.

Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil–DNA glycosylase impair learning in a mouse model of vascular cognitive impairment (2015)
Journal Article
Jadavji, N. M., Farr, T. D., Lips, J., Khalil, A. A., Boehm-Sturm, P., Foddis, M., …Dirnagl, U. (2015). Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil–DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behavioural Brain Research, 283, https://doi.org/10.1016/j.bbr.2015.01.040

Dietary deficiencies in folic acid result in elevated levels of plasma homocysteine, which has been associated with the development of dementia and other neurodegenerative disorders. Previously, we have shown that elevated levels of plasma homocystei... Read More about Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil–DNA glycosylase impair learning in a mouse model of vascular cognitive impairment.

Do orally administered antibiotics reach concentrations in the middle ear sufficient to eradicate planktonic and biofilm bacteria?: a review (2015)
Journal Article
Belfield, K., Bayston, R., Birchall, J., & Daniel, M. (2015). Do orally administered antibiotics reach concentrations in the middle ear sufficient to eradicate planktonic and biofilm bacteria?: a review. International Journal of Pediatric Otorhinolaryngology, 79(3), 296-300. https://doi.org/10.1016/j.ijporl.2015.01.003

INTRODUCTION: Infectious conditions of the middle ear are a common and significant cause of morbidity and mortality worldwide. Systemic antibiotics are frequently used, but their effectiveness will depend on whether an adequate antibiotic concentrat... Read More about Do orally administered antibiotics reach concentrations in the middle ear sufficient to eradicate planktonic and biofilm bacteria?: a review.

Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial (2015)
Journal Article

Background: Poor prognosis after intracerebral haemorrhage (ICH) is related to haemorrhage characteristics. Along with developing therapeutic interventions, we sought to understand the performance of haemorrhage descriptors in large clinical trials.... Read More about Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial.

Hyperpolarization methods for MRS (2015)
Journal Article
Goodson, B. M., Whiting, N., Coffey, A. M., Nikolaou, P., Shi, F., Gust, B. M., …Chekmenev, E. Y. (2015). Hyperpolarization methods for MRS. https://doi.org/10.1002/9780470034590.emrstm1457

© 2015 John Wiley & Sons, Ltd. This article covers the fundamental principles and practice of NMR hyperpolarization techniques, which are proving useful for in vivo magnetic resonance spectroscopy (MRS) studies of metabolism in animal models, and c... Read More about Hyperpolarization methods for MRS.

PAMFix, a fixative developed to enable remote platelet function testing: uses and applications (2015)
Journal Article
Heptinstall, S., Fox, S., May, J., White, A., & Dovlatova, N. (2015). PAMFix, a fixative developed to enable remote platelet function testing: uses and applications. Current Topics in Pharmacology, 19,

PAMFix is a fixative that was developed to stabilise the platelet biomarker P-selectin on activated platelets. Stabilisation of this biomarker introduced the possibility of performing measurements of platelet function remotelywhere there was no acces... Read More about PAMFix, a fixative developed to enable remote platelet function testing: uses and applications.

Pharyngeal electrical stimulation for treatment of poststroke dysphagia: individual patient data meta-analysis of randomised controlled trials (2015)
Journal Article
Scutt, P., Lee, H. S., Hamdy, S., & Bath, P. M. (2015). Pharyngeal electrical stimulation for treatment of poststroke dysphagia: individual patient data meta-analysis of randomised controlled trials. Stroke Research and Treatment, 2015, Article 429053. https://doi.org/10.1155/2015/429053

Background. Dysphagia after stroke is common, associated independently with poor outcome, and has limited treatment options. Pharyngeal electrical stimulation (PES) is a novel treatment being evaluated for treatment of poststroke dysphagia. Methods.... Read More about Pharyngeal electrical stimulation for treatment of poststroke dysphagia: individual patient data meta-analysis of randomised controlled trials.

Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial (2014)
Journal Article
Bath, P. M., Robson, K., Woodhouse, L. J., Sprigg, N., Dineen, R. A., & Pocock, S. J. (2015). Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial. International Journal of Stroke, 10(3), https://doi.org/10.1111/ijs.12445

Rationale: Antiplatelet agents such as aspirin, clopidogrel and dipyridamole are effective in reducing the risk of recurrence after a stroke. Importantly, the risk of recurrence is highest immediately after the index event while antiplatelets cause b... Read More about Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial.

Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes (2014)
Journal Article
Funk, A. M., Finney, K.-L. N. A., Harvey, P., Kenwright, A. M., Neil, E. R., Rogers, N. J., …Parker, D. (2014). Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes. Chemical Science, 6(3), 1655-1662. https://doi.org/10.1039/c4sc03429e

The origins of the breakdown of Bleaney's theory of magnetic anisotropy are described, based on an analysis of eleven different complexes of the second half of the 4f elements that form isostructural series. An examination of the chemical shift and r... Read More about Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes.

