Boyd M. Goodson
Hyperpolarization methods for MRS
Goodson, Boyd M.; Whiting, Nicholas; Coffey, Aaron M.; Nikolaou, Panayiotis; Shi, Fan; Gust, Brogan M.; Gemeinhardt, Max E.; Shchepin, Roman V.; Skinner, Jason G.; Birchall, Jonathan R.; Barlow, Michael J.; Chekmenev, Eduard Y.
Authors
Nicholas Whiting
Aaron M. Coffey
Panayiotis Nikolaou
Fan Shi
Brogan M. Gust
Max E. Gemeinhardt
Roman V. Shchepin
Jason G. Skinner
Jonathan R. Birchall
Michael J. Barlow
Eduard Y. Chekmenev
Contributors
Paul A. Bottomley
Editor
John R. Griffiths
Editor
Abstract
© 2015 John Wiley & Sons, Ltd. This article covers the fundamental principles and practice of NMR hyperpolarization techniques, which are proving useful for in vivo magnetic resonance spectroscopy (MRS) studies of metabolism in animal models, and clinical trials with hyper-enhanced sensitivity. Fundamentally, hyperpolarization methods enhance nuclear spin polarization by orders-of-magnitude, resulting in concomitant improvement in NMR detection sensitivity. The hyperpolarization methods described here - dynamic nuclear polarization (DNP), para-hydrogen induced polarization (PHIP), signal amplification by reversible exchange (SABRE), and spin-exchange optical pumping (SEOP) - are capable of achieving nuclear spin polarization approaching the theoretical maximum of unity on nuclear spin sites of molecular or atomic agents suitable for in vivo administration. Importantly, hyperpolarization is inherently nonequilibrium in nature: The duration of the hyperpolarization is frequently shortlived, often being limited by the in vivo spin-lattice relaxation times (T 1) that are on the order of seconds to a minute. Nevertheless, sufficient amounts of nuclear spin polarization can survive the process of preparation, administration, and in vivo circulation to provide extraordinary enhancement of the hyperpolarized agent. The chemical shift dispersion of these agents at the molecular location of interest reports on functional, metabolic, and other processes at the molecular level, enabling true molecular MRS imaging.
Citation
Goodson, B. M., Whiting, N., Coffey, A. M., Nikolaou, P., Shi, F., Gust, B. M., …Chekmenev, E. Y. (2015). Hyperpolarization methods for MRS. https://doi.org/10.1002/9780470034590.emrstm1457
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 5, 2015 |
Online Publication Date | Dec 15, 2015 |
Publication Date | Jan 1, 2015 |
Deposit Date | Oct 3, 2018 |
Publicly Available Date | Oct 3, 2018 |
Journal | eMagRes |
Electronic ISSN | 2055-6101 |
Publisher | Wiley |
Volume | 4 |
Issue | 4 |
Pages | 797-810 |
Series Title | eMagRes Books |
Series Number | 4 |
Book Title | Handbook of Magnetic Resonance Spectroscopy In Vivo: MRS Theory, Practice and Applications |
Chapter Number | 33 |
ISBN | 9780470034590; 9780470058213 |
DOI | https://doi.org/10.1002/9780470034590.emrstm1457 |
Public URL | https://nottingham-repository.worktribe.com/output/1144785 |
Additional Information | © 2016 John Wiley & Sons, Ltd. https://www.wiley.com/en-us/Handbook+of+Magnetic+Resonance+Spectroscopy+In+Vivo%3A+MRS+Theory%2C+Practice+and+Applications-p-9781118997666 |
Contract Date | Oct 3, 2018 |
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