Alterations in effective connectivity anchored on the insula in major depressive disorder (2014)
Journal Article
Iwabuchi, S. J., Peng, D., Fang, Y., Jiang, K., Liddle, E. B., Liddle, P. F., & Palaniyappan, L. (2014). Alterations in effective connectivity anchored on the insula in major depressive disorder. European Neuropsychopharmacology, 24(11), 1784-1792. https://doi.org/10.1016/j.euroneuro.2014.08.005

Recent work has identified disruption of several brain networks involving limbic and cortical regions that contribute to the generation of diverse symptoms of major depressive disorder (MDD). Of particular interest are the networks anchored on the ri... Read More about Alterations in effective connectivity anchored on the insula in major depressive disorder.

Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis (2014)
Journal Article
Welton, T., Kent, D., Constantinescu, C. S., Auer, D. P., & Dineen, R. A. (2015). Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis. Radiology, 275(1), 89-96. https://doi.org/10.1148/radiol.14140925

Purpose To identify statistical consensus between published studies for distribution and functional relevance of tract white matter (WM) degradation in multiple sclerosis (MS). Materials and Methods By systematically searching online databases... Read More about Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis.

White matter microstructure pathology in classic galactosemia revealed by neurite orientation dispersion and density imaging (2014)
Journal Article
Timmers, I., Zhang, H., Bastiani, M., Jansma, B. M., Roebroeck, A., & Rubio-Gozalbo, M. E. (2015). White matter microstructure pathology in classic galactosemia revealed by neurite orientation dispersion and density imaging. Journal of Inherited Metabolic Disease, 38(2), 295-304. https://doi.org/10.1007/s10545-014-9780-x

White matter abnormalities have been observed in patients with classic galactosemia, an inborn error of galactose metabolism. However, magnetic resonance imaging (MRI) data collected in the past were generally qualitative in nature. Our objective was... Read More about White matter microstructure pathology in classic galactosemia revealed by neurite orientation dispersion and density imaging.

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial (2014)
Journal Article
Bath, P. M. (2015). Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet, 385(9968), https://doi.org/10.1016/S0140-6736%2814%2961121-1

Background High blood pressure is associated with poor outcome after stroke. Whether blood pressure should be lowered early after stroke, and whether to continue or temporarily withdraw existing antihypertensive drugs, is not known. We assessed ou... Read More about Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial.

Searching for a talking face: The effect of degrading the auditory signal (2014)
Journal Article
Stacey, P. C., Murphy, T., Sumner, C. J., Kitterick, P. T., & Roberts, K. L. (2014). Searching for a talking face: The effect of degrading the auditory signal. Journal of Experimental Psychology: Human Perception and Performance, 40(6), 2106-2111. https://doi.org/10.1037/a0038220

Previous research (e.g., McGurk & MacDonald, 1976) suggests that faces and voices are bound automatically, but recent evidence suggests that attention is involved in a task of searching for a talking face (Alsius & Soto-Faraco, 2011). We hypothesized... Read More about Searching for a talking face: The effect of degrading the auditory signal.

Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model (2014)
Journal Article
Sidney, L. E., Heathman, T. R., Britchford, E., Abed, A. A., Rahman, C. V., & Buttery, L. D. (2015). Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model. Tissue Engineering Part A, 21(1-2), 362-373. https://doi.org/10.1089/ten.tea.2014.0100

Nonunion fractures and large bone defects are significant targets for osteochondral tissue engineering strategies. A major hurdle in the use of these therapies is the foreign body response of the host. Herein, we report the development of a bone tiss... Read More about Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model.

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells (2014)
Journal Article
Hartmann, F. J., Khademi, M., Aram, J., Ammann, S., Kockum, I., Constantinescu, C., …Becher, B. (2014). Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells. Nature Communications, 5, Article 5056. https://doi.org/10.1038/ncomms6056

© 2014 Macmillan Publishers Limited. All rights reserved. Genome-wide association studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T helper (TH) cell... Read More about Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells.

In vivo Magnetic Resonance Imaging of Tumor Protease Activity (2014)
Journal Article
Haris, M., Singh, A., Mohammed, I., Ittyerah, R., Nath, K., Nanga, R. P. R., …Reddy, R. (2015). In vivo Magnetic Resonance Imaging of Tumor Protease Activity. Scientific Reports, 4(1), Article 6081. https://doi.org/10.1038/srep06081

Increased expression of cathepsins has diagnostic as well as prognostic value in several types of cancer. Here, we demonstrate a novel magnetic resonance imaging (MRI) method, which uses poly-L-glutamate (PLG) as an MRI probe to map cathepsin express... Read More about In vivo Magnetic Resonance Imaging of Tumor Protease Activity.